The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Active scaffolds for on-demand drug and cell delivery
Open accessAbstract
Porous biomaterials have been widely used as scaffolds in tissue engineering and cell-based therapies. The release of biological agents from conventional porous scaffolds is typically governed by molecular diffusion, material degradation, and cell migration, which do not allow for dynamic external regulation. We present a new active porous scaffold that can be remotely controlled by a magnetic field to deliver various biological agents on demand. The active porous scaffold, in the form of a macroporous ferrogel, gives a large deformation and volume change of over 70% under a moderate magnetic field. The deformation and volume variation allows a new mechanism to trigger and enhance the release of various drugs including mitoxantrone, plasmid DNA, and a chemokine from the scaffold. The porous scaffold can also act as a depot of various cells, whose release can be controlled by external magnetic fields.
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Cites
Hydrogels for tissue engineering: scaffold design variables and applications
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Self-citationHydrogels in Biology and Medicine: From Molecular Principles to Bionanotechnology
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Ultra-large-scale syntheses of monodisperse nanocrystals
Park, J., An, K., Hwang, Y., Park, J.-G., Noh, H.-J., Kim, J.-Y., Park, J.-H., Hwang, N.-M., & Hyeon, T. (2004) · Nature Materials · doi:10.1038/nmat1251 · Cited by 4,076
Self-citationLanger, R. (1990) · Science · doi:10.1126/science.2218494 · Cited by 1,778
Cited by
Advances in engineering hydrogels
Zhang, Y. S., & Khademhosseini, A. (2017) · Science · doi:10.1126/science.aaf3627 · Cited by 2,908
Engineered Nanoparticles for Drug Delivery in Cancer Therapy
Sun, T., Zhang, Y. S., Pang, B., Hyun, D. C., Yang, M., & Xia, Y. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201403036 · Cited by 2,164
Liu, X., Liu, J., Lin, S., & Zhao, X. (2020) · Materials Today · doi:10.1016/j.mattod.2019.12.026 · Cited by 1,023
Self-citationFunctional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment
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Self-citationMagnetic Hydrogels and Their Potential Biomedical Applications
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Metadata
- Authors
- Zhao, X., Kim, J., Cezar, C. A., Huebsch, N., Lee, K., Bouhadir, K., & Mooney, D. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2010-12-13
- Volume
- 108
- Issue
- 1
- Pages
- 67-72
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W4231516524
- Cited by
- 644
- References
- 4
- FWCI
- 11.93
- Type
- journal article
- Language
- en
- Open access
- green
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- Zhao, X., Kim, J., Cezar, C. A., Huebsch, N., Lee, K., Bouhadir, K., & Mooney, D. J. (2011). Active scaffolds for on-demand drug and cell delivery. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1007862108
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