The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells
Open accessAbstract
The intestinal epithelium is maintained by a population of rapidly cycling ( Lgr5 + ) intestinal stem cells (ISCs). It has been postulated, however, that slowly cycling ISCs must also be present in the intestine to protect the genome from accumulating deleterious mutations and to allow for a response to tissue injury. Here, we identify a subpopulation of slowly cycling ISCs marked by mouse telomerase reverse transcriptase ( mTert ) expression that can give rise to Lgr5 + cells. mTert -expressing cells distribute in a pattern along the crypt–villus axis similar to long-term label-retaining cells (LRCs) and are resistant to tissue injury. Lineage-tracing studies demonstrate that mTert + cells give rise to all differentiated intestinal cell types, persist long term, and contribute to the regenerative response following injury. Consistent with other highly regenerative tissues, our results demonstrate that a slowly cycling stem cell population exists within the intestine.
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Citations
Cites
Identification of stem cells in small intestine and colon by marker gene Lgr5
Barker, N., van Es, J. H., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Haegebarth, A., Korving, J., Begthel, H., Peters, P. J., et al. (2007) · Nature · doi:10.1038/nature06196 · Cited by 5,687
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Defining the Epithelial Stem Cell Niche in Skin
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Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice
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“Consistent with this hypothesis, loss of telomerase has been shown to result in intestinal villus atrophy, suggesting a functional requirement for telomerase activity and/or telomere maintenance in ISC function (10).”
BackgroundCoexistence of Quiescent and Active Adult Stem Cells in Mammals
Li, L., & Clevers, H. (2010) · Science · doi:10.1126/science.1180794 · Cited by 1,247
Asymmetric cell divisions promote stratification and differentiation of mammalian skin
Lechler, T., & Fuchs, E. (2005) · Nature · doi:10.1038/nature03922 · Cited by 998
Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse
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Self-citationTelomerase modulates Wnt signalling by association with target gene chromatin
Park, J.-I., Venteicher, A. S., Hong, J. Y., Choi, J., Jun, S., Shkreli, M., Chang, W., Meng, Z., Cheung, P., Ji, H., et al. (2009) · Nature · doi:10.1038/nature08137 · Cited by 707 · cited 1×
“The Artandi lab has demonstrated that mTERT induction is sufficient to activate quiescent epidermal stem cells (12) and, in the intestine, functions as a transcriptional modulator of the Wnt/β-catenin signaling pathway (37).”
BackgroundEffects of Telomerase and Telomere Length on Epidermal Stem Cell Behavior
Flores, I., Cayuela, M. L., & Blasco, M. A. (2005) · Science · doi:10.1126/science.1115025 · Cited by 448
Conditional telomerase induction causes proliferation of hair follicle stem cells
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Cited by
The intestinal crypt, a prototype stem cell compartment
Clevers, H. (2013) · Cell · doi:10.1016/j.cell.2013.07.004 · Cited by 1,223
A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable
Tian, H., Biehs, B., Warming, S., Leong, K. G., Rangell, L., Klein, O. D., & de Sauvage, F. J. (2011) · Nature · doi:10.1038/nature10408 · Cited by 1,204
Growing Self-Organizing Mini-Guts from a Single Intestinal Stem Cell: Mechanism and Applications
Sato, T., & Clevers, H. (2013) · Science · doi:10.1126/science.1234852 · Cited by 1,170
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers
Muñoz, J., Stange, D. E., Schepers, A. G., van de Wetering, M., Koo, B., Itzkovitz, S., Volckmann, R., Kung, K. S., Koster, J., Radulescu, S., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.166 · Cited by 772
Intestinal label-retaining cells are secretory precursors expressing Lgr5
Buczacki, S. J. A., Zecchini, H. I., Nicholson, A. M., Russell, R., Vermeulen, L., Kemp, R., & Winton, D. J. (2013) · Nature · doi:10.1038/nature11965 · Cited by 761
Metadata
- Authors
- Montgomery, R. K., Carlone, D. L., Richmond, C. A., Farilla, L., Kranendonk, M. E. G., Henderson, D. E., Baffour-Awuah, N. Y., Ambruzs, D. M., Fogli, L. K., Algra, S., & Breault, D. T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2010-12-20
- Volume
- 108
- Issue
- 1
- Pages
- 179-184
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2047151533
- Cited by
- 540
- References
- 13
- FWCI
- 21.79
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells. https://app.cochat.ai/papers/10.1073/pnas.1013004108
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- Montgomery, R. K., Carlone, D. L., Richmond, C. A., Farilla, L., Kranendonk, M. E. G., Henderson, D. E., Baffour-Awuah, N. Y., Ambruzs, D. M., Fogli, L. K., Algra, S., & Breault, D. T. (2011). Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1013004108
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