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Glutathione-Related Factors and Oxidative Stress in Autism, A Review

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In This Issue

(2011) · Proceedings of the National Academy of Sciences · doi:10.1073/iti0111108 · Cited by 104 · see citing works

Glutamate receptor dysfunction and drug targets across models of autism spectrum disorders

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The enigma of fetal alcohol neurotoxicity

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Two-photon Imaging of Glutathione Levels in Intact Brain Indicates Enhanced Redox Buffering in Developing Neurons and Cells at the Cerebrospinal Fluid and Blood-Brain Interface

Sun, X., Shih, A. Y., Johannssen, H. C., Erb, H., Li, P., & Murphy, T. H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601567200 · Cited by 89 · see citing works

Human embryonic stem cell derived astrocytes mediate non-cell-autonomous neuroprotection through endogenous and drug-induced mechanisms

Gupta, K., Patani, R., Baxter, P. S., Serio, A., Story, D., Tsujita, T., Hayes, J. D., Pedersen, R. A., Hardingham, G. E., & Chandran, S. (2011) · Cell Death and Differentiation · doi:10.1038/cdd.2011.154 · Cited by 86 · see citing works

Knockdown of Glutamate-Cysteine Ligase by Small Hairpin RNA Reveals That Both Catalytic and Modulatory Subunits Are Essential for the Survival of Primary Neurons

Diaz-Hernandez, J. I., Almeida, A., Delgado-Esteban, M., Fernandez, E., & Bolaños, J. P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507065200 · Cited by 82 · see citing works

Triggers of apoptosis in the immature brain

Ikonomidou, C. (2009) · Brain and Development · doi:10.1016/j.braindev.2009.02.006 · Cited by 80 · see citing works

The influence of synaptic activity on neuronal health

Bell, K. F., & Hardingham, G. E. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.01.002 · Cited by 77 · see citing works

Decreased glutathione levels and altered antioxidant defense in an animal model of schizophrenia: Long-term effects of perinatal phencyclidine administration

Radonjić, N. V., Knežević, I. D., Vilimanovich, U., Kravić-Stevović, T., Marina, L. V., Nikolić, T., Todorović, V., Bumbaširević, V., & Petronijević, N. D. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.12.009 · Cited by 75 · see citing works

CNS Peroxiredoxins and Their Regulation in Health and Disease

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Regulation of Neuronal Oxidative and Nitrosative Stress by Endogenous Protective Pathways and Disease Processes

Hardingham, G. E., & Lipton, S. A. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3573 · Cited by 64 · see citing works

Hypoxic/ischemic conditions induce expression of the putative pro-death gene Clca1 via activation of extrasynaptic N-methyl-d-aspartate receptors

Wahl, A.-S., Buchthal, B., Rode, F., Bomholt, S. F., Freitag, H. E., Hardingham, G. E., Rønn, L. C. B., & Bading, H. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.06.018 · Cited by 64 · see citing works

PGC-1α Negatively Regulates Extrasynaptic NMDAR Activity and Excitotoxicity

Puddifoot, C. A., Martel, M., Soriano, F. X., Camacho‐Morales, A., Vidal‐Puig, A., Wyllie, D. J. A., & Hardingham, G. E. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.6407-11.2012 · Cited by 63 · see citing works

Genetic Data Supporting the NMDA Glutamate Receptor Hypothesis for Schizophrenia

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Regulation of N-Methyl-D-Aspartate Receptors by Disrupted-in-Schizophrenia-1

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Human stem cell-derived astrocytes and their application to studying Nrf2-mediated neuroprotective pathways and therapeutics in neurodegeneration

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Identification and characterization of an Nrf2‐mediated ARE upstream of the rat glutamate cysteine ligase catalytic subunit gene (GCLC)

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The Possible Involvement of NMDA Glutamate Receptor in the Etiopathogenesis of Bipolar Disorder

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13 reasons why the brain is susceptible to oxidative stress

Cobley, J. N., Fiorello, M. L., & Bailey, D. M. (2018) · Redox Biology · doi:10.1016/j.redox.2018.01.008 · Cited by 1,215 · see citing works

Inflammation, glutamate, and glia: a trio of trouble in mood disorders

Haroon, E., Miller, A. H., & Sanacora, G. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.199 · Cited by 584 · see citing works

Neuroprotective Effect of Antioxidants in the Brain

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Complex I assembly into supercomplexes determines differential mitochondrial ROS production in neurons and astrocytes

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Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism

Hasel, P., Dando, O., Jiwaji, Z., Baxter, P. S., Todd, A., Heron, S., Márkus, N. M., McQueen, J., Hampton, D. W., Torvell, M., et al. (2017) · Nature Communications · doi:10.1038/ncomms15132 · Cited by 305 · see citing works

Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis

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Interplay of gut microbiota and oxidative stress: Perspective on neurodegeneration and neuroprotection

Shandilya, S., Kumar, S., Jha, N. K., Kesari, K. K., & Ruokolainen, J. (2021) · Journal of Advanced Research · doi:10.1016/j.jare.2021.09.005 · Cited by 300 · see citing works

The origin of NMDA receptor hypofunction in schizophrenia

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Quantitative real-time imaging of glutathione

Jiang, X., Chen, J., Bajić, A., Zhang, C., Song, X., Carroll, S. L., Cai, Z., Tang, M., Xue, M., Cheng, N., et al. (2017) · Nature Communications · doi:10.1038/ncomms16087 · Cited by 270 · see citing works

Bioenergetics and redox adaptations of astrocytes to neuronal activity

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Adaptive regulation of the brain’s antioxidant defences by neurons and astrocytes

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Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology

Jiwaji, Z., Tiwari, S. S., Avilés-Reyes, R. X., Hooley, M., Hampton, D., Torvell, M., Johnson, D. A., McQueen, J., Baxter, P., Sabari-Sankar, K., et al. (2022) · Nature Communications · doi:10.1038/s41467-021-27702-w · Cited by 223 · see citing works

Glutathione in Brain Disorders and Aging

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Regulation of neuronal development and function by ROS

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Astrocytic mitochondrial ROS modulate brain metabolism and mouse behaviour

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Synaptic Activity Regulates Mitochondrial Iron Metabolism to Enhance Neuronal Bioenergetics

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Edinburgh Research Explorer

Baxter, P. S., Bell, K. F. S., Hasel, P., Kaindl, A. M., Fricker, M., Thomson, D., Cregan, S. P., Gillingwater, T. H., & Hardingham, G. E. (2016)

Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

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NMDA receptor activity regulates transcription of antioxidant pathways

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Coordinate Regulation of Glutathione Biosynthesis and Release by Nrf2-Expressing Glia Potently Protects Neurons from Oxidative Stress

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Nuclear Factor Erythroid 2-Related Factor 2 Facilitates Neuronal Glutathione Synthesis by Upregulating Neuronal Excitatory Amino Acid Transporter 3 Expression

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