Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning
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Many antioxidant genes transcriptionally controlled by synaptic activity in neurons are known NFE2L2 target genes, but are induced via NFE2L2-independent routes (e.g. AP-1 and ATF4), suggesting that activity-dependent signaling may act as a substitute for an absent NFE2L2 pathway.
“Interestingly, many of the antioxidant genes transcriptionally controlled by synaptic activity in neurons are known NFE2L2 target genes, but are induced via NFE2L2independent routes (e.g. via activator protein 1 (AP-1) family and activating transcription factor 4 (ATF4)), suggesting that activity-dependent signaling may act as a substitute for an absent NFE2L2 pathway 73,86,87 .”
From Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis (2016) · cites this paper as [86]
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Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses
Papadia, S., Soriano, F. X., Léveillé, F., Martel, M.-A., Dakin, K. A., Hansen, H. H., Kaindl, A., Sifringer, M., Fowler, J., Stefovska, V., et al. (2008) · Nature Neuroscience · doi:10.1038/nn2071 · Cited by 498 · see citing works
Self-citationHyslop, P. A., Zhang, Z., Pearson, D. V., & Phebus, L. A. (1995) · Brain Research · doi:10.1016/0006-8993(94)01291-o · Cited by 335 · see citing works
Haskew-Layton, R. E., Payappilly, J. B., Smirnova, N. A., Ma, T. C., Chan, K. K., Murphy, T. H., Guo, H., Langley, B. C., Rukhsana Sultana, A., Butterfield, D. A., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003996107 · Cited by 151 · see citing works
Soriano, F. X., Léveillé, F., Papadia, S., Higgins, L. G., Varley, J. A., Baxter, P. S., Hayes, J. D., & Hardingham, G. E. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05648.x · Cited by 144 · see citing works
Self-citationJoannides, A. J., Webber, D. J., Raineteau, O., Kelly, C. M., Irvine, K., Watts, C., Rosser, A., Kemp, P. J., Blakemore, W. F., Compston, A., et al. (2007) · Brain · doi:10.1093/brain/awm070 · Cited by 60 · see citing works
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Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis
Hardingham, G. E., & Do, K. Q. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.19 · Cited by 304 · see citing works
Self-citationBioenergetics and redox adaptations of astrocytes to neuronal activity
Bolaños, J. P. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13486 · Cited by 262 · see citing works
Antioxidant and bioenergetic coupling between neurons and astrocytes
Fernandez-Fernandez, S., Almeida, A., & Bolaños, J. P. (2012) · Biochemical Journal · doi:10.1042/bj20111943 · Cited by 247 · see citing works
Astrocyte NMDA receptors' activity sustains neuronal survival through a Cdk5–Nrf2 pathway
Jimenez-Blasco, D., Santofimia-Castaño, P., Gonzalez, A., Almeida, A., & Bolaños, J. P. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2015.49 · Cited by 196 · see citing works
Bell, K. F. S., Al-Mubarak, B., Martel, M.-A., McKay, S., Wheelan, N., Hasel, P., Márkus, N. M., Baxter, P., Deighton, R. F., Serio, A., et al. (2015) · Nature Communications · doi:10.1038/ncomms8066 · Cited by 191 · see citing works
Self-citationOxidative stress involving changes in Nrf2 and ER stress in early stages of Alzheimer's disease
Mota, S. I., Costa, R. O., Ferreira, I. L., Santana, I., Caldeira, G. L., Padovano, C., Fonseca, A. C., Baldeiras, I., Cunha, C., Letra, L., et al. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.03.015 · Cited by 183 · see citing works
Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system
Baxter, P. S., Bell, K. F. S., Hasel, P., Kaindl, A. M., Fricker, M., Thomson, D., Cregan, S. P., Gillingwater, T. H., & Hardingham, G. E. (2015) · Nature Communications · doi:10.1038/ncomms7761 · Cited by 139 · see citing works
Self-citationGatto, N., Dos Santos Souza, C., Shaw, A. C., Bell, S. M., Myszczynska, M. A., Powers, S., Meyer, K., Castelli, L. M., Karyka, E., Mortiboys, H., et al. (2021) · Aging Cell · doi:10.1111/acel.13281 · Cited by 58 · see citing works
- Authors
- Bell, K. F., Al-Mubarak, B., Fowler, J. H., Baxter, P. S., Gupta, K., Tsujita, T., Chowdhry, S., Patani, R., Chandran, S., Horsburgh, K., Hayes, J. D., & Hardingham, G. E.
- Affiliations
- University of Edinburgh (GB)
- University of Dundee (GB)
- Euan MacDonald Centre for Motor Neuron Disease Research (GB)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2010-12-21
- Volume
- 108
- Issue
- 1
- Pages
- E1-2; author reply E3
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3017195
- OpenAlex
- W2137927355
- Cited by
- 133
- References
- 5
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 5 · 2022: 5 · 2021: 8 · 2020: 7 · 2019: 10 · 2018: 7 · 2017: 15 · 2016: 11 · 2015: 14 · 2014: 11 · 2013: 14 · 2012: 14
- FWCI
- 4.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Discovery Research Portal (University of Dundee) (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust
- Alzheimer's Society
- Royal Society
- University of Tsukuba
- Canadian Institutes of Health Research
- Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- Nrf2, oxidative stress, astrocytes, ischemic preconditioning, neuroprotection, ischemic stroke, antioxidant response
- MeSH terms
- Animals, Astrocytes, Cells, Cultured, Heme Oxygenase (Decyclizing), Hydrogen Peroxide, Neurons, Gene Expression Regulation, Enzymologic, Oxidative Stress, Neuroprotective Agents, Ischemic Preconditioning, Oxidoreductases Acting on Sulfur Group Donors, NF-E2-Related Factor 2, Rats
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