The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Promotion of direct reprogramming by transformation-deficient Myc
Open accessAbstract
Induced pluripotent stem cells (iPSCs) are generated from mouse and human fibroblasts by the introduction of three transcription factors: Oct3/4, Sox2, and Klf4. The proto-oncogene product c-Myc markedly promotes iPSC generation, but also increases tumor formation in iPSC-derived chimeric mice. We report that the promotion of iPSC generation by Myc is independent of its transformation property. We found that another Myc family member, L-Myc, as well as c-Myc mutants (W136E and dN2), all of which have little transformation activity, promoted human iPSC generation more efficiently and specifically compared with WT c-Myc. In mice, L-Myc promoted germline transmission, but not tumor formation, in the iPSC-derived chimeric mice. These data demonstrate that different functional moieties of the Myc proto-oncogene products are involved in the transformation and promotion of directed reprogramming.
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Metadata
- Authors
- Nakagawa, M., Takizawa, N., Narita, M., Ichisaka, T., & Yamanaka, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2010-07-26
- Volume
- 107
- Issue
- 32
- Pages
- 14152-14157
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2074725342
- Cited by
- 402
- References
- 12
- FWCI
- 17.60
- Type
- journal article
- Language
- en
- Open access
- green
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