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Molecular vibration-sensing component in Drosophila melanogaster olfaction
Open accessAbstract
A common explanation of molecular recognition by the olfactory system posits that receptors recognize the structure or shape of the odorant molecule. We performed a rigorous test of shape recognition by replacing hydrogen with deuterium in odorants and asking whether Drosophila melanogaster can distinguish these identically shaped isotopes. We report that flies not only differentiate between isotopic odorants, but can be conditioned to selectively avoid the common or the deuterated isotope. Furthermore, flies trained to discriminate against the normal or deuterated isotopes of a compound, selectively avoid the corresponding isotope of a different odorant. Finally, flies trained to avoid a deuterated compound exhibit selective aversion to an unrelated molecule with a vibrational mode in the energy range of the carbon–deuterium stretch. These findings are inconsistent with a shape-only model for smell, and instead support the existence of a molecular vibration-sensing component to olfactory reception.
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“In contrast to this, theoretical work comparing the structure-activity/vibration-activity relationship of the histamine receptor and its various ligands suggests that molecular vibration does play some role in ligand function.”
From Quantum effects in the brain: A review (2020) · cites this paper as [119]
In the citing paper
“Furthermore, molecules with similar vibrational frequencies have been observed to elicit similar reactions from fruit flies in spite of being unrelated chemically [111].”
From The future of quantum biology (2018) · cites this paper as [111]
In the citing paper
“For example, the substitution with deuterium of hydrogen results in an odour change despite the fact that the two molecules have the same shape (figure 4) [111].”
From The future of quantum biology (2018) · cites this paper as [111]
In the citing paper
“In support of the theory, experiments with fruit flies have indicated that shape and size of odourants are insufficient for detection.”
From The future of quantum biology (2018) · cites this paper as [111]
In the citing paper
“This suggests that vibrational frequency might play a role in the detection of odourants[111].”
From The future of quantum biology (2018) · cites this paper as [111]
In the citing paper
“experiments with fruit flies have indicated that the substitution of hydrogen with deuterium results in an odour change in spite of their having the same shape.”
From The future of quantum biology (2018) · cites this paper as [111]
In the citing paper
“In recent years, quantum biology too has been benefitting considerably from the refinement of experimental tools that are beginning to provide direct access to the observation of quantum dynamics in biological systems [11-14]”
From Vibrations, quanta and biology (2013) · cites this paper as [14]
In the citing paper
“More importantly, this principle is sufficiently general to provide a mechanism that can support the surprisingly long-lasting oscillatory features observed in recent ultra-fast laser spectroscopy experiments [11-14] and explain key aspects of the dynamics that may underlie the process olfaction.”
From Vibrations, quanta and biology (2013) · cites this paper as [14]
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Citations
Cites
Rescorla, R. A. (1972) · Medical Entomology and Zoology · Cited by 7,268
A novel multigene family may encode odorant receptors: A molecular basis for odor recognition
Buck, L., & Axel, R. (1991) · Cell · doi:10.1016/0092-8674(91)90418-x · Cited by 4,987
Classical conditioning II: Current research and theory.
Black, A. H., & Prokasy, W. F. (1972) · Appleton-Century-Crofts eBooks · Cited by 4,449
Combinatorial Receptor Codes for Odors
Malnic, B., Hirono, J., Sato, T., & Buck, L. B. (1999) · Cell · doi:10.1016/s0092-8674(00)80581-4 · Cited by 2,302
Coding of Odors by a Receptor Repertoire
Hallem, E. A., & Carlson, J. R. (2006) · Cell · doi:10.1016/j.cell.2006.01.050 · Cited by 1,286
How the olfactory system makes sense of scents
Firestein, S. (2001) · Nature · doi:10.1038/35093026 · Cited by 1,261
Handbook of Olfaction and Gustation
Doty, R. L. (2003) · CRC Press eBooks · doi:10.1201/9780203911457 · Cited by 1,228
Classical conditioning and retention in normal and mutantDrosophila melanogaster
Tully, T., & Quinn, W. G. (1985) · Journal of Comparative Physiology A · doi:10.1007/bf01350033 · Cited by 1,189
Atypical Membrane Topology and Heteromeric Function of Drosophila Odorant Receptors In Vivo
Benton, R., Sachse, S., Michnick, S. W., & Vosshall, L. B. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040020 · Cited by 1,016
The Molecular Basis of Odor Coding in the Drosophila Antenna
Hallem, E. A., Ho, M. G.-R., & Carlson, J. R. (2004) · Cell · doi:10.1016/j.cell.2004.05.012 · Cited by 993
Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels
Wicher, D., Schäfer, R., Bauernfeind, R., Stensmyr, M. C., Heller, R., Heinemann, S. H., & Hansson, B. S. (2008) · Nature · doi:10.1038/nature06861 · Cited by 895
Molecular Architecture of Smell and Taste in Drosophila
Vosshall, L. B., & Stocker, R. F. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094306 · Cited by 860
Molecular evolution of the insect chemoreceptor gene superfamily in Drosophila melanogaster
Robertson, H. M., Warr, C. G., & Carlson, J. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2335847100 · Cited by 801
Molecular Vibration Spectra by Inelastic Electron Tunneling
Lambe, J., & Jaklevic, R. C. (1968) · Physical Review · doi:10.1103/physrev.165.821 · Cited by 585
The molecular receptive range of an odorant receptor
Araneda, R. C., Kini, A. D., & Firestein, S. (2000) · Nature Neuroscience · doi:10.1038/81774 · Cited by 525
A Spectroscopic Mechanism for Primary Olfactory Reception
Turin, L. (1996) · Chemical Senses · doi:10.1093/chemse/21.6.773 · Cited by 388
Self-citationAversive Learning Enhances Perceptual and Cortical Discrimination of Indiscriminable Odor Cues
Li, W., Howard, J. D., Parrish, T. B., & Gottfried, J. A. (2008) · Science · doi:10.1126/science.1152837 · Cited by 351
Rossiter, K. J. (1996) · Chemical Reviews · doi:10.1021/cr950068a · Cited by 291
Fan, L., & Ziegler, T. (1992) · The Journal of Chemical Physics · doi:10.1063/1.462258 · Cited by 266
Fan, L., & Ziegler, T. (1992) · The Journal of Physical Chemistry · doi:10.1021/j100196a016 · Cited by 223
Perfumery and Flavoring Synthetics
Bedoukian, P. Z. (1986) · Medical Entomology and Zoology · Cited by 219
Olfactory Receptors and Odor Coding in Mammals
Buck, L. B. (2004) · Nutrition Reviews · doi:10.1111/j.1753-4887.2004.tb00097.x · Cited by 218
Olfactory Learning Deficits in Mutants for leonardo, a Drosophila Gene Encoding a 14-3-3 Protein
Skoulakis, E. M. C., & Davis, R. L. (1996) · Neuron · doi:10.1016/s0896-6273(00)80224-x · Cited by 209
Self-citationOn the Unpredictability of Odor
Sell, C. S. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200600782 · Cited by 202
Scents and Sensibility: A Molecular Logic of Olfactory Perception (Nobel Lecture)
Axel, R. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200501726 · Cited by 201
Deuterium isotope effects on noncovalent interactions between molecules
Wade, D. C. (1999) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(98)00097-0 · Cited by 193
Could Humans Recognize Odor by Phonon Assisted Tunneling?
Brookes, J. C., Hartoutsiou, F., Horsfield, A. P., & Stoneham, A. M. (2007) · Physical Review Letters · doi:10.1103/physrevlett.98.038101 · Cited by 179
Controversy and consensus: noncanonical signaling mechanisms in the insect olfactory system
Nakagawa, T., & Vosshall, L. B. (2009) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.07.015 · Cited by 164
The Nose as a Stereochemist. Enantiomers and Odor
Bentley, R. (2006) · Chemical Reviews · doi:10.1021/cr050049t · Cited by 160
Olfaction and olfactory learning in Drosophila: recent progress
Fiala, A. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2007.11.009 · Cited by 124
The Olfactory Sensory Map in Drosophila
Laissue, P. P., & Vosshall, L. B. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-78261-4_7 · Cited by 112
A psychophysical test of the vibration theory of olfaction
Keller, A., & Vosshall, L. B. (2004) · Nature Neuroscience · doi:10.1038/nn1215 · Cited by 112
Stimulus generalization: Some predictions from a model of Pavlovian conditioning.
Rescorla, R. A. (1976) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037//0097-7403.2.1.88 · Cited by 109
Stimulus generalization: Some predictions from a model of Pavlovian conditioning.
Rescorla, R. A. (1976) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037/0097-7403.2.1.88 · Cited by 94
A Method for the Calculation of Odor Character from Molecular Structure
Turin, L. (2002) · Journal of Theoretical Biology · doi:10.1006/jtbi.2001.2504 · Cited by 87
Self-citationChapter 18 Olfactory memory traces in Drosophila
Berry, J. A., Krause, W. C., & Davis, R. L. (2008) · Progress in brain research · doi:10.1016/s0079-6123(07)00018-0 · Cited by 62
Neural and behavioral mechanisms of olfactory perception
Wilson, R. I. (2008) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2008.08.015 · Cited by 56
Skoulakis, E. M. C., & Grammenoudi, S. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-006-6023-9 · Cited by 55
Self-citationPavlopoulos, E., Anezaki, M., & Skoulakis, E. M. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801605105 · Cited by 50
Self-citationComputation of olfactory signals inDrosophila melanogaster
Borst, A. (1983) · Journal of Comparative Physiology A · doi:10.1007/bf00606242 · Cited by 47
Distinct memories of odor intensity and quality in Drosophila
Masek, P., & Heisenberg, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804086105 · Cited by 44
A Dual Role for the Adaptor Protein DRK inDrosophilaOlfactory Learning and Memory
Moressis, A., Friedrich, A. R., Pavlopoulos, E., Davis, R. L., & Skoulakis, E. M. C. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3670-08.2009 · Cited by 34
Self-citationAcevedo, S. F., Froudarakis, E., Tsiorva, A.-A., & Skoulakis, E. M. C. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2006.11.011 · Cited by 25
Self-citationGuo, S. J., & Kim, J. (2009) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.22556 · Cited by 25
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Sorted by citations
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Huelga, S. F., & Plenio, M. B. (2013) · Contemporary Physics · doi:10.1080/00405000.2013.829687 · Cited by 568
Quantum coherence in biological systems
Lloyd, S. (2011) · Journal of Physics Conference Series · doi:10.1088/1742-6596/302/1/012037 · Cited by 341
Marais, A., Adams, B., Ringsmuth, A. K., Ferretti, M., Gruber, J. M., Hendrikx, R., Schuld, M., Smith, S. L., Sinayskiy, I., Krüger, T. P. J., et al. (2018) · Journal of The Royal Society Interface · doi:10.1098/rsif.2018.0640 · Cited by 274
Realist Magic: Objects, Ontology, Causality
Morton, T. (2013) · Open Humanities Press eBooks · doi:10.3998/ohp.13106496.0001.001 · Cited by 251
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O’Reilly, E. J., & Olaya-Castro, A. (2014) · Nature Communications · doi:10.1038/ncomms4012 · Cited by 230
Metadata
- Authors
- Franco, M. I., Turin, L., Mershin, A., & Skoulakis, E. M. C.
- Affiliations
- Alexander Fleming Biomedical Sciences Research Center (GR)
- Massachusetts Institute of Technology (US)
- Corresponding author
- Skoulakis, Efthimios M. C.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2011-02-14
- Volume
- 108
- Issue
- 9
- Pages
- 3797-3802
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3048096
- OpenAlex
- W2049498218
- Cited by
- 183
- References
- 43
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 5 · 2023: 6 · 2022: 7 · 2021: 7 · 2020: 12 · 2019: 7 · 2018: 11 · 2017: 19 · 2016: 19 · 2015: 18 · 2014: 16 · 2013: 10 · 2012: 17
- FWCI
- 7.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Advanced Research Projects Agency
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Agricultural and Biological Sciences › Insect Science › Insect Pheromone Research and Control
- Keywords
- olfaction, Drosophila melanogaster, odorant recognition, deuteration, vibrational modes
- MeSH terms
- Animals, Conditioning, Classical, Cues, Deuterium, Discrimination, Psychological, Drosophila melanogaster, Sensation, Smell, Vibration
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