A more efficient method to generate integration-free human iPS cells

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Generation of germline-competent induced pluripotent stem cells

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Human induced pluripotent stem cells free of vector and transgene sequences

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Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors

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Generation of Human Induced Pluripotent Stem Cells by Direct Delivery of Reprogramming Proteins

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piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells

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The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain

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Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome

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Suppression of induced pluripotent stem cell generation by the p53–p21 pathway

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A nonviral minicircle vector for deriving human iPS cells

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Adenoviral gene delivery can reprogram human fibroblasts to induced pluripotent stem cells

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Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury

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Generation of dopaminergic neurons and pigmented epithelia from primate ES cells by stromal cell-derived inducing activity

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In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction

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Promotion of direct reprogramming by transformation-deficient Myc

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HLA-haplotype banking and iPS cells

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High-throughput DNA typing of HLA-A, -B, -C, and -DRB1 loci by a PCR–SSOP–Luminex method in the Japanese population

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Twelve Years' Experience with National Sharing of HLA-Matched Cadaveric Kidneys for Transplantation

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Dental Pulp Cells for Induced Pluripotent Stem Cell Banking

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Small‐molecule inhibitors of bone morphogenic protein and activin/nodal signals promote highly efficient neural induction from human pluripotent stem cells

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The impact of human leukocyte antigen matching on transplant complications and immunosuppression dosage

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Chemically defined generation of human cardiomyocytes

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Induced pluripotent stem cell technology: a decade of progress.

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FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders

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Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness

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Chromatin Fibers Are Formed by Heterogeneous Groups of Nucleosomes In Vivo

Ricci, M. A., Manzo, C., García-Parajo, M. F., Lakadamyali, M., & Cosma, M. P. (2015) · Cell · doi:10.1016/j.cell.2015.01.054 · Cited by 736 · see citing works

A novel efficient feeder-free culture system for the derivation of human induced pluripotent stem cells

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Targeting RNA Foci in iPSC-Derived Motor Neurons from ALS Patients with a <i>C9ORF72</i> Repeat Expansion

Sareen, D., O’Rourke, J. G., Meera, P., Muhammad, A. K. M. G., Grant, S., Simpkinson, M., Bell, S., Carmona, S., Ornelas, L., Sahabian, A., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3007529 · Cited by 670 · see citing works

Establishing Cerebral Organoids as Models of Human-Specific Brain Evolution

Pollen, A. A., Bhaduri, A., Andrews, M. G., Nowakowski, T. J., Meyerson, O. S., Mostajo-Radji, M. A., Di Lullo, E., Alvarado, B., Bedolli, M., Dougherty, M. L., et al. (2019) · Cell · doi:10.1016/j.cell.2019.01.017 · Cited by 600 · see citing works

Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

Talantova, M., Sanz-Blasco, S., Zhang, X., Xia, P., Akhtar, M. W., Okamoto, S.-I., Dziewczapolski, G., Nakamura, T., Cao, G., Pratt, A. E., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1306832110 · Cited by 600 · see citing works

Human iPSC-Derived Cerebral Organoids Model Cellular Features of Lissencephaly and Reveal Prolonged Mitosis of Outer Radial Glia

Bershteyn, M., Nowakowski, T. J., Pollen, A. A., Di Lullo, E., Nene, A., Wynshaw-Boris, A., & Kriegstein, A. R. (2017) · Cell Stem Cell · doi:10.1016/j.stem.2016.12.007 · Cited by 566 · see citing works

Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons

Shi, Y., Lin, S., Staats, K. A., Li, Y., Chang, W.-H., Hung, S.-T., Hendricks, E., Linares, G. R., Wang, Y., Son, E. Y., et al. (2018) · Nature Medicine · doi:10.1038/nm.4490 · Cited by 566 · see citing works

Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility

Xu, H., Wang, B., Ono, M., Kagita, A., Fujii, K., Sasakawa, N., Ueda, T., Gee, P., Nishikawa, M., Nomura, M., et al. (2019) · Cell stem cell · doi:10.1016/j.stem.2019.02.005 · Cited by 581 · see citing works

Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids

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Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq

Wienert, B., Wyman, S. K., Richardson, C. D., Yeh, C. D., Akcakaya, P., Porritt, M. J., Morlock, M., Vu, J. T., Kazane, K. R., Watry, H. L., et al. (2019) · Science · doi:10.1126/science.aav9023 · Cited by 434 · see citing works

Generating an iPSC bank for HLA-matched tissue transplantation based on known donor and recipient HLA types

Taylor, C. J., Peacock, S., Chaudhry, A. N., Bradley, J. A., & Bolton, E. M. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.07.014 · Cited by 428 · see citing works

Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance

Zhao, Z., Sagare, A. P., Ma, Q., Halliday, M. R., Kong, P., Kisler, K., Winkler, E. A., Ramanathan, A., Kanekiyo, T., Bu, G., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4025 · Cited by 410 · see citing works

Pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson’s disease

Doi, D., Magotani, H., Kikuchi, T., Ikeda, M., Hiramatsu, S., Yoshida, K., Amano, N., Nomura, M., Umekage, M., Morizane, A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17165-w · Cited by 350 · see citing works

Mutations in <i>BCKD-kinase</i> Lead to a Potentially Treatable Form of Autism with Epilepsy

Novarino, G., El-Fishawy, P., Kayserili, H., Meguid, N. A., Scott, E. M., Schroth, J., Silhavy, J. L., Kara, M., Khalil, R. O., Ben-Omran, T., et al. (2012) · Science · doi:10.1126/science.1224631 · Cited by 320 · see citing works

Genomic Instability of iPSCs: Challenges Towards Their Clinical Applications

Yoshihara, M., Hayashizaki, Y., & Murakawa, Y. (2017) · Stem Cell Reviews and Reports · doi:10.1007/s12015-016-9680-6 · Cited by 283 · see citing works

HLA engineering of human pluripotent stem cells

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MHC matching improves engraftment of iPSC-derived neurons in non-human primates

Morizane, A., Kikuchi, T., Hayashi, T., Mizuma, H., Takara, S., Doi, H., Mawatari, A., Glasser, M. F., Shiina, T., Ishigaki, H., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00926-5 · Cited by 244 · see citing works

Toward the development of a global induced pluripotent stem cell library

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Defining human cardiac transcription factor hierarchies using integrated single-cell heterogeneity analysis

Churko, J. M., Garg, P., Treutlein, B., Venkatasubramanian, M., Wu, H., Lee, J., Wessells, Q. N., Chen, S.-Y., Chen, W.-Y., Chetal, K., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07333-4 · Cited by 207 · see citing works

Influence of donor age on induced pluripotent stem cells

Lo Sardo, V., Ferguson, W., Erikson, G. A., Topol, E. J., Baldwin, K. K., & Torkamani, A. (2017) · Nature Biotechnology · doi:10.1038/nbt.3749 · Cited by 223 · see citing works

Developmental alterations in Huntington’s disease neural cells and pharmacological rescue in cells and mice

The HD iPSC Consortium, Lim, R. G., Salazar, L. L., Wilton, D. K., King, A. R., Stocksdale, J. T., Sharifabad, D., Lau, A. L., Stevens, B., Reidling, J. C., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4532 · Cited by 221 · see citing works

Cell transplantation therapies for spinal cord injury focusing on induced pluripotent stem cells

Nakamura, M., & Okano, H. (2013) · Cell Research · doi:10.1038/cr.2012.171 · Cited by 214 · see citing works

cGMP-Manufactured Human Induced Pluripotent Stem Cells Are Available for Pre-clinical and Clinical Applications

Baghbaderani, B. A., Tian, X., Neo, B. H., Burkall, A., Dimezzo, T., Sierra, G., Zeng, X., Warren, K., Kovarcik, D. P., Fellner, T., et al. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.08.015 · Cited by 212 · see citing works

Generation of hypoimmunogenic T cells from genetically engineered allogeneic human induced pluripotent stem cells

Wang, B., Iriguchi, S., Waseda, M., Ueda, N., Ueda, T., Xu, H., Minagawa, A., Ishikawa, A., Yano, H., Ishi, T., et al. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00730-z · Cited by 189 · see citing works

Induced pluripotent stem cells: at the heart of cardiovascular precision medicine

Chen, I. Y., Matsa, E., & Wu, J. C. (2016) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.36 · Cited by 191 · see citing works

HLA-Matched Allogeneic iPS Cells-Derived RPE Transplantation for Macular Degeneration

Sugita, S., Mandai, M., Hirami, Y., Takagi, S., Maeda, T., Fujihara, M., Matsuzaki, M., Yamamoto, M., Iseki, K., Hayashi, N., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9072217 · Cited by 190 · see citing works

Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS

Hall, C. E., Yao, Z., Choi, M., Tyzack, G. E., Serio, A., Luisier, R., Harley, J., Preza, E., Arber, C., Crisp, S. J., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.05.024 · Cited by 179 · see citing works

Human pluripotent reprogramming with CRISPR activators

Weltner, J., Balboa, D., Katayama, S., Bespalov, M., Krjutškov, K., Jouhilahti, E.-M., Trokovic, R., Kere, J., & Otonkoski, T. (2018) · Nature Communications · doi:10.1038/s41467-018-05067-x · Cited by 181 · see citing works

The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans

Xiang, X., Piers, T. M., Wefers, B., Zhu, K., Mallach, A., Brunner, B., Kleinberger, G., Song, W., Colonna, M., Herms, J., et al. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0280-6 · Cited by 170 · see citing works

Successful Transplantation of Retinal Pigment Epithelial Cells from MHC Homozygote iPSCs in MHC-Matched Models

Sugita, S., Iwasaki, Y., Makabe, K., Kamao, H., Mandai, M., Shiina, T., Ogasawara, K., Hirami, Y., Kurimoto, Y., & Takahashi, M. (2016) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.08.010 · Cited by 156 · see citing works

Cellular phenotypes in human iPSC-derived neurons from a genetic model of autism spectrum disorder

Deshpande, A., Yadav, S., Dao, D. Q., Wu, Z.-Y., Hokanson, K. C., Cahill, M. K., Wiita, A. P., Jan, Y.-N., Ullian, E. M., & Weiss, L. A. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.11.037 · Cited by 151 · see citing works

Familial Alzheimer’s disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta

Arber, C., Toombs, J., Lovejoy, C., Ryan, N. S., Paterson, R. W., Willumsen, N., Gkanatsiou, E., Portelius, E., Blennow, K., Heslegrave, A., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0410-8 · Cited by 148 · see citing works

A deleterious Nav1.1 mutation selectively impairs telencephalic inhibitory neurons derived from Dravet Syndrome patients

Sun, Y., Paşca, S. P., Portmann, T., Goold, C., Worringer, K. A., Guan, W., Chan, K. C., Gai, H., Vogt, D., Chen, Y.-J. J., et al. (2016) · eLife · doi:10.7554/elife.13073 · Cited by 141 · see citing works

A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC-derived microglia

Piers, T. M., Cosker, K., Mallach, A., Johnson, G. T., Guerreiro, R., Hardy, J., & Pocock, J. M. (2020) · The FASEB Journal · doi:10.1096/fj.201902447r · Cited by 135 · see citing works

Overcoming the Specific Toxicity of Large Plasmids Electrotransfer in Primary Cells In Vitro

Lesueur, L. L., Mir, L. M., & André, F. M. (2016) · Molecular Therapy - Nucleic Acids · doi:10.1038/mtna.2016.4 · Cited by 118 · see citing works

Overview: An iPS cell stock at CiRA

Umekage, M., Sato, Y., & Takasu, N. (2019) · Inflammation and Regeneration · doi:10.1186/s41232-019-0106-0 · Cited by 122 · see citing works

Assembly and Function of a Bioengineered Human Liver for Transplantation Generated Solely from Induced Pluripotent Stem Cells

Takeishi, K., Collin de l’Hortet, A., Wang, Y., Handa, K., Guzman-Lepe, J., Matsubara, K., Morita, K., Jang, S., Haep, N., Florentino, R. M., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107711 · Cited by 118 · see citing works

A simple, cost-effective but highly efficient system for deriving ventricular cardiomyocytes from human pluripotent stem cells

Weng, Z., Kong, C.-W., Ren, L., Karakikes, I., Geng, L., He, J., Chow, M. Z. Y., Mok, C. F., Chan, H. Y. S., Webb, S. E., et al. (2014) · Stem Cells and Development · doi:10.1089/scd.2013.0509 · Cited by 109 · see citing works

Repurposing the Cord Blood Bank for Haplobanking of HLA-Homozygous iPSCs and Their Usefulness to Multiple Populations

Lee, S., Huh, J. Y., Turner, D. M., Lee, S., Robinson, J., Stein, J. E., Shim, S. H., Hong, C. P., Kang, M. S., Nakagawa, M., et al. (2018) · Stem Cells · doi:10.1002/stem.2865 · Cited by 99 · see citing works

Rapid, efficient, and simple motor neuron differentiation from human pluripotent stem cells

Shimojo, D., Onodera, K., Doi-Torii, Y., Ishihara, Y., Hattori, C., Miwa, Y., Tanaka, S., Okada, R., Ohyama, M., Shoji, M., et al. (2015) · Molecular Brain · doi:10.1186/s13041-015-0172-4 · Cited by 99 · see citing works

Modeling the early phenotype at the neuromuscular junction of spinal muscular atrophy using patient-derived iPSCs

Yoshida, M., Kitaoka, S., Egawa, N., Yamane, M., Ikeda, R., Tsukita, K., Amano, N., Watanabe, A., Morimoto, M., Takahashi, J., et al. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.02.010 · Cited by 102 · see citing works

Generation of human-induced pluripotent stem cells by a nonintegrating RNA Sendai virus vector in feeder-free or xeno-free conditions

MacArthur, C. C., Fontes, A., Ravinder, N., Kuninger, D., Kaur, J., Bailey, M., Taliana, A., Vemuri, M. C., & Lieu, P. T. (2012) · Stem Cells International · doi:10.1155/2012/564612 · Cited by 91 · see citing works

Enhanced cortical neural stem cell identity through short SMAD and WNT inhibition in human cerebral organoids facilitates emergence of outer radial glial cells

Rosebrock, D., Arora, S., Mutukula, N., Volkman, R., Gralinska, E., Balaskas, A., Aragonés Hernández, A., Buschow, R., Brändl, B., Müller, F.-J., et al. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00929-5 · Cited by 89 · see citing works

Genome engineering of induced pluripotent stem cells to manufacture natural killer cell therapies

Shankar, K., Capitini, C. M., & Saha, K. (2020) · Stem Cell Research &amp; Therapy · doi:10.1186/s13287-020-01741-4 · Cited by 85 · see citing works

NK Cell Alloreactivity against KIR-Ligand-Mismatched HLA-Haploidentical Tissue Derived from HLA Haplotype-Homozygous iPSCs

Ichise, H., Nagano, S., Maeda, T., Miyazaki, M., Miyazaki, Y., Kojima, H., Yawata, N., Yawata, M., Tanaka, H., Saji, H., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.07.020 · Cited by 80 · see citing works

Individualized patient tumor organoids faithfully preserve human brain tumor ecosystems and predict patient response to therapy

Peng, T., Ma, X., Hua, W., Wang, C., Chu, Y., Sun, M., Fermi, V., Hamelmann, S., Lindner, K., Shao, C., et al. (2025) · Cell Stem Cell · doi:10.1016/j.stem.2025.01.002 · Cited by 86 · see citing works

Utility of iPSC-Derived Cells for Disease Modeling, Drug Development, and Cell Therapy

Nicholson, M. W., Ting, C.-Y., Chan, D. Z. H., Cheng, Y.-C., Lee, Y.-C., Hsu, C.-C., Huang, C.-Y., & Hsieh, P. C. H. (2022) · Cells · doi:10.3390/cells11111853 · Cited by 66 · see citing works

Remodeling neurodegeneration: somatic cell reprogramming-based models of adult neurological disorders

Qiang, L., Fujita, R., & Abeliovich, A. (2013) · Neuron · doi:10.1016/j.neuron.2013.06.002 · Cited by 59 · see citing works

ALDH1A1-related stemness in high-grade serous ovarian cancer is a negative prognostic indicator but potentially targetable by EGFR/mTOR-PI3K/aurora kinase inhibitors

Kaipio, K., Chen, P., Roering, P., Huhtinen, K., Mikkonen, P., Östling, P., Lehtinen, L., Mansuri, N., Korpela, T., Potdar, S., et al. (2020) · The Journal of Pathology · doi:10.1002/path.5356 · Cited by 54 · see citing works

Development of a Modular Automated System for Maintenance and Differentiation of Adherent Human Pluripotent Stem Cells

Crombie, D. E., Daniszewski, M., Liang, H. H., Kulkarni, T., Li, F., Lidgerwood, G. E., Conquest, A., Hernández, D., Hung, S. S., Gill, K. P., et al. (2017) · SLAS Discovery · doi:10.1177/2472555217696797 · Cited by 46 · see citing works

Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes

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Applications of induced pluripotent stem cells in studying the neurodegenerative diseases

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