The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Targeting kidney mesangium by nanoparticles of defined size
Open accessAbstract
Nanoparticles are being investigated for numerous medical applications and are showing potential as an emerging class of carriers for drug delivery. Investigations on how the physicochemical properties (e.g., size, surface charge, shape, and density of targeting ligands) of nanoparticles enable their ability to overcome biological barriers and reach designated cellular destinations in sufficient amounts to elicit biological efficacy are of interest. Despite proven success in nanoparticle accumulation at cellular locations and occurrence of downstream therapeutic effects (e.g., target gene inhibition) in a selected few organs such as tumor and liver, reports on effective delivery of engineered nanoparticles to other organs still remain scarce. Here, we show that nanoparticles of ~75 ± 25-nm diameters target the mesangium of the kidney. These data show the effects of particle diameter on targeting the mesangium of the kidney. Because many diseases originate from this area of the kidney, our findings establish design criteria for constructing nanoparticle-based therapeutics for targeting diseases that involve the mesangium of the kidney.
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Cited by
Danaei, M., Dehghankhold, M., Ataei, S., Hasanzadeh Davarani, F., Javanmard, R., Dokhani, A., Khorasani, S., & Mozafari, M. R. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics10020057 · Cited by 4,832
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The Effect of Nanoparticle Size on In Vivo Pharmacokinetics and Cellular Interaction
Hoshyar, N., Gray, S., Han, H., & Bao, G. (2016) · Nanomedicine · doi:10.2217/nnm.16.5 · Cited by 1,990
Targeted drug delivery strategies for precision medicines
Manzari, M. T., Shamay, Y., Kiguchi, H., Rosen, N., Scaltriti, M., & Heller, D. A. (2021) · Nature Reviews Materials · doi:10.1038/s41578-020-00269-6 · Cited by 1,183
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Metadata
- Authors
- Choi, C. H. J., Zuckerman, J. E., Webster, P., & Davis, M. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2011-04-04
- Volume
- 108
- Issue
- 16
- Pages
- 6656-6661
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2031406458
- Cited by
- 502
- References
- 18
- FWCI
- 8.77
- Type
- journal article
- Language
- en
- Open access
- green
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- Choi, C. H. J., Zuckerman, J. E., Webster, P., & Davis, M. E. (2011). Targeting kidney mesangium by nanoparticles of defined size. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1103573108
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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