The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age
Open accessAbstract
In the human hematopoietic system, aging is associated with decreased bone marrow cellularity, decreased adaptive immune system function, and increased incidence of anemia and other hematological disorders and malignancies. Recent studies in mice suggest that changes within the hematopoietic stem cell (HSC) population during aging contribute significantly to the manifestation of these age-associated hematopoietic pathologies. Though the mouse HSC population has been shown to change both quantitatively and functionally with age, changes in the human HSC and progenitor cell populations during aging have been incompletely characterized. To elucidate the properties of an aged human hematopoietic system that may predispose to age-associated hematopoietic dysfunction, we evaluated immunophenotypic HSC and other hematopoietic progenitor populations from healthy, hematologically normal young and elderly human bone marrow samples. We found that aged immunophenotypic human HSC increase in frequency, are less quiescent, and exhibit myeloid-biased differentiation potential compared with young HSC. Gene expression profiling revealed that aged immunophenotypic human HSC transcriptionally up-regulate genes associated with cell cycle, myeloid lineage specification, and myeloid malignancies. These age-associated alterations in the frequency, developmental potential, and gene expression profile of human HSC are similar to those changes observed in mouse HSC, suggesting that hematopoietic aging is an evolutionarily conserved process.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Although the number of peripheral B cells decreases with age, a more pronounced decrease of B cells in AD was observed, suggesting that ongoing disease may exacerbate ageing effects [88,89].”
From Is there a role for B cells in Alzheimer's disease? (2026) · cites this paper as [89]
In the citing paper
“This shift has been correlated with increased expression of myeloid lineage genes and downregulation of those specifying a lymphoid lineage fate (11,17).”
From Causes, consequences, and reversal of immune system aging (2013) · cites this paper as [17]
In the citing paper
“From an immunologic perspective, the most profound effect of stem cell aging in both mice (11,18) and humans (17) is a decreased capacity to produce lymphocytes and an increase in myeloid potential.”
From Causes, consequences, and reversal of immune system aging (2013) · cites this paper as [17]
In the citing paper
“The age-related increase in expression of myeloid lineage genes in the studies noted above (11,17) likely resulted from the accumulation of myeloid-biased HSCs, as these analyses were performed on unseparated pools of HSCs.”
From Causes, consequences, and reversal of immune system aging (2013) · cites this paper as [17]
In the citing paper
“HSCs exhibit multiple age-related changes that include impaired adherence to stromal cells and, in some strains of mice (15,16) and elderly humans (17), an increase in number.”
From Causes, consequences, and reversal of immune system aging (2013) · cites this paper as [17]
In the citing paper
“an age-dependent increase in the frequency of putative stem cells, coinciding with impaired functionality and reduced lymphoid potential, has also been in the human system.”
From Aging of hematopoietic stem cells (2018) · cites this paper as [28]
In the citing paper
“As humans age, they typically experience an increase in total phenotypic HSC numbers as the cell pool grows with time (de Haan and Van Zant, 1999; Pang et al., 2011; Sudo et al., 2000).”
From Unraveling Hematopoiesis through the Lens of Genomics (2020) · cites this paper as Pang et al., 2011
Citations
Cites
In silico prediction of protein-protein interactions in human macrophages
Souiai, O., Guerfali, F. Z., Miled, S. B., Brun, C., & Benkahla, A. (2014) · BMC Research Notes · doi:10.1186/1756-0500-7-157 · Cited by 10,785
Significance analysis of microarrays applied to the ionizing radiation response
Tusher, V. G., Tibshirani, R., & Chu, G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091062498 · Cited by 10,568
Guralnik, J. M., Eisenstaedt, R. S., Ferrucci, L., Klein, H. G., & Woodman, R. C. (2004) · Blood · doi:10.1182/blood-2004-05-1812 · Cited by 1,450
McCune, J. M., Namikawa, R., Kaneshima, H., Shultz, L. D., Lieberman, M., & Weissman, I. L. (1988) · Science · doi:10.1126/science.2971269 · Cited by 1,404
Self-citationAge-related changes in lymphocyte development and function
Linton, P. J., & Dorshkind, K. A. (2004) · Nature Immunology · doi:10.1038/ni1033 · Cited by 1,199
Cell intrinsic alterations underlie hematopoietic stem cell aging
Rossi, D. J., Bryder, D., Zahn, J. M., Ahlenius, H., Sonu, R., Wagers, A. J., & Weissman, I. L. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503280102 · Cited by 1,152 · cited 3×
“Notably, the results from our functional analysis and gene expression profiling of young and elderly human HSC significantly parallel the data we and others have generated on young and elderly mouse HSC (2, 6, 36).”
BackgroundResultSelf-citationIsolation of a candidate human hematopoietic stem-cell population.
Baum, C. M., Weissman, I. L., Tsukamoto, A. S., Buckle, A., & Péault, B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.7.2804 · Cited by 1,084
Self-citationDevelopment of functional human blood and immune systems in NOD/SCID/IL2 receptor γ chainnull mice
Ishikawa, F., Yasukawa, M., Lyons, B. L., Yoshida, S., Miyamoto, T., Yoshimoto, G., Watanabe, T., Akashi, K., Shultz, L. D., & Harada, M. (2005) · Blood · doi:10.1182/blood-2005-02-0516 · Cited by 933
The aging of hematopoietic stem cells
Morrison, S. J., Wandycz, A. M., Akashi, K., Globerson, A., & Weissman, I. L. (1996) · Nature Medicine · doi:10.1038/nm0996-1011 · Cited by 853
Self-citationPurification of primitive human hematopoietic cells capable of repopulating immune-deficient mice
Bhatia, M., Wang, J. C. Y., Kapp, U., Bonnet, D. A., & Dick, J. E. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5320 · Cited by 849
Cited by
Sorted by citations
Items 401–500 of 985
Genetic regulation of thymocyte progenitor aging
Berent-Maoz, B., Montecino‐Rodriguez, E., & Dorshkind, K. A. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.04.006 · Cited by 25
The role of myeloid derived suppressor cells in musculoskeletal disorders
Ren, Y., Bäcker, H. C., Müller, M., & Kienzle, A. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1139683 · Cited by 23
Zhou, Z., Zhu, S., Hong, Y., Jin, G., Ma, R., Lin, F., Zhang, Y., Lee, H., & Liu, N. (2025) · Cell · doi:10.1016/j.cell.2025.07.014 · Cited by 24
Reversing lysosomal dysfunction restores youthful state in aged hematopoietic stem cells
Arif, T., Qiu, J., Khademian, H., Lohithakshan, A., Menon, A., Menon, V., Slavinsky, M., Batignes, M., Miao, L., Sebra, R., et al. (2025) · Cell stem cell · doi:10.1016/j.stem.2025.10.012 · Cited by 25
Concise Review: Modulating Cancer Immunity with Hematopoietic Stem and Progenitor Cells
Wildes, T. J., Flores, C., & Mitchell, D. A. (2018) · Stem Cells · doi:10.1002/stem.2933 · Cited by 23
Höpner, S., Raykova, A., Radpour, R., Amrein, M. A., Koller, D., Baerlocher, G. M., Riether, C., & Ochsenbein, A. F. (2021) · Nature Communications · doi:10.1038/s41467-021-21317-x · Cited by 25
Engineering bioactive nanoparticles to rejuvenate vascular progenitor cells
Bui, L., Edwards, S. K. E., Hall, E., Alderfer, L., Round, K. J., Owen, M. M., Sainaghi, P., Zhang, S., Nallathamby, P. D., Haneline, L. S., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-03578-4 · Cited by 24
Orschell, C. M., Wu, T., & Patterson, A. M. (2022) · Current Stem Cell Reports · doi:10.1007/s40778-022-00214-z · Cited by 23
LAIR-1 agonism as a therapy for acute myeloid leukemia
Lovewell, R. R., Hong, J., Kundu, S., Fielder, C. M., Hu, Q., Kim, K. W., Ramsey, H. E., Gorska, A. E., Fuller, L., Tian, L., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci169519 · Cited by 23
Weissman, I. L. (2016) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112003 · Cited by 24
Self-citationDimitriou, M., Woll, P. S., Blanco, T. M., Karimi, M., Wedge, D. C., Doolittle, H., Douagi, I., Papaemmanuil, E., Jacobsen, S. E. W., & Hellström‐Lindberg, E. (2016) · Oncotarget · doi:10.18632/oncotarget.12234 · Cited by 23
Senescence and Aging: Does It Impact Cancer Immunotherapies?
Maggiorani, D., & Beausejour, C. M. (2021) · Cells · doi:10.3390/cells10071568 · Cited by 25
Austin, M. J., Kalampalika, F., Cawthorn, W. P., & Patel, B. G. (2023) · British Journal of Haematology · doi:10.1111/bjh.18748 · Cited by 23
The role of immune cells settled in the bone marrow on adult hematopoietic stem cells
Xu, H., Li, Y., & Gao, Y. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05445-3 · Cited by 22
How age affects human hematopoietic stem and progenitor cells and the strategies to mitigate aging
Li, X., Wang, J., Hu, L., & Cheng, T. (2025) · Experimental Hematology · doi:10.1016/j.exphem.2025.104711 · Cited by 25
Lin, R. J., Elias, H. K., & van den Brink, M. R. M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.674093 · Cited by 22
Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-Cbx2 axis
Wang, D., Tanaka-Yano, M., Meader, E., Kinney, M. A., Morris, V., da Rocha, E. L., Liu, N., Liu, T., Zhu, Q., Orkin, S. H., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110587 · Cited by 24
Filipek-Gorzała, J., Kwiecińska, P., Szade, A., & Szade, K. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1308709 · Cited by 24
Venkataraman, A., Kordic, I., Li, J., Zhang, N. Y., Bharadwaj, N. S., Fang, Z., Das, S., & Coskun, A. F. (2024) · npj Aging · doi:10.1038/s41514-024-00178-w · Cited by 21
Age-related reduction of structural complexity in spleen hematopoietic tissue architecture in mice
Pantic, I. V., Paunović-Pantić, J., Basta-Jovanović, G., Perović, M., Pantic, S., & Milošević, N. T. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.06.011 · Cited by 22
Lnk deficiency partially mitigates hematopoietic stem cell aging
Bersenev, A., Rozenova, K., Balcerek, J., Jiang, J., Wu, C., & Tong, W. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00862.x · Cited by 24
Elkrief, A., Richard, C., Malo, J., Cvetkovic, L., Florescu, M., Blais, N., Tehfe, M. A., Messaoudene, M., Gagné, A., Orain, M., et al. (2020) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2020.01.002 · Cited by 22
Aging, hematopoiesis, and the myelodysplastic syndromes
Chung, S. S., & Park, C. Y. (2017) · Hematology · doi:10.1182/asheducation-2017.1.73 · Cited by 24
Anselmi, C., Kowarsky, M., Gasparini, F., Caicci, F., Ishizuka, K. J., Palmeri, K. J., Raveh, T., Sinha, R., Neff, N. F., Quake, S. R., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2203032119 · Cited by 22
Self-citationLin, Z., Gao, Q., Qian, F., Jinlian, M., Lishi, Z., Yu, Q., Tian, C., Zhenhua, C., Ping, W., & Lin, B. (2020) · SSRN Electronic Journal · doi:10.2139/ssrn.3561932 · Cited by 22
How aging influences the gut-bone marrow axis and alters hematopoietic stem cell regulation
Wells, C., Robertson, T., Sheth, P. M., & Abraham, S. A. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e32831 · Cited by 22
Continuous map of early hematopoietic stem cell differentiation across human lifetime
Komic, H., Schmachtel, T., Simoes, C. P., Külp, M., Yu, W., Jolly, A., Nilsson, M. S., González, C., Prósper, F., Bonig, H. B., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-57096-y · Cited by 23
Chen, Z., Mao, Z., Tang, W., Shi, Y., Liu, J., & You, Y. (2025) · Translational Neurodegeneration · doi:10.1186/s40035-025-00517-1 · Cited by 27
Is adult stem cell aging driven by conflicting modes of chromatin remodeling?
Przybilla, J., Galle, J., & Rohlf, T. (2012) · BioEssays · doi:10.1002/bies.201100190 · Cited by 21
New insight into the causes, consequences, and correction of hematopoietic stem cell aging
Mansell, E., Lin, D. S. Y., Loughran, S. J., Milsom, M. D., & Trowbridge, J. J. (2023) · Experimental Hematology · doi:10.1016/j.exphem.2023.07.002 · Cited by 21
Stem cell heterogeneity, plasticity, and regulation
Cui, Z., Wei, H., Goding, C. R., & Cui, R. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122240 · Cited by 21
Li, J., Zhang, Y.-R., Wang, H.-F., Guo, Y., Shen, X., Li, M., Song, J., Tan, L., Xie, A., & Yu, J. (2023) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12517 · Cited by 21
Singh, A., Chia, J. J., Rao, D. S., & Hoffmann, A. (2025) · Blood · doi:10.1182/blood.2024025598 · Cited by 21
Samaras, P., Pfrommer, S., Seifert, B., Petrausch, U., Mischo, A., Schmidt, A., Schanz, U., Nair, G., Bargetzi, M. J., Taverna, C., et al. (2014) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2014.09.020 · Cited by 21
Dvorak, C. C., Horn, B. N., Puck, J. M., Adams, S. P., Veys, P. A., Czechowicz, A. D., & Cowan, M. J. (2014) · Pediatric Transplantation · doi:10.1111/petr.12310 · Cited by 21
Immunological aspects of age-related diseases
Isobe, K., Nishio, N., & Hasegawa, T. (2017) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v8.i2.129 · Cited by 22
Endogenous Stem Cells in Homeostasis and Aging
Lim, J. E., & Son, Y. (2017) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-017-0097-3 · Cited by 21
Evaluation of Partitioning Around Medoids Algorithm with Various Distances on Microarray Data
Mohammed, N. N., & Abdulazeez, A. M. (2017) · IEEE International Conference on Internet of Things (iThings) and IEEE Green Computing and Communications (GreenCom) and IEEE Cyber, Physical and Social Computing (CPSCom) and IEEE Smart Data (SmartData) · doi:10.1109/ithings-greencom-cpscom-smartdata.2017.155 · Cited by 21
The Role of Targeted Agents and Immunotherapy in Older Patients with Non-small Cell Lung Cancer
Gomes, F., Tay, R. Y., Chiramel, J., & Califano, R. (2018) · Drugs & Aging · doi:10.1007/s40266-018-0573-z · Cited by 22
Balogh, P., Adelman, E. R., Pluvinage, J. V., Capaldo, B. J., Freeman, K. C., Singh, S., Elagib, K. E., Nakamura, Y., Kurita, R., Sashida, G., et al. (2019) · Haematologica · doi:10.3324/haematol.2018.208918 · Cited by 21
Self-citationWang, C., Oshima, M., Sashida, G., Tomioka, T., Hasegawa, N., Mochizuki‐Kashio, M., Nakajima‐Takagi, Y., Kusunoki, Y., Kyoizumi, S., Imai, K., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132041 · Cited by 22
Kidney Disease as a Driver of Immunosenescence
Song, Z., Tsou, S., Martin, F., Kayumov, M., Xiao, Y., Zhou, H., Abdi, R., & Tullius, S. G. (2025) · Journal of the American Society of Nephrology · doi:10.1681/asn.0000000896 · Cited by 21
Extracellular Vesicles and Hematopoietic Stem Cell Aging
Goldberg, L. R. (2021) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.314643 · Cited by 20
Age-related mechanisms in the context of rheumatic disease
Alsaleh, G., Richter, F. C., & Simon, A. K. (2022) · Nature Reviews Rheumatology · doi:10.1038/s41584-022-00863-8 · Cited by 20
Iyer, S., Brooks, R., Gumbleton, M., & Kerr, W. G. (2014) · Stem Cells and Development · doi:10.1089/scd.2014.0501 · Cited by 20
Minireview: Complexity of Hematopoietic Stem Cell Regulation in the Bone Marrow Microenvironment
Hoffman, C. M., & Calvi, L. M. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1079 · Cited by 21
Kocełak, P., Olszanecka‐Glinianowicz, M., Owczarek, A. J., Bożentowicz‐Wikarek, M., Brzozowska, A., Mossakowska, M., Zdrojewski, T. R., Grodzicki, T. K., Więcek, A., & Chudek, J. T. (2014) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2014.11.002 · Cited by 20
Thymic Engraftment by in vitro-Derived Progenitor T Cells in Young and Aged Mice
Singh, J., Mohtashami, M., Anderson, G., & Zúñiga‐Pflücker, J. C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01850 · Cited by 21
TNFAIP3 Plays a Role in Aging of the Hematopoietic System
Smith, M. A., Culver‐Cochran, A. E., Adelman, E. R., Rhyasen, G. W., Ma, A. I., Figueroa, M. E., & Starczynowski, D. T. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.536442 · Cited by 20
Organization of the Immune System
Lewis, D. E., & Blutt, S. E. (2019) · Elsevier eBooks · doi:10.1016/b978-0-7020-6896-6.00002-8 · Cited by 21
Arai, F., Stumpf, P. S., Ikushima, Y. M., Hosokawa, K., Roch, A., Lutolf, M. P., Suda, T., & MacArthur, B. D. (2020) · Cell Systems · doi:10.1016/j.cels.2020.11.004 · Cited by 19
Santamaria, J. C., & Irla, M. (2026) · Science Advances · doi:10.1126/sciadv.aeb2970 · Cited by 20
Clarke, M. L., Lemma, R. B., Walton, D. S., Volpe, G., Noyvert, B., Gabrielsen, O. S., & Frampton, J. (2023) · Blood · doi:10.1182/blood.2022019138 · Cited by 20
Inflammation as a mediator of arterial ageing
Trott, D. W., & Fadel, P. J. (2019) · Experimental Physiology · doi:10.1113/ep087499 · Cited by 20
Hematopoietic Stem Cell Heterogeneity
Jurecic, R. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-24108-7_10 · Cited by 22
Human Lymphoid Development in the Absence of Common γ-Chain Receptor Signaling
Kohn, L. A., Seet, C. S., Scholes, J., Codrea, F., Chan, R., Zaidi-Merchant, S., Zhu, Y., Oliveira, S. N. D., Kapoor, N., Shah, A. J., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1303496 · Cited by 19
Epigenetic Control of Haematopoietic Stem Cell Aging and Its Clinical Implications
Choudry, F., & Frontini, M. (2015) · Stem Cells International · doi:10.1155/2016/5797521 · Cited by 19
Aging and neoteny in the B lineage
Melamed, D., & Scott, D. W. (2012) · Blood · doi:10.1182/blood-2012-07-444711 · Cited by 19
Trends in Incidence and Mortality of Waldenström Macroglobulinemia: A Population-Based Study
Yin, X., Chen, L., Fan, F., Yan, H., Zhang, Y., Huang, Z., Sun, C., & Hu, Y. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01712 · Cited by 18
Functionalized 3D scaffolds for engineering the hematopoietic niche
Bruschi, M., Vanzolini, T., Sahu, N., Balduini, A., Magnani, M., & Fraternale, A. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.968086 · Cited by 20
Cancer Immunotherapies Based on Genetically Engineered Macrophages
Cannac, M., Nikolić, J., & Benaroch, P. (2022) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-22-0030 · Cited by 18
Jani, P. K., Petkau, G., Kawano, Y., Klemm, U., Guerra, G. M., Heinz, G. A., Heinrich, F., Durek, P., Mashreghi, M., & Melchers, F. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3002015 · Cited by 18
Tissue mosaicism following stem cell aging: blood as an exemplar
Kapadia, C. D., & Goodell, M. A. (2024) · Nature Aging · doi:10.1038/s43587-024-00589-0 · Cited by 18
NOX4-reactive oxygen species axis: critical regulators of bone health and metabolism
Dzubanova, M., Bond, J. M., Craige, S. M., & Tencerová, M. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1432668 · Cited by 18
Score, J., Chase, A., Forsberg, L. A., Feng, L., Waghorn, K., Jones, A. V., Rasi, C., Linch, D. C., Dumanski, J. P., Gale, R. E., et al. (2015) · Leukemia · doi:10.1038/leu.2015.13 · Cited by 18
Mechanisms underlying the heterogeneity of myelodysplastic syndromes
Dussiau, C., & Fontenay, M. (2017) · Experimental Hematology · doi:10.1016/j.exphem.2017.10.004 · Cited by 19
The Instructive Role of the Bone Marrow Niche in Aging and Leukemia
Lazzari, E., & Butler, J. M. (2018) · Current Stem Cell Reports · doi:10.1007/s40778-018-0143-7 · Cited by 20
Mineral-Coated Microparticles Enhance mRNA-Based Transfection of Human Bone Marrow Cells
Fontana, G., Martin, H. L., Lee, J. S., Schill, K., Hematti, P., & Murphy, W. L. (2019) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2019.09.004 · Cited by 18
Epigenetics of paediatric acute myeloid leukaemia
Jones, L., McCarthy, P., & Bond, J. (2019) · British Journal of Haematology · doi:10.1111/bjh.16361 · Cited by 18
B‐cell capacity for differentiation changes with age
Xie, X., Shrimpton, J., Doody, G. M., Conaghan, P. G., & Ponchel, F. (2021) · Aging Cell · doi:10.1111/acel.13341 · Cited by 18
Li, Z., & MacDougald, O. A. (2021) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2021.101547 · Cited by 18
Meza-León, B., Gratzinger, D. A., Aguilar-Navarro, A. G., Juárez-Aguilar, F. G., Rebel, V. I., Torlakovic, E., Purton, L. E., Dorantes-Acosta, E. M., Escobar‐Sánchez, A., Dick, J. E., et al. (2021) · Experimental Hematology · doi:10.1016/j.exphem.2021.06.006 · Cited by 18
Vascular Regulation of Hematopoietic Stem Cell Homeostasis, Regeneration, and Aging
Ramalingam, P., Butler, J. M., & Poulos, M. G. (2021) · Current Stem Cell Reports · doi:10.1007/s40778-021-00198-2 · Cited by 18
Parietti, V., Nelson, E., Telliam, G., Noir, S. L., Pla, M., Delord, M., Vanneaux, V., Mohtashami, M., Macintyre, E. A., Gluckman, J. C., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201251 · Cited by 18
A cellular identity crisis? Plasticity changes during aging and rejuvenationPreprint
Gorelov, R. A., & Hochedlinger, K. (2024) · Genes & Development · doi:10.1101/gad.351728.124 · Cited by 18
Han, J., Cherry, C., Mejías, J. C., Krishnan, K., Ruta, A., Maestas, D. R., Peña, A. N., Nguyen, H. H., Nagaraj, S., Yang, B., et al. (2024) · Advanced Materials · doi:10.1002/adma.202310476 · Cited by 17
Furer, N., Rappoport, N., Milman, O., Tavor, S., Lifshitz, A., Bercovich, A., Ben-Kiki, O., Danin, A., Kedmi, M., Shipony, Z., et al. (2025) · Nature Medicine · doi:10.1038/s41591-025-03716-5 · Cited by 17
Peng, T., & Zhan, Q. (2025) · npj Precision Oncology · doi:10.1038/s41698-025-01129-8 · Cited by 18
Alonso, M., Zabala, C., Mansilla, S., Brun, L. D., Martínez, J., Garau, M., Rivas, G., Acosta, C., Lens, D., Cerisola, A., et al. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.09.004 · Cited by 17
Immune Aging and Its Implication for Age-Related Disease Progression
Sato, Y. (2025) · Physiology · doi:10.1152/physiol.00051.2024 · Cited by 17
Genetic control of circadian rhythms and aging
Solovev, I. A., Dobrovolskaya, E., & Moskalev, A. (2016) · Russian Journal of Genetics · doi:10.1134/s1022795416040104 · Cited by 17
Jeong, B. M., Walker, M. T., Rodriguez, R., Coden, M. E., Nagasaka, R., Doan, T. C., Politanska, Y., Abdala-Valencia, H., & Berdnikovs, S. (2021) · Journal of Leukocyte Biology · doi:10.1002/jlb.1ab0519-170rr · Cited by 17
DNA damage and aging on hematopoietic stem cells: Impact of oxidative stress in ApoE−/− mice
Aires, R., Porto, M. L., de Assis, L. M., Pereira, P. A. N., Carvalho, G. R., Côco, L. Z., Vasquez, E. C., Pereira, T. D. M. C., Campagnaro, B. P., & Meyrelles, S. S. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111607 · Cited by 17
Dvorak, C. C., Horn, B. N., Puck, J. M., Czechowicz, A. D., Shizuru, J. A., Ko, R. M., & Cowan, M. J. (2014) · Pediatric Transplantation · doi:10.1111/petr.12309 · Cited by 17
Al-Ajmi, N., Saretzki, G. C., Miles, C. G., & Spyridopoulos, I. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.07.010 · Cited by 17
Targets of Immune Regeneration in Rheumatoid Arthritis
Hohensinner, P. J., Goronzy, J. J., & Weyand, C. M. (2014) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2014.01.020 · Cited by 17
Ghosh, J., Koussa, R. E., Mohamad, S., Liu, J., Kacena, M. A., & Srour, E. F. (2021) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000656 · Cited by 17
Ruiz-Aparicio, P. F., & Vernot, J. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12050716 · Cited by 17
Prescott, J. N., Keyser, A. J., Litwin, P., Dunbar, M. D., McClelland, R. L., Ruple, A., Ernst, H., Butler, B. L., Kauffman, M., Avery, A. C., et al. (2025) · GeroScience · doi:10.1007/s11357-025-01571-3 · Cited by 17
Lifestyle and host determinants of antitumor immunity and cancer health disparities
Swaby, A. M., Atallah, A., Varol, O., Cristea, A., & Quail, D. F. (2023) · Trends in cancer · doi:10.1016/j.trecan.2023.08.007 · Cited by 16
Sex-dependent differences in hematopoietic stem cell aging and leukemogenic potential
Zhang, C., Hao, T., Bortoluzzi, A., Chen, M.-H., Wu, X., Wang, J., Ermel, R. W., Kim, Y., Chen, S., & Chen, W. (2024) · Oncogene · doi:10.1038/s41388-024-03197-9 · Cited by 17
Ross, E. A., Flores‐Langarica, A., Bobat, S., Coughlan, R. E., Marshall, J. L., Hitchcock, J. R., Cook, C. N. L., Carvalho‐Gaspar, M., Mitchell, A. M., Clarke, M. L., et al. (2014) · European Journal of Immunology · doi:10.1002/eji.201344350 · Cited by 16
Khoo, M. L. M., Carlin, S. M., Lutherborrow, M. A., Jayaswal, V., Ma, D. D. F., & Moore, J. J. (2014) · Aging Cell · doi:10.1111/acel.12229 · Cited by 16
CD133 expression in circulating hematopoietic progenitor cells
Cimato, T. R., Conway, A. N., Nichols, J., & Wallace, P. K. (2018) · Cytometry Part B Clinical Cytometry · doi:10.1002/cyto.b.21732 · Cited by 16
Immunosenescence and Inflammaging in COVID-19
Asghari, F., Asghary, A., Zolbanin, N. M., Faraji, F., & Jafari, R. (2023) · Viral Immunology · doi:10.1089/vim.2023.0045 · Cited by 17
Smurf2 regulates hematopoietic stem cell self‐renewal and aging
Ramkumar, C., Kong, Y., Trabucco, S. E., Gerstein, R. M., & Zhang, H. (2014) · Aging Cell · doi:10.1111/acel.12195 · Cited by 17
Implications of hematopoietic stem cells heterogeneity for gene therapies
Epah, J., & Schäfer, R. (2021) · Gene Therapy · doi:10.1038/s41434-021-00229-x · Cited by 17
Platelet life cycle during aging: function, production and clearance
Reusswig, F., An, O. I., & Deppermann, C. (2024) · Platelets · doi:10.1080/09537104.2024.2433750 · Cited by 15
Platelet factor 4 regulates hematopoietic stem cell aging
Zhang, S., Ayemoba, C. E., Staulo, A. M. D., Joves, K., Patel, C. M., Leung, E. H. W., Bueno, M. L. P., Du, X., Poncz, M., Ong, S., et al. (2025) · Blood · doi:10.1182/blood.2024027432 · Cited by 19
Madl, C. M. (2023) · iScience · doi:10.1016/j.isci.2023.106825 · Cited by 16
Metadata
- Authors
- Pang, W. W., Price, E. A., Sahoo, D., Beerman, I., Maloney, W. J., Rossi, D. J., Schrier, S. L., & Weissman, I. L.
- Affiliations
- Institute for Stem Cell Biology and Regenerative Medicine (IN)
- Department of Internal Medicine, Division of Hematology, and
- Harvard University (US)
- Stanford Medicine (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2011-11-28
- Volume
- 108
- Issue
- 50
- Pages
- 20012-20017
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3250139
- OpenAlex
- W2028815852
- Cited by
- 991
- References
- 49
- Citations by year
- 2026: 79 · 2025: 79 · 2024: 93 · 2023: 87 · 2022: 85 · 2021: 91 · 2020: 83 · 2019: 55 · 2018: 59 · 2017: 54 · 2016: 51 · 2015: 49 · 2014: 63 · 2013: 36 · 2012: 26
- FWCI
- 27.35
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (R01AG029124)
- National Cancer Institute (R01CA086065, K99CA151673)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Keywords
- hematopoietic stem cells, aging, bone marrow, myeloid differentiation, HSC quiescence, hematopoietic progenitor cells, gene expression profiling, immunophenotype, myeloid neoplasms
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Animals, Bone Marrow Cells, Cell Count, Cell Differentiation, Gene Expression Regulation, Hematopoietic Stem Cells, Humans, Middle Aged, Cell Lineage, Gene Expression Profiling, Myeloid Cells, Mice, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review