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A program of microRNAs controls osteogenic lineage progression by targeting transcription factor Runx2
Open accessAbstract
Lineage progression in osteoblasts and chondrocytes is stringently controlled by the cell-fate–determining transcription factor Runx2. In this study, we directly addressed whether microRNAs (miRNAs) can control the osteogenic activity of Runx2 and affect osteoblast maturation. A panel of 11 Runx2-targeting miRNAs (miR-23a, miR-30c, miR-34c, miR-133a, miR-135a, miR-137, miR-204, miR-205, miR-217, miR-218, and miR-338) is expressed in a lineage-related pattern in mesenchymal cell types. During both osteogenic and chondrogenic differentiation, these miRNAs, in general, are inversely expressed relative to Runx2. Based on 3′UTR luciferase reporter, immunoblot, and mRNA stability assays, each miRNA directly attenuates Runx2 protein accumulation. Runx2-targeting miRNAs differentially inhibit Runx2 protein expression in osteoblasts and chondrocytes and display different efficacies. Thus, cellular context contributes to miRNA-mediated regulation of Runx2. All Runx2-targeting miRNAs (except miR-218) significantly impede osteoblast differentiation, and their effects can be reversed by the corresponding anti-miRNAs. These findings demonstrate that osteoblastogenesis is limited by an elaborate network of functionally tested miRNAs that directly target the osteogenic master regulator Runx2.
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“The experiments in vitro have demonstrated that it can control the progression of osteoblast and chondrocyte lineages and inhibit osteogenic differentiation by targeting the transcription factors Runx2 and Satb2 in mice.”
From Recent advances of miR-23 in human diseases and growth development (2025) · cites this paper as [109]
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“miR-23a is highly expressed in osteoblasts, chondrocytes, and fibroblast cell lines.”
From Recent advances of miR-23 in human diseases and growth development (2025) · cites this paper as [109]
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“there existed no notable variance in the number of osteoblasts and osteoclasts between miR-23 transgenic and wild-type mice, along with their activity in the bone.”
From Recent advances of miR-23 in human diseases and growth development (2025) · cites this paper as [109]
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“In addition, an increase in RANKL/OPG ratio expressed by osteocytes was also observed in connexin43-deficient rats, suggesting that a disruption in cell-to-cell communication between osteocytes may induce the release of local proosteoclastogenic cytokines [33, 196, 197].”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [33]
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“In addition, an increase in RANKL/OPG ratio expressed by osteocytes was also observed in connexin43-deficient rats, suggesting that a disruption in cell-to-cell communication between osteocytes may induce the release of local proosteoclastogenic cytokines [33, 196, 197].”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [33]
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Citations
Cites
Prediction of Mammalian MicroRNA Targets
Lewis, B. P., Shih, I.-H., Jones-Rhoades, M. W., Bartel, D. P., & Burge, C. B. (2003) · Cell · doi:10.1016/s0092-8674(03)01018-3 · Cited by 5,199
Combinatorial microRNA target predictions
Krek, A., Grün, D., Poy, M. N., Wolf, R., Rosenberg, L., Epstein, E. J., MacMenamin, P., da Piedade, I., Gunsalus, K. C., Stoffel, M., et al. (2005) · Nature Genetics · doi:10.1038/ng1536 · Cited by 4,603
John, B., Enright, A. J., Aravin, A., Tuschl, T., Sander, C., & Marks, D. S. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020363 · Cited by 3,796
Nakashima, K., Zhou, X., Kunkel, G., Zhang, Z., Deng, J. M., Behringer, R. R., & de Crombrugghe, B. (2002) · Cell · doi:10.1016/s0092-8674(01)00622-5 · Cited by 3,608
Small silencing RNAs: an expanding universe
Ghildiyal, M., & Zamore, P. D. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2504 · Cited by 2,418
Miranda, K. C., Huynh, T., Tay, Y., Ang, Y.-S., Tam, W.-L., Thomson, A. M., Lim, B., & Rigoutsos, I. (2006) · Cell · doi:10.1016/j.cell.2006.07.031 · Cited by 2,063
Sandberg, R., Neilson, J. R., Sarma, A., Sharp, P. A., & Burge, C. B. (2008) · Science · doi:10.1126/science.1155390 · Cited by 1,349
Canonical WNT Signaling Promotes Osteogenesis by Directly Stimulating Runx2 Gene Expression
Gaur, T., Lengner, C. J., Hovhannisyan, H., Bhat, R. A., Bodine, P. V. N., Komm, B. S., Javed, A., van Wijnen, A. J., Stein, J. L., Stein, G. S., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500608200 · Cited by 1,170
Self-citationRegulation of bone development and extracellular matrix protein genes by RUNX2
Komori, T. (2009) · Cell and Tissue Research · doi:10.1007/s00441-009-0832-8 · Cited by 806
MicroRNA-204 Regulates Runx2 Protein Expression and Mesenchymal Progenitor Cell Differentiation
Huang, J. H., Zhao, L., Xing, L., & Chen, D. (2009) · Stem Cells · doi:10.1002/stem.288 · Cited by 607
Cited by
Sorted by citations
Items 201–300 of 420
Tian, F., Ji, X., Xiao, W., Wang, B., & Wang, F. (2015) · Stem Cells International · doi:10.1155/2015/632305 · Cited by 30
RetractedCanonical Wnt signaling activates miR-34 expression during osteoblastic differentiation
Tamura, M., Uyama, M., Sugiyama, Y., & Sato, M. M. (2013) · Molecular Medicine Reports · doi:10.3892/mmr.2013.1713 · Cited by 30
DGCR5 induces osteogenic differentiation by up-regulating Runx2 through miR-30d-5p
Wu, Z.-H., Huang, K., Liu, K., Wang, G., & Sun, Q. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.09.033 · Cited by 30
Malavika, D., Shreya, S., Priya, V. R., Rohini, M., He, Z., Partridge, N. C., & Selvamurugan, N. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29454 · Cited by 30
Wei, B., & Wei, W. (2015) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2015.07.016 · Cited by 30
Tissue engineering and microRNAs: future perspectives in regenerative medicine
Gori, M., Trombetta, M., Santini, D., & Rainer, A. (2015) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2015.1071349 · Cited by 30
Liao, H., Chang, C.-H., Huang, C. F., & Chen, H.-T. (2022) · Biomolecules · doi:10.3390/biom12030386 · Cited by 29
Maintenance of “stem cell” features of cartilage cell sub-populations during in vitro propagation
Benz, K., Stippich, C., Freudigmann, C., Mollenhauer, J. A., & Aicher, W. K. (2013) · Journal of Translational Medicine · doi:10.1186/1479-5876-11-27 · Cited by 29
Epigenetic mechanisms of bone regeneration and homeostasis
Liu, Y., Zhang, X., Chen, L., Lin, X., Xiong, D., Xu, F., Yuan, L., & Liao, E.-Y. (2016) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2016.01.005 · Cited by 29
You, Y., Ma, W., Wang, F., Jiao, G., Zhang, L., Zhou, H., Wu, W., Wang, H., & Chen, Y. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118680 · Cited by 28
MicroRNAs in the skeleton: Cell-restricted or potent intercellular communicators?
van der Eerden, B. C. J. (2014) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.04.016 · Cited by 28
MicroRNA-205 acts as a tumor suppressor in osteosarcoma via targeting RUNX2
Zhang, C., LONG, F., WAN, J., Hu, Y., & He, H. (2016) · Oncology Reports · doi:10.3892/or.2016.4700 · Cited by 28
RetractedEpigenetic alterations in aging tooth and the reprogramming potential
Hodjat, M., Khan, F., & Saadat, K. A. S. M. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101140 · Cited by 27
Role of noncoding RNAs in orthodontic tooth movement: new insights into periodontium remodeling
Chen, Y., & Zhang, C. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-03951-9 · Cited by 27
The role of the gasotransmitter hydrogen sulfide in pathological calcification
Castelblanco, M., Nasi, S., Pasch, A., So, A. K.-L., & Busso, N. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14772 · Cited by 27
Zeng, X., Yuan, X., Liao, H., Wei, Y., Wu, Q., Zhu, X., Li, Q., Chen, S., & Hu, M. (2024) · American Journal Of Pathology · doi:10.1016/j.ajpath.2024.07.022 · Cited by 26
Dunn, C. M., Nevitt, M. C., Lynch, J. A., & Jeffries, M. A. (2019) · Scientific Reports · doi:10.1038/s41598-019-53298-9 · Cited by 26
Melnik, S., Gabler, J., Dreher, S. I., Hecht, N., Hofmann, N., Grossner, T. L., & Richter, W. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-02026-6 · Cited by 26
Alipour, M., Ghorbani, M., Khatoonabad, M. J., & Aghazadeh, M. (2023) · Scientific Reports · doi:10.1038/s41598-022-23708-6 · Cited by 26
Concise Review: New Frontiers in MicroRNA-Based Tissue Regeneration
Frith, J. E., Porrello, E. R., & Cooper-White, J. J. (2014) · Stem Cells Translational Medicine · doi:10.5966/sctm.2014-0032 · Cited by 26
Tian, F., Ji, X., Xiao, W., Wang, B., & Wang, F. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16023178 · Cited by 26
Chen, R., Liao, X., Chen, F., Wang, B., Huang, J., Jian, G., Huang, Z., Yin, G., Liu, H., & Jin, D. (2018) · PubMed Central · Cited by 26
Mitochondrial epigenetics in bone remodeling during hyperhomocysteinemia
Kalani, A., Kamat, P. K., Voor, M. J., Tyagi, S. C., & Tyagi, N. (2014) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-014-2114-3 · Cited by 26
Bu, Y., Zheng, D., Wang, L., & Liu, J. (2017) · Connective Tissue Research · doi:10.1080/03008207.2017.1413362 · Cited by 25
Extracellular Vesicles in Musculoskeletal Regeneration: Modulating the Therapy of the Future
Abreu, H., Canciani, E., Raineri, D., Cappellano, G., Rimondini, L., & Chiocchetti, A. (2021) · Cells · doi:10.3390/cells11010043 · Cited by 26
miR‐204 is dysregulated in metastatic prostate cancer in vitro
Todorova, K. O., Metodiev, M. V., Metodieva, G., Zasheva, D., Mincheff, M. S., & Hayrabedyan, S. (2015) · Molecular Carcinogenesis · doi:10.1002/mc.22263 · Cited by 25
miR‑204‑5p inhibits the occurrence and development of osteoarthritis by targeting Runx2
Cao, J., Han, X., Qi, X., Jin, X., & Li, X. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3811 · Cited by 25
miR‑10a‑5p inhibits osteogenic differentiation of bone marrow‑derived mesenchymal stem cells
Zhang, Y., Zhou, L., Zhang, Z., Ren, F., Chen, L., & Lan, Z. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11110 · Cited by 25
Self-citationGordon, J. A. R., Montecino, M. A., Aqeilan, R. I., Stein, J. L., Stein, G. S., & Lian, J. B. (2014) · Current Osteoporosis Reports · doi:10.1007/s11914-014-0240-1 · Cited by 24
Self-citationMethylation‐associated miR‐193b silencing activates master drivers of aggressive prostate cancer
Mazzu, Y. Z., Yoshikawa, Y., Nandakumar, S., Chakraborty, G., Armenia, J., Jehane, L. E., Lee, G. M., & Kantoff, P. W. (2019) · Molecular Oncology · doi:10.1002/1878-0261.12536 · Cited by 24
MiR-30 family: a novel avenue for treating bone and joint diseases?
Huang, J., Li, Y., Zhu, S., Wang, L., Yang, L., & He, C. (2023) · International Journal of Medical Sciences · doi:10.7150/ijms.81990 · Cited by 23
Zhang, R., Weng, Y., Li, B., Jiang, Y., Yan, S., He, F., Chen, X., Deng, F., Wang, J., & Shi, Q. (2015) · Journal of Molecular Histology · doi:10.1007/s10735-015-9628-1 · Cited by 23
Rad, E. B., Musumeci, G., Pichler, K., Heidary, M., Szychlinska, M. A., Castrogiovanni, P., Marth, E., Böhm, C., Srinivasaiah, S., Krönke, G., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-18044-z · Cited by 23
Wang, W., Yang, L., Zhang, D., Gao, C., Wu, J., Zhu, Y., & Zhang, H. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000491740 · Cited by 23
Feurer, E., Kan, C. W. S., Croset, M., Sornay‐Rendu, E., & Chapurlat, R. D. (2019) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3685 · Cited by 23
Kirankumar, S., Gurusamy, N., Rajasingh, S., Sigamani, V., Vasanthan, J., Perales, S. G., & Rajasingh, J. (2021) · Experimental Biology and Medicine · doi:10.1177/15353702211052927 · Cited by 23
Regulatory role of miRNA‑23a in diabetic retinopathy
Sun, L., Liu, X., & Zuo, Z. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.10912 · Cited by 23
Novel Biomarkers of Bone Metabolism
Fernández-Villabrille, S., Martín-Carro, B., Martín-Vírgala, J., Rodríguez-Santamaría, M., Baena-Huerta, F. J., Muñoz-Castañeda, J. R., Martín, J. L. F., Alonso‐Montes, C., Naves‐Díaz, M., Carrillo‐López, N., et al. (2024) · Nutrients · doi:10.3390/nu16050605 · Cited by 23
Lin, L., Qiu, Q., Zhou, N., Dong, W., Shen, J., Jiang, W., Ji, F., Hao, J., & Hu, Z. (2016) · BMB Reports · doi:10.5483/bmbrep.2016.49.3.206 · Cited by 23
Arroyo, R., López, S., Romo, E., Montoya, G. A., Hoz, L., Pedraza, C., Garfias, Y., & Arzate, H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041307 · Cited by 23
MicroRNAs in bone development and their diagnostic and therapeutic potentials in osteoporosis
Suttamanatwong, S. (2016) · Connective Tissue Research · doi:10.3109/03008207.2016.1139580 · Cited by 22
Sulistyowati, E., Hsu, J., Lee, S.-J., Huang, S., Sihotang, W. Y., Wu, B., Dai, Z., Lin, M.-C., & Yeh, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105673 · Cited by 22
Impact of Environmental and Epigenetic Changes on Mesenchymal Stem Cells during Aging
Smith, N., Shirazi, S., Cakouros, D., & Gronthos, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076499 · Cited by 23
Exosomes in bone remodeling and breast cancer bone metastasis
Murari, L. S. S., Krishnan, R., Akshaya, R. L., Das, U. R., Satishkumar, S., & Selvamurugan, N. (2022) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2022.09.008 · Cited by 21
Guo, R., Wu, C., Liu, F., Dong, T., & Zhang, T. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02201-w · Cited by 21
McClure, L. V., Kincaid, R. P., Burke, J. M., Grundhoff, A. T., & Sullivan, C. S. (2013) · Journal of Virology · doi:10.1128/jvi.02374-13 · Cited by 22
Laxman, N., Rubin, C., Mallmin, H., Nilsson, O., Tellgren‐Roth, C., & Kindmark, A. (2015) · Bone · doi:10.1016/j.bone.2015.12.053 · Cited by 21
Amelogenin Exon4 Forms a Novel miRNA That Directs Ameloblast and Osteoblast Differentiation
Le, M. H., Warotayanont, R., Stahl, J., Besten, P. K. D., & Nakano, Y. (2015) · Journal of Dental Research · doi:10.1177/0022034515622443 · Cited by 21
Epigenetic Aspects of Osteoporosis
Grebennikova, T. A., Belaya, Z. E., Rozhinskaya, L. Y., Mel'nichenko, G. A., & Dedov, I. I. (2015) · Annals of the Russian academy of medical sciences · doi:10.15690/vramn.v70.i5.1440 · Cited by 21
Vascular calcification: the role of microRNAs
Alkagiet, S., & Τζιόμαλος, Κ. (2017) · BioMolecular Concepts · doi:10.1515/bmc-2017-0001 · Cited by 21
miR-137 and miR-141 regulate tail defects in zebrafish embryos caused by triphenyl phosphate (TPHP)
Tran, C. M., & Kim, K. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.114286 · Cited by 21
Wang, R., Lu, A., Liu, W., Yue, J., Sun, Q., Chen, J., Luan, H., Zhai, Y., Li, B., Jiang, Z.-C., et al. (2020) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.14307 · Cited by 21
An, S., Gao, Y., & Ling, J. (2015) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2015.2706 · Cited by 20
Skeletal muscle-derived exosomes prevent osteoporosis by promoting osteogenesis
Xing, Z., Guo, L., Li, S., Huang, W., Su, J., Chen, X., Li, Y., & Zhang, J. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.123079 · Cited by 20
Do microRNAs regulate bone marrow stem cell niche physiology?
Laine, S. K., Hentunen, T. A., & Laitala‐Leinonen, T. (2012) · Gene · doi:10.1016/j.gene.2012.01.045 · Cited by 20
Prudnikova, T. Y., Mostovich, L. A., Kashuba, V. I., Ernberg, I. T., Zabarovsky, E. R., & Витальевна, Г. Э. (2012) · Epigenetics · doi:10.4161/epi.22103 · Cited by 20
Huang, X., Wang, Z., Li, D., Huang, Z., Dong, X., Li, C., & Lan, J. Q. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26392 · Cited by 20
The Role of Epigenomics in Osteoporosis and Osteoporotic Vertebral Fracture
Kim, K., Lee, Y., & Han, I. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249455 · Cited by 20
Therapeutic application of extracellular vesicles for musculoskeletal repair & regeneration
Baradie, K. B. Y. E., & Hamrick, M. W. (2020) · Connective Tissue Research · doi:10.1080/03008207.2020.1781102 · Cited by 19
MicroRNAs Regulation in Osteogenic Differentiation of Mesenchymal Stem Cells
Han, X. Y., & Fan, Z. (2021) · Frontiers in Dental Medicine · doi:10.3389/fdmed.2021.747068 · Cited by 19
Jiménez-Ortega, R. F., Ortega-Meléndez, A. I., Patiño, N., Rivera‐Paredez, B., Hidalgo‐Bravo, A., & Velázquez‐Cruz, R. (2024) · Biology · doi:10.3390/biology13070505 · Cited by 19
Varela, N., Aránguiz, A., Lizama, C. O., Sepúlveda, H., Antonelli, M., Thaler, R., Moreno, R. D., Montecino, M. A., Stein, G. S., van Wijnen, A. J., et al. (2015) · Journal of Cellular Physiology · doi:10.1002/jcp.25188 · Cited by 19
Self-citationLi, X., Ji, J., Wei, W., & Liu, L. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.01.103 · Cited by 19
miR-433-3p suppresses bone formation and mRNAs critical for osteoblast function in mice
Garcia, J., Smith, S. S., Karki, S., Drissi, H., Hrdlicka, H. H., Youngstrom, D. W., & Delany, A. M. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4339 · Cited by 16
Epigenetic approaches to regeneration of bone and cartilage from stem cells
Im, G., & Shin, K.-J. (2014) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2015.960838 · Cited by 19
Dysregulated miRNAs in bone cells of patients with Gorham‐Stout disease
Rossi, M., Rana, I., Buonuomo, P. S., Battafarano, G., Mariani, E., D’Agostini, M., Porzio, O., Martino, V. D., Minisola, S., Macchiaiolo, M., et al. (2021) · The FASEB Journal · doi:10.1096/fj.202001904rr · Cited by 19
Shen, H., Lu, C., Shi, J., Li, H., Si, J., & Shen, G. (2019) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmz037 · Cited by 18
Jiang, E., Kang, Z., Wang, X., Liu, Y., Liu, X., Wang, Z., Li, X., & Lan, X. (2019) · Animal Biotechnology · doi:10.1080/10495398.2019.1671858 · Cited by 18
Engineering Human-Scale Artificial Bone Grafts for Treating Critical-Size Bone Defects
Cianciosi, A., Costantini, M., Bergamasco, S., Testa, S., Fornetti, E., Jaroszewicz, J., Baldi, J., Latini, A., Choińska, E., Heljak, M. K., et al. (2019) · ACS Applied Bio Materials · doi:10.1021/acsabm.9b00756 · Cited by 18
Retracted: Inhibition of miR‐23a‐3p promotes osteoblast proliferation and differentiation
(2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29497 · Cited by 18
RetractedA microRNA Approach to Discriminate Cortical Low Bone Turnover in Renal Osteodystrophy
Nickolas, T. L., Chen, N. X., McMahon, D. J., Dempster, D. W., Zhou, H., Dominguez, J. M., Aponte, M. A., Sung, J. C., Evenepoel, P., D’Haese, P. C., et al. (2020) · JBMR Plus · doi:10.1002/jbm4.10353 · Cited by 18
miR‐142a‐5p promoted osteoblast differentiation via targeting nuclear factor IA
Yuan, H., Li, M., Feng, X., Zhu, E., & Wang, B. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29963 · Cited by 18
MicroRNA Regulation of Adipose Derived Stem Cells in Aging Rats
Fei, J., Tamski, H., Cook, C. R., & Santanam, N. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059238 · Cited by 17
Sun, K., Wang, J., Liu, F., Ji, Z., Guo, Z., Zhang, C., & Yao, M. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.08.025 · Cited by 17
Vitamin K2 promotes mesenchymal stem cell differentiation by inhibiting miR-133a expression
Zhang, Y., Weng, S., Yin, J., Ding, H., Zhang, C., & Gao, Y. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6308 · Cited by 17
Self-citationAraya, H., Sepúlveda, H., Lizama, C. O., Vega, O. A., Jerez, S., Briceño, P., Thaler, R., Riester, S. M., Antonelli, M., Salazar‐Onfray, F., et al. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26832 · Cited by 17
Self-citationGu, H., Xu, J., Huang, Z., Wu, L., Zhou, K., Zhang, Y., Chen, J., Xia, J., & Yin, X. (2017) · Europe PMC (PubMed Central) · Cited by 17
Self-citationZou, J., Du, J., Tu, H., Chen, H., Cong, K., Bi, Z., & Sun, J. (2021) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.3176 · Cited by 17
The "dark matter" of DNA and the regulation of bone metabolism: The role of non-coding RNAs.
Yavropoulou, M. P., & Yovos, J. G. (2018) · PubMed · Cited by 16
Role of Exosomal Non-Coding RNAs in Bone-Related Diseases
Li, H., Zheng, Q., Xie, X., Wang, J., Zhu, H., Hu, H., He, H., & Lu, Q. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.811666 · Cited by 16
The MicroRNA-23a Has Limited Roles in Bone Formation and Homeostasis In Vivo
PARK, J., WADA, S., USHIDA, T., & AKIMOTO, T. (2015) · Physiological Research · doi:10.33549/physiolres.932901 · Cited by 14
Mishra, A., Kumar, R., Mishra, S. N., Vijayaraghavalu, S., Tiwari, N. K., Shukla, G. C., Gurusamy, N., & Kumar, M. (2023) · Cells · doi:10.3390/cells12081159 · Cited by 15
MicroRNAs as Biomarkers for Clinical Features of Lung Cancer
Hubaux, R. (2012) · Journal of Postgenomics Drug & Biomarker Development · doi:10.4172/2153-0769.1000108 · Cited by 14
miR-30c-1 encourages human corneal endothelial cells to regenerate through ameliorating senescence
Bae, Y., Hwang, J. S., & Shin, Y. J. (2021) · Aging · doi:10.18632/aging.202719 · Cited by 14
Crabbe, M., Gijbels, K., Visser, A., Craeye, D., Walbers, S., Pinxteren, J., Deans, R., Annaert, W. G., & Vaes, B. L. T. (2016) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0154 · Cited by 14
Barilani, M., Lavazza, C., Boldrin, V., Ragni, E., Parazzi, V., Crosti, M., Montelatici, E., Giordano, R., & Lazzari, L. (2016) · Cell Transplantation · doi:10.3727/096368916x690827 · Cited by 14
Dicer-dependent pathway contribute to the osteogenesis mediated by regulation of Runx2.
Zhou, J., Hu, Y. Y., Chen, Y., Yang, L., Song, J., Tang, Y., Deng, F., & Zheng, L. (2016) · PubMed Central · Cited by 14
The multiple therapeutic applications of miRNAs for bone regenerative medicine
Scimeca, J., & Verron, É. (2017) · Drug Discovery Today · doi:10.1016/j.drudis.2017.04.007 · Cited by 13
MicroRNA-204 regulates osteogenic induction in dental follicle cells
Ito, K., Tomoki, R., Ogura, N., Takahashi, K., Eda, T., Yamazaki, F., Kato, Y., Goss, A. N., & Kondoh, T. (2020) · Journal of Dental Sciences · doi:10.1016/j.jds.2019.11.004 · Cited by 13
Ishiwata, S., Iizuka, H., Sonoda, H., Tsunoda, D., Tajika, Y., Chikuda, H., Koibuchi, N., & Shimokawa, N. (2020) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-020-03859-8 · Cited by 13
Karimi, Z., Seyedjafari, E., Khojasteh, A., Hashemi, S. M., Kazemi, B., & Mohammadi‐Yeganeh, S. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05885-7 · Cited by 13
Gene-activated titanium implants for gene delivery to enhance osseointegration
Wang, Z., Zhang, J., Hu, J., & Yang, G. (2022) · Biomaterials Advances · doi:10.1016/j.bioadv.2022.213176 · Cited by 13
Courtois, A., Nusgens, B., Garbacki, N., Hustinx, R., Gomez, P., Defraigne, J.-O., Colige, A., & Sakalihasan, N. (2017) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2016.12.112 · Cited by 13
Haddouti, E.-M., Randau, T. M., Hilgers, C., Masson, W., Pflugmacher, R., Burger, C., Gravius, S., & Schildberg, F. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218309 · Cited by 13
Aravindraja, C., Jeepipalli, S. P. K., Duncan, W. D., Vekariya, K. M., Rahaman, S. O., Chan, E. K. L., & Kesavalu, L. N. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25116217 · Cited by 14
Kim, B.-B., Kim, M., Park, Y., Ko, Y., & Park, J. (2017) · Journal of International Medical Research · doi:10.1177/0300060517701035 · Cited by 12
Costa, M., Zhu, Y., & Ortiz, A. (2021) · Journal of Carcinogenesis · doi:10.4103/jcar.jcar_22_20 · Cited by 12
Bajpai, A. K., Gu, Q., Jiao, Y., Starlard‐Davenport, A., Gu, W., Quarles, L. D., Xiao, Z., & Lu, L. (2023) · Genomics · doi:10.1016/j.ygeno.2023.110769 · Cited by 11
The Role of miR-137 in Neurodegenerative Disorders
Bodai, L., Borosta, R., Ferencz, Á., Kovács, M., & Zsindely, N. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137229 · Cited by 11
Fujiwara, Y., Ding, C., Sanada, Y., Yimiti, D., Ishikawa, M., Nakasa, T., Kamei, N., Imaizumi, K., Lotz, M., Akimoto, T., et al. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1043259 · Cited by 11
Metadata
- Authors
- Zhang, Y., Xie, R.-L., Croce, C. M., Stein, J. L., Lian, J. B., van Wijnen, A. J., & Stein, G. S.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- The Ohio State University (US)
- Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, MA 01655; and
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2011-05-31
- Volume
- 108
- Issue
- 24
- Pages
- 9863-9868
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3116419
- OpenAlex
- W2028928108
- Cited by
- 423
- References
- 48
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 19 · 2023: 20 · 2022: 15 · 2021: 27 · 2020: 36 · 2019: 42 · 2018: 32 · 2017: 36 · 2016: 35 · 2015: 46 · 2014: 24 · 2013: 42 · 2012: 27
- FWCI
- 12.71
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (P01CA129242, P01CA082834)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR049069, R01AR039588)
- National Institute of Dental and Craniofacial Research (R37DE012528)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- microRNA, Runx2, osteogenic differentiation, osteoblasts, chondrogenic differentiation, mesenchymal lineage, microRNA target regulation, miR-218, transcription factor regulation
- MeSH terms
- Animals, Base Sequence, Cell Differentiation, Cell Line, Gene Expression Regulation, Luciferases, Osteoblasts, Osteogenesis, RNA, Messenger, Blotting, Western, Cell Lineage, Chondrocytes, 3' Untranslated Regions, Gene Expression Profiling, RNA Stability, MicroRNAs, NIH 3T3 Cells, Core Binding Factor Alpha 1 Subunit, Mice
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