The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Direct involvement of σ-1 receptors in the dopamine D 1 receptor-mediated effects of cocaine
Open accessAbstract
It is well known that cocaine blocks the dopamine transporter. This mechanism should lead to a general increase in dopaminergic neurotransmission, and yet dopamine D 1 receptors (D 1 Rs) play a more significant role in the behavioral effects of cocaine than the other dopamine receptor subtypes. Cocaine also binds to σ-1 receptors, the physiological role of which is largely unknown. In the present study, D 1 R and σ 1 R were found to heteromerize in transfected cells, where cocaine robustly potentiated D 1 R-mediated adenylyl cyclase activation, induced MAPK activation per se and counteracted MAPK activation induced by D 1 R stimulation in a dopamine transporter-independent and σ 1 R-dependent manner. Some of these effects were also demonstrated in murine striatal slices and were absent in σ 1 R KO mice, providing evidence for the existence of σ 1 R-D 1 R heteromers in the brain. Therefore, these results provide a molecular explanation for which D 1 R plays a more significant role in the behavioral effects of cocaine, through σ 1 R-D 1 R heteromerization, and provide a unique perspective toward understanding the molecular basis of cocaine addiction.
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Citations
Cites
Compulsive Drug‐Seeking Behavior and Relapse: Neuroadaptation, Stress, and Conditioning Factors
WEISS, F., CICCOCIOPPO, R., PARSONS, L. H., KATNER, S., LIU, X., ZORRILLA, E. P., VALDEZ, G. R., BEN‐SHAHAR, O., ANGELETTI, S., & RICHTER, R. R. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb03556.x · Cited by 430
Cited by
Pharmacology of Adenosine Receptors: The State of the Art
Borea, P. A., Gessi, S., Merighi, S., Vincenzi, F., & Varani, K. (2018) · Physiological Reviews · doi:10.1152/physrev.00049.2017 · Cited by 783
The Sigma-1 Receptor as a Pluripotent Modulator in Living Systems
Su, T.-P., Su, T.-C., Nakamura, Y., & Tsai, S.-Y. (2016) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2016.01.003 · Cited by 320
The sigma-1 receptor: roles in neuronal plasticity and disease
Kourrich, S., Su, T.-P., Fujimoto, M., & Bonci, A. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.09.007 · Cited by 245
The Molecular Function of σ Receptors: Past, Present, and Future
Schmidt, H. R., & Kruse, A. C. (2019) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2019.07.006 · Cited by 177
Zhang, C.-L., Feng, Z.-J., Liu, Y., Ji, X.-H., Peng, J.-Y., Zhang, X.-H., Zhen, X.-C., & Li, B.-M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051910 · Cited by 41
Metadata
- Authors
- Navarro, G., Moreno, E., Aymerich, M., Marcellino, D., McCormick, P. J., Mallol, J., Cortés, A., Casadó, V., Canela, E. I., Ortiz, J., Fuxe, K., Lluís, C., Ferré, S., & Franco, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2010-10-18
- Volume
- 107
- Issue
- 43
- Pages
- 18676-18681
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2088872562
- Cited by
- 171
- References
- 1
- FWCI
- 3.43
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Navarro, G., Moreno, E., Aymerich, M., Marcellino, D., McCormick, P. J., Mallol, J., Cortés, A., Casadó, V., Canela, E. I., Ortiz, J., Fuxe, K., Lluís, C., Ferré, S., & Franco, R. (2010). Direct involvement of σ-1 receptors in the dopamine D 1 receptor-mediated effects of cocaine. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1008911107
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