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A program of microRNAs controls osteogenic lineage progression by targeting transcription factor Runx2
Open accessAbstract
Lineage progression in osteoblasts and chondrocytes is stringently controlled by the cell-fate–determining transcription factor Runx2. In this study, we directly addressed whether microRNAs (miRNAs) can control the osteogenic activity of Runx2 and affect osteoblast maturation. A panel of 11 Runx2-targeting miRNAs (miR-23a, miR-30c, miR-34c, miR-133a, miR-135a, miR-137, miR-204, miR-205, miR-217, miR-218, and miR-338) is expressed in a lineage-related pattern in mesenchymal cell types. During both osteogenic and chondrogenic differentiation, these miRNAs, in general, are inversely expressed relative to Runx2. Based on 3′UTR luciferase reporter, immunoblot, and mRNA stability assays, each miRNA directly attenuates Runx2 protein accumulation. Runx2-targeting miRNAs differentially inhibit Runx2 protein expression in osteoblasts and chondrocytes and display different efficacies. Thus, cellular context contributes to miRNA-mediated regulation of Runx2. All Runx2-targeting miRNAs (except miR-218) significantly impede osteoblast differentiation, and their effects can be reversed by the corresponding anti-miRNAs. These findings demonstrate that osteoblastogenesis is limited by an elaborate network of functionally tested miRNAs that directly target the osteogenic master regulator Runx2.
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“The experiments in vitro have demonstrated that it can control the progression of osteoblast and chondrocyte lineages and inhibit osteogenic differentiation by targeting the transcription factors Runx2 and Satb2 in mice.”
From Recent advances of miR-23 in human diseases and growth development (2025) · cites this paper as [109]
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“miR-23a is highly expressed in osteoblasts, chondrocytes, and fibroblast cell lines.”
From Recent advances of miR-23 in human diseases and growth development (2025) · cites this paper as [109]
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“there existed no notable variance in the number of osteoblasts and osteoclasts between miR-23 transgenic and wild-type mice, along with their activity in the bone.”
From Recent advances of miR-23 in human diseases and growth development (2025) · cites this paper as [109]
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“In addition, an increase in RANKL/OPG ratio expressed by osteocytes was also observed in connexin43-deficient rats, suggesting that a disruption in cell-to-cell communication between osteocytes may induce the release of local proosteoclastogenic cytokines [33, 196, 197].”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [33]
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“In addition, an increase in RANKL/OPG ratio expressed by osteocytes was also observed in connexin43-deficient rats, suggesting that a disruption in cell-to-cell communication between osteocytes may induce the release of local proosteoclastogenic cytokines [33, 196, 197].”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [33]
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Cites
Prediction of Mammalian MicroRNA Targets
Lewis, B. P., Shih, I.-H., Jones-Rhoades, M. W., Bartel, D. P., & Burge, C. B. (2003) · Cell · doi:10.1016/s0092-8674(03)01018-3 · Cited by 5,199
Combinatorial microRNA target predictions
Krek, A., Grün, D., Poy, M. N., Wolf, R., Rosenberg, L., Epstein, E. J., MacMenamin, P., da Piedade, I., Gunsalus, K. C., Stoffel, M., et al. (2005) · Nature Genetics · doi:10.1038/ng1536 · Cited by 4,603
John, B., Enright, A. J., Aravin, A., Tuschl, T., Sander, C., & Marks, D. S. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020363 · Cited by 3,796
Nakashima, K., Zhou, X., Kunkel, G., Zhang, Z., Deng, J. M., Behringer, R. R., & de Crombrugghe, B. (2002) · Cell · doi:10.1016/s0092-8674(01)00622-5 · Cited by 3,608
Small silencing RNAs: an expanding universe
Ghildiyal, M., & Zamore, P. D. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2504 · Cited by 2,418
Miranda, K. C., Huynh, T., Tay, Y., Ang, Y.-S., Tam, W.-L., Thomson, A. M., Lim, B., & Rigoutsos, I. (2006) · Cell · doi:10.1016/j.cell.2006.07.031 · Cited by 2,063
Sandberg, R., Neilson, J. R., Sarma, A., Sharp, P. A., & Burge, C. B. (2008) · Science · doi:10.1126/science.1155390 · Cited by 1,349
Canonical WNT Signaling Promotes Osteogenesis by Directly Stimulating Runx2 Gene Expression
Gaur, T., Lengner, C. J., Hovhannisyan, H., Bhat, R. A., Bodine, P. V. N., Komm, B. S., Javed, A., van Wijnen, A. J., Stein, J. L., Stein, G. S., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500608200 · Cited by 1,170
Self-citationRegulation of bone development and extracellular matrix protein genes by RUNX2
Komori, T. (2009) · Cell and Tissue Research · doi:10.1007/s00441-009-0832-8 · Cited by 806
MicroRNA-204 Regulates Runx2 Protein Expression and Mesenchymal Progenitor Cell Differentiation
Huang, J. H., Zhao, L., Xing, L., & Chen, D. (2009) · Stem Cells · doi:10.1002/stem.288 · Cited by 607
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Items 301–400 of 420
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Cai, M., Peng, H., Liu, M., Huang, M., Zheng, W. T., Zhang, G., Lai, W., Liao, C., Cai, L., Zhang, D., et al. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s438229 · Cited by 11
Osteoblastic microRNAs in skeletal diseases: Biological functions and therapeutic implications
Yu, L., Li, W., Yang, P., Zhang, W., Tao, H., Ge, G., Yang, H., Bai, J., Wang, H., & Geng, D. (2022) · Engineered Regeneration · doi:10.1016/j.engreg.2022.06.002 · Cited by 11
Boyce, B. F., Zuscik, M. J., & Xing, L. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804182-6.00011-3 · Cited by 14
Osthole ameliorates simulated microgravity-induced bone loss through down-regulation of miR-34c-5p
Feng, X., Zhou, H., Zhang, Y., Yang, P., Bai, H., Zhang, T., Hua, J., Zhang, L., Liu, Y., Xie, X., et al. (2021) · Acta Astronautica · doi:10.1016/j.actaastro.2021.03.015 · Cited by 11
Self-citationHong, G., Zhou, Y., Yang, S., Yan, S., Lu, J., Xu, B., Zhan, Z., Jiang, H.-S., Wei, B., & Wang, J. (2024) · Stem Cells · doi:10.1093/stmcls/sxae057 · Cited by 10
MicroRNAs: emerging biomarkers and therapeutic targets of bone fragility in chronic kidney disease
Smout, D., Craenenbroeck, A. H. V., Jørgensen, H. S., & Evenepoel, P. (2022) · Clinical Kidney Journal · doi:10.1093/ckj/sfac219 · Cited by 10
MicroRNAs and Connexins in Bone: Interaction and Mechanisms of Delivery
Plotkin, L. I., Pacheco‐Costa, R., & Davis, H. M. (2017) · Current Molecular Biology Reports · doi:10.1007/s40610-017-0058-6 · Cited by 10
Mansurabadi, R., Abroun, S., Hajifathali, A., Kojabad, A. A., Atashi, A., & Haghighi, M. (2017) · Europe PMC (PubMed Central) · doi:10.22074/cellj.2017.4480 · Cited by 10
Kanakis, I., Alameddine, M., Scalabrin, M., Hof, R. V., Liloglou, T., Ozanne, S. E., Goljanek‐Whysall, K., & Vasilaki, A. (2020) · The FASEB Journal · doi:10.1096/fj.202001131r · Cited by 10
Huang, M., Li, X., & Guo, L. (2021) · Differentiation · doi:10.1016/j.diff.2021.05.002 · Cited by 10
Wang, Q., Shi, D., Geng, Y., Huang, Q.-S., & Xiang, L. (2019) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-019-03632-6 · Cited by 10
RetractedMechanisms of Cardiovascular Calcification and Experimental Models: Impact of Vitamin K Antagonists
Siracusa, C., Carino, A., Carabetta, N., Manica, M., Sabatino, J., Cianflone, E., Leo, I., Strangio, A., Torella, D., & Rosa, S. D. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13051405 · Cited by 9
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Bella, E. D., Menzel, U., Naros, A., Kubosch, E. J., Alini, M., & Stoddart, M. J. (2024) · PLoS ONE · doi:10.1371/journal.pone.0303035 · Cited by 9
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Li, H., Wang, J., Xie, X., Chen, Y., Zheng, Q., He, J., & Lu, Q. (2023) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2023.116793 · Cited by 9
Alečković, M., & Kang, Y. (2015) · BoneKEy Reports · doi:10.1038/bonekey.2015.38 · Cited by 9
Chung, J.-E., Park, J., Yun, J., Kang, Y., Park, B.-W., Hwang, S., Cho, Y., Sung, I., Woo, D. K., & Byun, J. (2016) · International Journal of Medical Sciences · doi:10.7150/ijms.16484 · Cited by 9
Lan, C., Long, L., Xie, K., Liu, J., Zhou, L., Pan, S., Liang, J., Tu, Z., Gao, Z., & Tang, Y. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.8246 · Cited by 9
RetractedMancinelli, R., Filippo, E. S. D., Tumedei, M., Marrone, M., Fontana, A., Ettorre, V., Giordani, S., Baldrighi, M., Iezzi, G., Piattelli, A., et al. (2021) · Applied Sciences · doi:10.3390/app11073218 · Cited by 9
The Role of miR-34c-5p in Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells
Liu, B., Gan, W., Zhang, J., Wang, M., Cui, G., Zhang, H., & Wang, H. (2021) · International Journal of Stem Cells · doi:10.15283/ijsc20188 · Cited by 8
Zhan, Y., Deng, B., Wu, H., Xu, C., Wang, R., Li, W., & Pan, Z. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.736301 · Cited by 8
MicroRNA-101a enhances trabecular bone accrual in male mice
Dudakovic, A., Jerez, S., Deosthale, P. J., Denbeigh, J. M., Paradise, C. R., Gluscevic, M., Zan, P., Begun, D. L., Camilleri, E. T., Pichurin, O., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-17579-0 · Cited by 8
Self-citationKearney, M., Cooper, P. R., Smith, A. J., & Duncan, H. F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24108631 · Cited by 8
MICROmanagement of Runx2 Function in Skeletal Cells
Wildman, B. J., Godfrey, T. C., Rehan, M., Chen, Y., Afreen, L. H., & Hassan, Q. (2019) · Current Molecular Biology Reports · doi:10.1007/s40610-019-0115-4 · Cited by 8
The role of epigenetic modifications in the osteogenic differentiation of adipose-derived stem cells
Chen, R., Ren, L., Cai, Q., Zou, Y., Fu, Q., & Ma, Y. (2019) · Connective Tissue Research · doi:10.1080/03008207.2019.1593395 · Cited by 8
Valenti, M. T., Mattè, A., Federti, E., Puder, M., Anez‐Bustillos, L., Deiana, M., Cheri, S., Minoia, A., Brugnara, C., Paolo, M. L. D., et al. (2021) · Antioxidants · doi:10.3390/antiox10050799 · Cited by 8
Emerging areas of bone repair materials
Chambers, P., McCarthy, H. O., & Dunne, N. (2019) · Elsevier eBooks · doi:10.1016/b978-0-08-102451-5.00016-0 · Cited by 8
The Role of Epigenetics on Dental Implant Therapy: A Systematic Review
Gianfilippo, R. D., Gianfilippo, C. D., & Prato, G. P. (2017) · Epigenomes · doi:10.3390/epigenomes1020012 · Cited by 7
Barrault, L., Gide, J., Qing, T., Lesueur, L., Tost, J., Denis, J. A., Cailleret, M., Aubry, L., Peschanski, M., Martinat, C., et al. (2019) · Cells · doi:10.3390/cells8121523 · Cited by 9
Deng, L., Lai, S., Fan, L., Li, X., Huang, H., & Mu, Y. (2022) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-022-03315-x · Cited by 7
Buitrago, D. L., Jover, E., Mameli, E., Mellis, D. J., Nosalski, R., Charlton, L., Sanso, R. B., Dunn-Davies, H., MacAskill, M. G., Tavares, A., et al. (2025) · Cardiovascular Research · doi:10.1093/cvr/cvaf117 · Cited by 6
Sousa, K. D. S. J., Parisi, J. R., de Souza, A., Cruz, M. D. A., Erbereli, R., Silva, J. D. A., Santo, G. D. E., Amaral, G. O., Martignago, C. C. S., Fortulan, C. A., et al. (2023) · Marine Biotechnology · doi:10.1007/s10126-023-10202-x · Cited by 6
miRNAs in Circulation: Mirroring Bone Conditions?
Huang, J. H., & Chen, D. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2297 · Cited by 6
Ragni, E., Parazzi, V., Crosti, M., Moro, M., Giordano, R., & Lazzari, L. (2014) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2014.09.017 · Cited by 6
van Leeuwen, J. P. T. M., van der Eerden, B. C. J., van de Peppel, J., Stein, G. S., & Lian, J. B. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-415853-5.00009-1 · Cited by 7
Self-citationRecent advances of miR-23 in human diseases and growth development
Qian, X., Jiang, Y., Yang, Y., Zhang, Y., Xu, N., Xu, B., Pei, K., Yu, Z., & Wu, W. (2025) · Non-coding RNA Research · doi:10.1016/j.ncrna.2024.12.010 · Cited by 5
Self-citationRUNX2/miR‑31/SATB2 pathway in nickel‑induced BEAS‑2B cell transformation
Zhu, Y., Chen, Q. Y., Jordan, A., Sun, H., Roy, N. K., & Costa, M. (2021) · Oncology Reports · doi:10.3892/or.2021.8105 · Cited by 5
Chen, B., Zhang, Y., & Liu, O. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1355312 · Cited by 5
Self-citationRole of MicroRNA in Mesenchymal Stem Cells Differentiation Into Osteoblasts
Shah, A., & Ahmad, A. (2013) · Razavi International Journal of Medicine · doi:10.17795/rijm14849 · Cited by 5
Site-1 protease regulates skeletal stem cell population and osteogenic differentiation in mice
Patra, D., DeLassus, E. N., Mueller, J. E., Abou‐Ezzi, G., & Sandell, L. J. (2018) · Biology Open · doi:10.1242/bio.032094 · Cited by 5
Shen, Y., Liu, Y., Gao, H., Fei, H., Yu, W., Hu, T., Zheng, Y., Bi, X., & Lin, C. (2018) · RSC Advances · doi:10.1039/c7ra12548h · Cited by 5
Potential Therapeutic Applications of Exosomes in Bone Regenerative Medicine
Yang, J., Zhu, W., Lu, J., Xie, K., Fang, S., & Kan, L. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.81069 · Cited by 5
Han, U., Hwang, J., Lee, J., 김현이, Jung, H.-S., Hong, J., & Hong, J. (2019) · Biotechnology and Bioengineering · doi:10.1002/bit.27183 · Cited by 5
miR-155-5p can be involved in acquisition of osseointegration on titanium surface
Yamamura, Y., Miyoshi, K., Mouri, Y., Kudo, Y., & Miyamoto, Y. (2022) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-022-00718-2 · Cited by 4
Xu, C., Xu, Q., Li, G., Li, J., Li, Y., Yang, N., & Du, Y. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e32498 · Cited by 4
Breulmann, F. L., Berger, S. A., Bella, E. D., & Stoddart, M. J. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04589-8 · Cited by 4
Aslani, S., Kalantary‐Charvadeh, A., Abbasalipourkabir, R., & Ziamajidi, N. (2026) · Experimental Cell Research · doi:10.1016/j.yexcr.2026.114921 · Cited by 4
Tan, Y.-L., Ju, S.-H., Wang, Q., Zhong, R., Gao, J., Wang, M., Kang, Y.-L., & Xu, M.-Z. (2024) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-024-05085-0 · Cited by 4
Transcriptional Control of Osteogenesis
Witkowska-Zimny, M. (2012) · InTech eBooks · doi:10.5772/35826 · Cited by 4
miRNAs in Bone Formation and Homeostasis
Papaioannou, G., Lisse, T. S., & Kobayashi, T. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405544-5.00014-9 · Cited by 4
Yue, W., Sun, J., Zhang, J., Chang, Y., Shen, Q., Zhu, Z., Yu, S., Wu, X., Peng, S., Li, N., et al. (2021) · Cells and Development · doi:10.1016/j.cdev.2021.203665 · Cited by 4
Photobiomodulation guided healing in a sub-critical bone defect in calvarias of rats
Magri, A. M. P., Fernandes, K. R., Kido, H. W., Fernandes, G. S., Fermino, S. D. S., Gabbai‐Armelin, P. R., Braga, F. J. C., Góes, C. P., Prado, J. L. D. S., Granito, R. N., et al. (2019) · LASER THERAPY · doi:10.5978/islsm.28_19-or-13 · Cited by 4
Expression of Musashi-1 Increases in Bone Healing
Padial‐Molina, M., Crespo‐Lora, V., Candido-Corral, C., Martín‐Morales, N., Abril‐García, D., Galindo‐Moreno, P., Hernández‐Cortés, P., & O’Valle, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073395 · Cited by 4
ZHUANG, J., Gao, R., Wu, H., Wu, X., & Pan, F. (2015) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2015.2464 · Cited by 4
RUNX2 Transcriptional Regulation in Development and Disease
Brusgard, J. L., & Passaniti, A. (2013) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-1-4614-8039-6_3 · Cited by 4
Nishiguchi, Y., Ueda, M., Kubo, H., Jo, J., Hashimoto, Y., & Takenobu, T. (2024) · Journal of Dental Sciences · doi:10.1016/j.jds.2024.07.028 · Cited by 3
Shin, M. W., Kim, H., Ryu, S., & Kim, S.-H. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27031230 · Cited by 3
Cheung, D. G., Buzzetti, M., & Leva, G. D. (2017) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2017.1383893 · Cited by 3
Role of MicroRNAs in Cardiovascular Calcification
Goettsch, C., & Aikaw, E. (2013) · InTech eBooks · doi:10.5772/55326 · Cited by 3
Mei, F., & Tu, Y. (2019) · Biotechnology & Biotechnological Equipment · doi:10.1080/13102818.2019.1684842 · Cited by 3
Small RNA Delivery for In Situ Tissue Regeneration
Kim, N. J., Yoo, J. J., Atala, A., & Lee, S. J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802225-2.00007-6 · Cited by 3
Zhang, H., Song, J., & Zhou, X. (2022) · Journal of Biomaterials and Tissue Engineering · doi:10.1166/jbt.2022.3125 · Cited by 2
Jiang, Y.-S., Wei, W., Xie, D.-T., & Guo, G. (2025) · World Journal of Stem Cells · doi:10.4252/wjsc.v17.i5.101638 · Cited by 2
Franceschetti, T., & Delany, A. M. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405544-5.00025-3 · Cited by 2
Osteoblasts: more than we thought
Franceschi, R. T., Ge, C., & Li, Y. (2012) · IBMS BoneKEy · doi:10.1038/bonekey.2012.26 · Cited by 2
Balmayor, E. R., Tellado, S. F., & van Griensven, M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803581-8.09320-6 · Cited by 2
Spinal malformation − A biochemical analysis using congenital kyphosis rats
Shimokawa, N., Takahashi, I., & Iizuka, H. (2022) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30206 · Cited by 2
MicroRNAs are central to osteogenesis: a review with a focus on cardiovascular calcification
Coffey, S., & Jones, G. T. (2015) · microRNA Diagnostics and Therapeutics · doi:10.2478/micrnat-2014-0005 · Cited by 2
Association of AXIN2 gene polymorphisms with nonsyndromic oligodontia in Turkish families
Dinçkan, N., Uyguner, Z. O., Kayserili, H., & Letra, A. (2016) · Dentistry 3000 · doi:10.5195/d3000.2016.57 · Cited by 2
Liu, F., Wang, Z., Liu, F., Xu, J., Liu, Q., & Lan, J. Q. (2019) · PubMed Central · doi:10.7518/hxkq.2019.02.013 · Cited by 2
A novel mineralization-inductive peptide derived from CEMP1functinal domains
Wang, Y. C., Li, M., Zheng, H., Xing, X., & Sun, W. (2025) · Scientific Reports · doi:10.1038/s41598-025-12663-7 · Cited by 1
Azari, M., Bella, E. D., & Wildemann, B. (2026) · Bone and Joint Research · doi:10.1302/2046-3758.157.bjr-2025-0576.r1 · Cited by 1
Bone Repair and Regeneration Are Regulated by the Wnt Signaling Pathway
Houschyar, K. S., Duscher, D., Maan, Z. N., Chelliah, M. P., Borrelli, M. R., Harati, K., Wallner, C., Rein, S., Tapking, C., Reumuth, G., et al. (2019) · Springer eBooks · doi:10.1007/978-3-030-19962-3_17 · Cited by 1
Haddouti, E.-M., Reinhardt, N., Ossendorff, R., Burger, C., Wirtz, D. C., de la Fuente, M., & Schildberg, F. A. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1207655 · Cited by 1
Cheng, Z., Liu, J., Shao, C., Li, J., Chen, J., Han, L., Jiang, X., Shang, L., & Cao, J. (2026) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-025-06652-9 · Cited by 1
Engineering of Inflammation-Resistant Osteochondral Cells
O, J., Janne, E., Tommy, A., Jakobsen, R. B., Astrid, K., Syversen, U., Engebretsen, L., Lyngstadaas, S. P., & Jorgense, C. (2013) · InTech eBooks · doi:10.5772/55544 · Cited by 1
Bone, Growth Plate and Mineral Metabolism
Raimann, A., Padidela, R., & Mäkitie, O. (2018) · Yearbook of pediatric endocrinology · doi:10.1530/ey.15.5 · Cited by 1
Li, Z., Wen, J., Jia, W., Ding, S., Xia, X., Zhou, C., & Huang, Y. (2016) · Chemical Research in Chinese Universities · doi:10.1007/s40242-016-5510-2 · Cited by 1
[A review on microRNAs regulation in osteoclast differentiation and function].
Lian, J., Du, W. T., & Meng, S. (2015) · PubMed Central · doi:10.7518/hxkq.2015.05.022 · Cited by 1
Self-citationIdentification of key mi RNA s in unilateral mastication‐induced disruption of cartilage homeostasis
Wu, M., Wang, X., Shuai, J., Deng, L., Lu, H., Zhou, Y., & Wu, M. (2023) · Oral Diseases · doi:10.1111/odi.14504 · Cited by 1
Franceschetti, T., & Delany, A. M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-820719-2.00019-3 · Cited by 1
Congenital kyphoscoliosis: Analysis of vertebral abnormalities using model animals (Review)
Sato, T., Takahashi, I., Watanabe, Y., Yokoyama, D., & Shimokawa, N. (2024) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2024.12705 · Cited by 1
Progress in understanding the role and mechanism of miRNAs in osteoporosis
Meng, F., Yang, C., Li, N., & Wang, H. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1544944 · Cited by 1
MicroRNA-29 Family Suppresses Mineralization in Dental Follicle Cells
Tomoki, R., Ogura, N., Takahashi, K., Ito, K., & Kondoh, T. (2015) · Journal of Hard Tissue Biology · doi:10.2485/jhtb.24.23 · Cited by 1
Валерьевна, Г. Е., Bukharova, T. B., Vasilyev, A. V., & Goldshtein, D. V. (2019) · Genes and Cells · doi:10.23868/201903005 · Cited by 1
Takai, H., van Wijnen, A. J., & Ogata, Y. (2021) · Gene Reports · doi:10.1016/j.genrep.2021.101414 · Cited by 1
The role of Stat3 in skeletal development
Davidson, R. K. (2017) · Purdue e-Pubs (Purdue University System) · doi:10.7912/c2/2192 · Cited by 1
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The Retinoblastoma Protein in Osteogenesis and Osteosarcoma Formation
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Franceschetti, T. (2014) · OpenCommons at University of Connecticut (University of Connecticut)
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Clinical and basic research papers – July 2011
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Metadata
- Authors
- Zhang, Y., Xie, R.-L., Croce, C. M., Stein, J. L., Lian, J. B., van Wijnen, A. J., & Stein, G. S.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- The Ohio State University (US)
- Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, MA 01655; and
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2011-05-31
- Volume
- 108
- Issue
- 24
- Pages
- 9863-9868
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3116419
- OpenAlex
- W2028928108
- Cited by
- 423
- References
- 48
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 19 · 2023: 20 · 2022: 15 · 2021: 27 · 2020: 36 · 2019: 42 · 2018: 32 · 2017: 36 · 2016: 35 · 2015: 46 · 2014: 24 · 2013: 42 · 2012: 27
- FWCI
- 12.71
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (P01CA129242, P01CA082834)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR049069, R01AR039588)
- National Institute of Dental and Craniofacial Research (R37DE012528)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- microRNA, Runx2, osteogenic differentiation, osteoblasts, chondrogenic differentiation, mesenchymal lineage, microRNA target regulation, miR-218, transcription factor regulation
- MeSH terms
- Animals, Base Sequence, Cell Differentiation, Cell Line, Gene Expression Regulation, Luciferases, Osteoblasts, Osteogenesis, RNA, Messenger, Blotting, Western, Cell Lineage, Chondrocytes, 3' Untranslated Regions, Gene Expression Profiling, RNA Stability, MicroRNAs, NIH 3T3 Cells, Core Binding Factor Alpha 1 Subunit, Mice
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