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Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses
Open accessAbstract
The propensity of helminths, such as schistosomes, to immunomodulate the host's immune system is an essential aspect of their survival. Previous research has demonstrated how soluble schistosomal egg antigens (SEA) dampen TLR-signaling during innate immune responses. We show here that the suppressive effect by SEA on TLR signaling is simultaneously coupled to the activation of the Nlrp3 (NLR family, pyrin domain containing 3) inflammasome and thus IL-1β production. Therefore, the responsible protein component of SEA contains the second signal that is required to trigger proteolytic pro-IL-1β processing. Moreover, the SEA component binds to the Dectin-2/FcRγ (Fc receptor γ chain) complex and activates the Syk kinase signaling pathway to induce reactive oxygen species and potassium efflux. As IL-1β has been shown to be an essential orchestrator against several pathogens we studied the in vivo consequences of Schistosoma mansoni infection in mice deficient in the central inflammasome adapter ASC and Nlrp3 molecule. These mice failed to induce local IL-1β levels in the liver and showed decreased immunopathology. Interestingly, antigen-specific Th1, Th2, and Th17 responses were down-regulated. Overall, these data imply that component(s) within SEA induce IL-1β production and unravel a crucial role of Nlrp3 during S. mansoni infection.
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“schistosome glycans bind to the C-type lectin receptors Dectin-1 and Dectin-2 (Ritter et al., 2010) and prime DCs for enhanced Th2 cell development via autocrine prostaglandin-E2 (PGE2) and OX40L”
From Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules (2018) · cites this paper as Ritter et al., 2010
Citations
Cites
Gout-associated uric acid crystals activate the NALP3 inflammasome
Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A., & Tschopp, J. (2006) · Nature · doi:10.1038/nature04516 · Cited by 5,326
Self-citationBiologic basis for interleukin-1 in disease.
Dinarello, C. (1996) · Blood · doi:10.1182/blood.v87.6.2095.bloodjournal8762095 · Cited by 4,344
Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica
Dostert, C., Pétrilli, V., Van Bruggen, R., Steele, C., Mossman, B. T., & Tschopp, J. (2008) · Science · doi:10.1126/science.1156995 · Cited by 2,658
Self-citationA novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes
Thornberry, N. A., Bull, H. G., Calaycay, J. R., Chapman, K. T., Howard, A. D., Kostura, M. J., Miller, D. K., Molineaux, S. M., Weidner, J. R., Aunins, J. G., et al. (1992) · Nature · doi:10.1038/356768a0 · Cited by 2,613
The NALP3 inflammasome is involved in the innate immune response to amyloid-β
Halle, A., Hornung, V., Petzold, G. C., Stewart, C. R., Monks, B. G., Reinheckel, T., Fitzgerald, K. A., Latz, E., Moore, K. J., & Golenbock, D. T. (2008) · Nature Immunology · doi:10.1038/ni.1636 · Cited by 2,441
The Cytolytic P 2Z Receptor for Extracellular ATP Identified as a P 2X Receptor (P2X 7 )
Surprenant, A., Rassendren, F., Kawashima, E., North, R. A., & Buell, G. (1996) · Science · doi:10.1126/science.272.5262.735 · Cited by 1,739
Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants
Eisenbarth, S. C., Colegio, O. R., O’Connor, W., Sutterwala, F. S., & Flavell, R. A. (2008) · Nature · doi:10.1038/nature06939 · Cited by 1,542
The immunobiology of schistosomiasis
Pearce, E. J., & MacDonald, A. S. (2002) · Nature reviews. Immunology · doi:10.1038/nri843 · Cited by 1,170
Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence
Groß, O., Poeck, H., Bscheider, M., Dostert, C., Hannesschläger, N., Endres, S., Hartmann, G., Tardivel, A., Schweighoffer, E., Tybulewicz, V. L. J., et al. (2009) · Nature · doi:10.1038/nature07965 · Cited by 947
Self-citationInflammatory caspases and inflammasomes: master switches of inflammation
Martinon, F., & Tschopp, J. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402038 · Cited by 848
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Dunn, J., & Fujita, M. (2015) · Atlas of Genetics and Cytogenetics in Oncology and Haematology · doi:10.4267/2042/56440 · Cited by 4
Flores-Sotelo, I., Juárez, N., González, M. I., Chávez, A., Vannan, D. T., Eksteen, B., Terrazas, L. I., & Reyes, J. L. (2024) · Immunologic Research · doi:10.1007/s12026-024-09496-3 · Cited by 3
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Brown, G. D., & Crocker, P. R. (2017) · ASM Press eBooks · doi:10.1128/9781555819194.ch25 · Cited by 3
Silva, C. L. M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801078-5.00015-7 · Cited by 3
Montasser, A., Dakrory, A. I., Ibrahim, M., Zayyat, E. E., Tallima, H., & Ridi, R. E. (2024) · Infection and Immunity · doi:10.1128/iai.00362-24 · Cited by 2
Soboslay, P. T., Orlikowsky, T. W., Huang, X., Gille, C., Spring, B., Kocherscheidt, L., Agossou, A., Banla, M., von Bonin, M., & Köhler, C. (2016) · Molecular Immunology · doi:10.1016/j.molimm.2016.03.015 · Cited by 2
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Kenealy, S., & Creagh, E. M. (2018) · EMJ Allergy & Immunology · doi:10.33590/emjallergyimmunol/10314723 · Cited by 2
Programmed genome editing of the omega-1 ribonuclease 1 of the blood fluke, Schistosoma mansoniPreprint
Ittiprasert, W., Mann, V. H., Karinshak, S. E., Coghlan, A., Rinaldi, G., Sankaranarayanan, G., Chaidee, A., Tanno, T., Kumkhaek, C., Prangtaworn, P., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/358424 · Cited by 2
Helminths Derived Immune-Modulatory Molecules: Implications in Host-Parasite Interaction
Das, K., Upadhyay, S., & Mahindroo, N. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.102927 · Cited by 1
Differential Cell–Specific, Regulatory Roles of Fcγ Receptor IIB through IgG in IgA Nephropathy
Liu, T.-Y., Wu, C., Chen, X., Sung, C., Chou, Y.-L., Liu, F., Lamprinaki, D., Yang, S., Wu, C., Tsai, Y., et al. (2025) · Journal of the American Society of Nephrology · doi:10.1681/asn.0000000835 · Cited by 1
Yang, P.-K., Chen, J., Lin, Y.-X., Zeng, B.-X., Chen, T.-Y., Aweya, J., Zou, X., Zheng, Y.-Z., & Wang, R. (2026) · Journal of the World Aquaculture Society · doi:10.1111/jwas.70085 · Cited by 1
C-type lectin receptor signaling in schistosomiasis
Chaudhary, S., & Kalantari, P. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1816742 · Cited by 1
Pattern Recognition Receptors and Infectious Diseases
Liaunardy, A., Chris, B., Ben, L., Alexander, D., & Tom, P. (2012) · InTech eBooks · doi:10.5772/33481 · Cited by 3
Roles of C-Type Lectin Receptors in Inflammatory Responses
Saijo, S. (2016) · Springer eBooks · doi:10.1007/978-4-431-56068-5_26 · Cited by 1
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Hoving, J. C., Wilson, G. J., & Brown, G. D. (2014) · Cited by 1
Signaling Pathways Governing Activation of Innate Immune Cells
Neves, B. M., & Almeida, C. R. (2020) · Springer eBooks · doi:10.1007/978-3-030-44436-5_4 · Cited by 1
Lima, J., Brito, R. M. D. M., Pereira, L. C., Pereira, N. D. S., Nascimento, M. S. L., de Melo, A. L., & Guedes, P. M. M. (2024) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/0074-02760240013 · Cited by 1
C-Type Lectin (C-Type Lectin Receptor)
Kim, C.-H. (2022) · Springer eBooks · doi:10.1007/978-981-16-9081-5_8 · Cited by 1
Mechanisms for activation and inhibition of inflammasomes
Janczy, J. R. (2014) · doi:10.17077/etd.gqld9sco · Cited by 1
Inflammasome Activation in Response to Eukaryotic Pathogens
Gross, O., Thomas, C. J., & Layland, L. E. (2011) · Springer eBooks · doi:10.1007/978-3-0348-0148-5_5
Self-citationStraubinger, K., & da Costa, C. P. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-1489-0_2
Vitamin D induces the release of IL-1b via activation of the NLRP3 inflammasome
Tulk, S. E. (2012) · Libraries and Cultural Resources (University of Calgary) · doi:10.11575/prism/28659
Immunobiology of C-Type Lectin Receptors
Roth, S., Thomas, C. J., & Ruland, J. (2013) · Else Kröner-Fresenius Symposia · doi:10.1159/000346538
Self-citationAtlas of Genetics and Cytogenetics in Oncology and Haematology
Dunn, J. H., & Fujita, M. (2015)
[Bone marrow hematopoiesis. Evaluation of the myelogram].
Vladimirskaia, E. B. (1990) · PubMed
Corrêa, R. (2016) · RIUnB Institutional Repository (University of Brasília) · doi:10.26512/2016.02.d.21081
Interfering With Inflammatory Cytokine Production During Antibody-Enhanced Dengue Virus Infection
Callaway, J. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/w97g-h526
Reassessing Twenty Years of Vaccine Development Against Tuberculosis
Schaible, U. E., & Kaufmann, S. H. E. (2018) · Frontiers research topics · doi:10.3389/978-2-88945-446-4 · Cited by 2
The Role of Dectin-2 during infection with Mycobacteria that are able to survive in Macrophages
Sieberhagen, J. M. (2018)
Middleton, D. D. (2021) · The Research Repository @ WVU (West Virginia University) · doi:10.33915/etd.8292
chen, C., Zhang, Y., wang, Z., Wang, H., & Fan, H. (2020) · Research Square · doi:10.21203/rs.3.rs-44372/v1
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Yadav, S., Kaur, H., Dhanda, R. S., & Yadav, M. C. (2024) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815223941124010008
Role of pattern recognition receptors in cardiac remodeling
Duttaroy, A. K., & Mallick, R. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-99570-2.00003-5
Arndts, K., Wiszniewsky, A., Neumann, A., Wiszniewsky, K., Katawa, G., Hoerauf, A., Layland, L. E., Ritter, M., & Hübner, M. P. (2024) · Parasitology Research · doi:10.1007/s00436-024-08365-0
Self-citationInnate Immunity and Inflammation
McKarns, S. C. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.50005-9
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Nunez, N. (2017) · theses.fr (ABES) · doi:10.70675/8636c8afzcac0z4f40za0ffz5a6d9da835c0
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Michaud, E. (2020) · theses.fr (ABES) · doi:10.70675/92102dfez11caz4732zad57z20a2f16673e1
Influence of Dectin-1 and Dectin-2 receptors on the susceptibility to gut inflammation
Wang, Y. (2021) · theses.fr (ABES) · doi:10.70675/751b61b5z192ez48e3z8e90ze02ddeaea311 · Cited by 1
No Simple Fluke: Schistosomiasis as an Emerging Regulator of Haematopoiesis
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Metadata
- Authors
- Ritter, M., Gross, O., Kays, S., Ruland, J., Nimmerjahn, F., Saijo, S., Tschopp, J., Layland, L. E., & Prazeres da Costa, C.
- Affiliations
- Technical University of Munich (DE)
- University of Lausanne (CH)
- TUM Klinikum (DE)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Institute of Medical Science, The University of Tokyo (JP)
- University Hospital Bonn (DE)
- Institute for Microbiology, Immunology and Hygiene, Technische Universität München, 81675 Munich, Germany;
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2010-11-08
- Volume
- 107
- Issue
- 47
- Pages
- 20459-20464
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2996650
- OpenAlex
- W2129113472
- Cited by
- 243
- References
- 38
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 11 · 2023: 7 · 2022: 13 · 2021: 11 · 2020: 20 · 2019: 12 · 2018: 22 · 2017: 14 · 2016: 29 · 2015: 16 · 2014: 15 · 2013: 22 · 2012: 22
- FWCI
- 7.95
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- IRIS (submittedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Site cant be reached (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- Schistosoma mansoni, Dectin-2, NLRP3 inflammasome, soluble egg antigen, IL-1β, helminth immunomodulation, Syk signaling, reactive oxygen species, potassium efflux, ASC, Th1/Th2/Th17 responses, innate immunity
- MeSH terms
- NLR Family, Pyrin Domain-Containing 3 Protein, Analysis of Variance, Animals, Antigens, Helminth, Carrier Proteins, Dendritic Cells, Gene Expression Regulation, Mice, Inbred C57BL, Schistosomiasis, Specific Pathogen-Free Organisms, Blotting, Western, Mice, Knockout, Lectins, C-Type, Toll-Like Receptors, Mice, Interleukin-1beta, Adaptive Immunity, Inflammasomes
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