The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Arp2/3 complex is bound and activated by two WASP proteins
Open accessAbstract
Actin related protein 2/actin related protein 3 (Arp2/3) complex nucleates new actin filaments in eukaryotic cells in response to signals from proteins in the Wiskott–Aldrich syndrome protein (WASP) family. The conserved VCA domain of WASP proteins activates Arp2/3 complex by inducing conformational changes and delivering the first actin monomer of the daughter filament. Previous models of activation have invoked a single VCA acting at a single site on Arp2/3 complex. Here we show that activation most likely involves engagement of two distinct sites on Arp2/3 complex by two VCA molecules, each delivering an actin monomer. One site is on Arp3 and the second is on ARPC1 and Arp2. The VCAs at these sites have distinct roles in activation. Our findings reconcile apparently conflicting literature on VCA activation of Arp2/3 complex and lead to a new model for this process.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex
Machesky, L. M., Mullins, R. D., Higgs, H. N., Kaiser, D. A., Blanchoin, L., May, R. C., Hall, M. E., & Pollard, T. D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.3739 · Cited by 773
Blanchoin, L., Amann, K. J., Higgs, H. N., Marchand, J.-B., Kaiser, D. A., & Pollard, T. D. (2000) · Nature · doi:10.1038/35010008 · Cited by 586
Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex
Marchand, J.-B., Kaiser, D. A., Pollard, T. D., & Higgs, H. N. (2001) · Nature Cell Biology · doi:10.1038/35050590 · Cited by 331
Brautigam, C. A., Wynn, R. M., Chuang, J. L., & Chuang, D. T. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m806563200 · Cited by 70
Self-citation
Cited by
Actin and Actin-Binding Proteins
Pollard, T. D. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018226 · Cited by 912
Phagocytosis: Receptors, signal integration, and the cytoskeleton
Freeman, S. A., & Grinstein, S. (2014) · Immunological Reviews · doi:10.1111/imr.12212 · Cited by 548
New insights into the regulation and cellular functions of the ARP2/3 complex
Rotty, J. D., Wu, C., & Bear, J. E. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3492 · Cited by 516
Stoichiometry controls activity of phase-separated clusters of actin signaling proteins
Case, L. B., Zhang, X., Ditlev, J. A., & Rosen, M. K. (2019) · Science · doi:10.1126/science.aau6313 · Cited by 499
Self-citationHetrick, B., Han, M. S., Helgeson, L. A., & Nolen, B. J. (2013) · Chemistry & Biology · doi:10.1016/j.chembiol.2013.03.019 · Cited by 353
Metadata
- Authors
- Padrick, S. B., Doolittle, L. K., Brautigam, C. A., King, D. S., & Rosen, M. K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2011-06-15
- Volume
- 108
- Issue
- 33
- Pages
- E472-9
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2154637838
- Cited by
- 210
- References
- 4
- FWCI
- 7.62
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Arp2/3 complex is bound and activated by two WASP proteins. https://app.cochat.ai/papers/10.1073/pnas.1100236108
- The paper
- Padrick, S. B., Doolittle, L. K., Brautigam, C. A., King, D. S., & Rosen, M. K. (2011). Arp2/3 complex is bound and activated by two WASP proteins. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1100236108
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
