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A program of microRNAs controls osteogenic lineage progression by targeting transcription factor Runx2
Open accessAbstract
Lineage progression in osteoblasts and chondrocytes is stringently controlled by the cell-fate–determining transcription factor Runx2. In this study, we directly addressed whether microRNAs (miRNAs) can control the osteogenic activity of Runx2 and affect osteoblast maturation. A panel of 11 Runx2-targeting miRNAs (miR-23a, miR-30c, miR-34c, miR-133a, miR-135a, miR-137, miR-204, miR-205, miR-217, miR-218, and miR-338) is expressed in a lineage-related pattern in mesenchymal cell types. During both osteogenic and chondrogenic differentiation, these miRNAs, in general, are inversely expressed relative to Runx2. Based on 3′UTR luciferase reporter, immunoblot, and mRNA stability assays, each miRNA directly attenuates Runx2 protein accumulation. Runx2-targeting miRNAs differentially inhibit Runx2 protein expression in osteoblasts and chondrocytes and display different efficacies. Thus, cellular context contributes to miRNA-mediated regulation of Runx2. All Runx2-targeting miRNAs (except miR-218) significantly impede osteoblast differentiation, and their effects can be reversed by the corresponding anti-miRNAs. These findings demonstrate that osteoblastogenesis is limited by an elaborate network of functionally tested miRNAs that directly target the osteogenic master regulator Runx2.
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“The experiments in vitro have demonstrated that it can control the progression of osteoblast and chondrocyte lineages and inhibit osteogenic differentiation by targeting the transcription factors Runx2 and Satb2 in mice.”
From Recent advances of miR-23 in human diseases and growth development (2025) · cites this paper as [109]
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“miR-23a is highly expressed in osteoblasts, chondrocytes, and fibroblast cell lines.”
From Recent advances of miR-23 in human diseases and growth development (2025) · cites this paper as [109]
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“there existed no notable variance in the number of osteoblasts and osteoclasts between miR-23 transgenic and wild-type mice, along with their activity in the bone.”
From Recent advances of miR-23 in human diseases and growth development (2025) · cites this paper as [109]
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“In addition, an increase in RANKL/OPG ratio expressed by osteocytes was also observed in connexin43-deficient rats, suggesting that a disruption in cell-to-cell communication between osteocytes may induce the release of local proosteoclastogenic cytokines [33, 196, 197].”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [33]
In the citing paper
“In addition, an increase in RANKL/OPG ratio expressed by osteocytes was also observed in connexin43-deficient rats, suggesting that a disruption in cell-to-cell communication between osteocytes may induce the release of local proosteoclastogenic cytokines [33, 196, 197].”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [33]
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Cites
Prediction of Mammalian MicroRNA Targets
Lewis, B. P., Shih, I.-H., Jones-Rhoades, M. W., Bartel, D. P., & Burge, C. B. (2003) · Cell · doi:10.1016/s0092-8674(03)01018-3 · Cited by 5,199
Combinatorial microRNA target predictions
Krek, A., Grün, D., Poy, M. N., Wolf, R., Rosenberg, L., Epstein, E. J., MacMenamin, P., da Piedade, I., Gunsalus, K. C., Stoffel, M., et al. (2005) · Nature Genetics · doi:10.1038/ng1536 · Cited by 4,603
John, B., Enright, A. J., Aravin, A., Tuschl, T., Sander, C., & Marks, D. S. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020363 · Cited by 3,796
Nakashima, K., Zhou, X., Kunkel, G., Zhang, Z., Deng, J. M., Behringer, R. R., & de Crombrugghe, B. (2002) · Cell · doi:10.1016/s0092-8674(01)00622-5 · Cited by 3,608
Small silencing RNAs: an expanding universe
Ghildiyal, M., & Zamore, P. D. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2504 · Cited by 2,418
Miranda, K. C., Huynh, T., Tay, Y., Ang, Y.-S., Tam, W.-L., Thomson, A. M., Lim, B., & Rigoutsos, I. (2006) · Cell · doi:10.1016/j.cell.2006.07.031 · Cited by 2,063
Sandberg, R., Neilson, J. R., Sarma, A., Sharp, P. A., & Burge, C. B. (2008) · Science · doi:10.1126/science.1155390 · Cited by 1,349
Canonical WNT Signaling Promotes Osteogenesis by Directly Stimulating Runx2 Gene Expression
Gaur, T., Lengner, C. J., Hovhannisyan, H., Bhat, R. A., Bodine, P. V. N., Komm, B. S., Javed, A., van Wijnen, A. J., Stein, J. L., Stein, G. S., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500608200 · Cited by 1,170
Self-citationRegulation of bone development and extracellular matrix protein genes by RUNX2
Komori, T. (2009) · Cell and Tissue Research · doi:10.1007/s00441-009-0832-8 · Cited by 806
MicroRNA-204 Regulates Runx2 Protein Expression and Mesenchymal Progenitor Cell Differentiation
Huang, J. H., Zhao, L., Xing, L., & Chen, D. (2009) · Stem Cells · doi:10.1002/stem.288 · Cited by 607
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Items 101–200 of 420
Levingstone, T. J., Herbaj, S., Redmond, J., McCarthy, H. O., & Dunne, N. (2020) · Nanomaterials · doi:10.3390/nano10010146 · Cited by 68
Wang, Y., Chen, S., Deng, C., Li, F., Wang, Y., Hu, X., Shi, F., & Dong, N. (2015) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000244 · Cited by 66
Sun, Z., Cao, X., Hu, Z., Zhang, L., Wang, H., Zhou, H., Li, D., Zhang, S., & Xie, M. (2015) · Bone · doi:10.1016/j.bone.2015.04.006 · Cited by 64
MicroRNAs and post-transcriptional regulation of skeletal development
Gámez, B., Rodríguez-Carballo, E., & Ventura, F. (2014) · Journal of Molecular Endocrinology · doi:10.1530/jme-13-0294 · Cited by 63
CDK11 in TREX/THOC Regulates HIV mRNA 3′ End Processing
Pak, V., Eifler, T., Jäger, S., Krogan, N. J., Fujinaga, K., & Peterlin, B. M. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.10.012 · Cited by 66
Stromal Androgen Receptor in Prostate Cancer Development and Progression
Leach, D. A., & Buchanan, G. (2017) · Cancers · doi:10.3390/cancers9010010 · Cited by 63
Ko, J., Chuang, P.-C., Chen, M.-W., Ke, H.-C., Wu, S.-L., Chang, Y., Chen, Y., & Wang, F. (2013) · Bone · doi:10.1016/j.bone.2013.09.019 · Cited by 62
Vega, O. A., Lucero, C. M. J., Araya, H., Jerez, S., Tapia, J. C., Antonelli, M., Salazar‐Onfray, F., Heras, F. L., Thaler, R., Riester, S. M., et al. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26011 · Cited by 62
Self-citationVitamin D and MicroRNAs in Bone
Lisse, T. S., Adams, J. S., & Hewison, M. (2013) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukaryotgeneexpr.2013007147 · Cited by 61
MicroRNA‐503‐5p inhibits stretch‐induced osteogenic differentiation and bone formation
Liu, L., Liu, M., Li, R., Liu, H., Du, L., Chen, H., Zhang, Y., Zhang, S., & Liu, D. (2016) · Cell Biology International · doi:10.1002/cbin.10704 · Cited by 61
Self-citationChen, Q., Liu, W., Sinha, K. M., Yasuda, H., & Crombrugghe, B. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058104 · Cited by 60
Wang, P., Li, Y., Meng, T., Zhang, J., Wei, Y., Meng, Z., Lin, Y., Liu, D., & Sui, L. (2017) · Cell Proliferation · doi:10.1111/cpr.12413 · Cited by 59
Gong, Y., Xu, F., Zhang, L., Qian, Y., Chen, J., Huang, H., & Yu, Y. (2013) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-013-1888-z · Cited by 58
Chakravorty, N., Ivanovski, S., Prasadam, I., Crawford, R., Oloyede, A., & Xiao, Y. (2012) · Acta Biomaterialia · doi:10.1016/j.actbio.2012.05.008 · Cited by 58
Qiao, W., Chen, L., & Zhang, M. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000362971 · Cited by 58
MicroRNAs are critical regulators of senescence and aging in mesenchymal stem cells
Potter, M. L., Hill, W., Isales, C. M., Hamrick, M. W., & Fulzele, S. (2020) · Bone · doi:10.1016/j.bone.2020.115679 · Cited by 59
Myeloma cell–derived Runx2 promotes myeloma progression in bone
Trotter, T. N., Li, M., Pan, Q., Peker, D., Rowan, P. D., Li, J., Zhan, F., Suva, L. J., Javed, A., & Yang, Y. (2015) · Blood · doi:10.1182/blood-2014-12-613968 · Cited by 56
Baniwal, S. K., Shah, P. K., Shi, Y., HaDuong, J. H., DeClerck, Y. A., Gabet, Y., & Frenkel, B. (2011) · Osteoporosis International · doi:10.1007/s00198-011-1728-5 · Cited by 56
Chen, R., Qiu, H., Tong, Y., Liao, F., Hu, X., Qiu, Y.-R., & Liao, Y. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.06.083 · Cited by 56
Mazzu, Y. Z., Hu, Y., Soni, R. K., Mojica, K. M., Qin, L., Agius, P., Waxman, Z. M., Mihailovic, A., Socci, N. D., Hendrickson, R. C., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-2253 · Cited by 55
Costa, V., Raimondi, L., Conigliaro, A., Salamanna, F., Carina, V., Luca, A. D., Bellavia, D., Alessandro, R., Fini, M., & Giavaresi, G. (2017) · Cytotherapy · doi:10.1016/j.jcyt.2017.09.007 · Cited by 55
Ding, W. J., Li, J., Singh, J., Alif, R., Vázquez-Padrón, R. I., Gomes, S. A., Hare, J. M., & Shehadeh, L. A. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvv030 · Cited by 54
Exosomes in Extracellular Matrix Bone Biology
Petho, A., Chen, Y., & George, A. (2018) · Current Osteoporosis Reports · doi:10.1007/s11914-018-0419-y · Cited by 55
Impact of RUNX2 on drug-resistant human pancreatic cancer cells with p53 mutations
Ozaki, T., Yu, M., Yin, D., Sun, D., Zhu, Y., Bu, Y., & Sang, M. (2018) · BMC Cancer · doi:10.1186/s12885-018-4217-9 · Cited by 57
GIBSON, G. J., & Asahara, H. (2013) · Journal of Orthopaedic Research® · doi:10.1002/jor.22397 · Cited by 55
MicroRNA‐145 regulates osteoblastic differentiation by targeting the transcription factor Cbfb
Fukuda, T., Ochi, H., Sunamura, S., Haiden, A., Bando, W., Inose, H., Okawa, A., Asou, Y., & Takeda, S. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.09.024 · Cited by 53
Rea, G., Cristofaro, F., Pani, G., Pascucci, B., Ghuge, S. A., Corsetto, P. A., Imbriani, M., Visai, L., & Rizzo, A. M. (2015) · Journal of Proteomics · doi:10.1016/j.jprot.2015.11.005 · Cited by 56
Vascular calcification in CKD: New insights into its mechanisms
Ding, N., Lv, Y., Su, H., Wang, Z., Kong, X., Zhen, J., Lv, Z., & Wang, R. (2023) · Journal of Cellular Physiology · doi:10.1002/jcp.31021 · Cited by 52
Osteoblast ontogeny and implications for bone pathology: an overview
Titorencu, I. D., Prună, V., Jinga, V. V., & Simionescu, M. (2013) · Cell and Tissue Research · doi:10.1007/s00441-013-1750-3 · Cited by 55
MiR-142-5p promotes bone repair by maintaining osteoblast activity
Tu, M., Tang, J., He, H., Cheng, P., & Chen, C. (2016) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-016-0757-8 · Cited by 52
Chen, H., Ji, X., She, F., Gao, Y., & Tang, P. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2839 · Cited by 52
Vaspin regulates the osteogenic differentiation of MC3T3-E1 through the PI3K-Akt/miR-34c loop
Liu, Y., Xu, F., Hong-xia, P., Zhu, X., Lin, X., Song, C., Liang, Q.-H., Liao, E.-Y., & Yuan, L. (2016) · Scientific Reports · doi:10.1038/srep25578 · Cited by 51
Mieczkowska, A., Schumacher, A., Filipowicz, N. H., Wardowska, A., Zieliński, M., Madanecki, P., Nowicka, E., Langa, P., Deptuła, M., Zieliński, J., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-29477-5 · Cited by 51
Bone fracture healing: perspectives according to molecular basis
Ruggieri, I. N. C., Cícero, A. M., Issa, J. P. M., & Feldman, S. (2020) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-020-01168-0 · Cited by 52
MiR‐455‐3p regulates early chondrogenic differentiation via inhibiting Runx2
Zhang, Z., Hou, C., Meng, F., Zhao, X., Zhang, Z., Huang, G., Chen, W., Fu, M., & Liao, W. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.09.032 · Cited by 50
Role of miRNAs in bone and their potential as therapeutic targets
Kim, K. M., & Lim, S.-K. (2014) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2014.05.001 · Cited by 52
MicroRNA-34c promotes osteoclast differentiation through targeting LGR4
Cong, F., Wu, N., Tian, X., Fan, J., Liu, J., Song, T., & Fu, H. (2017) · Gene · doi:10.1016/j.gene.2017.01.028 · Cited by 50
Liu, H., Zhong, L., Yuan, T., Chen, S., Zhou, Y., An, L., Guo, Y., Fan, M., Li, Y., Sun, Y., et al. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3526 · Cited by 50
PCAF acetylates Runx2 and promotes osteoblast differentiation
Wang, C., Yang, S., Wang, Z., Tan, J.-M., Xing, S., Chen, D., Xu, S., & Yuan, W. (2013) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-013-0428-y · Cited by 51
MicroRNA signature associated with osteogenic lineage commitment
Bakhshandeh, B., Soleimani, M., Hafizi, M., Paylakhi, S. H., & Ghaemi, N. (2012) · Molecular Biology Reports · doi:10.1007/s11033-012-1591-2 · Cited by 49
hsa-mir-30c promotes the invasive phenotype of metastatic breast cancer cells by targeting NOV/CCN3
Dobson, J. R., Taipaleenmäki, H., Hu, Y., Hong, D., van Wijnen, A. J., Stein, J. L., Stein, G. S., Lian, J. B., & Pratap, J. (2014) · Cancer Cell International · doi:10.1186/s12935-014-0073-0 · Cited by 49
Self-citationBottani, M., Banfi, G., & Lombardi, G. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.01044 · Cited by 49
Global miRNA expression and correlation with mRNA levels in primary human bone cells
Laxman, N., Rubin, C., Mallmin, H., Nilsson, O., Pastinen, T., Grundberg, E., & Kindmark, A. (2015) · RNA · doi:10.1261/rna.049148.114 · Cited by 50
WANG, B., Peng, Y., Li, T., Bian, Y., & Weng, X. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4386 · Cited by 47
miRNAs Related to Skeletal Diseases
Seeliger, C., Balmayor, E. R., & van Griensven, M. (2016) · Stem Cells and Development · doi:10.1089/scd.2016.0133 · Cited by 47
Zhang, Y., Fukui, N., Yahata, M., Katsuragawa, Y., Tashiro, T., Ikegawa, S., & Lee, M. T. M. (2016) · Scientific Reports · doi:10.1038/srep34460 · Cited by 47
Self-citationLi, T., Li, H., Li, T., Fan, J., Zhao, R. C., & Weng, X. (2014) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24831 · Cited by 46
MicroRNAs and Bone Regeneration
Nakasa, T., Yoshizuka, M., Usman, M., Mahmoud, E. E., & Ochi, M. (2015) · Current Genomics · doi:10.2174/1389202916666150817213630 · Cited by 46
Evidences for a New Role of miR-214 in Chondrogenesis
Roberto, V. P., Gavaia, P. J., Nunes, M. J., Rodrigues, E., Cancela, M. L., & Tiago, D. M. (2018) · Scientific Reports · doi:10.1038/s41598-018-21735-w · Cited by 48
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Sjöström, T., Brydone, A. S., Meek, R. D., Dalby, M. J., Su, B., & McNamara, L. E. (2012) · Nanomedicine · doi:10.2217/nnm.12.177 · Cited by 45
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Delgado‐Calle, J., Garmilla, P., & Riancho, J. A. (2012) · Current Genomics · doi:10.2174/138920212800543129 · Cited by 44
Mai, Z., Peng, Z., Zhang, J., Chen, L., Liang, H.-Y., Cai, B., & Ai, H. (2013) · Chinese Medical Journal · doi:10.3760/cma.j.issn.0366-6999.20123137 · Cited by 44
Song, R., Fullerton, D. A., Ao, L., Zhao, K., Reece, T. B., Cleveland, J. C., & Meng, X. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.116.005364 · Cited by 45
The Emerging Role of MicroRNAs in Bone Diseases and Their Therapeutic Potential
Bravo-Vázquez, L. A., Becerril, M. Y. M., Hernández, E. O. M., Carmona, G. G. D. L., Padilla, M. E. A., Chakraborty, S., Bandyopadhyay, A., & Paul, S. (2021) · Molecules · doi:10.3390/molecules27010211 · Cited by 44
Samsonraj, R. M., Dudakovic, A., Manzar, B., Sen, B., Dietz, A. B., Cool, S. M., Rubin, J. E., & van Wijnen, A. J. (2017) · Stem Cells Translational Medicine · doi:10.1002/sctm.17-0086 · Cited by 43
Krevvata, M., Shan, X., Zhou, C., Santos, C. D., Ndikuyeze, G. H., Secreto, A. J., Glover, J. A., Trotman, W., Brake-Sillá, G., Nuñez-Cruz, S., et al. (2018) · Haematologica · doi:10.3324/haematol.2017.183202 · Cited by 43
Zhang, L., Li, G., Wang, K., Wang, Y., Dong, J., Wang, H., Xu, L., Shi, F., Cao, X., Hu, Z., et al. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.11.057 · Cited by 43
Seenprachawong, K., Tawornsawutruk, T., Nantasenamat, C., Nuchnoi, P., Hongeng, S., & Supokawej, A. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00543 · Cited by 43
Wang, X. B., Zhao, D., Zhu, Y., Dong, Y., & Liu, Y. (2019) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2019.110534 · Cited by 42
Guo, Z., Zhao, L., Ji, S., Long, T., Huang, Y., Ju, R., Tang, W. D., Tian, W., & Long, J. (2020) · Cell and Tissue Research · doi:10.1007/s00441-020-03305-7 · Cited by 42
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microRNA‐Mediated Regulation of Bone Remodeling: A Brief Review
Liu, J., Dang, L., Wu, X., Li, D., Ren, Q., Lü, A., & Zhang, G. (2019) · JBMR Plus · doi:10.1002/jbm4.10213 · Cited by 41
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Jang, S. H., Cha, J. W., Han, N. S., & Jeong, K. J. (2018) · Scientific Reports · doi:10.1038/s41598-018-27091-z · Cited by 39
Plummer, J. D., Park, M., Perodin, F., Horowitz, M. C., & Hens, J. R. (2016) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25604 · Cited by 39
Fang, M., Wang, C., Zheng, C., Luo, J., Hou, S., Liu, K., & Li, X. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26545 · Cited by 39
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Yu, S.-H., Geng, Q., Ma, J., Sun, F., Yu, Y., Pan, Q., & Hong, A. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.363 · Cited by 39
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Gao, B. (2015) · Frontiers in bioscience · doi:10.2741/4301 · Cited by 38
Saidi, N., Ghalavand, M., Hashemzadeh, M. S., Dorostkar, R., Mohammadi, H., & Mahdian-shakib, A. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.02.093 · Cited by 38
Puppo, M., Taipaleenmäki, H., Hesse, E., & Clézardin, P. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14836 · Cited by 40
Godfrey, T. C., Wildman, B. J., Beloti, M. M., Kemper, A. G., Ferraz, E. P., Roy, B., Rehan, M., Afreen, L. H., Kim, E., Lengner, C. J., et al. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.003052 · Cited by 37
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Yu, S.-H., Geng, Q., Pan, Q., Liu, Z., Ding, S., Xiang, Q., Sun, F., Wang, C., Huang, Y., & Hong, A. (2016) · Cell & Bioscience · doi:10.1186/s13578-016-0073-y · Cited by 35
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Chen, S., Xu, Z., Shao, J., Fu, P., & Wu, H. (2019) · BMC Biotechnology · doi:10.1186/s12896-018-0496-0 · Cited by 35
miR-23a impairs bone differentiation in osteosarcoma via down-regulation of GJA1
Gindin, Y., Jiang, Y., Francis, P., Walker, R. L., Abaan, O. D., Zhu, Y. J., & Meltzer, P. S. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00233 · Cited by 34
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Shi, X., Inchauste, S. M., Guo, H., Shan, J., Xiao, Z., Xu, H., Miettenen, M., Zhang, M. R., Hong, J. A., Raiji, M. T., et al. (2015) · Oncogene · doi:10.1038/onc.2015.10 · Cited by 34
Junmei, Z., Wang, C., Song, Y., & Fang, B. (2014) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmu082 · Cited by 34
Hodges, W. M., O’Brien, F., Fulzele, S., & Hamrick, M. W. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122597 · Cited by 34
Shi, L., Lu, F., Liu, Y., Duan, J.-Q., Lin, W., Zhang, J., & Li, G. (2018) · Calcified Tissue International · doi:10.1007/s00223-018-0410-8 · Cited by 34
Wu, Y., Ou, Y., Liao, C., Liang, S., & Wang, Y. (2019) · Europe PMC (PubMed Central) · Cited by 34
Kim, J., Park, S.-Y., Lee, S. A., Park, M.-G., Yu, S., Lee, M., Park, M., Kim, S.-G., Oh, J., Lee, S., et al. (2013) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-013-1872-7 · Cited by 34
Peng, W., Zhu, S., Wang, J., Chen, L., Weng, J., & Chen, S. L. (2017) · Clinical Implant Dentistry and Related Research · doi:10.1111/cid.12553 · Cited by 33
MicroRNA Regulation of Smooth Muscle Phenotype.
Joshi, S. R., Comer, B. S., McLendon, J. M., & Gerthoffer, W. T. (2012) · PubMed · Cited by 33
Farina, N. H., Zingiryan, A., Akech, J., Callahan, C. J., Lu, H., Stein, J. L., Languino, L. R., Stein, G. S., & Lian, J. B. (2016) · Oncotarget · doi:10.18632/oncotarget.11992 · Cited by 32
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Moghaddam, T., & Neshati, Z. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28689 · Cited by 32
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Huai, Y., Zhang, W., Chen, Z., Zhao, F., Wang, W. T., Dang, K., Xue, K., Gao, Y., Jiang, S., Miao, Z., et al. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.516213 · Cited by 32
Correa, R., Arenas, J., Montoya, G. A., Hoz, L., López, S., Chavarría, F. S., Arroyo, R., Salmerón-Valdés, E. N., Romo, E., Zeichner‐David, M., et al. (2018) · The FASEB Journal · doi:10.1096/fj.201800434rr · Cited by 32
de Souza, W., Piperni, S. G., Grenho, L., Rocha, L. A., Granjeiro, J. M., Melo, S. A., Fernandes, M. H., & Ribeiro, A. R. (2023) · Biomaterials Science · doi:10.1039/d2bm01854c · Cited by 31
Kumar, Y., Kapoor, I., Khan, K., Thacker, G., Khan, M. P., Shukla, N., Kanaujiya, J. K., Sanyal, S., Chattopadhyay, N., & Trivedi, A. K. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.669531 · Cited by 31
RetractedIcariine Restores LPS-Induced Bone Loss by Downregulating miR-34c Level
Liu, J., Li, D., Sun, X., Wang, Y., Qiangbing, X., & Chen, A. (2016) · Inflammation · doi:10.1007/s10753-016-0411-6 · Cited by 31
Metadata
- Authors
- Zhang, Y., Xie, R.-L., Croce, C. M., Stein, J. L., Lian, J. B., van Wijnen, A. J., & Stein, G. S.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- The Ohio State University (US)
- Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, MA 01655; and
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2011-05-31
- Volume
- 108
- Issue
- 24
- Pages
- 9863-9868
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3116419
- OpenAlex
- W2028928108
- Cited by
- 423
- References
- 48
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 19 · 2023: 20 · 2022: 15 · 2021: 27 · 2020: 36 · 2019: 42 · 2018: 32 · 2017: 36 · 2016: 35 · 2015: 46 · 2014: 24 · 2013: 42 · 2012: 27
- FWCI
- 12.71
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (P01CA129242, P01CA082834)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR049069, R01AR039588)
- National Institute of Dental and Craniofacial Research (R37DE012528)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- microRNA, Runx2, osteogenic differentiation, osteoblasts, chondrogenic differentiation, mesenchymal lineage, microRNA target regulation, miR-218, transcription factor regulation
- MeSH terms
- Animals, Base Sequence, Cell Differentiation, Cell Line, Gene Expression Regulation, Luciferases, Osteoblasts, Osteogenesis, RNA, Messenger, Blotting, Western, Cell Lineage, Chondrocytes, 3' Untranslated Regions, Gene Expression Profiling, RNA Stability, MicroRNAs, NIH 3T3 Cells, Core Binding Factor Alpha 1 Subunit, Mice
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