Use of Caenorhabditis elegans as a model to study Alzheimer’s disease and other neurodegenerative diseases

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The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

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A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

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Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

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AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease

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Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

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Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

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The new mutation, E46K, of α‐synuclein causes parkinson and Lewy body dementia

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TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

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Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

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daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

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Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

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Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

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The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

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Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

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Endonuclease G is an apoptotic DNase when released from mitochondria

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A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

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Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes?

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The distribution of tau in the mammalian central nervous system.

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TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis

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Acceleration of oligomerization, not fibrillization, is a shared property of both α-synuclein mutations linked to early-onset Parkinson's disease: Implications for pathogenesis and therapy

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Regulation of aging and age-related disease by DAF-16 and heat-shock factor

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daf-16 : An HNF-3/forkhead Family Member That Can Function to Double the Life-Span of Caenorhabditis elegans

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Trinucleotide Repeat Disorders

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Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene

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Hyperphosphorylation induces self-assembly of τ into tangles of paired helical filaments/straight filaments

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daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans

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Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments

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A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

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Alzheimer’s disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules

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Opposing activities protect against age-onset proteotoxicity

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LRP/Amyloid β-Peptide Interaction Mediates Differential Brain Efflux of Aβ Isoforms

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Altered microtubule organization in small-calibre axons of mice lacking tau protein

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aph-1 and pen-2 Are Required for Notch Pathway Signaling, γ-Secretase Cleavage of βAPP, and Presenilin Protein Accumulation

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Heterochronic Mutants of the Nematode <i>Caenorhabditis elegans</i>

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Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: Distinction between PHF-like immunoreactivity and microtubule binding

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COPPER-ZINC SUPEROXIDE DISMUTASE AND AMYOTROPHIC LATERAL SCLEROSIS

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Fibrils Formed in Vitro from α-Synuclein and Two Mutant Forms Linked to Parkinson's Disease are Typical Amyloid

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γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

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REST and stress resistance in ageing and Alzheimer’s disease

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Reviewed by:

Alex, A. G., Marfil, V., Li, C., Hu, P., Budovskaya, Y. V., & Alex, A. G. (2014)

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