The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Cholinergic chemosensory cells in the trachea regulate breathing
Open accessAbstract
In the epithelium of the lower airways, a cell type of unknown function has been termed “brush cell” because of a distinctive ultrastructural feature, an apical tuft of microvilli. Morphologically similar cells in the nose have been identified as solitary chemosensory cells responding to taste stimuli and triggering trigeminal reflexes. Here we show that brush cells of the mouse trachea express the receptors (Tas2R105, Tas2R108), the downstream signaling molecules (α-gustducin, phospholipase C β2 ) of bitter taste transduction, the synthesis and packaging machinery for acetylcholine, and are addressed by vagal sensory nerve fibers carrying nicotinic acetylcholine receptors. Tracheal application of an nAChR agonist caused a reduction in breathing frequency. Similarly, cycloheximide, a Tas2R108 agonist, evoked a drop in respiratory rate, being sensitive to nicotinic receptor blockade and epithelium removal. This identifies brush cells as cholinergic sensors of the chemical composition of the lower airway luminal microenvironment that are directly linked to the regulation of respiration.
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Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia
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Lighting up the Senses: FM1-43 Loading of Sensory Cells through Nonselective Ion Channels
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Nadjsombati, M. S., McGinty, J. W., Lyons-Cohen, M. R., Jaffe, J. B., DiPeso, L., Schneider, C., Miller, C. N., Pollack, J. L., Nagana Gowda, G. A., Fontana, M. F., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.06.016 · Cited by 556
Internal senses of the vagus nerve
Prescott, S. L., & Liberles, S. D. (2022) · Neuron · doi:10.1016/j.neuron.2021.12.020 · Cited by 331
Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development
Miller, C. N., Proekt, I., von Moltke, J., Wells, K. L., Rajpurkar, A. R., Wang, H., Rattay, K., Khan, I. S., Metzger, T. C., Pollack, J. L., et al. (2018) · Nature · doi:10.1038/s41586-018-0345-2 · Cited by 289
Recent Developments in mRNA-Based Protein Supplementation Therapy to Target Lung Diseases
Sahu, I., Haque, A. K. M. A., Weidensee, B., Weinmann, P., & Kormann, M. S. D. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.02.019 · Cited by 104
Metadata
- Authors
- Krasteva, G., Canning, B. J., Hartmann, P., Veres, T. Z., Papadakis, T., Mühlfeld, C., Schliecker, K., Tallini, Y. N., Braun, A., Hackstein, H., Baal, N., Weihe, E., Schütz, B., Kotlikoff, M., Ibanez-Tallon, I., & Kummer, W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2011-05-23
- Volume
- 108
- Issue
- 23
- Pages
- 9478-9483
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1976133370
- Cited by
- 291
- References
- 31
- FWCI
- 7.70
- Type
- journal article
- Language
- en
- Open access
- green
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- Krasteva, G., Canning, B. J., Hartmann, P., Veres, T. Z., Papadakis, T., Mühlfeld, C., Schliecker, K., Tallini, Y. N., Braun, A., Hackstein, H., Baal, N., Weihe, E., Schütz, B., Kotlikoff, M., Ibanez-Tallon, I., & Kummer, W. (2011). Cholinergic chemosensory cells in the trachea regulate breathing. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1019418108
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
