NF-κB dysregulation in microRNA-146a–deficient mice drives the development of myeloid malignancies
Open accessAbstract
MicroRNA miR-146a has been implicated as a negative feedback regulator of NF-κB activation. Knockout of the miR-146a gene in C57BL/6 mice leads to histologically and immunophenotypically defined myeloid sarcomas and some lymphomas. The sarcomas are transplantable to immunologically compromised hosts, showing that they are true malignancies. The animals also exhibit chronic myeloproliferation in their bone marrow. Spleen and marrow cells show increased transcription of NF-κB–regulated genes and tumors have higher nuclear p65. Genetic ablation of NF-κB p50 suppresses the myeloproliferation, showing that dysregulation of NF-κB is responsible for the myeloproliferative disease.
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miR-146a knockout mice develop LPS hypersensitivity, autoimmune disorders, myeloproliferative disorders, and lymphomas due to NF-κB dysregulation.
“Mice with miR-146a knock-out develop LPS hypersensitivity, autoimmune disorders, myeloproliferative disorders, and lymphomas [219] due to NF-κB dysregulation [220].”
From MicroRNAs as Regulators of Phagocytosis (2022) · cites this paper as [220]
The Abstract reports that miR-146a knockout mice develop myeloproliferation and some lymphomas, and that NF-κB p50 ablation suppresses myeloproliferation. This supports NF-κB dysregulation as a cause of the myeloproliferative disease, but the passage does not establish it as the cause of LPS hypersensitivity, autoimmune disorders, or lymphomas. The phenotype list is separately cited to [219]. (LLM, conf=0.86)
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MicroRNAs as regulatory elements in immune system logic
Mehta, A., & Baltimore, D. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.40 · Cited by 704 · see citing works
Self-citationChronic immune response dysregulation in MDS pathogenesis
Barreyro, L., Chlon, T. M., & Starczynowski, D. T. (2018) · Blood · doi:10.1182/blood-2018-03-784116 · Cited by 226 · see citing works
Heterogeneous Responses of Hematopoietic Stem Cells to Inflammatory Stimuli Are Altered with Age
Mann, M., Mehta, A., de Boer, C. G., Kowalczyk, M. S., Lee, K., Haldeman, P., Rogel, N., Knecht, A. R., Farouq, D., Regev, A., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.11.056 · Cited by 188 · see citing works
Self-citationDNA damage response (DDR) and senescence: shuttled inflamma-miRNAs on the stage of inflamm-aging
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Noncoding RNAs regulate NF-κB signaling to modulate blood vessel inflammation
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MicroRNAs as Regulators of Phagocytosis
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- Authors
- Zhao, J. L., Rao, D. S., Boldin, M. P., Taganov, K. D., O'Connell, R. M., & Baltimore, D.
- Affiliations
- California Institute of Technology (US)
- City Of Hope National Medical Center (US)
- Regulus Therapeutics (United States) (US)
- Division of Biology, California Institute of Technology, Pasadena, CA 91125;
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2011-05-16
- Volume
- 108
- Issue
- 22
- Pages
- 9184-9189
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3107319
- OpenAlex
- W2016466834
- Cited by
- 386
- References
- 1
- Citations by year
- 2026: 10 · 2025: 6 · 2024: 23 · 2023: 8 · 2022: 20 · 2021: 19 · 2020: 33 · 2019: 18 · 2018: 30 · 2017: 23 · 2016: 31 · 2015: 37 · 2014: 37 · 2013: 53 · 2012: 30
- FWCI
- 13.93
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Funders
- California Institute of Technology
- National Institutes of Health
- University of California, Los Angeles
- National Heart, Lung, and Blood Institute (K99HL102228)
- National Cancer Institute (K08CA133521)
- National Institute of Allergy and Infectious Diseases (R01AI079243)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Keywords
- miR-146a, NF-κB, myeloid neoplasms, myeloid sarcoma, lymphoma, myeloproliferation, p50 subunit, NF-κB p65, negative feedback regulation, microRNA knockout mice, bone marrow, tumor transplantation
- MeSH terms
- Animals, Bone Marrow Cells, Genotype, Inflammation, Mice, Inbred C57BL, Mice, Transgenic, Models, Genetic, Myeloproliferative Disorders, Neoplasm Transplantation, Neoplasms, Spleen, Transcription, Genetic, NF-kappa B, Mice, Knockout, MicroRNAs, Mice, Primary Myelofibrosis
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