The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Injectable hydrogel microbeads for fluorescence-based in vivo continuous glucose monitoring
Open accessAbstract
Fluorescent microbeads hold great promise for in vivo continuous glucose monitoring with wireless transdermal transmission and long-lasting activity. The full potential of fluorescent microbeads has yet to be realized due to insufficient intensity for transdermal transmission and material toxicity. This paper illustrates the highly-sensitive, biostable, long-lasting, and injectable fluorescent microbeads for in vivo continuous glucose monitoring. We synthesized a fluorescent monomer composed of glucose-recognition sites, a fluorogenic site, spacers, and polymerization sites. The spacers are designed to be long and hydrophilic for increasing opportunities to bind glucose molecules; consequently, the fluorescent monomers enable high-intensive responsiveness to glucose. We then fabricated injectable-sized fluorescent polyacrylamide hydrogel beads with high uniformity and high throughput. We found that our fluorescent beads provide sufficient intensity to transdermally monitor glucose concentrations in vivo. The fluorescence intensity successfully traced the blood glucose concentration fluctuation, indicating our method has potential uses in highly-sensitive and minimally invasive continuous blood glucose monitoring.
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Cites
Biochemistry and molecular cell biology of diabetic complications
Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107
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BackgroundEnzyme-Based Biosensors for in Vivo Measurements
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Cited by
Liu, X., Liu, J., Lin, S., & Zhao, X. (2020) · Materials Today · doi:10.1016/j.mattod.2019.12.026 · Cited by 1,023
Hydrogels as intelligent materials: A brief review of synthesis, properties and applications
Mahinroosta, M., Jomeh Farsangi, Z., Allahverdi, A., & Shakoori, Z. (2018) · Materials Today Chemistry · doi:10.1016/j.mtchem.2018.02.004 · Cited by 551
Hydrogel Based Sensors for Biomedical Applications: An Updated Review
Tavakoli, J., & Tang, Y. (2017) · Polymers · doi:10.3390/polym9080364 · Cited by 434
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Glucose Sensing in Supramolecular Chemistry
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Metadata
- Authors
- Shibata, H., Heo, Y. J., Okitsu, T., Matsunaga, Y., Kawanishi, T., & Takeuchi, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2010-10-04
- Volume
- 107
- Issue
- 42
- Pages
- 17894-17898
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2027544789
- Cited by
- 287
- References
- 4
- FWCI
- 5.50
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Shibata, H., Heo, Y. J., Okitsu, T., Matsunaga, Y., Kawanishi, T., & Takeuchi, S. (2010). Injectable hydrogel microbeads for fluorescence-based in vivo continuous glucose monitoring. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1006911107
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