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The Molecular Function of σ Receptors: Past, Present, and Future

Schmidt, Hayden R., Kruse, Andrew C.·2019·Trends in Pharmacological Sciences
DOI 10.1016/j.tips.2019.07.006PMC PMC6748033
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  • The crystal structure added additional confirmation that S2R is structurally distinct from the sigma-1 receptor.

    “This crystal structure also added additional confirmation that S2R is structurally distinct from the sigma-1 receptor [16,61,68].”

    From Sigma-2 Receptors—From Basic Biology to Therapeutic Target: A Focus on Age-Related Degenerative Diseases (2023) · cites this paper as [16]

  • Reduction or ablation of S2R activity was observed when TMEM97 expression was reduced or absent in calf liver cells or human cervical cancer cells.

    “This was confirmed in pharmacological studies assessing the activity of S2R ligands where reduction, or ablation, of S2R activity was observed when TMEM97 expression was reduced, or absent, in calf liver cells [16,61] or human cervical cancer cells [66], respectively.”

    From Sigma-2 Receptors—From Basic Biology to Therapeutic Target: A Focus on Age-Related Degenerative Diseases (2023) · cites this paper as [16]

  • Sigma-2 receptors have been studied for more than four decades and are drug targets for several conditions including cancer, pain and diverse CNS disorders.

    “Sigma-2 receptors have been studied for more than four decades and are drug targets for several conditions including cancer, pain and diverse CNS disorders [22, 58]; and most notably, a Sigma-2 modulator, CT1812, is in clinical development in Phase 2 trials for Alzheimer’s disease and dementia with Lewy bodies [11, 21].”

    From Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer’s disease (2024) · cites this paper as [58]

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Metadata

Authors
Schmidt, H. R., & Kruse, A. C.
ORCID
Venue
Trends in Pharmacological Sciences
Publisher
Elsevier BV
Published
2019-09
Volume
40
Issue
9
Pages
636-654
ISSN
0165-6147
DOI
10.1016/j.tips.2019.07.006
PMC
PMC6748033
Cited by
177
References
8
Language
en
Licence
Funders
  • National Science Foundation (DGE1745303)
  • National Institutes of Health (R01GM119185)

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