Antioxidant and bioenergetic coupling between neurons and astrocytes

How mitochondria produce reactive oxygen species

Murphy, M. P. (2009) · Biochemical Journal · doi:10.1042/bj20081386 · Cited by 8,207 · see citing works

Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide

Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., & Freeman, B. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1620 · Cited by 7,029 · see citing works

Astrocytes: Biology and pathology

Sofroniew, M. V., & Vinters, H. V. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0619-8 · Cited by 5,196 · see citing works

Ischemic Cell Death in Brain Neurons

Lipton, P. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.4.1431 · Cited by 3,043 · see citing works

Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization.

Pellerin, L., & Magistretti, P. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.22.10625 · Cited by 2,927 · see citing works

Nitric oxide synthases in mammals

Knowles, R. G., & Moncada, S. (1994) · Biochemical Journal · doi:10.1042/bj2980249 · Cited by 2,752 · see citing works

Oxidative stress and neurodegeneration: where are we now?

Halliwell, B. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03907.x · Cited by 2,614 · see citing works

Molecular dissection of reactive astrogliosis and glial scar formation

Sofroniew, M. V. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.08.002 · Cited by 2,594 · see citing works

Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain

Garthwaite, J., Charles, S. L., & Chess‐Williams, R. (1988) · Nature · doi:10.1038/336385a0 · Cited by 2,540 · see citing works

Glial and neuronal control of brain blood flow

Attwell, D., Buchan, A. M., Charpak, S., Lauritzen, M., MacVicar, B. A., & Newman, E. A. (2010) · Nature · doi:10.1038/nature09613 · Cited by 2,511 · see citing works

Peroxynitrite oxidation of sulfhydryls.

Radí, R., Beckman, J. S., Bush, K., & Freeman, B. Α. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)64313-7 · Cited by 2,499 · see citing works

Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators

St-Pierre, J., Drori, S., Uldry, M., Silvaggi, J. M., Rhee, J., Jäger, S., Handschin, C., Zheng, K., Lin, J., Yang, W., et al. (2006) · Cell · doi:10.1016/j.cell.2006.09.024 · Cited by 2,233 · see citing works

The Role Of Glutamate Neurotoxicity In Hypoxic-Ischemic Neuronal Death

Choi, D. W., & Rothman, S. M. (1990) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.13.030190.001131 · Cited by 2,210 · see citing works

Peroxynitrite-induced membrane lipid peroxidation: The cytotoxic potential of superoxide and nitric oxide

Radí, R., Beckman, J. S., Bush, K. M., & Freeman, B. Α. (1991) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(91)90224-7 · Cited by 2,196 · see citing works

Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.

Bredt, D. S., & Snyder, S. H. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.22.9030 · Cited by 1,849 · see citing works

Role of endothelium-derived nitric oxide in the regulation of blood pressure.

Rees, D. D., Palmer, R. M. J., & Moncada, S. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.9.3375 · Cited by 1,827 · see citing works

Tripartite synapses: astrocytes process and control synaptic information

Perea, G., Navarrete, M., & Araque, A. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.05.001 · Cited by 1,820 · see citing works

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

Suzuki, A., Stern, S. A., Bozdagi, O., Huntley, G. W., Walker, R. H., Magistretti, P. J., & Alberini, C. M. (2011) · Cell · doi:10.1016/j.cell.2011.02.018 · Cited by 1,711 · see citing works

Metabolism and functions of glutathione in brain

Dringen, R. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00060-x · Cited by 1,702 · see citing works

Transcriptional paradigms in mammalian mitochondrial biogenesis and function

Scarpulla, R. C. (2008) · Physiological Reviews · doi:10.1152/physrev.00025.2007 · Cited by 1,666 · see citing works

Nrf2:INrf2 (Keap1) signaling in oxidative stress

Kaspar, J. W., Niture, S. K., & Jaiswal, A. K. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.07.035 · Cited by 1,646 · see citing works

Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase

Ischiropoulos, H., Zhu, L., Chen, J., Tsai, M., Martin, J. C., Smith, C. D. L., & Beckman, J. S. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90431-u · Cited by 1,495 · see citing works

Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase.

Knowles, R. G., Palacios‐Callender, M., Palmer, R. M. J., & Moncada, S. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.13.5159 · Cited by 1,431 · see citing works

Nrf2 signaling in coordinated activation of antioxidant gene expression

Jaiswal, A. K. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.02.074 · Cited by 1,254 · see citing works

Biochemical, physiological and medical aspects of ubiquinone function

Ernster, L., & Dallner, G. (1995) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(95)00028-3 · Cited by 1,232 · see citing works

Nitric Oxide Activation of Poly(ADP-Ribose) Synthetase in Neurotoxicity

Zhang, J., Dawson, V. L., Dawson, T. M., & Snyder, S. H. (1994) · Science · doi:10.1126/science.8080500 · Cited by 1,118 · see citing works

S-Nitrosylation of Drp1 Mediates β-Amyloid-Related Mitochondrial Fission and Neuronal Injury

Cho, D.-H., Nakamura, T., Fang, J., Cieplak, P., Godzik, A., Gu, Z., & Lipton, S. A. (2009) · Science · doi:10.1126/science.1171091 · Cited by 1,092 · see citing works

Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase

Brown, G. C., & Cooper, C. E. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)01290-3 · Cited by 1,055 · see citing works

Bright and dark sides of nitric oxide in ischemic brain injury

Iadecola, C. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10074-6 · Cited by 1,044 · see citing works

Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase 1 gene

Radjendirane, V., & Jaiswal, A. K. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.25.14960 · Cited by 1,034 · see citing works

Transcriptional Repression of PGC-1α by Mutant Huntingtin Leads to Mitochondrial Dysfunction and Neurodegeneration

Cui, L., Jeong, H., Borovecki, F., Parkhurst, C. N., Tanese, N., & Krainc, D. (2006) · Cell · doi:10.1016/j.cell.2006.09.015 · Cited by 1,012 · see citing works

Positron Emission Tomography in Evaluation of Dementia

Silverman, D. H. S., Small, G. W., Chang, C. Y., Lu, C. S., de Aburto, M. A. K., Chen, W., Czernin, J. G., Rapoport, S. I., Pietrini, P., Alexander, G. E., et al. (2001) · JAMA · doi:10.1001/jama.286.17.2120 · Cited by 939 · see citing works

Selective vulnerability of the hippocampus in brain ischemia

Schmidt‐Kastner, R., & Freund, T. F. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90001-5 · Cited by 890 · see citing works

ALS, SOD and peroxynitrite

Beckman, J. S., Carson, M. A., Smith, C. D. L., & Koppenol, W. H. (1993) · Nature · doi:10.1038/364584a0 · Cited by 876 · see citing works

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

Hayes, J. D., & McMahon, M. J. (2009) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2008.12.008 · Cited by 870 · see citing works

The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1

Herrero-Mendez, A., Almeida, A., Fernández, E., Maestre, C., Moncada, S., & Bolaños, J. P. (2009) · Nature Cell Biology · doi:10.1038/ncb1881 · Cited by 844 · see citing works

Environmental Risk Factors and Parkinson's Disease: Selective Degeneration of Nigral Dopaminergic Neurons Caused by the Herbicide Paraquat

McCormack, A. L., Thiruchelvam, M. J., Manning-Bog, A., Thiffault, C., Langston, J. W., Cory‐Slechta, D. A., & Monte, D. A. D. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2002.0507 · Cited by 838 · see citing works

Activity-dependent regulation of energy metabolism by astrocytes: an update

Pellerin, L., Bouzier‐Sore, A., Aubert, A., Serres, S., Merle, M., Costalat, R., & Magistretti, P. J. (2007) · Glia · doi:10.1002/glia.20528 · Cited by 805 · see citing works

Coordinate Regulation of Glutathione Biosynthesis and Release by Nrf2-Expressing Glia Potently Protects Neurons from Oxidative Stress

Shih, A. Y., Johnson, D. A., Wong, G., Kraft, A. D., Jiang, L., Erb, H., Johnson, J. A., & Murphy, T. H. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03394.2003 · Cited by 786 · see citing works

Identification of the NF-E2-related Factor-2-dependent Genes Conferring Protection against Oxidative Stress in Primary Cortical Astrocytes Using Oligonucleotide Microarray Analysis

Lee, J., Calkins, M. J., Chan, K., Kan, Y. W., & Johnson, J. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211558200 · Cited by 783 · see citing works

Evidence Supporting the Existence of an Activity-Dependent Astrocyte-Neuron Lactate Shuttle

Pellerin, L., Pellegri, G., Bittar, P. G., Charnay, Y., Bouras, C., Martin, J., Stella, N., & Magistretti, P. J. (1998) · Developmental Neuroscience · doi:10.1159/000017324 · Cited by 757 · see citing works

Neural activity triggers neuronal oxidative metabolism followed by astrocytic glycolysis

Kasischke, K. A., Vishwasrao, H. D., Fisher, P. J., Zipfel, W. R., & Webb, W. W. (2004) · Science · doi:10.1126/science.1096485 · Cited by 742 · see citing works

Neuron-glia metabolic coupling and plasticity

Magistretti, P. J. (2006) · Experimental Physiology · doi:10.1113/expphysiol.2010.053157 · Cited by 739 · see citing works

Sweet Sixteen for ANLS

Pellerin, L., & Magistretti, P. J. (2011) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.149 · Cited by 726 · see citing works

Neuroinflammation, Oxidative Stress and the Pathogenesis of Alzheimers Disease

Agostinho, P., A. Cunha, R., & Oliveira, C. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210793176572 · Cited by 685 · see citing works

Astrocytes Are Endogenous Regulators of Basal Transmission at Central Synapses

Panatier, A., Vallée, J., Haber, M., Murai, K. K., Lacaille, J.-C., & Robitaille, R. (2011) · Cell · doi:10.1016/j.cell.2011.07.022 · Cited by 650 · see citing works

Synthesis of nitric oxide in CNS glial cells

Murphy, S. P., Simmons, M. L., Agulló, L., Garcı́a, A., Feinstein, D. L., Galea, E., Reis, D. J., Minc‐Golomb, D., & Schwartz, J. P. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90109-y · Cited by 633 · see citing works

Astrocyte glycogen and brain energy metabolism

Brown, A. M., & Ransom, B. R. (2007) · Glia · doi:10.1002/glia.20557 · Cited by 626 · see citing works

Basic mechanisms of neurodegeneration: a critical update

Jellinger, K. A. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01010.x · Cited by 608 · see citing works

Synthesis of the Antioxidant Glutathione in Neurons: Supply by Astrocytes of CysGly as Precursor for Neuronal Glutathione

Dringen, R., Pfeiffer, B., & Hamprecht, B. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-02-00562.1999 · Cited by 589 · see citing works

Energy metabolism in astrocytes: High rate of oxidative metabolism and spatiotemporal dependence on glycolysis/glycogenolysis

Hertz, L., Peng, L., & Dienel, G. A. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600343 · Cited by 587 · see citing works

Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson’s disease: Critical role for the astrocyte

Chen, P.-C., Vargas, M. R., Pani, A. K., Smeyne, R. J., Johnson, D. A., Kan, Y. W., & Johnson, J. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813361106 · Cited by 579 · see citing works

Mice Deficient in Cellular Glutathione Peroxidase Develop Normally and Show No Increased Sensitivity to Hyperoxia

Ho, Y., Magnenat, J.-L., Bronson, R. T., Cao, J., Gargano, M. D., Sugawara, M., & Funk, C. D. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.26.16644 · Cited by 562 · see citing works

Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1α in Huntington's disease neurodegeneration

Weydt, P., Pineda, V. V., Torrence, A. E., Libby, R. T., Satterfield, T. F., Lazarowski, E. R., Gilbert, M. L., Morton, G. J., Bammler, T. K., Strand, A. D., et al. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.10.004 · Cited by 562 · see citing works

Coenzyme Q ₁₀ administration increases brain mitochondrial concentrations and exerts neuroprotective effects

Matthews, R. T., Yang, L., Browne, S., Baik, M., & Beal, M. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.8892 · Cited by 557 · see citing works

Nitric oxide, cell bioenergetics and neurodegeneration

Moncada, S., & Bolaños, J. P. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03988.x · Cited by 556 · see citing works

Animal and human studies with the mitochondria‐targeted antioxidant MitoQ

Smith, R. A. J., & Murphy, M. P. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05627.x · Cited by 553 · see citing works

Nuclear Factor E2-Related Factor 2-Dependent Antioxidant Response Element Activation by tert -Butylhydroquinone and Sulforaphane Occurring Preferentially in Astrocytes Conditions Neurons against Oxidative Insult

Kraft, A. D., Johnson, D. A., & Johnson, J. A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3817-03.2004 · Cited by 541 · see citing works

Inflammatory Neurodegeneration and Mechanisms of Microglial Killing of Neurons

Brown, G. C., & Neher, J. J. (2010) · Molecular Neurobiology · doi:10.1007/s12035-010-8105-9 · Cited by 526 · see citing works

Reaction of superoxide with nitric oxide to form peroxonitrite in alkaline aqueous solution

Blough, N. V., & Zafiriou, O. C. (1985) · Inorganic Chemistry · doi:10.1021/ic00216a003 · Cited by 525 · see citing works

Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene. Characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants.

Rushmore, T. H., & Pickett, C. B. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77351-1 · Cited by 522 · see citing works

Nitric Oxide‐Mediated Mitochondrial Damage in the Brain: Mechanisms and Implications for Neurodegenerative Diseases

Bolaños, J. P., Almeida, Á., Stewart, V. C., Peuchen, S., Land, J. M., Clark, J. B., & Heales, S. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68062227.x · Cited by 519 · see citing works

Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

Papadia, S., Soriano, F. X., Léveillé, F., Martel, M.-A., Dakin, K. A., Hansen, H. H., Kaindl, A., Sifringer, M., Fowler, J., Stefovska, V., et al. (2008) · Nature Neuroscience · doi:10.1038/nn2071 · Cited by 498 · see citing works

Effect of Peroxynitrite on the Mitochondrial Respiratory Chain: Differential Susceptibility of Neurones and Astrocytes in Primary Culture

Bolaños, J. P., Heales, S., Land, J. M., & Clark, J. B. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64051965.x · Cited by 492 · see citing works

Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway

Almeida, Á., Moncada, S., & Bolaños, J. P. (2003) · Nature Cell Biology · doi:10.1038/ncb1080 · Cited by 481 · see citing works

Nrf2 Activation in Astrocytes Protects against Neurodegeneration in Mouse Models of Familial Amyotrophic Lateral Sclerosis

Vargas, M. R., Johnson, D. A., Sirkis, D. W., Messing, A., & Johnson, J. A. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4099-08.2008 · Cited by 479 · see citing works

NAD(P)H:Quinone Oxidoreductase 1: Role as a Superoxide Scavenger

Siegel, D. M., Gustafson, D. L., Dehn, D. L., Han, J. Y., Boonchoong, P., Berliner, L. J., & Ross, D. (2004) · Molecular Pharmacology · doi:10.1124/mol.65.5.1238 · Cited by 455 · see citing works

Peroxide detoxification by brain cells

Dringen, R., Pawlowski, P. G., & Hirrlinger, J. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20280 · Cited by 452 · see citing works

Regulation of the pentose phosphate cycle

Eggleston, L. V., & Krebs, H. A. (1974) · Biochemical Journal · doi:10.1042/bj1380425 · Cited by 445 · see citing works

The Nrf2/ARE Pathway as a Potential Therapeutic Target in Neurodegenerative Disease

Calkins, M. J., Johnson, D. A., Townsend, J. A., Vargas, M. R., Dowell, J. A., Williamson, T. P., Kraft, A. D., Lee, J., Li, J., & Johnson, J. A. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2242 · Cited by 440 · see citing works

Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content

Vos, K. J. D., Chapman, A. L., Tennant, M. E., Manser, C., Tudor, E. L., Lau, K., Brownlees, J., Ackerley, S., Shaw, P. J., McLoughlin, D. M., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm226 · Cited by 420 · see citing works

Glutathione is present in high concentrations in cultured astrocytes but not in cultured neurons

Raps, S. P., Lai, J. C. K., Hertz, L., & Cooper, A. J. L. (1989) · Brain Research · doi:10.1016/0006-8993(89)91178-5 · Cited by 417 · see citing works

Vitamin E, Ascorbate, Glutathione, Glutathicne Disulfide, and Enzymes of Glutathione Metabolism in Cultures of Chick Astrocytes and Neurons: Evidence that Astrocytes Play an Important Role in Antioxidative Processes in the Brain

Makar, T. K., Nedergaard, M., Preuss, A. K., Gelbard, A. S., Perumal, A. S., & Cooper, A. J. L. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.62010045.x · Cited by 415 · see citing works

A Small-Molecule-Inducible Nrf2-Mediated Antioxidant Response Provides Effective Prophylaxis against Cerebral Ischemia<i>In Vivo</i>

Shih, A. Y., Li, P., & Murphy, T. H. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4014-05.2005 · Cited by 413 · see citing works

Nitric Oxide‐Mediated Inhibition of the Mitochondrial Respiratory Chain in Cultured Astrocytes

Bolaños, J. P., Peuchen, S., Heales, S., Land, J. M., & Clark, J. B. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.63030910.x · Cited by 413 · see citing works

Mice Lacking Catalase Develop Normally but Show Differential Sensitivity to Oxidant Tissue Injury

Ho, Y.-S., Xiong, Y., Ma, W., Spector, A., & Ho, D. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404800200 · Cited by 403 · see citing works

Maintenance of Neuronal Glutathione by Glial Cells

Sagara, J., Miura, K., & Bannai, S. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb09802.x · Cited by 402 · see citing works

Therapeutic Effects of Coenzyme Q₁₀and Remacemide in Transgenic Mouse Models of Huntington's Disease

Ferrante, R. J., Andreassen, O. A., Dedeoglu, A., Ferrante, K. L., Jenkins, B. G., Hersch, S. M., & Beal, M. F. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01592.2002 · Cited by 391 · see citing works

Mechanisms of excitotoxicity in neurologic diseases

Beal, M. F. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.15.1464368 · Cited by 389 · see citing works

PGC-1α Expression Decreases in the Alzheimer Disease Brain as a Function of Dementia

Qin, W., Haroutunian, V. H., Katsel, P., Cardozo, C. P., Ho, L., Buxbaum, J. D., & Pasinetti, G. M. (2009) · Archives of Neurology · doi:10.1001/archneurol.2008.588 · Cited by 381 · see citing works

Glycolysis: a bioenergetic or a survival pathway?

Bolaños, J. P., Almeida, Á., & Moncada, S. (2009) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2009.10.006 · Cited by 359 · see citing works

Cytochrome c oxidase and mitochondrial F1F0-ATPase (ATP synthase) activities in platelets and brain from patients with Alzheimer’s disease

Bosetti, F. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00314-1 · Cited by 348 · see citing works

A Reevaluation of the Role of Mitochondria in Neuronal Ca2+ Homeostasis

Budd, S. L., & Nicholls, D. G. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66010403.x · Cited by 346 · see citing works

Activation of the Keap1/Nrf2 pathway for neuroprotection by electrophillic phase II inducers

Satoh, T., Okamoto, S.-I., Cui, J., Watanabe, Y., Furuta, K., Suzuki, M., Tohyama, K., & Lipton, S. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505723102 · Cited by 342 · see citing works

Nitric Oxide Potently and Reversibly Deenergizes Mitochondria at Low Oxygen Tension

Schweizer, M., & Richter, C. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2441 · Cited by 331 · see citing works

The biochemistry, metabolism and inherited defects of the pentose phosphate pathway: A review

Wamelink, M. M. C., Struys, E. A., & Jakobs, C. (2008) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-008-1015-6 · Cited by 330 · see citing works

The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin

Hayes, J. D., Chanas, S. A., Henderson, C. J., McMahon, M. J., Sun, C., Moffat, G. J., Wolf, C. R., & Yamamoto, M. P. (2000) · Biochemical Society Transactions · doi:10.1042/bst0280033 · Cited by 321 · see citing works

Lactate: The Ultimate Cerebral Oxidative Energy Substrate?

Schurr, A. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600174 · Cited by 313 · see citing works

Roles of nitric oxide in brain hypoxia-ischemia

Bolaños, J. P., & Almeida, Á. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00030-4 · Cited by 313 · see citing works

NF-E2-related Factor-2 Mediates Neuroprotection against Mitochondrial Complex I Inhibitors and Increased Concentrations of Intracellular Calcium in Primary Cortical Neurons

Lee, J.-M., Shih, A. Y., Murphy, T. H., & Johnson, J. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305204200 · Cited by 308 · see citing works

Role of retinal glial cells in neurotransmitter uptake and metabolism.

Bringmann, A., Pannicke, T., Biedermann, B., Francke, M., Iandiev, I., Grosche, J., Wiedemann, P., Albrecht, J., & Reichenbach, A. (2009) · Neurochemistry International · doi:10.1016/j.neuint.2008.10.014 · Cited by 281 · see citing works

Induction of the Nrf2-driven Antioxidant Response Confers Neuroprotection during Mitochondrial Stress in Vivo

Shih, A. Y., Imbeault, S., Barakauskas, V., Erb, H., Jiang, L., Li, P., & Murphy, T. H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414635200 · Cited by 273 · see citing works

Nitric oxide-mediated mitochondrial damage: A potential neuroprotective role for glutathione

Bolaños, J. P., Heales, S. J. R., Peuchen, S., Barker, J. E., Land, J. M., & Clark, J. B. (1996) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00240-7 · Cited by 263 · see citing works

Nitric oxide as a potential pathological mechanism in demyelination: Its differential effects on primary glial cellsin vitro

Mitrovic, B., Ignarro, L. J., Montestruque, S., Smoll, A., & Merrill, J. E. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90435-9 · Cited by 259 · see citing works

Neuroexcitatory Amino Acids and Their Relation to Infarct Size and Neurological Deficit in Ischemic Stroke

Castillo, J., Dávalos, A., Naveiro, J., & Noya, M. (1996) · Stroke · doi:10.1161/01.str.27.6.1060 · Cited by 258 · see citing works

The Regulation of Glucose Metabolism by HIF-1 Mediates a Neuroprotective Response to Amyloid Beta Peptide

Soucek, T., Cumming, R., Dargusch, R., Maher, P., & Schubert, D. (2003) · Neuron · doi:10.1016/s0896-6273(03)00367-2 · Cited by 258 · see citing works

Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice

Beal, M. F., Matthews, R. T., Tieleman, A., & Shults, C. W. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01192-x · Cited by 256 · see citing works

Neurobiology and treatment of Parkinson's disease

Schapira, A. H. V. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.10.005 · Cited by 252 · see citing works

Nrf2-mediated protection against 6-hydroxydopamine

Jakel, R. J., Townsend, J. A., Kraft, A. D., & Johnson, J. A. (2007) · Brain Research · doi:10.1016/j.brainres.2007.01.131 · Cited by 252 · see citing works

A Comparison of Thiol Peroxidase Mechanisms

Flohé, L., Toppo, S., Cozza, G., & Ursini, F. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3397 · Cited by 250 · see citing works

Protection from mitochondrial complex II inhibition <i>in vitro</i> and <i>in vivo</i> by Nrf2-mediated transcription

Calkins, M. J., Jakel, R. J., Johnson, D. A., Chan, K., Kan, Y. W., & Johnson, J. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408487101 · Cited by 247 · see citing works

The Glutathione System of Peroxide Detoxification Is Less Efficient in Neurons than in Astroglial Cells

Dringen, R., Kußmaul, L., Gutterer, J. M., Hirrlinger, J., & Hamprecht, B. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0722523.x · Cited by 243 · see citing works

Extracellular superoxide dismutase, nitric oxide, and central nervous system O2 toxicity.

Oury, T. D., Ho, Y.-S., Piantadosi, C. A., & Crapo, J. D. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.20.9715 · Cited by 238 · see citing works

Antioxidants in Central Nervous System Diseases: Preclinical Promise and Translational Challenges

Kamat, C. D., Gadal, S., Mhatre, M., Williamson, K. S., Pye, Q. N., & Hensley, K. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-15314 · Cited by 237 · see citing works

Bioenergetic analysis of isolated cerebrocortical nerve terminals on a microgram scale: spare respiratory capacity and stochastic mitochondrial failure

Choi, S. W., Gerencser, A. A., & Nicholls, D. G. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06055.x · Cited by 204 · see citing works

Assessment of the Role of the Glutathione and Pentose Phosphate Pathways in the Protection of Primary Cerebrocortical Cultures from Oxidative Stress

Ben‐Yoseph, O., Boxer, P. A., & Ross, B. D. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66062329.x · Cited by 189 · see citing works

In vivo modulation of the Parkinsonian phenotype by Nrf2

Burton, N. C., Kensler, T. W., & Guilarte, T. R. (2006) · NeuroToxicology · doi:10.1016/j.neuro.2006.07.019 · Cited by 187 · see citing works

Phenotypically aberrant astrocytes that promote motoneuron damage in a model of inherited amyotrophic lateral sclerosis

Díaz‐Amarilla, P., Olivera‐Bravo, S., Trías, E., Cragnolini, A. B., Palma, L. M., Cassina, P., Beckman, J. S., & Barbeito, L. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110689108 · Cited by 186 · see citing works

Fast and Reversible Stimulation of Astrocytic Glycolysis by K+and a Delayed and Persistent Effect of Glutamate

Bittner, C. X., Valdebenito, R., Ruminot, I., Loaiza, A., Larenas, V., Sotelo-Hitschfeld, T., Moldenhauer, H. J., Martín, A. S., Gutiérrez, R., Zambrano, M., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5311-10.2011 · Cited by 186 · see citing works

Astrocyte Glycogen Sustains Neuronal Activity during Hypoglycemia: Studies with the Glycogen Phosphorylase Inhibitor CP-316,819 ([R-R*,S*]-5-Chloro-N-[2-hydroxy-3-(methoxymethylamino)-3-oxo-1-(phenylmethyl)propyl]-1 H-indole-2-carboxamide)

Suh, S. W., Bergher, J. P., Anderson, C. M., Treadway, J. L., Fosgerau, K., & Swanson, R. A. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.115550 · Cited by 178 · see citing works

The AMP-activated protein kinase: a multisubstrate regulator of lipid metabolism

Hardie, D. G., Carling, D., & Sim, A. T. R. (1989) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(89)90084-4 · Cited by 175 · see citing works

The cytosolic redox state of astrocytes: Maintenance, regulation and functional implications for metabolite trafficking

Hirrlinger, J., & Dringen, R. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.10.003 · Cited by 171 · see citing works

Peroxynitrite Protects Neurons against Nitric Oxide-mediated Apoptosis

Garcı́a-Nogales, P., Almeida, Á., & Bolaños, J. P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m206835200 · Cited by 165 · see citing works

Therapeutic effects of coenzyme Q 10 (CoQ 10 ) and reduced CoQ 10 in the MPTP model of Parkinsonism

Cléren, C., Yang, L., Lorenzo, B. J., Calingasan, N. Y., Schomer, A. C., Sireci, A. N., Wille, E. J., & Beal, M. F. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05097.x · Cited by 158 · see citing works

A transient inhibition of mitochondrial ATP synthesis by nitric oxide synthase activation triggered apoptosis in primary cortical neurons

Almeida, Á., & Bolaños, J. P. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00276.x · Cited by 157 · see citing works

Activation of the antioxidant response element in primary cortical neuronal cultures derived from transgenic reporter mice

Johnson, D. A., Andrews, G. K., Xu, W., & Johnson, J. A. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00913.x · Cited by 156 · see citing works

Cdh1/Hct1-APC Is Essential for the Survival of Postmitotic Neurons

Almeida, Á., Bolaños, J. P., & Moreno, S. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1143-05.2005 · Cited by 155 · see citing works

Differential Vulnerability of the CA1 and CA3 Subfields of the Hippocampus to Superoxide and Hydroxyl Radicals In Vitro

Wilde, G. J. C., Pringle, A. K., Wright, P., & Iannotti, F. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69020883.x · Cited by 151 · see citing works

Controlled enzymatic production of astrocytic hydrogen peroxide protects neurons from oxidative stress via an Nrf2-independent pathway

Haskew-Layton, R. E., Payappilly, J. B., Smirnova, N. A., Ma, T. C., Chan, K. K., Murphy, T. H., Guo, H., Langley, B. C., Rukhsana Sultana, A., Butterfield, D. A., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003996107 · Cited by 151 · see citing works

Inducible Alterations of Glutathione Levels in Adult Dopaminergic Midbrain Neurons Result in Nigrostriatal Degeneration

Chinta, S. J., Kumar, M. J., Hsu, M., Rajagopalan, S., Kaur, D., Rane, A., Nicholls, D. G., Choi, J., & Andersen, J. K. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3885-07.2007 · Cited by 145 · see citing works

Glutathione release from cultured brain cells: Multidrug resistance protein 1 mediates the release of GSH from rat astroglial cells

Hirrlinger, J., Schulz, J. B., & Dringen, R. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10308 · Cited by 142 · see citing works

Glutamate mediates acute glucose transport inhibition in hippocampal neurons

Porras, O. H., Loaiza, A., & Barros, L. F. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1882-04.2004 · Cited by 139 · see citing works

The regional vulnerability to hypoglycemia-induced neurotoxicity in organotypic hippocampal culture: protection by early tetrodotoxin or delayed MK-801

Tasker, R. C., Coyle, J., & Vornov, J. J. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-11-04298.1992 · Cited by 135 · see citing works

Increased neuronal glucose-6-phosphate dehydrogenase and sulfhydryl levels indicate reductive compensation to oxidative stress in Alzheimer disease.

Russell, R. L., Siedlak, S., Raina, A., Bautista, J., Smith, M. A., & Perry, G. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1404 · Cited by 135 · see citing works

Interaction of Peroxynitrite with Mitochondrial Cytochrome Oxidase

Sharpe, M. A., & Cooper, C. E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.47.30961 · Cited by 133 · see citing works

Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning

Bell, K. F., Al-Mubarak, B., Fowler, J. H., Baxter, P. S., Gupta, K., Tsujita, T., Chowdhry, S., Patani, R., Chandran, S., Horsburgh, K., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015229108 · Cited by 133 · see citing works

PGC-1α, a New Therapeutic Target in Huntington's Disease?

McGill, J. K., & Beal, M. F. (2006) · Cell · doi:10.1016/j.cell.2006.10.023 · Cited by 131 · see citing works

Comparison of excitotoxic profiles of ATPA, AMPA, KA and NMDA in organotypic hippocampal slice cultures

Kristensen, B. W., Noraberg, J., & Zimmer, J. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02900-6 · Cited by 128 · see citing works

Glutathione Protects Astrocytes from Peroxynitrite-Mediated Mitochondrial Damage: Implications for Neuronal/ Astrocytic Trafficking and Neurodegeneration

Barker, J. E., Bolaños, J. P., Land, J. M., Clark, J. B., & Heales, S. (2007) · Developmental Neuroscience · doi:10.1159/000111432 · Cited by 125 · see citing works

Mitochondria and reactive oxygen and nitrogen species in neurological disorders and stroke: Therapeutic implications☆

Bolaños, J. P., Moro, M. Á., Lizasoaín, I., & Almeida, Á. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.05.009 · Cited by 119 · see citing works

The regeneration of reduced glutathione in rat forebrain mitochondria identifies metabolic pathways providing the NADPH required

Vogel, R., Wiesinger, H., Hamprecht, B., & Dringen, R. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00748-x · Cited by 115 · see citing works

Role of nitric oxide in neurodegenerative diseases

Schulz, J. B., Matthews, R. T., & Beal, M. F. (1995) · Current Opinion in Neurology · doi:10.1097/00019052-199512000-00016 · Cited by 107 · see citing works

Emerging roles of thioredoxin cycle enzymes in the central nervous system

Patenaude, A., Murthy, M. R., & Mirault, M. (2005) · Cellular and Molecular Life Sciences (CMLS) · doi:10.1007/s00018-005-4541-5 · Cited by 101 · see citing works

The pentose‐phosphate pathway in neuronal survival against nitrosative stress

Bolaños, J. P., & Almeida, Á. (2009) · IUBMB Life · doi:10.1002/iub.280 · Cited by 101 · see citing works

Nuclear Factor Erythroid 2-Related Factor 2 Facilitates Neuronal Glutathione Synthesis by Upregulating Neuronal Excitatory Amino Acid Transporter 3 Expression

Escartin, C., Won, S. J., Malgorn, C., Aurégan, G., Berman, A., Chen, P., Déglon, N., Johnson, J. A., Suh, S. W., & Swanson, R. A. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6577-10.2011 · Cited by 96 · see citing works

Oct1 loss of function induces a coordinate metabolic shift that opposes tumorigenicity

Shakya, A., Cooksey, R. C., Cox, J. E., Wang, V. E. H., McClain, D. A., & Tantin, D. R. (2009) · Nature Cell Biology · doi:10.1038/ncb1840 · Cited by 96 · see citing works

Mouse Hippocampal Organotypic Tissue Cultures Exposed to In Vitro ???Ischemia??? Show Selective and Delayed CA1 Damage That Is Aggravated by Glucose

Rytter, A., Cronberg, T., Asztély, F., Nemali, S., & Wieloch, T. W. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000034361.37277.1b · Cited by 93 · see citing works

Changes in xanthine oxidase in ischemic rat brain

Kinuta, Y., Kimura, M., Itokawa, Y., Ishikawa, M., & Kikuchi, H. (1989) · Journal of neurosurgery · doi:10.3171/jns.1989.71.3.0417 · Cited by 92 · see citing works

The activity of the pentose phosphate pathway is increased in response to oxidative stress in Alzheimer's disease

Palmer, A. M. (1999) · Journal of Neural Transmission · doi:10.1007/s007020050161 · Cited by 92 · see citing works

Nitrosylation and nitration of mitochondrial complex I in Parkinson's disease

Chinta, S. J., & Andersen, J. K. (2010) · Free Radical Research · doi:10.3109/10715762.2010.509398 · Cited by 87 · see citing works

Knockdown of Glutamate-Cysteine Ligase by Small Hairpin RNA Reveals That Both Catalytic and Modulatory Subunits Are Essential for the Survival of Primary Neurons

Diaz-Hernandez, J. I., Almeida, A., Delgado-Esteban, M., Fernandez, E., & Bolaños, J. P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507065200 · Cited by 82 · see citing works

A Disruption in Iron-Sulfur Center Biogenesis via Inhibition of Mitochondrial Dithiol Glutaredoxin 2 May Contribute to Mitochondrial and Cellular Iron Dysregulation in Mammalian Glutathione-Depleted Dopaminergic Cells: Implications for Parkinson's Disease

Lee, D. W., Kaur, D., Chinta, S. J., Rajagopalan, S., & Andersen, J. K. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2489 · Cited by 81 · see citing works

D‐Glucose Prevents Glutathione Oxidation and Mitochondrial Damage After Glutamate Receptor Stimulation in Rat Cortical Primary Neurons

Delgado‐Esteban, M., Almeida, Á., & Bolaños, J. P. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0751618.x · Cited by 78 · see citing works

Energy sources for glutamate neurotransmission in the retina: absence of the aspartate/glutamate carrier produces reliance on glycolysis in glia

Xu, Y., Ola, M. S., Berkich, D. A., Gardner, T. W., Barber, A. J., Palmieri, F., Hutson, S. M., & LaNoue, K. F. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04349.x · Cited by 73 · see citing works

Impairment of brain mitochondrial function by reactive nitrogen species: the role of glutathione in dictating susceptibility

Heales, S. (2002) · Neurochemistry International · doi:10.1016/s0197-0186(01)00117-6 · Cited by 73 · see citing works

Failure to Maintain Glycolysis in Anoxic Nerve Terminals

Kauppinen, R. A., & Nicholls, D. G. (1986) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1986.tb13100.x · Cited by 71 · see citing works

Levodopa Deactivates Enzymes That Regulate Thiol−Disulfide Homeostasis and Promotes Neuronal Cell Death: Implications for Therapy of Parkinson’s Disease

Sabens, E. A., Distler, A. M., & Mieyal, J. J. (2010) · Biochemistry · doi:10.1021/bi9018658 · Cited by 70 · see citing works

Should the word ‘dementia’ be forgotten?

Jellinger, K. A. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01159.x · Cited by 66 · see citing works

Regulation of Neuronal Oxidative and Nitrosative Stress by Endogenous Protective Pathways and Disease Processes

Hardingham, G. E., & Lipton, S. A. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3573 · Cited by 64 · see citing works

Regional vulnerability to endogenous and exogenous oxidative stress in organotypic hippocampal culture.

Vornov, J., Park, J., & Thomas, A. (1998) · Experimental Neurology · doi:10.1006/exnr.1997.6673 · Cited by 62 · see citing works

Levodopa Activates Apoptosis Signaling Kinase 1 (ASK1) and Promotes Apoptosis in a Neuronal Model: Implications for the Treatment of Parkinson's Disease

Liedhegner, E. S., Steller, K. M., & Mieyal, J. J. (2011) · Chemical Research in Toxicology · doi:10.1021/tx200082h · Cited by 60 · see citing works

Bioenergetic dysfunction in Huntington's disease human cybrids

Ferreira, I. L., Cunha‐Oliveira, T., Nascimento, M. V., Ribeiro, M., Proença, M. T., Januário, C., Oliveira, C. R., & Rego, A. C. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.05.024 · Cited by 59 · see citing works

Glutathione depletion and overproduction both initiate degeneration of nigral dopaminergic neurons

Garrido, M., Tereshchenko, Y., Zhevtsova, Z., Taschenberger, G., Bähr, M., & Kügler, S. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0791-x · Cited by 59 · see citing works

Lactate Transport and Metabolism in the Human Brain: Implications for the Astrocyte-Neuron Lactate Shuttle Hypothesis: Figure 1.

Figley, C. R. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6612-10.2011 · Cited by 57 · see citing works

Induction of the Protective Antioxidant Response Element Pathway by 6-Hydroxydopamine In Vivo and In Vitro

Jakel, R. J., Kern, J. T., Johnson, D. A., & Johnson, J. A. (2005) · Toxicological Sciences · doi:10.1093/toxsci/kfi241 · Cited by 55 · see citing works

Poly(ADP-ribose) polymerase-1 protects neurons against apoptosis induced by oxidative stress

Díaz‐Hernandéz, J. I., Moncada, S., Bolaños, J. P., & Almeida, Á. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402117 · Cited by 49 · see citing works

Provoking Neuroprotection by Peroxynitrite

Bolanos, J., Garcia-Nogales, P., & Almeida, A. (2004) · Current Pharmaceutical Design · doi:10.2174/1381612043452910 · Cited by 47 · see citing works

Simultaneous single neuron recording of O2 consumption, [Ca2+]i and mitochondrial membrane potential in glutamate toxicity

Gleichmann, M., Collis, L. P., Smith, P. J., & Mattson, M. P. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05997.x · Cited by 41 · see citing works

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in rat brain

Ventura, F., Rosa, J. L., Ambrosio, S., Gil, J., & Bartrons, R. (1991) · Biochemical Journal · doi:10.1042/bj2760455 · Cited by 23 · see citing works

Selective susceptibility of different populations of sympathetic neurons to diabetic neuropathy in vivo is reflected by increased vulnerability to oxidative stress in vitro

Semra, Y. K., Wang, M., Peat, N. J., Smith, N. C. E., Shotton, H. R., & Lincoln, J. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.08.045 · Cited by 21 · see citing works

Alterations in glutathione S-transferase pi expression following exposure to MPP+-induced oxidative stress in the blood of Parkinson’s disease patients

Korff, A., Pfeiffer, B., Smeyne, M., Koçak, M., Pfeiffer, R. F., & Smeyne, R. J. (2011) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2011.06.026 · Cited by 13 · see citing works

The return of metabolism: biochemistry and physiology of the pentose phosphate pathway

Stincone, A., Prigione, A., Cramer, T., Wamelink, M. M. C., Campbell, K., Cheung, E., Olin‐Sandoval, V., Grüning, N., Krüger, A., Tauqeer Alam, M., et al. (2015) · Biological Reviews · doi:10.1111/brv.12140 · Cited by 1,576 · see citing works

Inflammation in Parkinson’s Disease: Mechanisms and Therapeutic Implications

Pajares, M., I. Rojo, A., Manda, G., Boscá, L., & Cuadrado, A. (2020) · Cells · doi:10.3390/cells9071687 · Cited by 779 · see citing works

Complex I assembly into supercomplexes determines differential mitochondrial ROS production in neurons and astrocytes

López-Fabuel, I., Douce, J. L., Logan, A., James, A. M., Bonvento, G., Murphy, M. P., Almeida, Á., & Bolaños, J. P. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1613701113 · Cited by 474 · see citing works

Short Overview of ROS as Cell Function Regulators and Their Implications in Therapy Concepts

Milković, L., Gašparović, A. Č., Cindrić, M., Mouthuy, P., & Žarković, N. (2019) · Cells · doi:10.3390/cells8080793 · Cited by 330 · see citing works

The role of astrocytes in oxidative stress of central nervous system: A mixed blessing

Chen, Y., Chen, Q., Huang, J., Tang, X., Liu, C., Huang, K., Xu, J., Guo, G. F., Tong, A., & Zhou, L. (2020) · Cell Proliferation · doi:10.1111/cpr.12781 · Cited by 308 · see citing works

Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis

Hardingham, G. E., & Do, K. Q. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.19 · Cited by 304 · see citing works

Formaldehyde in brain: an overlooked player in neurodegeneration?

Tulpule, K., & Dringen, R. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12356 · Cited by 238 · see citing works

Adaptive regulation of the brain’s antioxidant defences by neurons and astrocytes

Baxter, P. S., & Hardingham, G. E. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.06.027 · Cited by 235 · see citing works

Oxidative Stress‐Related Mechanisms in Schizophrenia Pathogenesis and New Treatment Perspectives

Ermakov, E. A., Dmitrieva, E. M., Parshukova, D. A., Kazantseva, D. V., Vasilieva, A. R., & Smirnova, L. P. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/8881770 · Cited by 252 · see citing works

Oxidized cholesterol as the driving force behind the development of Alzheimer’s disease

Gamba, P., Testa, G., Gargiulo, S., Staurenghi, E., Poli, G., & Leonarduzzi, G. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00119 · Cited by 202 · see citing works

The Role of Astrocytes in the Central Nervous System Focused on BK Channel and Heme Oxygenase Metabolites: A Review

Kim, Y. H., Park, J., & Choi, Y. K. (2019) · Antioxidants · doi:10.3390/antiox8050121 · Cited by 203 · see citing works

Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes

Fuente-Martín, E., García‐Cáceres, C., Granado, M., CEBALLOS, M. L. D., Sanchez-Garrido, M. A., Sármán, B., Liu, Z.-W., Dietrich, M. O., Tena‐Sempere, M., Argente-Arizón, P., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci64102 · Cited by 198 · see citing works

Metabolomics of Human Brain Aging and Age-Related Neurodegenerative Diseases

Jové, M., Portero-Otín, M., Naudí, A., Ferrer, I., & Pamplona, R. (2014) · Journal of Neuropathology &amp; Experimental Neurology · doi:10.1097/nen.0000000000000091 · Cited by 195 · see citing works

Astrocyte NMDA receptors' activity sustains neuronal survival through a Cdk5–Nrf2 pathway

Jimenez-Blasco, D., Santofimia-Castaño, P., Gonzalez, A., Almeida, A., & Bolaños, J. P. (2015) · Cell Death &amp; Differentiation · doi:10.1038/cdd.2015.49 · Cited by 196 · see citing works

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2

Bell, K. F. S., Al-Mubarak, B., Martel, M.-A., McKay, S., Wheelan, N., Hasel, P., Márkus, N. M., Baxter, P., Deighton, R. F., Serio, A., et al. (2015) · Nature Communications · doi:10.1038/ncomms8066 · Cited by 191 · see citing works

Glutathione-Dependent Detoxification Processes in Astrocytes

Dringen, R., Brandmann, M., Hohnholt, M. C., & Blumrich, E. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1481-1 · Cited by 184 · see citing works

Thiol redox homeostasis in neurodegenerative disease

McBean, G. J., Aslan, M., Griffiths, H. R., & Torrão, R. C. (2015) · Redox Biology · doi:10.1016/j.redox.2015.04.004 · Cited by 178 · see citing works

Antioxidant gene therapy against neuronal cell death

Navarro-Yepes, J., Zavala-Flores, L. M., Anandhan, A., Wang, F., Skotak, M., Chandra, N., Li, M., Pappa, A., Martínez‐Fong, D., Razo, L. M. D., et al. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.12.007 · Cited by 177 · see citing works

Human iPSC-derived astrocytes from ALS patients with mutated C9ORF72 show increased oxidative stress and neurotoxicity

Birger, A., Ben‐Dor, I., Ottolenghi, M., Turetsky, T. T., Gil, Y., Sweetat, S., Perez, L., Belzer, V., Casden, N., Steiner, D., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.11.026 · Cited by 164 · see citing works

Metabolic Dysfunction in Parkinson’s Disease: Bioenergetics, Redox Homeostasis and Central Carbon Metabolism

Anandhan, A., Jacome, M. S., Lei, S., Hernández-Franco, P., Pappa, A., Panayiotidis, M. I., Powers, R., & Franco, R. (2017) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.03.009 · Cited by 161 · see citing works

Role of AMPK-mediated adaptive responses in human cells with mitochondrial dysfunction to oxidative stress

Wu, S., Wu, Y., Wu, T.-P., & Wei, Y. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.10.034 · Cited by 159 · see citing works

Mitochondrial dysfunction in glial cells: Implications for neuronal homeostasis and survival

Rose, J., Brian, C., Woods, J., Pappa, A., Panayiotidis, M. I., Powers, R., & Franco, R. (2017) · Toxicology · doi:10.1016/j.tox.2017.06.011 · Cited by 155 · see citing works

Neuroimmunological Implications of AQP4 in Astrocytes

Ikeshima‐Kataoka, H. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17081306 · Cited by 148 · see citing works

Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system

Baxter, P. S., Bell, K. F. S., Hasel, P., Kaindl, A. M., Fricker, M., Thomson, D., Cregan, S. P., Gillingwater, T. H., & Hardingham, G. E. (2015) · Nature Communications · doi:10.1038/ncomms7761 · Cited by 139 · see citing works

Hypoxia-Inducible Factor (HIF) in Ischemic Stroke and Neurodegenerative Disease

Mitroshina, Е. V., Saviuk, M. O., Ponimaskin, E. G., & Vedunova, M. V. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.703084 · Cited by 130 · see citing works

Mitochondrial Dysfunction in Neural Injury

Zhao, X., Lu, M., Yuan, D., Xu, D.-E., Yao, P.-P., Ji, W., Chen, H., Liu, W., Yan, C.-X., Xia, Y., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00030 · Cited by 126 · see citing works

Berberine Ameliorate Oxidative Stress and Astrogliosis in the Hippocampus of STZ-Induced Diabetic Rats

Moghaddam, H. K., Baluchnejadmojarad, T., Roghani, M., Khaksari, M., Norouzi, P., Ahooie, M., & Mahboobi, F. S. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8559-7 · Cited by 119 · see citing works

Ketone Bodies in the Brain Beyond Fuel Metabolism: From Excitability to Gene Expression and Cell Signaling

García-Rodríguez, D., & Giménez-Cassina, A. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.732120 · Cited by 123 · see citing works

Cross-talk between energy and redox metabolism in astrocyte-neuron functional cooperation

Almeida, Á., Jiménez-Blasco, D., & Bolaños, J. P. (2023) · Essays in Biochemistry · doi:10.1042/ebc20220075 · Cited by 115 · see citing works

Repair Mechanisms of the Neurovascular Unit after Ischemic Stroke with a Focus on VEGF

Moon, S., Chang, M., Koh, S., & Choi, Y. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168543 · Cited by 110 · see citing works

Glutathione in multiple sclerosis: More than just an antioxidant?

Carvalho, A., Lim, J. L., Nijland, P., Witte, M., & van Horssen, J. (2014) · Multiple Sclerosis · doi:10.1177/1352458514533400 · Cited by 101 · see citing works

Anti-inflammatory treatments for stroke: from bench to bedside

Drieu, A., Levard, D., Vivien, D., & Rubio, M. (2018) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756286418789854 · Cited by 101 · see citing works

β-Caryophyllene protects the C6 glioma cells against glutamate-induced excitotoxicity through the Nrf2 pathway

Assis, L. C., Straliotto, M. R., Engel, D. F., Hort, M. A., Dutra, R. C., & Bem, A. F. D. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.08.043 · Cited by 96 · see citing works

Mitochondrial dysfunction in astrocytes: A role in Parkinson’s disease?

Bantle, C. M., Hirst, W. D., Weihofen, A., & Shlevkov, E. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.608026 · Cited by 95 · see citing works

TRP Channels Coordinate Ion Signalling in Astroglia

Verkhratsky, A., Reyes, R. C., & Parpura, V. (2013) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/112_2013_15 · Cited by 92 · see citing works

Regulation of neuron-astrocyte metabolic coupling across the sleep-wake cycle

Petit, J.-M., & Magistretti, P. J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.12.007 · Cited by 92 · see citing works

Corticostriatal dysfunction and glutamate transporter 1 (GLT1) in Huntington’s disease: Interactions between neurons and astrocytes

Estrada‐Sánchez, A. M., & Rebec, G. V. (2012) · Basal Ganglia · doi:10.1016/j.baga.2012.04.029 · Cited by 92 · see citing works

DJ-1 in neurodegenerative diseases: Pathogenesis and clinical application

Huang, M., & Chen, S. (2021) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2021.102114 · Cited by 87 · see citing works

Effects of Natural Polyphenols on Oxidative Stress-Mediated Blood-Brain Barrier Dysfunction

Kim, Y., Cho, A. Y., Kim, H. C., Ryu, D., Jo, S. A., & Jung, Y. (2022) · Antioxidants · doi:10.3390/antiox11020197 · Cited by 84 · see citing works

Structure, regulation, and biological functions of TIGAR and its role in diseases

Tang, J., Chen, L., Qin, Z.-H., & Sheng, R. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-00588-y · Cited by 76 · see citing works

Safinamide and flecainide protect axons and reduce microglial activation in models of multiple sclerosis

Morsali, D., Bechtold, D. A., Lee, W., Chauhdry, S., Palchaudhuri, U., Hassoon, P., Snell, D. M., Malpass, K., Piers, T. M., Pocock, J. M., et al. (2013) · Brain · doi:10.1093/brain/awt041 · Cited by 81 · see citing works

Ferroptosis: From regulation of lipid peroxidation to the treatment of diseases

Lv, Y., Wu, M., Wang, Z., & Wang, J. (2022) · Cell Biology and Toxicology · doi:10.1007/s10565-022-09778-2 · Cited by 83 · see citing works

The AMPK-PGC-1α signaling axis regulates the astrocyte glutathione system to protect against oxidative and metabolic injury

Guo, X., Jiang, Q., Tuccitto, A., Chan, D. W.-H., Alqawlaq, S., Won, G.-J., & Sivak, J. M. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.02.004 · Cited by 80 · see citing works

Resveratrol: A potential therapeutic natural polyphenol for neurodegenerative diseases associated with mitochondrial dysfunction

Yadav, E., Yadav, P. S., Khan, M. M. U., Singh, H., & Verma, A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.922232 · Cited by 81 · see citing works

Role and Therapeutic Potential of Astrocytes in Amyotrophic Lateral Sclerosis

Pehar, M., Harlan, B. A., Killoy, K. M., & Vargas, M. R. (2018) · Current Pharmaceutical Design · doi:10.2174/1381612823666170622095802 · Cited by 77 · see citing works

Brain energy metabolism in glutamate-receptor activation and excitotoxicity: Role for APC/C-Cdh1 in the balance glycolysis/pentose phosphate pathway

Rodriguez‐Rodriguez, P., Almeida, Á., & Bolaños, J. P. (2013) · Neurochemistry International · doi:10.1016/j.neuint.2013.02.005 · Cited by 74 · see citing works

Aerobic Glycolysis in the Brain: Warburg and Crabtree Contra Pasteur

Barros, L. F., Ruminot, I., Martín, A. S., Lerchundi, R., Fernández‐Moncada, I., & Baeza‐Lehnert, F. (2020) · Neurochemical Research · doi:10.1007/s11064-020-02964-w · Cited by 72 · see citing works

Activation of the hypoxia-inducible factor pathway protects against acute ischemic stroke by reprogramming central carbon metabolism

Madai, S., Kilic, P., Schmidt, R. M., Orth, C. B., Korff, T., Büttner, M., Klinke, G., Poschet, G., Marti, H. H., & Kunze, R. (2024) · Theranostics · doi:10.7150/thno.88223 · Cited by 70 · see citing works

Astrocytes require insulin-like growth factor I to protect neurons against oxidative injury

Genı́s, L., Dávila, D., Fernández, S., Pozo-Rodrigálvarez, A., Martínez‐Murillo, R., & Torres‐Alemán, I. (2014) · F1000Research · doi:10.12688/f1000research.3-28.v2 · Cited by 72 · see citing works

Prolonged Dysfunction of Astrocytes and Activation of Microglia Accelerate Degeneration of Dopaminergic Neurons in the Rat Substantia Nigra and Block Compensation of Early Motor Dysfunction Induced by 6-OHDA

Kuter, K., Olech, Ł., & Głowacka, U. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0529-z · Cited by 65 · see citing works

Targeting of astrocytic glucose metabolism by beta-hydroxybutyrate

Valdebenito, R., Ruminot, I., Garrido-Gerter, P., Fernández‐Moncada, I., Forero-Quintero, L. S., Alegría, K., Becker, H. M., Deitmer, J. W., & Barros, L. F. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x15613955 · Cited by 69 · see citing works

Human adipose-Derived Mesenchymal Stem Cells Improve Motor Functions and are Neuroprotective in the 6-Hydroxydopamine-Rat Model for Parkinson’s Disease when Cultured in Monolayer Cultures but Suppress Hippocampal Neurogenesis and Hippocampal Memory Function when Cultured in Spheroids

Berg, J., Roch, M., Altschüler, J., Winter, C., Schwerk, A. M. K., Kurtz, A., & Steiner, B. (2014) · Stem Cell Reviews and Reports · doi:10.1007/s12015-014-9551-y · Cited by 66 · see citing works

Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates

Bartolomé, F. B., Esteras, N., Martín‐Requero, Á., Boutoleau‐Bretonnière, C., Vercelletto, M., Gabelle, A., Ber, I. L., Honda, T., Dinkova‐Kostova, A. T., Hardy, J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-01678-4 · Cited by 66 · see citing works

Emerging role of glial cells in the control of body weight

García‐Cáceres, C., Fuente-Martín, E., Argente, J., & Chowen, J. A. (2012) · Molecular Metabolism · doi:10.1016/j.molmet.2012.07.001 · Cited by 64 · see citing works

Oxidative Stress and Maxi Calcium-Activated Potassium (BK) Channels

Hermann, A., Ситдикова, Г. Ф., & Weiger, T. M. (2015) · Biomolecules · doi:10.3390/biom5031870 · Cited by 65 · see citing works

Nrf2 Activation in Astrocytes Contributes to Spinal Cord Ischemic Tolerance Induced by Hyperbaric Oxygen Preconditioning

Xu, J., Huang, G., Zhang, K., Sun, J., Xu, T., Li, R., Tao, H., & Xu, W. (2014) · Journal of Neurotrauma · doi:10.1089/neu.2013.3222 · Cited by 64 · see citing works

Pyruvate kinase isoform M2 impairs cognition in systemic lupus erythematosus by promoting microglial synaptic pruning via the β-catenin signaling pathway

Lu, L., Wang, H., Liu, X., Tan, L., Qiao, X., Ni, J., Sun, Y., Liang, J., Hou, Y., & Dou, H. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02279-9 · Cited by 63 · see citing works

Exposure to human relevant mixtures of halogenated persistent organic pollutants (POPs) alters neurodevelopmental processes in human neural stem cells undergoing differentiation

Davidsen, N., Lauvås, A. J., Myhre, O., Ropstad, E., Carpi, D., Gyves, E. M., Berntsen, H. F., Dirven, H. A. A. M., Paulsen, R. E., Bal‐Price, A., et al. (2020) · Reproductive Toxicology · doi:10.1016/j.reprotox.2020.12.013 · Cited by 62 · see citing works

Diphenyl diselenide protects neuronal cells against oxidative stress and mitochondrial dysfunction: Involvement of the glutathione-dependent antioxidant system

Quispe, R. L., Jaramillo, M. L., Galant, L. S., Engel, D. F., Dafré, A. L., da Rocha, J. B. T., Radí, R., Farina, M., & Bem, A. F. D. (2018) · Redox Biology · doi:10.1016/j.redox.2018.09.014 · Cited by 60 · see citing works

Oxidative Stress and Neurobiology of Demyelination

Ljubisavljević, S. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-9041-x · Cited by 60 · see citing works

Lysosomal iron liberation is responsible for the vulnerability of brain microglial cells to iron oxide nanoparticles: comparison with neurons and astrocytes

Petters, C., Thiel, K., & Dringen, R. (2016) · Nanotoxicology · doi:10.3109/17435390.2015.1071445 · Cited by 59 · see citing works

A Preliminary Investigation into the Impact of a Pesticide Combination on Human Neuronal and Glial Cell Lines In Vitro

Coleman, M. D., O’Neil, J. D., Woehrling, E. K., Ndunge, O. B. A., Hill, E. J., Menache, A., & Reiss, C. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042768 · Cited by 58 · see citing works

Nrf2 Orchestrates Fuel Partitioning for Cell Proliferation

Hayes, J. D., & Ashford, M. L. J. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.07.009 · Cited by 57 · see citing works

Dietary restriction in cerebral bioenergetics and redox state

Amigo, I., & Kowaltowski, A. J. (2014) · Redox Biology · doi:10.1016/j.redox.2013.12.021 · Cited by 57 · see citing works

Single-cell imaging tools for brain energy metabolism: a review

Martín, A. S., Sotelo-Hitschfeld, T., Lerchundi, R., Fernández‐Moncada, I., Ceballo, S., Valdebenito, R., Baeza‐Lehnert, F., Alegría, K., Contreras‐Baeza, Y., Garrido-Gerter, P., et al. (2014) · Neurophotonics · doi:10.1117/1.nph.1.1.011004 · Cited by 57 · see citing works

Molecular mechanisms involved in the protective actions of Selective Estrogen Receptor Modulators in brain cells

Báez-Jurado, E., Rincon‐Benavides, M. A., Hidalgo‐Lanussa, O., Guio-Vega, G. P., Ashraf, G. M., Sahebkar, A., Echeverrı́a, V., García‐Segura, L. M., & Barreto, G. E. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.09.001 · Cited by 62 · see citing works

Prevention of neuronal apoptosis by astrocytes through thiol-mediated stress response modulation and accelerated recovery from proteotoxic stress

Gutbier, S., Spreng, A., Delp, J., Schildknecht, S., Karreman, C., Suciu, I., Brunner, T., Groettrup, M., & Leist, M. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0229-x · Cited by 55 · see citing works

Mitochondria focused neurotherapeutics for spinal cord injury

Rabchevsky, A. G., Michael, F. M., & Patel, S. P. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113332 · Cited by 56 · see citing works

Neuroprotective Effects of Physical Activity via the Adaptation of Astrocytes

Maugeri, G., D’Agata, V., Magrì, B., Roggio, F., Castorina, A., Ravalli, S., Rosa, M. D., & Musumeci, G. (2021) · Cells · doi:10.3390/cells10061542 · Cited by 52 · see citing works

Astrocyte‐mediated mechanisms contribute to traumatic brain injury pathology

Muñoz‐Ballester, C., & Robel, S. (2023) · WIREs Mechanisms of Disease · doi:10.1002/wsbm.1622 · Cited by 53 · see citing works

How expensive is the astrocyte?

Barros, L. (2022) · Journal of Cerebral Blood Flow &amp; Metabolism · doi:10.1177/0271678x221077343 · Cited by 51 · see citing works

Good, bad, and neglectful: Astrocyte changes in neurodegenerative disease

Jiwaji, Z., & Hardingham, G. E. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.02.020 · Cited by 51 · see citing works

Kynurenine 3-Monooxygenase Activity in Human Primary Neurons and Effect on Cellular Bioenergetics Identifies New Neurotoxic Mechanisms

Castellano‐González, G., Jacobs, K. R., Don, E. K., Cole, N. J., Adams, S., Lim, C. K., Lovejoy, D. B., & Guillemin, G. J. (2019) · Neurotoxicity Research · doi:10.1007/s12640-019-9997-4 · Cited by 50 · see citing works

Involvement of endogenous antioxidant systems in the protective activity of pituitary adenylate cyclase‐activating polypeptide against hydrogen peroxide‐induced oxidative damages in cultured rat astrocytes

Douiri, S., Bahdoudi, S., Hamdi, Y., Cubí, R., Basille, M., Fournier, A., Vaudry, H., Tonon, M., Amri, M., Vaudry, D., et al. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13614 · Cited by 49 · see citing works

Expression of Ambra1 in mouse brain during physiological and Alzheimer type aging

Sepe, S., Nardacci, R., Fanelli, F., Rosso, P., Bernardi, C., Cecconi, F., Mastroberardino, P. G., Piacentini, M., & Moreno, S. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.07.001 · Cited by 48 · see citing works

Effect of DJ-1 on the neuroprotection of astrocytes subjected to cerebral ischemia/reperfusion injury

Li, P., Zhao, Y., Li, Y., Zhou, Y., Lei, S., Lei, S., Yu, S., & Zhao, Y. (2018) · Journal of Molecular Medicine · doi:10.1007/s00109-018-1719-5 · Cited by 48 · see citing works

Enhanced Neuronal Glucose Transporter Expression Reveals Metabolic Choice in a HD Drosophila Model

Besson, M. T., Alegría, K., Garrido-Gerter, P., Barros, L. F., & Liévens, J.-C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118765 · Cited by 47 · see citing works

Near‐critical GLUT1 and Neurodegeneration

Barros, L. F., Martín, A. S., Ruminot, I., Sandoval, P. Y., Fernández‐Moncada, I., Baeza‐Lehnert, F., Arce‐Molina, R., Contreras‐Baeza, Y., Cortés‐Molina, F., Galaz, A., et al. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.23998 · Cited by 47 · see citing works

Early and Persistent O-GlcNAc Protein Modification in the Streptozotocin Model of Alzheimer’s Disease

dos Santos, J. P. A., Vizuete, A. F. K., Hansen, F., Biasibetti, R., & Gonçalves, C. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170211 · Cited by 46 · see citing works

Hippocampal neurons require a large pool of glutathione to sustain dendrite integrity and cognitive function

Fernández-Fernández, S., Bobo-Jiménez, V., Requejo-Aguilar, R., Gónzalez-Fernández, S., Resch-Beusher, M., Carabias-Carrasco, M., Ros, J., Almeida, Á., & Bolaños, J. P. (2018) · Redox Biology · doi:10.1016/j.redox.2018.08.003 · Cited by 46 · see citing works

Effects of salidroside on glioma formation and growth inhibition together with improvement of tumor microenvironment.

Zhang, Y., Yao, Y., Wang, H., Guo, Y., Zhang, H., & Chen, L. (2013) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.1000-9604.2013.10.01 · Cited by 44 · see citing works

Fluorescence Probe for Imaging N-Methyl- d -aspartate Receptors and Monitoring GSH Selectively Using Two-Photon Microscopy

Kwon, N., Lim, C. S., Ko, G., Ha, J., Lee, D., Yin, J., Kim, H. M., & Yoon, J. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.1c02350 · Cited by 43 · see citing works

Sex Differences and Effects of Estrogenic Compounds on the Expression of Inflammatory Molecules by Astrocytes Exposed to the Insecticide Dimethoate

Astiz, M., Acaz‐Fonseca, E., & García‐Segura, L. M. (2013) · Neurotoxicity Research · doi:10.1007/s12640-013-9417-0 · Cited by 43 · see citing works

Astroglial DJ-1 over-expression up-regulates proteins involved in redox regulation and is neuroprotective in vivo

Frøyset, A. K., Edson, A. J., Gharbi, N., Khan, E. A., Dondorp, D. C., Bai, Q., Tiraboschi, E., Suster, M. L., Connolly, J. B., Burton, E. A., et al. (2018) · Redox Biology · doi:10.1016/j.redox.2018.02.010 · Cited by 43 · see citing works

Nrf2 Signaling in the Oxidative Stress Response After Spinal Cord Injury

Guo, X., Kang, J., Wang, Z., Wang, Y., Liu, M., Zhu, D., Yang, F., & Kang, X. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.06.007 · Cited by 42 · see citing works

Appraising the Role of Astrocytes as Suppliers of Neuronal Glutathione Precursors

Pérez‐Sala, D., & Pajares, M. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24098059 · Cited by 42 · see citing works

Epigallocatechin-3-gallate induces oxidative phosphorylation by activating cytochrome c oxidase in human cultured neurons and astrocytes

Castellano‐González, G., Pichaud, N., Ballard, J. W. O., Bessede, A., Marçal, H., & Guillemin, G. J. (2016) · Oncotarget · doi:10.18632/oncotarget.6863 · Cited by 41 · see citing works

Nilotinib Improves Bioenergetic Profiling in Brain Astroglia in the 3xTg Mouse Model of Alzheimer’s Disease

Adlimoghaddam, A., Odero, G. G., Glazner, G., Turner, R. S., & Albensi, B. C. (2021) · Aging and disease · doi:10.14336/ad.2020.0910 · Cited by 38 · see citing works

Glial Perturbation in Metal Neurotoxicity: Implications for Brain Disorders

Ijomone, O. K., Inelo, U. I., Aneke, V. O., Olajide, T. S., Inyang, H. O., Omotosho, O. I., Oyerinde, T. O., Anadu, V. E., Gbayisomore, T. J., Okeowo, O. M., et al. (2025) · Neuroglia · doi:10.3390/neuroglia6010004 · Cited by 40 · see citing works

Cisplatin Toxicity in Dorsal Root Ganglion Neurons Is Relieved by Meclizine via Diminution of Mitochondrial Compromise and Improved Clearance of DNA Damage

Gorgun, M. F., Zhuo, M., & Englander, E. W. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0273-9 · Cited by 41 · see citing works

Role of cyclic AMP in the eye with glaucoma

Shim, M. S., Keun-young Kim, A., & Ju, W. (2017) · BMB Reports · doi:10.5483/bmbrep.2017.50.2.200 · Cited by 40 · see citing works

Blockade of Neuroglobin Reduces Protection of Conditioned Medium from Human Mesenchymal Stem Cells in Human Astrocyte Model (T98G) Under a Scratch Assay

Báez-Jurado, E., Guio-Vega, G. P., Aliev, G. M., Tarasov, V. V., Esquinas, P., Echeverrı́a, V., & Barreto, G. E. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0481-y · Cited by 40 · see citing works

Aluminum induced oxidative stress, astrogliosis and cell death in rat astrocytes, is prevented by curcumin

Laabbar, W., Abbaoui, A., Elgot, A., Mokni, M., Amri, M., Masmoudi‐Kouki, O., & Gamrani, H. (2020) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2020.101915 · Cited by 40 · see citing works

The Dichotomous Role of Inflammation in the CNS: A Mitochondrial Point of View

Vezzani, B., Carinci, M., Patergnani, S., Pasquin, M., Guarino, A., Aziz, N., Pinton, P., Simonato, M., & Giorgi, C. (2020) · Biomolecules · doi:10.3390/biom10101437 · Cited by 40 · see citing works

Hypothalamic Inflammation Without Astrogliosis in Response to High Sucrose Intake Is Modulated by Neonatal Nutrition in Male Rats

Fuente-Martín, E., García‐Cáceres, C., Díaz, F., Argente-Arizón, P., Granado, M., Barrios, V., Argente, J., & Chowen, J. A. (2013) · Endocrinology · doi:10.1210/en.2012-2196 · Cited by 39 · see citing works

Oxygen consumption deficit in Huntington disease mouse brain under metabolic stress

Lou, S., Lepak, V. C., Eberly, L. E., Roth, B., Cui, W., Zhu, X., Öz, G., & Dubinsky, J. M. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw138 · Cited by 39 · see citing works

mNos2Deletion and HumanNOS2Replacement in Alzheimer Disease Models

Colton, C. A., Wilson, J. G., Everhart, A. L., Wilcock, D. M., Puoliväli, J. T., Heikkinen, T., Oksman, J., Jääskeläinen, O., Lehtimäki, K. K., Laitinen, T., et al. (2014) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000094 · Cited by 37 · see citing works

The Contribution of Astrocyte Autophagy to Systemic Metabolism

Ortiz‐Rodriguez, A., & Arévalo, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072479 · Cited by 36 · see citing works

Photobiomodulation augments the effects of mitochondrial transplantation in the treatment of spinal cord injury in rats by facilitating mitochondrial transfer to neurons via Connexin 36

Zhu, Z., Li, X., Wang, X., Zuo, X., Ma, Y., Gao, X., Liang, Z., Zhang, Z., Song, Z., Ding, T., et al. (2022) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10473 · Cited by 35 · see citing works

Nrf2 is predominantly expressed in hippocampal neurons in a rat model of temporal lobe epilepsy

Sandouka, S., Saadi, A., Singh, P. K., Taiwo, R. O., & Shekh‐Ahmad, T. (2023) · Cell & Bioscience · doi:10.1186/s13578-022-00951-y · Cited by 36 · see citing works

Neuron-glia metabolic coupling: Role in plasticity and neuroprotection

Magistretti, P. J. (2017) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2017.08.107 · Cited by 3 · see citing works

The consequences of neurodegenerative disease on neuron-astrocyte metabolic and redox interactions

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Cross-talk between energy and redox metabolism in astrocyte-neuron functional cooperation

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Multifunctional role of astrocytes as gatekeepers of neuronal energy supply

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Astrocyte-neuron metabolic cooperation shapes brain activity

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