Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs
Open accessAbstract
Despite evidence of chronic inflammation in myelodysplastic syndrome (MDS) and cell-intrinsic dysregulation of Toll-like receptor (TLR) signaling in MDS hematopoietic stem and progenitor cells (HSPCs), the mechanisms responsible for the competitive advantage of MDS HSPCs in an inflammatory milieu over normal HSPCs remain poorly defined. Here, we found that chronic inflammation was a determinant for the competitive advantage of MDS HSPCs and for disease progression. The cell-intrinsic response of MDS HSPCs, which involves signaling through the noncanonical NF-κB pathway, protected these cells from chronic inflammation as compared to normal HSPCs. In response to inflammation, MDS HSPCs switched from canonical to noncanonical NF-κB signaling, a process that was dependent on TLR-TRAF6-mediated activation of A20. The competitive advantage of TLR-TRAF6-primed HSPCs could be restored by deletion of A20 or inhibition of the noncanonical NF-κB pathway. These findings uncover the mechanistic basis for the clonal dominance of MDS HSPCs and indicate that interfering with noncanonical NF-κB signaling could prevent MDS progression.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Tet2-deficient HSPCs exhibit a TLR-TRAF6A and noncanonical NF-κB-dependent competitive advantage during low-grade inflammation.
“and exhibit a toll-like receptor–TNF receptor associated factor 6A (TLR-TRAF6A) and noncanonical NF-κB–dependent competitive advantage during low-grade inflammation.17”
From Aging drives <i>Tet2</i> <i>+/−</i> clonal hematopoiesis via IL-1 signaling (2023) · cites this paper as [17]
The Results section on TET2-deficient HSPCs (page unavailable) reports increased myeloid contribution after competitive transplantation under low-dose LPS, preservation of Tet2-deficient HSPCs, and TRAF6-dependent activation of noncanonical NF-κB. It does not establish that the competitive advantage of Tet2-deficient HSPCs itself depends on noncanonical NF-κB; the long-term competitive-advantage experiment in the separate TLR–TRAF6-primed HSPCs section used TRAF6-overexpressing cells. (LLM, conf=0.85)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625 · see citing works
The non-canonical NF-κB pathway in immunity and inflammation
Sun, S. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.52 · Cited by 1,911 · see citing works
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling
Wertz, I. E., O’Rourke, K. M., Zhou, H., Eby, M. T., Aravind, L., Seshagiri, S., Wu, P., Wiesmann, C., Baker, R. T., Boone, D. L., et al. (2004) · Nature · doi:10.1038/nature02794 · Cited by 1,852 · see citing works
Self-citationHaeussler, M., Schönig, K., Eckert, H., Eschstruth, A., Mianné, J., Renaud, J.-B., Schneider-Maunoury, S., Shkumatava, A., Teboul, L., Kent, J., et al. (2016) · Genome biology · doi:10.1186/s13059-016-1012-2 · Cited by 1,756 · see citing works
Greenberg, P. L., Attar, E., Bennett, J. M., Bloomfield, C. D., Borate, U., Castro, C. M. D., Deeg, H. J., Frankfurt, O., Gaensler, K. M. L., Garcia-Manero, G., et al. (2013) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2013.0104 · Cited by 1,623 · see citing works
Self-citationFailure to Regulate TNF-Induced NF-κB and Cell Death Responses in A20-Deficient Mice
Lee, E. G., Boone, D. L., Chai, S., Libby, S. L., Chien, M., Lodolce, J. P., & Ma, A. (2000) · Science · doi:10.1126/science.289.5488.2350 · Cited by 1,409 · see citing works
Self-citationTet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6
Zhang, Q., Zhao, K., Shen, Q., Han, Y., Gu, Y., Li, X., Zhao, D., Liu, Y., Wang, C., Zhang, X., et al. (2015) · Nature · doi:10.1038/nature15252 · Cited by 807 · see citing works
Sato, S., Sugiyama, M., Yamamoto, M., Watanabe, Y., Kawai, T., Takeda, K., & Akira, S. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.8.4304 · Cited by 709 · see citing works
Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotype
Starczynowski, D. T., Kuchenbauer, F. C., Argiropoulos, B., Sung, S., Morin, R. D., Muranyi, A., Hirst, M., Hogge, D. E., Marra, M. A., Wells, R. A., et al. (2009) · Nature Medicine · doi:10.1038/nm.2054 · Cited by 655 · see citing works
Self-citationInflammation: a key regulator of hematopoietic stem cell fate in health and disease
Pietras, E. M. (2017) · Blood · doi:10.1182/blood-2017-06-780882 · Cited by 417 · see citing works
Cai, Z., Kotzin, J. J., Ramdas, B., Chen, S., Nelanuthala, S., Palam, L. R., Pandey, R., Mali, R. S., Liu, Y., Kelley, M. R., et al. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.10.013 · Cited by 394 · see citing works
NF-κB dysregulation in microRNA-146a–deficient mice drives the development of myeloid malignancies
Zhao, J. L., Rao, D. S., Boldin, M. P., Taganov, K. D., O'Connell, R. M., & Baltimore, D. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105398108 · Cited by 386 · see citing works
Nimer, S. D. (2008) · Blood · doi:10.1182/blood-2007-08-078139 · Cited by 337 · see citing works
Hematopoietic progenitor cells as integrative hubs for adaptation to and fine-tuning of inflammation
Chavakis, T., Mitroulis, I., & Hajishengallis, G. (2019) · Nature Immunology · doi:10.1038/s41590-019-0402-5 · Cited by 328 · see citing works
Chronic Exposure to a TLR Ligand Injures Hematopoietic Stem Cells
Esplin, B. L., Shimazu, T., Welner, R. S., Garrett, K. P., Nie, L., Zhang, Q., Humphrey, M. B., Yang, Q., Borghesi, L., & Kincade, P. W. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003438 · Cited by 327 · see citing works
Gohda, J., Matsumura, T., & Inoue, J. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.5.2913 · Cited by 312 · see citing works
Tet2 restrains inflammatory gene expression in macrophages
Cull, A. H., Snetsinger, B., Buckstein, R., Wells, R. A., & Rauh, M. J. (2017) · Experimental Hematology · doi:10.1016/j.exphem.2017.08.001 · Cited by 295 · see citing works
Deregulated gene expression pathways in myelodysplastic syndrome hematopoietic stem cells
Pellagatti, A., Cazzola, M., Giagounidis, A. A. N., Perry, J., Malcovati, L., Porta, M. G. D., Jädersten, M., Killick, S. B., Verma, A. K., Norbury, C. J., et al. (2010) · Leukemia · doi:10.1038/leu.2010.31 · Cited by 288 · see citing works
Takizawa, H., Fritsch, K., Kovtonyuk, L. V., Saito, Y., Yakkala, C., Jacobs, K., Ahuja, A. K., Lopes, M., Hausmann, A., Hardt, W., et al. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.06.013 · Cited by 272 · see citing works
The Ubiquitin Modifying Enzyme A20 Restricts B Cell Survival and Prevents Autoimmunity
Tavares, R. M., Turer, E. E., Liu, C. L., Advincula, R., Scapini, P., Rhee, L., Barrera, J., Lowell, C. A., Utz, P. J., Malynn, B. A., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.07.017 · Cited by 270 · see citing works
Self-citationMacrophages in age-related chronic inflammatory diseases
Oishi, Y., & Manabe, I. (2016) · npj Aging and Mechanisms of Disease · doi:10.1038/npjamd.2016.18 · Cited by 262 · see citing works
Smith, M. A., Choudhary, G. S., Pellagatti, A., Choi, K., Bolanos, L. C., Bhagat, T. D., Gordon-Mitchell, S., Ahrens, D. V., Pradhan, K., Steeples, V., et al. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0314-5 · Cited by 247 · see citing works
Self-citationNilsson, L., Åstrand‐Grundström, I., Arvidsson, I., Jacobsson, B., Hellström‐Lindberg, E., Hast, R., & Jacobsen, S. E. W. (2000) · Blood · doi:10.1182/blood.v96.6.2012 · Cited by 241 · see citing works
Gerstung, M., Pellagatti, A., Malcovati, L., Giagounidis, A. A. N., Porta, M. G. D., Jädersten, M., Dolatshad, H., Verma, A. K., Cross, N. C. P., Vyas, P., et al. (2015) · Nature Communications · doi:10.1038/ncomms6901 · Cited by 238 · see citing works
Chronic immune response dysregulation in MDS pathogenesis
Barreyro, L., Chlon, T. M., & Starczynowski, D. T. (2018) · Blood · doi:10.1182/blood-2018-03-784116 · Cited by 226 · see citing works
Self-citationSynthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations
Lee, S. C.-W., North, K., Kim, E., Jang, E., Obeng, E., Lu, S. X., Liu, B., Inoue, D., Yoshimi, A., Ki, M., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.07.003 · Cited by 219 · see citing works
Li, X., Zhang, Q., Ding, Y., Liu, Y., Zhao, D., Zhao, K., Shen, Q., Liu, X., Zhu, X., Li, N., et al. (2016) · Nature Immunology · doi:10.1038/ni.3464 · Cited by 202 · see citing works
Targeting IRAK1 as a therapeutic approach for myelodysplastic syndrome
Rhyasen, G. W., Bolanos, L., Fang, J., Jerez, A., Wunderlich, M., Rigolino, C., Mathews, L., Ferrer, M., Southall, N., Guha, R., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.05.006 · Cited by 199 · see citing works
Self-citationConcurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders
Muto, T., Sashida, G., Oshima, M., Wendt, G. R., Mochizuki‐Kashio, M., Nagata, Y., Sanada, M., Miyagi, S., Saraya, A., Kamio, A., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20131144 · Cited by 179 · see citing works
Self-citationNilsson, L., Åstrand‐Grundström, I., Anderson, K., Arvidsson, I., Hokland, P., Bryder, D., Kjeldsen, L., Johansson, B., Hellström-Lindberg, E., Hast, R., et al. (2002) · Blood · doi:10.1182/blood-2001-12-0188 · Cited by 163 · see citing works
Regulation of Hematopoietic Stem Cell Activity by Inflammation
Schuettpelz, L. G., & Link, D. C. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00204 · Cited by 155 · see citing works
S100-alarmin-induced innate immune programming protects newborn infants from sepsis
Ulas, T., Pirr, S. M., Fehlhaber, B., Bickes, M. S., Loof, T. G., Vogl, T., Mellinger, L., Heinemann, A. S., Burgmann, J., Schöning, J., et al. (2017) · Nature Immunology · doi:10.1038/ni.3745 · Cited by 155 · see citing works
<i>Dnmt3a</i> restrains mast cell inflammatory responses
Leoni, C., Montagner, S., Rinaldi, A., Bertoni, F., Polletti, S., Balestrieri, C., & Monticelli, S. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1616420114 · Cited by 138 · see citing works
Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations
Starczynowski, D. T., Morin, R. D., McPherson, A., Lam, J., Chari, R., Węgrzyn, J., Kuchenbauer, F. C., Hirst, M., Tohyama, K., Humphries, R. K., et al. (2010) · Blood · doi:10.1182/blood-2010-03-277012 · Cited by 125 · see citing works
Self-citationZhang, H., Rodrı́guez, S., Wang, L., Wang, S., Serezani, C. H., Kapur, R., Cardoso, A. A., & Carlesso, N. (2016) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.05.002 · Cited by 118 · see citing works
Magness, S. T., Jijon, H. B., Fisher, N. V. H., Sharpless, N. E., Brenner, D. A., & Jobin, C. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.3.1561 · Cited by 113 · see citing works
Varney, M. E., Niederkorn, M., Konno, H., Matsumura, T., Gohda, J., Yoshida, N., Akiyama, T., Christie, S., Fang, J., Miller, D., et al. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20141898 · Cited by 111 · see citing works
Self-citationCoordinate loss of a microRNA and protein-coding gene cooperate in the pathogenesis of 5q− syndrome
Kumar, M. S., Narla, A., Nonami, A., Mullally, A., Dimitrova, N., Ball, B. J., McAuley, J. R., Poveromo, L., Kutok, J. L., Galili, N., et al. (2011) · Blood · doi:10.1182/blood-2010-12-324715 · Cited by 110 · see citing works
Ma, S., Wan, X., Deng, Z., Shi, L., Hao, C., Zhou, Z., Zhou, C., Fang, Y., Liu, J., Yang, J. C., et al. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20161149 · Cited by 110 · see citing works
Thanopoulou, E., Cashman, J. D., Kakagianne, T., Eaves, A. C., Zoumbos, N. C., & Eaves, C. J. (2004) · Blood · doi:10.1182/blood-2003-09-3192 · Cited by 98 · see citing works
Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia
Fang, J., Bolanos, L. C., Choi, K., Liu, X., Christie, S., Akunuru, S., Kumar, R., Wang, D., Chen, X., Greis, K. D., et al. (2016) · Nature Immunology · doi:10.1038/ni.3654 · Cited by 97 · see citing works
Self-citationWei, Y., Chen, R., Dimicoli, S., Bueso‐Ramos, C. E., Neuberg, D. S., Pierce, S. A., Wang, H., Yang, H., Jia, Y., Zheng, H., et al. (2013) · Leukemia · doi:10.1038/leu.2013.91 · Cited by 83 · see citing works
Self-citationFang, J., Liu, X., Bolanos, L., Barker, B., Rigolino, C., Cortelezzi, A., Oliva, E. N., Cuzzola, M., Grimes, H. L., Fontanillo, C., et al. (2016) · Nature Medicine · doi:10.1038/nm.4127 · Cited by 83 · see citing works
Self-citationShi, H., Han, X., Sun, Y., Shang, C., Wei, M., Ba, X., & Zeng, X. (2018) · Cancer Science · doi:10.1111/cas.13809 · Cited by 82 · see citing works
TRAF6 Mediates Basal Activation of NF-κB Necessary for Hematopoietic Stem Cell Homeostasis
Fang, J., Muto, T., Kleppe, M., Bolanos, L. C., Hueneman, K. M., Walker, C. S., Sampson, L. L., Wellendorf, A. M., Chetal, K., Choi, K., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.01.013 · Cited by 78 · see citing works
Self-citationMyelodysplastic syndrome-associated spliceosome gene mutations enhance innate immune signaling
Pollyea, D. A., Harris, C., Rabe, J. L., Hedin, B. R., Arras, L. D., Katz, S., Wheeler, E. C., Bejar, R. L., Walter, M. J., Jordan, C. T., et al. (2019) · Haematologica · doi:10.3324/haematol.2018.214155 · Cited by 72 · see citing works
Fang, J., Barker, B., Bolanos, L. C., Liu, X., Jerez, A., Makishima, H., Christie, S., Chen, X., Rao, D. S., Grimes, H. L., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.07.062 · Cited by 66 · see citing works
Self-citationLiu, A., Wang, Y., Ding, Y., Báez, I., Payne, K. J., & Borghesi, L. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1501231 · Cited by 62 · see citing works
Waterstrat, A., Liang, Y., Swiderski, C. F., Shelton, B. J., & Zant, G. E. V. (2009) · Blood · doi:10.1182/blood-2008-03-143370 · Cited by 59 · see citing works
Involvement of A20 in the molecular switch that activates the non-canonical NF-кB pathway
Yamaguchi, N., Oyama, M., Kozuka‐Hata, H., & Inoue, J. (2013) · Scientific Reports · doi:10.1038/srep02568 · Cited by 57 · see citing works
iGEAK: an interactive gene expression analysis kit for seamless workflow using the R/shiny platform
Choi, K., & Ratner, N. (2019) · BMC Genomics · doi:10.1186/s12864-019-5548-x · Cited by 57 · see citing works
Self-citationLack of the ubiquitin-editing enzyme A20 results in loss of hematopoietic stem cell quiescence
Nakagawa, M. M., Thummar, K., Mandelbaum, J., Pasqualucci, L., & Rathinam, C. V. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20132544 · Cited by 53 · see citing works
Paracatu, L. C., & Schuettpelz, L. G. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01236 · Cited by 50 · see citing works
An MDS xenograft model utilizing a patient-derived cell line
Rhyasen, G. W., Wunderlich, M., Tohyama, K., Garcia‐Manero, G., Mulloy, J. C., & Starczynowski, D. T. (2013) · Leukemia · doi:10.1038/leu.2013.372 · Cited by 47 · see citing works
Self-citationEpistasis between TIFAB and miR-146a: neighboring genes in del(5q) myelodysplastic syndrome
Varney, M. E., Choi, K., Bolanos, L. C., Christie, S., Fang, J., Grimes, H. L., Maciejewski, J., Inoue, J.-I., & Starczynowski, D. T. (2016) · Leukemia · doi:10.1038/leu.2016.276 · Cited by 30 · see citing works
Self-citationNuclear factor k B is activated in myelodysplastic bone marrow cells.
Sanz, C., Richard, C., Prósper, F., & Fernandez-Luna, J. L. (2002) · PubMed · Cited by 24 · see citing works
Concurrent Loss Of Ezh2 and Tet2 Cooperates In The Pathogenesis Of Myelodysplastic Disorders,
Muto, T., Sashida, G., Oshima, M., Wendt, G. R., Mochizuki‐Kashio, M., Sanada, M., Miyagi, S., Saraya, A., Nakaseko, C., Yokote, K., et al. (2013) · Blood · doi:10.1182/blood.v122.21.480.480 · Cited by 12 · see citing works
Self-citationDnmt3a restrains mast cell inflammatory responses.
Leoni, C., Montagner, S., Rinaldi, A., Bertoni, F., Polletti, S., Balestrieri, C., & Monticelli, S. (2017) · reroDoc Digital Library · doi:10.7892/boris.106743 · Cited by 11 · see citing works
Bird, L. (2015) · Nature reviews. Immunology · doi:10.1038/nri3912 · Cited by 4 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Tumor initiation and early tumorigenesis: molecular mechanisms and interventional targets
Zhang, S., Xiao, X., Yi, Y., Wang, X., Zhu, L., Shen, Y., Lin, D., & Wu, C. H. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01848-7 · Cited by 440 · see citing works
Inflammation-Induced Tumorigenesis and Metastasis
Hibino, S., Kawazoe, T., Kasahara, H., Itoh, S., Ishimoto, T., Sakata‐Yanagimoto, M., & Taniguchi, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115421 · Cited by 314 · see citing works
Caiado, F., Pietras, E. M., & Manz, M. G. (2021) · Journal of Experimental Medicine · doi:10.1084/jem.20201541 · Cited by 289 · see citing works
Innate immune pathways and inflammation in hematopoietic aging, clonal hematopoiesis, and MDS
Trowbridge, J. J., & Starczynowski, D. T. (2021) · Journal of Experimental Medicine · doi:10.1084/jem.20201544 · Cited by 189 · see citing works
Self-citationAging drives <i>Tet2</i> <i>+/−</i> clonal hematopoiesis via IL-1 signaling
Caiado, F., Kovtonyuk, L. V., Gonullu, N. G., Fullin, J., Boettcher, S., & Manz, M. G. (2023) · Blood · doi:10.1182/blood.2022016835 · Cited by 161 · see citing works
TET Enzymes in the Immune System: From DNA Demethylation to Immunotherapy, Inflammation, and Cancer
López-Moyado, I. F., Ko, M., Hogan, P. G., & Rao, A. (2024) · Annual Review of Immunology · doi:10.1146/annurev-immunol-080223-044610 · Cited by 116 · see citing works
IRAK1 and IRAK4 as emerging therapeutic targets in hematologic malignancies
Bennett, J., & Starczynowski, D. T. (2021) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000693 · Cited by 100 · see citing works
Self-citationClonal hematopoiesis and associated diseases: A review of recent findings
Asada, S., & Kitamura, T. (2021) · Cancer Science · doi:10.1111/cas.15094 · Cited by 103 · see citing works
Targeting PD-1/PD-L1 pathway in myelodysplastic syndromes and acute myeloid leukemia
Yang, X., Ma, L., Zhang, X., Huang, L., & Wei, J. (2022) · Experimental Hematology and Oncology · doi:10.1186/s40164-022-00263-4 · Cited by 98 · see citing works
Germline DDX41 mutations cause ineffective hematopoiesis and myelodysplasia
Chlon, T. M., Stepanchick, E., Hershberger, C. E., Daniels, N. J., Hueneman, K. M., Davis, A. K., Choi, K., Zheng, Y., Gurnari, C., Haferlach, T., et al. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.08.004 · Cited by 94 · see citing works
Self-citationPU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress
Chavez, J. S., Rabe, J. L., Loeffler, D., Higa, K. C., Hernandez, G., Mills, T. S., Ahmed, N., Gessner, R. L., Ke, Z., Idler, B. M., et al. (2021) · Journal of Experimental Medicine · doi:10.1084/jem.20201169 · Cited by 91 · see citing works
“Aberrant signaling via IL-1 and the downstream IL-1 receptor associated kinase/TNF receptor associated factor pathway shared by IL-1R and TLRs has been implicated as a driver of survival and/or expansion of MDS and myeloid leukemia stem cells (Ågerstam et al., 2016; Askmyr et al., 2013; Barreyro et al., 2012; Carey et…”
BackgroundLefkopoulos, S., Polyzou, A., Derecka, M., Bergo, V., Clapes, T., Cauchy, P., Jerez‐Longres, C., Onishi‐Seebacher, M., Yin, N., Calderón, N. M., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.10.007 · Cited by 84 · see citing works
Wang, T., Pine, A. R., Kotini, A. G., Yuan, H., Zamparo, L., Starczynowski, D. T., Leslie, C. S., & Papapetrou, E. P. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.01.011 · Cited by 76 · see citing works
Self-citationChavakis, T., Wielockx, B., & Hajishengallis, G. (2021) · Annual Review of Physiology · doi:10.1146/annurev-physiol-052521-013627 · Cited by 74 · see citing works
Muto, T., Guillamot, M., Yeung, J., Fang, J., Bennett, J. R., Nadorp, B., Lasry, A., Zea-Redondo, L., Choi, K., Gong, Y., et al. (2022) · Cell stem cell · doi:10.1016/j.stem.2021.12.007 · Cited by 57 · see citing works
Self-citationTET2: A cornerstone in normal and malignant hematopoiesis
Kunimoto, H., & Nakajima, H. (2020) · Cancer Science · doi:10.1111/cas.14688 · Cited by 55 · see citing works
Hand in hand: intrinsic and extrinsic drivers of aging and clonal hematopoiesis
SanMiguel, J. M., Young, K. A., & Trowbridge, J. J. (2020) · Experimental Hematology · doi:10.1016/j.exphem.2020.09.197 · Cited by 59 · see citing works
Inflammatory Cytokines Shape an Altered Immune Response During Myeloid Malignancies
Camacho, V., Kuznetsova, V., & Welner, R. S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.772408 · Cited by 60 · see citing works
Paracatu, L. C., & Schuettpelz, L. G. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01236 · Cited by 50 · see citing works
Microbial metabolite drives ageing-related clonal haematopoiesis via ALPK1
Agarwal, P., Sampson, A. M., Hueneman, K. M., Choi, K., Jakobsen, N. A., Uible, E. E., Ishikawa, C., Yeung, J., Bolanos, L. C., Zhao, X., et al. (2025) · Nature · doi:10.1038/s41586-025-08938-8 · Cited by 53 · see citing works
Self-citationInflammation and myeloid malignancy: quenching the flame
Stubbins, R. J., Platzbecker, U., & Karsan, A. (2022) · Blood · doi:10.1182/blood.2021015162 · Cited by 46 · see citing works
Bone Marrow Immune Microenvironment in Myelodysplastic Syndromes
Kouroukli, O., Symeonidis, A. S., Foukas, P. G., Maragkou, M., & Kourea, E. P. (2022) · Cancers · doi:10.3390/cancers14225656 · Cited by 52 · see citing works
Mechanisms involved in hematopoietic stem cell aging
Fujino, T., Asada, S., Goyama, S., & Kitamura, T. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04356-5 · Cited by 48 · see citing works
NF-κB and Human Cancer: What Have We Learned over the Past 35 Years?
Gilmore, T. D. (2021) · Biomedicines · doi:10.3390/biomedicines9080889 · Cited by 45 · see citing works
Blocking UBE2N abrogates oncogenic immune signaling in acute myeloid leukemia
Barreyro, L., Sampson, A. M., Ishikawa, C., Hueneman, K. M., Choi, K., Pujato, M. A., Chutipongtanate, S., Wyder, M. A., Haffey, W. D., O'Brien, E. J., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abb7695 · Cited by 45 · see citing works
Self-citationWu, Q., Zhang, W., Lu, Y., Li, H., Yang, Y., Geng, F., Liu, J., Li, L., Pan, Y., & Li, C. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.111558 · Cited by 47 · see citing works
de Boer, B., Sheveleva, S., Apelt, K., Vellenga, E., Mulder, A. B., Huls, G. A., & Schuringa, J. J. (2020) · Haematologica · doi:10.3324/haematol.2020.254987 · Cited by 43 · see citing works
McLemore, A. F., Hou, H., Meyer, B. S., Lam, N. B., Ward, G., Aldrich, A. L., Rodrigues, M. A., Vedder, A., Zhang, L., Padron, E., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.159430 · Cited by 42 · see citing works
Clonal Hematopoiesis, Inflammation, and Hematologic Malignancy
Kanagal‐Shamanna, R., Beck, D. B., & Calvo, K. R. (2023) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-051222-122724 · Cited by 43 · see citing works
Therapeutic targeting of the inflammasome in myeloid malignancies
Chakraborty, S., Shapiro, L. C., de Oliveira, S., Rivera-Peña, B., Verma, A. K., & Shastri, A. (2021) · Blood Cancer Journal · doi:10.1038/s41408-021-00547-8 · Cited by 40 · see citing works
Chen, R., Okeyo-Owuor, T., Patel, R. M., Casey, E. B., Cluster, A. S., Yang, W., & Magee, J. A. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108751 · Cited by 36 · see citing works
Mitochondrial Fragmentation Triggers Ineffective Hematopoiesis in Myelodysplastic Syndromes
Aoyagi, Y., Hayashi, Y., Harada, Y., Choi, K., Matsunuma, N., Sadato, D., Maemoto, Y., Ito, A., Yanagi, S., Starczynowski, D. T., et al. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0032 · Cited by 35 · see citing works
Self-citationCulver‐Cochran, A. E., Hassan, A., Hueneman, K. M., Choi, K., Ma, A. I., VanCauwenbergh, B., O'Brien, E. J., Wunderlich, M., Perentesis, J. P., & Starczynowski, D. T. (2024) · Nature Communications · doi:10.1038/s41467-024-53629-z · Cited by 35 · see citing works
Self-citationImmuno-Modulation of Hematopoietic Stem and Progenitor Cells in Inflammation
Sezaki, M., Hayashi, Y., Wang, Y., Johansson, A., Umemoto, T., & Takizawa, H. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.585367 · Cited by 35 · see citing works
Wang, Y., Hou, H., Lin, C., Kuo, Y., Yao, C., Hsu, C., Tseng, M., Tsai, C., Peng, Y., Kao, C., et al. (2021) · Blood Advances · doi:10.1182/bloodadvances.2021005141 · Cited by 35 · see citing works
Chen, L., Pronk, E., van Dijk, C., Bian, Y., Feyen, J., van Tienhoven, T. V. D., Yildirim, M., Pisterzi, P., de Jong, M. M. E., Bastidas, A., et al. (2023) · Blood Cancer Discovery · doi:10.1158/2643-3230.bcd-23-0043 · Cited by 34 · see citing works
Understanding the Continuum between High-Risk Myelodysplastic Syndrome and Acute Myeloid Leukemia
Zavras, P. D., Sinanidis, I., Tsakiroglou, P., & Karantanos, T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24055018 · Cited by 33 · see citing works
Emergency myelopoiesis in solid cancers
Aliazis, K., Yenyuwadee, S., Phikulsod, P., & Boussiotis, V. A. (2024) · British Journal of Haematology · doi:10.1111/bjh.19656 · Cited by 33 · see citing works
Sato, N., Goyama, S., Chang, Y., Miyawaki, M., Fujino, T., Koide, S., Denda, T., Liu, X., Ueda, K., Yamamoto, K., et al. (2024) · Nature Cardiovascular Research · doi:10.1038/s44161-024-00579-w · Cited by 36 · see citing works
TIFA and TIFAB: FHA-domain proteins involved in inflammation, hematopoiesis, and disease
Niederkorn, M., Agarwal, P., & Starczynowski, D. T. (2020) · Experimental Hematology · doi:10.1016/j.exphem.2020.08.010 · Cited by 30 · see citing works
Self-citationFate of Hematopoiesis During Aging. What Do We Really Know, and What are its Implications?
Broxmeyer, H. E., Liu, Y., Kapur, R., Orschell, C. M., Aljoufi, A., Ropa, J. P., Trinh, T. L. P., Burns, S. S., & Capitano, M. L. (2020) · Stem Cell Reviews and Reports · doi:10.1007/s12015-020-10065-y · Cited by 30 · see citing works
Myeloid neoplasms and clonal hematopoiesis from the RUNX1 perspective
Hayashi, Y., Harada, Y., & Harada, H. (2022) · Leukemia · doi:10.1038/s41375-022-01548-7 · Cited by 27 · see citing works
Targeting the Microenvironment in MDS: The Final Frontier
Teodorescu, P., Paşca, S., Dima, D. M., Tomuleasa, C., & Ghiaur, G. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01044 · Cited by 25 · see citing works
Cell Competition Boosts Clonal Evolution and Hypoxic Selection in Cancer
Madan, E., Peixoto, M. L., Dimitrion, P. M., Eubank, T. D., Yekelchyk, M., Talukdar, S., Fisher, P. B., Mi, Q., Moreno, E., & Gogna, R. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.10.002 · Cited by 26 · see citing works
TNFAIP3 Plays a Role in Aging of the Hematopoietic System
Smith, M. A., Culver‐Cochran, A. E., Adelman, E. R., Rhyasen, G. W., Ma, A. I., Figueroa, M. E., & Starczynowski, D. T. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.536442 · Cited by 20 · see citing works
Self-citationKong, T., Laranjeira, A. B. A., Letson, C. T., Yu, L. C., Lin, S., Fowles, J. S., Fisher, D. A. C., Ng, S., Yang, W., He, F., et al. (2025) · Nature Communications · doi:10.1038/s41467-024-55643-7 · Cited by 21 · see citing works
Plasmacytoid Dendritic Cells, a Novel Target in Myeloid Neoplasms
Roussel, X., Garnache‐Ottou, F., & Renosi, F. (2022) · Cancers · doi:10.3390/cancers14143545 · Cited by 20 · see citing works
Blockade of IL-22 signaling reverses erythroid dysfunction in stress-induced anemias
Raundhal, M. R., Ghosh, S., Myers, S. A., Cuoco, M. S., Singer, M., Carr, S. A., Waikar, S. S., Bonventre, J. V., Ritz, J., Stone, R. M., et al. (2021) · Nature Immunology · doi:10.1038/s41590-021-00895-4 · Cited by 20 · see citing works
Chronic TNF in the aging microenvironment exacerbates Tet2 loss-of-function myeloid expansion
Quin, C., DeJong, E. N., McNaughton, A. J. M., Buttigieg, M. M., Basrai, S., Abelson, S., LARCHÉ, M. J., Rauh, M. J., & Bowdish, D. M. E. (2024) · Blood Advances · doi:10.1182/bloodadvances.2023011833 · Cited by 20 · see citing works
Laranjeira, A. B. A., Kong, T., Snyder, S. C., Fulbright, M. C., Fisher, D. A. C., Starczynowski, D. T., & Oh, S. T. (2024) · Blood · doi:10.1182/blood.2023022804 · Cited by 18 · see citing works
Self-citationAljoufi, A., Zhang, C., Ropa, J. P., Chang, W., Palam, L. R., Cooper, S. H., Ramdas, B., Capitano, M. L., Broxmeyer, H. E., & Kapur, R. (2022) · Blood · doi:10.1182/blood.2022015499 · Cited by 17 · see citing works
Truncated CSF3 receptors induce pro‐inflammatory responses in severe congenital neutropenia
Olofsen, P. A., Bosch, D. A., de Looper, H. W. J., van Strien, P. M. H., Hoogenboezem, R. M., Roovers, O., van der Velden, V. H. J., Bindels, E. M., de Pater, E., & Touw, I. P. (2022) · British Journal of Haematology · doi:10.1111/bjh.18477 · Cited by 16 · see citing works
The Role of TRL7/8 Agonists in Cancer Therapy, with Special Emphasis on Hematologic Malignancies
Leśniak, M., Lipniarska, J., Majka, P., Kopyt, W., Lejman, M., & Zawitkowska, J. (2023) · Vaccines · doi:10.3390/vaccines11020277 · Cited by 15 · see citing works
PU.1 is required to restrain myelopoiesis during chronic inflammatory stress
Chavez, J. S., Rabe, J. L., Niño, K. E., Wells, H. H., Gessner, R. L., Mills, T. S., Hernandez, G., & Pietras, E. M. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1204160 · Cited by 14 · see citing works
“…in response to a wide range of physiological insults, and IL-1 signaling is closely linked to a wide variety of chronic inflammatory diseases, where it plays a critical role in the activation of inflammatory myelopoiesis (Ueda et al., 2009; Dinarello, 2011; Mirantes et al., 2014; Pietras, 2017).”
BackgroundEmerging Insights into Molecular Mechanisms of Inflammation in Myelodysplastic Syndromes
Vallelonga, V., Gandolfi, F., Ficara, F., Porta, M. G. D., & Ghisletti, S. (2023) · Biomedicines · doi:10.3390/biomedicines11102613 · Cited by 13 · see citing works
Barreyro, L., Sampson, A. M., Hueneman, K. M., Choi, K., Christie, S., Ramesh, V., Wyder, M. A., Wang, D., Pujato, M. A., Greis, K. D., et al. (2024) · iScience · doi:10.1016/j.isci.2024.109809 · Cited by 14 · see citing works
Self-citationCui, B., Ai, L., Lei, M., Duan, Y.-J., Tang, C., Zhang, J., Gao, Y., Li, X., Zhu, C., Zhang, Y., et al. (2024) · Blood · doi:10.1182/blood.2024025618 · Cited by 14 · see citing works
Kállai, A., Ungvari, A., Csabán, D., Őrfi, Z., Lehoczki, A., Harasztdombi, J., Yabluchanskiy, A., Benyó, Z., Szappanos, Á., Tarantini, S., et al. (2025) · GeroScience · doi:10.1007/s11357-025-01654-1 · Cited by 14 · see citing works
Gurnari, C., & Visconte, V. (2023) · Leukemia Research · doi:10.1016/j.leukres.2023.107038 · Cited by 13 · see citing works
Fan, A. C., Nakauchi, Y., Bai, L., Azizi, A., Nuno, K. A., Zhao, F., Köhnke, T., Karigane, D., Hernandez, D. C., Reinisch, A., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci167053 · Cited by 13 · see citing works
Epigenetic roles in clonal hematopoiesis and aging kidney-related chronic kidney disease
Ogura, Y., & Mimura, I. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1281850 · Cited by 13 · see citing works
The effect of inflammatory factors and their inhibitors on the hematopoietic stem cells fate
Najafi, S., Ghanavat, M., Shahrabi, S., Gatavizadeh, Z., & Saki, N. (2021) · Cell Biology International · doi:10.1002/cbin.11545 · Cited by 13 · see citing works
Restricting genomic actions of innate immune mediators on fetal hematopoietic progenitor cells
Tran, V. L., Liu, P., Katsumura, K. R., Kim, E., Schoff, B. M., Johnson, K. D., & Bresnick, E. H. (2023) · iScience · doi:10.1016/j.isci.2023.106297 · Cited by 13 · see citing works
CXCL8 secreted by immature granulocytes inhibits WT hematopoiesis in chronic myelomonocytic leukemia
Deschamps, P., Wacheux, M., Gosseye, A., Morabito, M., Pagès, A., Lyne, A.-M., Alfaro, A., Rameau, P., Imanci, A., Chelbi, R., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci180738 · Cited by 13 · see citing works
Cui, X., Dong, Y., Zhan, Q., Huang, Y., Zhu, Q., Zhang, Z., Yang, G., Wang, L., Shen, S., Zhao, J., et al. (2024) · Science China Life Sciences · doi:10.1007/s11427-024-2754-9 · Cited by 14 · see citing works
Stalmann, U. S. A., Ticconi, F., Snoeren, I., Li, R.-H., Gleitz, H. F. E., Cowley, G., McConkey, M., Wong, A., Schmitz, S., Fuchs, S. N. R., et al. (2022) · Blood Advances · doi:10.1182/bloodadvances.2021006061 · Cited by 10 · see citing works
Paracatu, L. C., Monlish, D. A., Greenberg, Z. J., Fisher, D. A. C., Walter, M. J., Oh, S. T., & Schuettpelz, L. G. (2022) · Experimental Hematology · doi:10.1016/j.exphem.2022.03.011 · Cited by 12 · see citing works
Sim, H., Park, H. J., Park, G., Kim, Y. J., Park, W., Lee, S., & Choi, M. (2024) · eLife · doi:10.7554/elife.96951 · Cited by 11 · see citing works
Yokomizo‐Nakano, T., Hamashima, A., Kubota, S., Bai, J., Sorin, S., Sun, Y., Kikuchi, K., Iimori, M., Morii, M., Kanai, A., et al. (2023) · The Journal of Experimental Medicine · doi:10.1084/jem.20220962 · Cited by 11 · see citing works
Bahmani, F., Shayanmanesh, M., Safari, M., Alaei, A., Pouriafar, Y., Rasti, Z., Zaker, F., Rostami, S., Damerchiloo, F., & Safa, M. (2025) · Cancer Cell International · doi:10.1186/s12935-025-03793-z · Cited by 12 · see citing works
Mangaonkar, A. A., & Patnaik, M. M. (2022) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428194.2022.2056175 · Cited by 11 · see citing works
Stem Cells in the Myelodysplastic Syndromes
Zhan, D., & Park, C. Y. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.719010 · Cited by 11 · see citing works
Zou, J., Shi, Q., Chen, H., Juskevicius, R., & Zinkel, S. S. (2021) · Experimental Hematology · doi:10.1016/j.exphem.2021.09.004 · Cited by 10 · see citing works
Metabolic reprogramming regulated by TRAF6 contributes to the leukemia progression
Matsui, S., Ri, C., Bolanos, L., Choi, K., Shibamiya, A., Ishii, A., Takaishi, K., Oshima-Hasegawa, N., Tsukamoto, S., Takeda, Y., et al. (2024) · Leukemia · doi:10.1038/s41375-024-02245-3 · Cited by 10 · see citing works
Self-citationStoddart, A., Fernald, A. A., Davis, E. M., McNerney, M. E., & Beau, M. M. L. (2022) · Experimental Hematology · doi:10.1016/j.exphem.2022.08.003 · Cited by 10 · see citing works
Merkerová, M. D., Kléma, J., Kundrát, D., Szikszai, K., Krejčík, Z., Hruštincová, A., Trsová, I., Le, A. V., Čermák, J., Jonasova, A. T., et al. (2022) · Cancer Genomics & Proteomics · doi:10.21873/cgp.20315 · Cited by 10 · see citing works
Diagnosis of Myelodysplastic Syndromes: From Immunological Observations to Clinical Applications
Simoni, Y., & Chapuis, N. (2022) · Diagnostics · doi:10.3390/diagnostics12071659 · Cited by 9 · see citing works
Pellagatti, A., & Boultwood, J. (2024) · Advances in Biological Regulation · doi:10.1016/j.jbior.2024.101055 · Cited by 9 · see citing works
Inflammatory signaling in the pathogenesis of acute myeloid leukemia
Baumann, A., & Ellegast, J. M. (2025) · HemaSphere · doi:10.1002/hem3.70188 · Cited by 9 · see citing works
Muto, T., Walker, C. S., Agarwal, P., Vick, E. J., Sampson, A. M., Choi, K., Niederkorn, M., Ishikawa, C., Hueneman, K. M., Varney, M. E., et al. (2023) · Haematologica · doi:10.3324/haematol.2022.282349 · Cited by 9 · see citing works
Self-citationTakashima, K., Olszewska, M., Jethalia, V., Sirenko, M., Silverman, L. R., Tomalin, L. E., Carcamo, S., Hasson, D., & Papapetrou, E. P. (2025) · Blood · doi:10.1182/blood.2024025670 · Cited by 8 · see citing works
Clough, C. A., Cunningham, C., Philbrook, S. Y., Hueneman, K. M., Sampson, A. M., Choi, K., Greis, K. D., & Starczynowski, D. T. (2025) · Leukemia · doi:10.1038/s41375-025-02671-x · Cited by 8 · see citing works
Self-citationChen, L., Bian, Y., Pronk, E., van Dijk, C., van Tienhoven, T. V. D., Hoogenboezem, R. M., Bindels, E. M., Bosch, D. A., Fazeli, S., de Graaf, A. O., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-65802-z · Cited by 8 · see citing works
The Mesenchymal Niche in Myelodysplastic Syndromes
Friedrich, C., & Kosmider, O. (2022) · Diagnostics · doi:10.3390/diagnostics12071639 · Cited by 8 · see citing works
Regulation of T-independent B-cell responses by microRNA-146a
King, J. K., Tran, T. M., Paing, M., Yin, Y., Jaiswal, A. K., Tso, C.-H., Roy, K., Casero, D., & Rao, D. S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.984302 · Cited by 8 · see citing works
Zhang, P., Whipp, E. C., Skuli, S. J., Gharghabi, M., Saygin, C., Sher, S., Carroll, M. P., Pan, X., Eisenmann, E. D., Lai, T.-H., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci184021 · Cited by 8 · see citing works
Self-citationImmune Dysregulation and Recurring Mutations in Myelodysplastic Syndromes Pathogenesis
de Matos, A. G., Magalhães, S. M. M., & Rauh, M. J. (2020) · Advances in experimental medicine and biology · doi:10.1007/5584_2020_608 · Cited by 7 · see citing works
Wang, Y., Lin, C., Yao, C., Hsu, C., Tsai, C., Hou, H., Chou, W., & Tien, H. (2021) · British Journal of Haematology · doi:10.1111/bjh.17837 · Cited by 7 · see citing works
Wei, Y., Kanagal‐Shamanna, R., Zheng, H., Bao, N., Lockyer, P. P., Class, C. A., Darbaniyan, F., Lü, Y., Lin, K., Yang, H., et al. (2022) · Leukemia · doi:10.1038/s41375-022-01605-1 · Cited by 6 · see citing works
Self-citationClonal hematopoiesis: Molecular basis and clinical relevance
Kunimoto, H., & Nakajima, H. (2020) · Leukemia Research · doi:10.1016/j.leukres.2020.106457 · Cited by 6 · see citing works
Yanir, A. D., Krauss, A. C., Stein, J., Steinberg‐Shemer, O., Gilad, O., Noy‐Lotan, S., Dgany, O., Krasnov, T., Kodman, Y., Feuerstein, T., et al. (2021) · Pediatric Blood & Cancer · doi:10.1002/pbc.29138 · Cited by 6 · see citing works
Extracellular Vesicles in Myeloid Neoplasms
Karantanou, C., Minciacchi, V. R., & Karantanos, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158827 · Cited by 6 · see citing works
Liang, Q., Zhao, J., Zhang, L., Gao, Z., Pan, H., Fang, L., & Shi, J. (2022) · Medicine · doi:10.1097/md.0000000000031427 · Cited by 6 · see citing works
Putnam, C., Kondeti, L., Kesler, M. B. A., & Varney, M. E. (2023) · Biochemistry and Cell Biology · doi:10.1139/bcb-2022-0374 · Cited by 6 · see citing works
Where There’s Smoke, There’s Fire: Inflammation Drives MDS
Datar, G. K., & Goodell, M. A. (2020) · Trends in Immunology · doi:10.1016/j.it.2020.05.007 · Cited by 6 · see citing works
Munteanu, R. A., Gulei, D., Moldovan, C. S., Azzoni, E., Belver, L., Feder, R., Pîrv, S., Buzoianu, A. D., Einsele, H., Mittelman, M., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07861-0 · Cited by 5 · see citing works
TIFAB accelerates MLL-AF9−Induced acute myeloid leukemia through upregulation of HOXA9
Zhao, J., Xiu, Y., Fu, L., Dong, Q., Borcherding, N. C., Wang, Y., Li, Q., Silva, N. S. D., Klein, U., Boyce, B. F., et al. (2021) · iScience · doi:10.1016/j.isci.2021.103425 · Cited by 5 · see citing works
Germline DDX41 mutations in myeloid neoplasms: the current clinical and molecular understanding
Kida, J., & Chlon, T. M. (2024) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000854 · Cited by 4 · see citing works
TLR2 agonism suppresses myeloid leukemogenesis by reprogramming leukemia stem cells
Lawler, M. E., Romer-Seibert, J. S., Bowman, M. S., Mitra, R., Eischen, C. M., Bowman, R. L., & Meyer, S. E. (2025) · Blood Advances · doi:10.1182/bloodadvances.2025017018 · Cited by 4 · see citing works
Park, C. S., Bridges, C. S., Lewis, A. H., Chen, T. J., Shai, S., Du, W., Puppi, M., Zorman, B., Pavel, S., & Lacorazza, H. D. (2025) · Experimental Hematology · doi:10.1016/j.exphem.2025.104730 · Cited by 4 · see citing works
- Authors
- Muto, T., Walker, C. S., Choi, K., Hueneman, K., Smith, M. A., Gul, Z., Garcia-Manero, G., Ma, A., Zheng, Y., & Starczynowski, D. T.
- Affiliations
- Cincinnati Children's Hospital Medical Center (US)
- University of Cincinnati (US)
- University of California, San Francisco (US)
- Corresponding author
- Starczynowski, Daniel T.
- ORCID
- Venue
- Nature Immunology
- Published
- 2020-04-20
- Volume
- 21
- Issue
- 5
- Pages
- 535-545
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- PMC
- PMC7402480
- OpenAlex
- W3017327186
- Cited by
- 155
- References
- 59
- Citations by year
- 2026: 11 · 2025: 21 · 2024: 30 · 2023: 24 · 2022: 24 · 2021: 28 · 2020: 16 · 2014: 1
- FWCI
- 14.53
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R35HL135787)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK102759, R01DK113639)
- Topics
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Keywords
- myelodysplastic syndrome, hematopoietic stem and progenitor cells, chronic inflammation, non-canonical NF-κB signaling, Toll-like receptor signaling, TRAF6, A20, clonal dominance, myelopoiesis, disease progression, competitive advantage
- MeSH terms
- Tumor Necrosis Factor alpha-Induced Protein 3, Aged, Animals, Cell Differentiation, Cells, Cultured, Hematopoietic Stem Cells, Humans, Inflammation, Male, Mice, Transgenic, Myelodysplastic Syndromes, Signal Transduction, NF-kappa B, Myelopoiesis, TNF Receptor-Associated Factor 6, Toll-Like Receptors, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
