The sigma-1 receptor: roles in neuronal plasticity and disease

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MAM: more than just a housekeeper

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The pharmacology of sigma-1 receptors.

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The Hallucinogen <i>N,N</i> -Dimethyltryptamine (DMT) Is an Endogenous Sigma-1 Receptor Regulator

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The sigma-1 receptor chaperone as an inter-organelle signaling modulator

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A mutation in sigma‐1 receptor causes juvenile amyotrophic lateral sclerosis

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Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site

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Neuroactive steroid regulation of neurotransmitter release in the CNS: Action, mechanism and possible significance

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Plasticity of intrinsic neuronal properties in CNS disorders

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N-methyl-D-aspartate-induced neuronal activation is selectively modulated by σ receptors

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The interaction between neuroactive steroids and the σ1 receptor function: behavioral consequences and therapeutic opportunities

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Targeting ligand-operated chaperone sigma-1 receptors in the treatment of neuropsychiatric disorders

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Sigma nonopioid intracellular receptor 1 mutations cause frontotemporal lobar degeneration–motor neuron disease

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Intracellular Dynamics of σ-1 Receptors (σ1 Binding Sites) in NG108-15 Cells

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The sigma‐1 receptor modulates NMDA receptor synaptic transmission and plasticity via SK channels in rat hippocampus

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The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke

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Low density of sigma1 receptors in early Alzheimer’s disease

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Direct involvement of σ-1 receptors in the dopamine D 1 receptor-mediated effects of cocaine

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Sigma-1 receptors regulate hippocampal dendritic spine formation via a free radical-sensitive mechanism involving Rac1·GTP pathway

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Selective loss of cerebral cortical Sigma, but not PCP binding sites in schizophrenia

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Sigma-1 Receptors Bind Cholesterol and Remodel Lipid Rafts in Breast Cancer Cell Lines

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Opipramol for the Treatment of Generalized Anxiety Disorder: A Placebo-Controlled Trial Including an Alprazolam-Treated Group

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Involvement of sigma (σ) receptors in the acute actions of methamphetamine: Receptor binding and behavioral studies

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Sigma-1 Receptor Regulation of Voltage-Gated Calcium Channels Involves a Direct Interaction

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Dendritic ion channel trafficking and plasticity

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Signaling complexes of voltage-gated sodium and calcium channels

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Variability in the subcellular distribution of ion channels increases neuronal diversity

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ς1 Receptor Modulation of Opioid Analgesia in the Mouse

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Sigma receptors: Potential targets for a new class of antidepressant drug

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Chronic antidepressants potentiate via sigma-1 receptors the brain-derived neurotrophic factor-induced signaling for glutamate release

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Activation of the spinal sigma‐1 receptor enhances NMDA‐induced pain via PKC‐ and PKA‐dependent phosphorylation of the NR1 subunit in mice

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Molecular mechanisms involving sigma receptor–mediated induction of MCP-1: implication for increased monocyte transmigration

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Evolution of the Human Ion Channel Set

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Ion channels and lymphocyte activation

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Sigma‐1 and Sigma‐2 sites in rat brain: Comparison of regional, ontogenetic, and subcellular patterns

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Membrane‐delimited coupling between sigma receptors and K+ channels in rat neurohypophysial terminals requires neither G‐protein nor ATP

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New Insights into the Role of Mitochondria-Associated Endoplasmic Reticulum Membrane

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Expression of the purported sigma1 (σ1) receptor in the mammalian brain and its possible relevance in deficits induced by antagonism of the NMDA receptor complex as revealed using an antisense strategy

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Voltage-gated sodium channel modulation by σ-receptors in cardiac myocytes and heterologous systems

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Fluvoxamine augmentation of antipsychotics improves negative symptoms in psychotic chronic schizophrenic patients: a placebo-controlled study

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Dextromethorphan: A Review of N‐methyl‐ d ‐aspartate Receptor Antagonist in the Management of Pain

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σ-1 Receptor Modulation of Acid-Sensing Ion Channel a (ASIC1a) and ASIC1a-Induced Ca2+ Influx in Rat Cortical Neurons

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Cocaine Hijacks σ1 Receptor to Initiate Induction of Activated Leukocyte Cell Adhesion Molecule: Implication for Increased Monocyte Adhesion and Migration in the CNS

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Sigma 1 receptor-related neuroactive steroids modulate cocaine-induced reward.

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Sigma ligands indirectly modulate the NMDA receptor-ion channel complex on intact neuronal cells via sigma 1 site

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Therapeutic Effects of Systemic Administration of Chaperone αB-Crystallin Associated with Binding Proinflammatory Plasma Proteins*

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A Presynaptic Action of the Neurosteroid Pregnenolone Sulfate on GABAergic Synaptic Transmission

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Dextromethorphan as a Potential Neuroprotective Agent With Unique Mechanisms of Action

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σ Receptor Activation Blocks Potassium Channels and Depresses Neuroexcitability in Rat Intracardiac Neurons

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Fluvoxamine alone in the treatment of delusional depression

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Development of the sigma-1 receptor in C-terminals of motoneurons and colocalization with the N,N′-dimethyltryptamine forming enzyme, indole-N-methyl transferase

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Expression of a Truncated Form of the Endoplasmic Reticulum Chaperone Protein, σ1 Receptor, Promotes Mitochondrial Energy Depletion and Apoptosis

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Cocaine and σ-1 receptors modulate HIV infection, chemokine receptors, and the HPA axis in the huPBL-SCID model

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The σ-Receptor Antagonist BD-1063 Decreases Ethanol Intake and Reinforcement in Animal Models of Excessive Drinking

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Sigma-1 receptor stimulation by dehydroepiandrosterone ameliorates cognitive impairment through activation of CaM kinase II, protein kinase C and extracellular signal-regulated kinase in olfactory bulbectomized mice

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Sig1R Protein Regulates hERG Channel Expression through a Post-translational Mechanism in Leukemic Cells

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Modification of the N-methyl-D-aspartate response by antidepressant σ receptor ligands

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Demonstration of a Direct Interaction between σ-1 Receptors and Acid-Sensing Ion Channels

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Neurosteroid dehydroepiandrosterone sulphate inhibits persistent sodium currents in rat medial prefrontal cortex via activation of sigma-1 receptors

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Cholesterol at the Endoplasmic Reticulum: Roles of the Sigma-1 Receptor Chaperone and Implications thereof in Human Diseases

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Selective serotonin re-uptake inhibitor augmentation in the treatment of negative symptoms of schizophrenia

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Steroid pregnenolone sulfate enhances NMDA‐receptor‐independent long‐term potentiation at hippocampal CA1 synapses: Role for L‐type calcium channels and sigma‐receptors

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An increase in spinal dehydroepiandrosterone sulfate (DHEAS) enhances NMDA-induced pain via phosphorylation of the NR1 subunit in mice: Involvement of the sigma-1 receptor

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Juxtaposition of the Steroid Binding Domain-like I and II Regions Constitutes a Ligand Binding Site in the σ-1 Receptor

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Sigma-1 receptor alters the kinetics of Kv1.3 voltage gated potassium channels but not the sensitivity to receptor ligands

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A Variant of the Sigma Receptor Type-1 Gene Is a Protective Factor for Alzheimer Disease

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Further evidence for an antidepressant potential of the selective σ1 agonist SA 4503: electrophysiological, morphological and behavioural studies

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Antidepressant Treatment of Psychotic Major Depression: Potential Role of the σ Receptor

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Targeting sigma-1 receptor signaling by endogenous ligands for cardioprotection

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Cocaine Up-Regulates Fra-2 and σ-1 Receptor Gene and Protein Expression in Brain Regions Involved in Addiction and Reward

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Biphasic effects of sigma ligands on the neuronal response to N-methyl-D-aspartate

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Distinct modulatory roles of sigma receptor subtypes on glutamatergic responses in the dorsal hippocampus

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Preserved sigma1 (σ1) receptor expression and behavioral efficacy in the aged C57BL/6 mouse

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Alterations in Fos-Related Antigen 2 and σ1 Receptor Gene and Protein Expression Are Associated with the Development of Cocaine-Induced Behavioral Sensitization: Time Course and Regional Distribution Studies

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Sigma receptors in schizophrenic cerebral cortices

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Organisation of potassium channels on the neuronal surface

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Sigma Receptor Type 1 Gene Variation in a Group of Polish Patients with Alzheimer’s Disease and Mild Cognitive Impairment

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Protein Kinase A Activation Down-Regulates, Whereas Extracellular Signal-Regulated Kinase Activation Up-Regulates σ-1 Receptors in B-104 Cells: Implication for Neuroplasticity

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Fluvoxamine as a sigma-1 receptor agonist improved cognitive impairments in a patient with schizophrenia

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Age-related changes of the binding of [3H]SA4503 to sigma1 receptors in the rat brain

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MS-377, a novel selective σ1 receptor ligand, reverses phencyclidine-induced release of dopamine and serotonin in rat brain

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Sigma1 receptor antagonists determine the behavioral pattern of the methamphetamine-induced stereotypy in mice

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Sigma receptor activation inhibits voltage-gated sodium channels in rat intracardiac ganglion neurons.

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Regulation of Ionotropic Glutamate Receptor Subunits in Different Rat Brain Areas by a Preferential Sigma1 Receptor Ligand and Potential Atypical Antipsychotic

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Patterns of symptom improvement during antidepressant treatment of delusional depression

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A Variant of the Sigma Receptor Type-1 Gene Is a Protective Factor for Alzheimer Disease

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No Association Found between the Type 1 Sigma Receptor Gene Polymorphisms and Methamphetamine Abuse in the Japanese Population: A Collaborative Study by the Japanese Genetics Initiative for Drug Abuse

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Fluvoxamine improved cognitive impairments in a patient with schizophrenia

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In-hospital adverse clinical outcomes of ST elevation myocardial infarction patients with renal dysfunction. Insights from the Saudi Project for Assessment of Coronary Events.

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Psychedelics and Neuroplasticity: A Systematic Review Unraveling the Biological Underpinnings of Psychedelics.

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Neuropharmacology of N,N-dimethyltryptamine

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Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms

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Sigma-1 Receptor Expression in Sensory Neurons and the Effect of Painful Peripheral Nerve Injury

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Administration of N,N-dimethyltryptamine (DMT) in psychedelic therapeutics and research and the study of endogenous DMT

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Dextromethorphan-bupropion (Auvelity) for the Treatment of Major Depressive Disorder

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Sigma-1 receptor: a potential therapeutic target for traumatic brain injury

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Sigma-1 receptor and seizures

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The sigma–1 receptor: a mechanistically–informed therapeutic target for antidepressants

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Detection and quantification of endoplasmic reticulum stress in living cells using the fluorescent compound, Thioflavin T

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The smooth endoplasmic reticulum in neurohypophysial axons of the rat: Possible involvement in transport, storage and release of neurosecretory material

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