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Retaining cell–cell contact enables preparation and culture of spheroids composed of pure primary cancer cells from colorectal cancer
Open accessAbstract
Primary culture of the cancer cells from patients’ tumors can provide crucial information of individual tumors, yet the technology has not been optimized until now. We developed an innovative culture method for primary colorectal cancer cells, based on the principle that cell–cell contact of cancer cells was maintained throughout the process. When tumor tissue was dissociated into cell clusters, in which cell–cell contact was retained, they rapidly formed spheroids that we termed cancer tissue-originated spheroids (CTOSs). CTOSs of colorectal cancer consisted of highly purified and viable cancer cells, and they were prepared with high efficiency. In immunodeficient mice, CTOSs formed xenograft tumors that retained the features of the parental tumors. Moreover, CTOSs were able to be cultured and expanded in vitro using a 3D culture system and stem cell culture medium. This method allowed evaluation of chemosensitivity and signal pathway activation in cancer cells from individual patients. Easy preparation and culture of pure primary cancer cells provides an innovative platform for studying cancer biology and developing personalized medicine.
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“While many studies on 3D cultures used established cancer cell lines, more recently, the use of patient-derived primary tumor cells in 3D cultures has been reported. 68,69”
From Three-dimensional cell culture systems and their applications in drug discovery and cell-based biosensors (2014) · cites this paper as [68]
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“A research team from Osaka Medical Center for Cancer and Cardiovacular Disease in Japan reported a successful method for 3D culture of patient-derived colorectal cancer cells 68 and the use of such 3D culture for the evaluation of chemosensitivity and signal pathway activation in cancer cells from individual patients.”
From Three-dimensional cell culture systems and their applications in drug discovery and cell-based biosensors (2014) · cites this paper as [68]
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Metadata
- Authors
- Kondo, J., Endo, H., Okuyama, H., Ishikawa, O., Iishi, H., Tsujii, M., Ohue, M., & Inoue, M.
- Affiliations
- Osaka International Cancer Institute (JP)
- University of California, San Francisco (US)
- Surgery, and
- The University of Osaka (JP)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2011-03-28
- Volume
- 108
- Issue
- 15
- Pages
- 6235-6240
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3076886
- OpenAlex
- W2043079400
- Cited by
- 322
- References
- 39
- Citations by year
- 2026: 12 · 2025: 16 · 2024: 24 · 2023: 29 · 2022: 29 · 2021: 33 · 2020: 28 · 2019: 25 · 2018: 29 · 2017: 23 · 2016: 25 · 2015: 21 · 2014: 15 · 2013: 10 · 2012: 2
- FWCI
- 4.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Japan Society for the Promotion of Science (22791240)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Mathematics › Modeling and Simulation › Mathematical Biology Tumor Growth
- Keywords
- colorectal cancer, cell-cell contact, tumor cell dissociation, tumor xenografts, 3D cell culture, cancer stem cells, chemosensitivity, personalized medicine, tumor microenvironment
- MeSH terms
- Animals, Cell Communication, Cell Survival, Humans, Tumor Cells, Cultured, Colorectal Neoplasms, Cadherins, Spheroids, Cellular, Cell Culture Techniques, Xenograft Model Antitumor Assays, Mice
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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