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Effects of senescent secretory phenotype acquisition on human retinal pigment epithelial stem cells

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MDM2 antagonist nutlin‐3a sensitizes tumors to V‐ATPase inhibition

Schneider, L. S., Ulrich, M. P., Lehr, T., Menche, D., Müller, R., & von Schwarzenberg, K. (2016) · Molecular Oncology · doi:10.1016/j.molonc.2016.04.005 · Cited by 19

Overexpression of Rab11-FIP2 in colorectal cancer cells promotes tumor migration and angiogenesis through increasing secretion of PAI-1

Dong, W., & Wu, X. (2018) · Cancer Cell International · doi:10.1186/s12935-018-0532-0 · Cited by 18

Role of plasminogen activator inhibitor-1 (PAI-1) in age-related cardiovascular pathophysiology

Khoddam, A., Vaughan, D. E., & Wilsbacher, L. D. (2025) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2024.38 · Cited by 15

Exosomes released from senescent cells and circulatory exosomes isolated from human plasma reveal aging-associated proteomic and lipid signatures

Patel, S. K., Bons, J., Rose, J., Chappel, J. R., Beres, R. L., Watson, M. A., Webster, C. M., Burton, J. B., Bruderer, R., Desprez, P. Y., et al. (2025) · Aging · doi:10.18632/aging.206292 · Cited by 18

Age-related increase in Wnt inhibitor causes a senescence-like phenotype in human cardiac stem cells

Nakamura, T., Hosoyama, T., Murakami, J., Samura, M., Ueno, K., Kurazumi, H., Suzuki, R., Mikamo, A., & Hamano, K. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.04.110 · Cited by 16

Expanded CUG Repeat RNA Induces Premature Senescence in Myotonic Dystrophy Model Cells

Hasuike, Y., Mochizuki, H., & Nakamori, M. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.865811 · Cited by 15

Engineered Aging Cardiac Tissue Chip Model for Studying Cardiovascular Disease

Budhathoki, S., Graham, C., Sethu, P., & Kannappan, R. (2021) · Cells Tissues Organs · doi:10.1159/000516954 · Cited by 15

Involvement of Matricellular Proteins in Cellular Senescence: Potential Therapeutic Targets for Age-Related Diseases

Fujita, M., Sasada, M., Iyoda, T., & Fukai, F. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126591 · Cited by 14

Upregulation of SOX4 antagonizes cellular senescence in esophageal squamous cell carcinoma

Han, R., Huang, S., Bao, Y., Liu, X. Z., Peng, X., Chen, Z., Wang, Q., Wang, J., Zhang, Q., Wang, T., et al. (2016) · Oncology Letters · doi:10.3892/ol.2016.4799 · Cited by 14

Identification of Putative Biomarkers for the Early Stage of Porcine Spermatogonial Stem Cells Using Next-Generation Sequencing

Lee, W.-Y., Tae, J., Park, C., Kim, J., Chung, H., Kim, K., Gil, C.-H., Kim, N., & Song, H. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147298 · Cited by 13

PAI-1 is a common driver of aging and diverse diseases

Khoddam, A., Miyata, T., & Vaughan, D. E. (2025) · Biomedical Journal · doi:10.1016/j.bj.2025.100892 · Cited by 12

PGF2α‐FP Receptor Ameliorates Senescence of VSMCs in Vascular Remodeling by Src/PAI‐1 Signal Pathway

Hu, B., Sai, W.-W., Jun, Y., Lan, H., Qi, J., Wang, D., Zhang, W., Wang, Z., Zhong, M., & Shang, Y. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/2908261 · Cited by 12

Insulin-like growth factor binding protein-3 induces senescence by inhibiting telomerase activity in MCF-7 breast cancer cells

Kwon, A., Chae, H. W., Lee, W. J., Kim, J. H., Kim, Y. J., Ahn, J., Oh, Y., & Kim, H.-S. (2023) · Scientific Reports · doi:10.1038/s41598-023-35291-5 · Cited by 14

Nitric oxide suppression by secreted frizzled-related protein 2 drives retinoblastoma

Jayabal, P., Zhou, F., Ma, X., Bondra, K. M., Blackman, B., Weintraub, S. T., Chen, Y., Chévez‐Barrios, P., Houghton, P. J., Gallie, B. L., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112103 · Cited by 12

Targeting Signaling Pathways of Hyaluronic Acid and Integrin Receptors by Synergistic Combination Nanocomposites Inhibits Systemic Metastases and Primary Triple Negative Breast Cancer

Zhang, T., Fu, C., Alradwan, I. A., Yen, T.-Y. C., Lip, H., Cai, P., Rauth, A. M., Zhang, L., & Wu, X. Y. (2021) · Advanced Therapeutics · doi:10.1002/adtp.202100022 · Cited by 11

EWS-FLI-1 creates a cell surface microenvironment conducive to IGF signaling by inducing pappalysin-1

Jayabal, P., Houghton, P. J., & Shiio, Y. (2017) · Genes & Cancer · doi:10.18632/genesandcancer.159 · Cited by 11

The Biomarkers in Extreme Longevity: Insights Gained from Metabolomics and Proteomics

Qiu, X., Lu, Y., Mu, C., Tang, P., Liu, Y., Huang, Y., Luo, H., Liu, J.-Y., & Li, X. (2024) · International Journal of Medical Sciences · doi:10.7150/ijms.98778 · Cited by 9

The Matrix Protein Tropoelastin Prolongs Mesenchymal Stromal Cell Vitality and Delays Senescence During Replicative Aging

Lee, S. S., Halawani, A. A., Teo, J. D., Weiss, A. S., & Yeo, G. C. (2024) · Advanced Science · doi:10.1002/advs.202402168 · Cited by 10

Slit2 signaling stimulates Ewing sarcoma growth

Suvarna, K., Jayabal, P., Ma, X., & Shiio, Y. (2022) · Genes & Cancer · doi:10.18632/genesandcancer.227 · Cited by 9

Effects of IGFBP3 knockdown on human endometrial mesenchymal stromal cells stress-induced senescence

Ushakov, R. E., Aksenov, N., Pugovkina, N. A., & Burova, E. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.07.046 · Cited by 8

PAI-1 regulates AT2-mediated re-alveolarization and ion permeability

Ali, G., Zhang, M., Chang, J., Zhao, R., Jin, Y., Zhang, J., & Ji, H. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03414-4 · Cited by 8

P2-04-01: Extracellular PAI-1 – t-PA – IGFBP3 Cascade Mediates Chemotherapy-Induced Senescence of Breast Cancer Cells.

Shiio, Y., Elzi, D. J., Song, M.-J., Hakala, K. W., & Weintraub, S. (2011) · Cancer Research · doi:10.1158/0008-5472.sabcs11-p2-04-01

IGFBP-rP1 induces p21 expression through a p53-independent pathway, leading to cellular senescence of MCF-7 breast cancer cells

Zuo, S., Liu, C., Wang, J., Wang, F., Xu, W., Cui, S., Yuan, L., Chen, X., Fan, W., Cui, M., et al. (2012) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-012-1153-y · Cited by 58

Molecular Mechanisms of Insulin-like Growth Factor Binding Protein-7 in Stem Cell Senescence: A Multi-Dimensional Regulator of Senescence-Associated Secretory Phenotype (SASP)

SIRAJ, Y. A. (2025) · Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli"

Insulin-like growth factor binding protein-6 delays replicative senescence of human fibroblasts

Mičutková, L., Diener, T., Li, C., Rogowska-Wrzesińska, A., Mück, C., Hütter, E., Weinberger, B., Grubeck‐Loebenstein, B., Roepstorff, P., Zeng, R., et al. (2011) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2011.07.005 · Cited by 39

Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence

Kortlever, R. M., Higgins, P. J., & Bernards, R. (2006) · Nature Cell Biology · doi:10.1038/ncb1448 · Cited by 637