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BDNF/TRKB axis provokes EMT progression to induce cell aggressiveness via crosstalk with cancer-associated fibroblasts in human parotid gland cancer

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De-differentiation in cultures of organoids from luminal-type breast cancer is restored by inhibition of NOTCH signaling

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Imitating Hypoxia and Tumor Microenvironment with Immune Evasion by Employing Three Dimensional In vitro Cellular Models: Impressive Tool in Drug Discovery

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Improved Oxygen Supply to Multicellular Spheroids Using A Gas-permeable Plate and Embedded Hydrogel Beads

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Polydopamine-Based Resveratrol-Hyaluronidase Nanomedicine Inhibited Pancreatic Cancer Cell Invasive Phenotype in Hyaluronic Acid Enrichment Tumor Sphere Model

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Hepatocellular-Carcinoma-Derived Organoids: Innovation in Cancer Research

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Intestinal Tumor in a Dish

Ohta, Y., & Sato, T. (2014) · Frontiers in Medicine · doi:10.3389/fmed.2014.00014 · Cited by 17

Small Cell Carcinomas of the Uterine Cervix and Lung: Proteomics Reveals Similar Protein Expression Profiles

Egawa‐Takata, T., Yoshino, K., Hiramatsu, K., Nakagawa, S., Serada, S., Nakajima, A., Endo, H., Kubota, S., Matsuzaki, S., Kobayashi, E., et al. (2018) · International Journal of Gynecological Cancer · doi:10.1097/igc.0000000000001354 · Cited by 17

Cancer-on-a-chip for Drug Screening

Lee, I. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190206235233 · Cited by 17

Organoid: Next-Generation Modeling of Cancer Research and Drug Development

Liu, J., Huang, X., Huang, L., Huang, J., Liang, D., Liao, L., Deng, Y., Zhang, L., Zhang, B., & Tang, W. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2021.826613 · Cited by 16

Breast cancer patient-derived microtumors resemble tumor heterogeneity and enable protein-based stratification and functional validation of individualized drug treatment

Anderle, N., Schäfer-Ruoff, F., Staebler, A., Kersten, N., Koch, A., Önder, C. E., Keller, A., Liebscher, S., Hartkopf, A., Hahn, M., et al. (2023) · Journal of experimental & clinical cancer research : CR · doi:10.1186/s13046-023-02782-2 · Cited by 16

Generation of a monoclonal antibody recognizing the CEACAM glycan structure and inhibiting adhesion using cancer tissue-originated spheroid as an antigen

Sato, Y., Tateno, H., Adachi, J., Okuyama, H., Endo, H., Tomonaga, T., & Inoue, M. (2016) · Scientific Reports · doi:10.1038/srep24823 · Cited by 15

Acquired resistance to an epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) in an uncommon G719S EGFR mutation

Osoegawa, A., Hashimoto, T., Takumi, Y., Abe, M., Yamada, T., Kobayashi, R., Miyawaki, M., Takeuchi, H., Okamoto, T., & Sugio, K. (2018) · Investigational New Drugs · doi:10.1007/s10637-018-0592-y · Cited by 15

Characteristics of multicellular tumor spheroids formed by pancreatic cells expressing different adhesion molecules

Svirshchevskaya, E. V., Doronina, E., Grechikhina, M. V., Matushevskaya, E., Kotsareva, O. D., Fattakhova, G. V., Sapozhnikov, A. M., & Felix, K. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.01.034 · Cited by 15

Computational pharmacokinetic modeling of organ-on-chip devices and microphysiological systems

Przekwas, A. J., & Somayaji, M. R. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-817202-5.00011-5 · Cited by 15

Whole exome sequencing and establishment of an organoid culture of the carcinoma showing thymus-like differentiation (CASTLE) of the parotid gland

Ishikawa, T., Ogawa, T., Nakanome, A., Yamauchi, Y., Usubuchi, H., Shiihara, M., Yoshida, T., Okamura, Y., Kinoshita, K., Katori, Y., et al. (2021) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-020-02981-8 · Cited by 15

Supramolecular Nanofibrillar Thermoreversible Hydrogel for Growth and Release of Cancer Spheroids

Li, Y., Khuu, N., Gevorkian, A., Sarjinsky, S., Thérien‐Aubin, H., Wang, Y., Cho, S., & Kumacheva, E. (2016) · Angewandte Chemie · doi:10.1002/ange.201610353 · Cited by 16

Polarity switching of ovarian cancer cell clusters via SRC family kinase is involved in the peritoneal dissemination

Kawata, M., Kondo, J., Onuma, K., Ito, Y., Yokoi, T., Hamanishi, J., Mandai, M., Kimura, T., & Inoue, M. (2022) · Cancer Science · doi:10.1111/cas.15493 · Cited by 15

Patient-derived three-dimensional culture techniques model tumor heterogeneity in head and neck cancer

Parikh, A. S., Yu, V. X., Flashner, S. P., Okolo, O. B., Lü, C., Henick, B. S., Momen‐Heravi, F., Puram, S. V., Teknos, T. N., Pan, Q., et al. (2023) · Oral Oncology · doi:10.1016/j.oraloncology.2023.106330 · Cited by 15

Unsung versatility of elastin-like polypeptide inspired spheroid fabrication: A review

Goel, R., Gulwani, D., Upadhyay, P., Sarangthem, V., & Singh, T. D. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.123664 · Cited by 15

Dynamic Change in p63 Protein Expression during Implantation of Urothelial Cancer Clusters

Yoshida, T., Okuyama, H., Nakayama, M., Endo, H., Tomita, Y., Nonomura, N., Nishimura, K., & Inoue, M. (2015) · Neoplasia · doi:10.1016/j.neo.2015.07.004 · Cited by 15

Self-assembly of vascularized tissue to support tumor explants in vitro

Bazou, D., Maimon, N., Gruionu, G., & Munn, L. L. (2016) · Integrative Biology · doi:10.1039/c6ib00108d · Cited by 16

Recent Innovations in Strategies for Breast Cancer Therapy by Electrospun Scaffolds: A Review

Ghaedamini, S., Hashemibeni, B., Honarvar, A., Rabiei, A., & Karbasi, S. (2023) · Journal of Polymers and the Environment · doi:10.1007/s10924-023-03022-6 · Cited by 14

LY6/PLAUR domain containing 3 has a role in the maintenance of colorectal cancer stem-like cells

Wang, L., Hirohashi, Y., Ogawa, T., Shen, M., Takeda, R., Murai, A., Yamamoto, E. M., Kubo, T., Nakatsugawa, M., Kanaseki, T., et al. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.02.112 · Cited by 14

Instructive Hydrogels for Primary Tumor Cell Culture: Current Status and Outlook

Jia, Y., Wei, Z., Zhang, S., Yang, B., & Li, Y. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202102479 · Cited by 13

Advances in the use of 3D colorectal cancer models for novel drug discovery

Baião, A., Dias, S., Soares, A. F., Pereira, C. L., Oliveíra, C., & Sarmento, B. F. C. C. (2022) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2022.2056162 · Cited by 13

Abnormality of apico–basal polarity in adenocarcinoma

Onuma, K., & Inoue, M. (2022) · Cancer Science · doi:10.1111/cas.15549 · Cited by 11

A high-throughput screen identifies inhibitors of lung cancer stem cells

She, X., Gao, Y., Zhao, Y. F., Yin, Y., & Dong, Z. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111748 · Cited by 15

Using 3D Organoid Cultures to Model Intestinal Physiology and Colorectal Cancer

Short, S. P., Costacurta, P. W., & Williams, C. S. (2017) · Current Colorectal Cancer Reports · doi:10.1007/s11888-017-0363-8 · Cited by 14

Spheroid Cultures of Primary Urothelial Cancer Cells: Cancer Tissue-Originated Spheroid (CTOS) Method

Yoshida, T., Okuyama, H., Endo, H., & Inoue, M. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-7234-0_12 · Cited by 24

Abstract 3832: Cancer tissue-derived spheroid, CTOS, for evaluation of drug response from individual patient tumor samples.

Inoue, M., Endo, H., Ohue, M., Nishimura, K., Imamura, F., Okami, J., & Okuyama, H. (2013) · Cancer Research · doi:10.1158/1538-7445.am2013-3832 · Cited by 1

Abstract 2718: Spheroid culture of colorectal cancer cells from patient tumor tissue preserves important cellular characteristics of the parental tumor.

Jeppesen, M., Hagel, G., Glenthøj, A. J., Thastrup, M., Jørgensen, L. N., & Thastrup, J. (2013) · Cancer Research · doi:10.1158/1538-7445.am2013-2718

Abstract 2020: Spheroid culture of primary colorectal cancer cells from liver metastases as an in vitro model of patient tumors

Jeppesen, M., Hagel, G., Vainer, B., Harling, H., Thastrup, M., Jørgensen, L. N., & Thastrup, J. (2014) · Cancer Research · doi:10.1158/1538-7445.am2014-2020 · Cited by 2

Short-term spheroid culture of primary colorectal cancer cells as an in vitro model for personalizing cancer medicine

Jeppesen, M., Hagel, G., Glenthøj, A. J., Vainer, B., Ibsen, P. H., Harling, H., Thastrup, M., Jørgensen, L. N., & Thastrup, J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0183074 · Cited by 92