The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Genetic analysis of age-dependent defects of the Caenorhabditis elegans touch receptor neurons
Open accessAbstract
Although many genes have been implicated in the pathogenesis of common neurodegenerative diseases, the genetic and cellular mechanisms that maintain neuronal integrity during normal aging remain elusive. Here we show that Caenorhabditis elegans touch receptor and cholinergic neurons display age-dependent morphological defects, including cytoskeletal disorganization, axon beading, and defasciculation. Progression of neuronal aging is regulated by DAF-2 and DAF-16 signaling, which also modulate adult life span. Mutations that disrupt touch-evoked sensory activity or reduce membrane excitability trigger accelerated neuronal aging, indicating that electrical activity is critical for adult neuronal integrity. Disrupting touch neuron attachment to the epithelial cells induces distinct neurodegenerative phenotypes. These results provide a detailed description of the age-dependent morphological defects that occur in identified neurons of C. elegans , demonstrate that the age of onset of these defects is regulated by specific genes, and offer experimental evidence for the importance of normal levels of neural activity in delaying neuronal aging.
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Cites
Regulation of aging and age-related disease by DAF-16 and heat-shock factor
Hsu, A.-L., Murphy, C. T., & Kenyon, C. (2003) · Science · doi:10.1126/science.1083701 · Cited by 1,513
Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans
Herndon, L. A., Schmeissner, P. J., Dudaronek, J. M., Brown, P. A., Listner, K. M., Sakano, Y., Paupard, M. C., Hall, D. H., & Driscoll, M. (2002) · Nature · doi:10.1038/nature01135 · Cited by 1,214
Yankner, B. A., Lu, T., & Loerch, P. (2008) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathmechdis.2.010506.092044 · Cited by 677
Cited by
Insulin/insulin-like growth factor signaling in C. elegans
Murphy, C. T. (2013) · WormBook · doi:10.1895/wormbook.1.164.1 · Cited by 532
Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants
Bansal, A., Zhu, L. J., Yen, K., & Tissenbaum, H. A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1412192112 · Cited by 367
Alexander, A. G., Marfil, V., & Li, C. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00279 · Cited by 310
Neurite Sprouting and Synapse Deterioration in the Aging Caenorhabditis elegans Nervous System
Toth, M. L., Melentijevic, I., Shah, L., Bhatia, A., Lu, K., Talwar, A., Naji, H., Ibanez-Ventoso, C., Ghose, P., Jevince, A., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1494-11.2012 · Cited by 205
Liu, J., Zhang, B., Lei, H., Feng, Z., Liu, J., Hsu, A.-L., & Xu, X. Z. S. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.08.007 · Cited by 154
Metadata
- Authors
- Pan, C.-L., Peng, C.-Y., Chen, C.-H., & McIntire, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2011-05-12
- Volume
- 108
- Issue
- 22
- Pages
- 9274-9279
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2160803607
- Cited by
- 171
- References
- 3
- FWCI
- 2.85
- Type
- journal article
- Language
- en
- Open access
- green
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- Pan, C.-L., Peng, C.-Y., Chen, C.-H., & McIntire, S. (2011). Genetic analysis of age-dependent defects of the Caenorhabditis elegans touch receptor neurons. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1011711108
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