The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
microRNA-34a regulates neurite outgrowth, spinal morphology, and function
Open accessAbstract
The p53 family member TAp73 is a transcription factor that plays a key role in many biological processes, including neuronal development. In particular, we have shown that p73 drives the expression of miR-34a, but not miR-34b and c, in mouse cortical neurons. miR-34a in turn modulates the expression of synaptic targets including synaptotagmin-1 and syntaxin-1A. Here we show that this axis is retained in mouse ES cells committed to differentiate toward a neurological phenotype. Moreover, overexpression of miR-34a alters hippocampal spinal morphology, and results in electrophysiological changes consistent with a reduction in spinal function. Therefore, the TAp73/miR-34a axis has functional relevance in primary neurons. These data reinforce a role for miR-34a in neuronal development.
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Cites
A microRNA component of the p53 tumour suppressor network
He, L., He, X., Lim, L. P., de Stanchina, E., Xuan, Z., Liang, Y., Xue, W., Zender, L., Magnus, J., Ridzon, D., et al. (2007) · Nature · doi:10.1038/nature05939 · Cited by 2,692
Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis
Chang, T.-C., Wentzel, E. A., Kent, O. A., Ramachandran, K., Mullendore, M., Lee, K. H., Feldmann, G., Yamakuchi, M., Ferlito, M., Lowenstein, C. J., et al. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.05.010 · Cited by 2,010
Makeyev, E. V., Zhang, J., Carrasco, M. A., & Maniatis, T. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.07.015 · Cited by 1,395
The miR-34 family in cancer and apoptosis
Hermeking, H. (2010) · Cell Death & Differentiation · doi:10.1038/cdd.2009.56 · Cited by 1,236 · cited 1×
“However, does miR-34a have a functional impact on neuronal development? Like p53 (29), TAp73 induces the expression of miR-34a by acting on the p53-like binding sequences on the promoter of miR34a, although in completely distinct contexts.”
BackgroundFiore, R., Khudayberdiev, S., Christensen, M., Siegel, G., Flavell, S. W., Kim, T., Greenberg, M. E., & Schratt, G. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.10 · Cited by 382
Cited by
Senescence and aging: the critical roles of p53
Rufini, A., Tucci, P., Celardo, I., & Melino, G. (2013) · Oncogene · doi:10.1038/onc.2012.640 · Cited by 798
Self-citationMicroRNAs shape the neuronal landscape
McNeill, E., & Van Vactor, D. (2012) · Neuron · doi:10.1016/j.neuron.2012.07.005 · Cited by 274
Sarkar, S., Jun, S., Rellick, S., Quintana, D. D., Cavendish, J. Z., & Simpkins, J. W. (2016) · Brain Research · doi:10.1016/j.brainres.2016.05.026 · Cited by 209
Intact p53-Dependent Responses in miR-34–Deficient Mice
Concepcion, C. P., Han, Y.-C., Mu, P., Bonetti, C., Yao, E., D'Andrea, A., Vidigal, J. A., Maughan, W. P., Ogrodowski, P., & Ventura, A. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002797 · Cited by 197
Self-citationBhattacharjee, S., Zhao, Y., Dua, P., Rogaev, E. I., & Lukiw, W. J. (2016) · PLOS ONE · doi:10.1371/journal.pone.0150211 · Cited by 147
Metadata
- Authors
- Agostini, M., Tucci, P., Steinert, J. R., Shalom-Feuerstein, R., Rouleau, M., Aberdam, D., Forsythe, I. D., Young, K. W., Ventura, A., Concepcion, C. P., Han, Y.-C., Candi, E., Knight, R. A., Mak, T. W., & Melino, G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2011-12-12
- Volume
- 108
- Issue
- 52
- Pages
- 21099-21104
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2137483641
- Cited by
- 185
- References
- 5
- FWCI
- 5.40
- Type
- journal article
- Language
- en
- Open access
- green
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- Agostini, M., Tucci, P., Steinert, J. R., Shalom-Feuerstein, R., Rouleau, M., Aberdam, D., Forsythe, I. D., Young, K. W., Ventura, A., Concepcion, C. P., Han, Y.-C., Candi, E., Knight, R. A., Mak, T. W., & Melino, G. (2011). microRNA-34a regulates neurite outgrowth, spinal morphology, and function. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1112063108
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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