The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Conversion of tryptophan to indole-3-acetic acid by TRYPTOPHAN AMINOTRANSFERASES OF ARABIDOPSIS and YUCCAs in Arabidopsis
Open accessAbstract
Auxin is an essential hormone, but its biosynthetic routes in plants have not been fully defined. In this paper, we show that the TRYPTOPHAN AMINOTRANSFERASE OF ARABIDOPSIS (TAA) family of amino transferases converts tryptophan to indole-3-pyruvate (IPA) and that the YUCCA (YUC) family of flavin monooxygenases participates in converting IPA to indole-3-acetic acid, the main auxin in plants. Both the YUCs and the TAAs have been shown to play essential roles in auxin biosynthesis, but it has been suggested that they participate in two independent pathways. Here, we show that all of the taa mutant phenotypes, including defects in shade avoidance, root resistance to ethylene and N -1-naphthylphthalamic acid (NPA), are phenocopied by inactivating YUC genes. On the other hand, we show that the taa mutants in several known auxin mutant backgrounds, including pid and npy1 , mimic all of the well-characterized developmental defects caused by combining yuc mutants with the auxin mutants. Furthermore, we show that overexpression of YUC1 partially suppresses the shade avoidance defects of taa1 and the sterile phenotypes of the weak but not the strong taa mutants. In addition, we discovered that the auxin overproduction phenotypes of YUC overexpression lines are dependent on active TAA genes. Our genetic data show that YUC and TAA work in the same pathway and that YUC is downstream of TAA . The yuc mutants accumulate IPA, and the taa mutants are partially IPA-deficient, indicating that TAA s are responsible for converting tryptophan to IPA, whereas YUCs play an important role in converting IPA to indole-3-acetic acid.
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Cites
Auxin Biosynthesis and Its Role in Plant Development
Zhao, Y. (2010) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-042809-112308 · Cited by 1,510
Self-citationA Role for Flavin Monooxygenase-Like Enzymes in Auxin Biosynthesis
Zhao, Y., Christensen, S. K., Fankhauser, C., Cashman, J. R., Cohen, J. D., Weigel, D., & Chory, J. (2001) · Science · doi:10.1126/science.291.5502.306 · Cited by 1,225
Self-citationTAA1-Mediated Auxin Biosynthesis Is Essential for Hormone Crosstalk and Plant Development
Stepanova, A. N., Robertson-Hoyt, J., Yun, J., Benavente, L. M., Xie, D.-Y., Doležal, K., Schlereth, A., Jürgens, G., & Alonso, J. M. (2008) · Cell · doi:10.1016/j.cell.2008.01.047 · Cited by 1,182
Cheng, Y., Dai, X., & Zhao, Y. (2006) · Genes & Development · doi:10.1101/gad.1415106 · Cited by 1,167
Self-citationTao, Y., Ferrer, J.-L., Ljung, K., Pojer, F., Hong, F., Long, J. A., Li, L., Moreno, J. E., Bowman, M. E., Ivans, L. J., et al. (2008) · Cell · doi:10.1016/j.cell.2008.01.049 · Cited by 1,059
Self-citationCheng, Y., Dai, X., & Zhao, Y. (2007) · The Plant Cell · doi:10.1105/tpc.107.053009 · Cited by 654
Self-citationTrp-dependent auxin biosynthesis in Arabidopsis: involvement of cytochrome P450s CYP79B2 and CYP79B3
Zhao, Y., Hull, A. K., Gupta, N. R., Goss, K. A., Alonso, J., Ecker, J. R., Normanly, J., Chory, J., & Celenza, J. L. (2002) · Genes & Development · doi:10.1101/gad.1035402 · Cited by 653
Self-citationBiochemical analyses of indole-3-acetaldoxime-dependent auxin biosynthesis in Arabidopsis
Sugawara, S., Hishiyama, S., Jikumaru, Y., Hanada, A., Nishimura, T., Koshiba, T., Zhao, Y., Kamiya, Y., & Kasahara, H. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811226106 · Cited by 341
Self-citationPhillips, K. A., Skirpan, A. L., Liu, X., Christensen, A., Slewinski, T. L., Hudson, C., Barazesh, S., Cohen, J. D., Malcomber, S., & McSteen, P. (2011) · The Plant Cell · doi:10.1105/tpc.110.075267 · Cited by 286
Yamada, M., Greenham, K., Prigge, M. J., Jensen, P. J., & Estelle, M. (2009) · Plant Physiology · doi:10.1104/pp.109.138859 · Cited by 206
Cited by
Structure and functions of the bacterial microbiota of plants
Bulgarelli, D., Schlaeppi, K., Spaepen, S., van Themaat, E. V. L., & Schulze-Lefert, P. (2013) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-050312-120106 · Cited by 3,308
Auxin biosynthesis and storage forms
Korasick, D. A., Enders, T. A., & Strader, L. C. (2013) · Journal of Experimental Botany · doi:10.1093/jxb/ert080 · Cited by 533
Skubacz, A., Daszkowska-Golec, A., & Szarejko, I. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.01884 · Cited by 499
Tissue‐specific profiling of the Arabidopsis thaliana auxin metabolome
Novák, O., Hényková, E., Sairanen, I., Kowalczyk, M., Pospíšil, T., & Ljung, K. (2012) · The Plant Journal · doi:10.1111/j.1365-313x.2012.05085.x · Cited by 304
Indole Glucosinolate Biosynthesis Limits Phenylpropanoid Accumulation in Arabidopsis thaliana
Kim, J. I., Dolan, W. L., Anderson, N. A., & Chapple, C. (2015) · The Plant Cell · doi:10.1105/tpc.15.00127 · Cited by 117
Metadata
- Authors
- Won, C., Shen, X., Mashiguchi, K., Zheng, Z., Dai, X., Cheng, Y., Kasahara, H., Kamiya, Y., Chory, J., & Zhao, Y.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2011-10-24
- Volume
- 108
- Issue
- 45
- Pages
- 18518-18523
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2158957969
- Cited by
- 641
- References
- 19
- FWCI
- 53.76
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Won, C., Shen, X., Mashiguchi, K., Zheng, Z., Dai, X., Cheng, Y., Kasahara, H., Kamiya, Y., Chory, J., & Zhao, Y. (2011). Conversion of tryptophan to indole-3-acetic acid by TRYPTOPHAN AMINOTRANSFERASES OF ARABIDOPSIS and YUCCAs in Arabidopsis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1108436108
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