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Recognition of Plasminogen Activator Inhibitor Type 1 as the Primary Regulator of Fibrinolysis

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PAI-1, the Plasminogen System, and Skeletal Muscle

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Glomerular endothelial cell senescence drives age‐related kidney disease through PAI‐1

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Aging Fits the Disease Criteria of the International Classification of Diseases

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Modeling transcriptomic age using knowledge-primed artificial neural networks

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Drug Targeting of Plasminogen Activator Inhibitor-1 Inhibits Metabolic Dysfunction and Atherosclerosis in a Murine Model of Metabolic Syndrome

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Emerging Therapeutic Approaches to Target the Dark Side of Senescent Cells: New Hopes to Treat Aging as a Disease and to Delay Age-Related Pathologies

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Multiomic blood correlates of genetic risk identify presymptomatic disease alterations

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Novel Oxidative Stress Biomarkers with Risk Prognosis Values in Heart Failure

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A signaling pathway map of plasminogen activator inhibitor-1 (PAI-1/SERPINE-1): a review of an innovative frontier in molecular aging and cellular senescence

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The senescence-associated secretory phenotype: Fueling a wound that never heals

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PAI-1 contributes to homocysteine-induced cellular senescence

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Intracellular tPA–PAI-1 interaction determines VLDL assembly in hepatocytes

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The hallmarks of aging in Ataxia-Telangiectasia

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Systemic low-dose anti-fibrotic treatment attenuates ovarian aging in the mouse

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Unbiased proteomics identifies plasminogen activator inhibitor-1 as a negative regulator of endothelial nitric oxide synthase

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Comparative Analysis of Mammal Genomes Unveils Key Genomic Variability for Human Life Span

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mTOR in metabolic homeostasis and disease.

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Metabolism-based isolation of invasive glioblastoma cells with specific gene signatures and tumorigenic potential

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The Fibrinolytic System: Mysteries and Opportunities

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Reducing oxidative protein folding alleviates senescence by minimizing ER‐to‐nucleus H2O2 release

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Inhibition of Plasminogen Activator Inhibitor 1 Attenuates Hepatic Steatosis but Does Not Prevent Progressive Nonalcoholic Steatohepatitis in Mice

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Phosphoproteomics of Acute Cell Stressors Targeting Exercise Signaling Networks Reveal Drug Interactions Regulating Protein Secretion

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Stereotactic Lung Irradiation in Mice Promotes Long-Term Senescence and Lung Injury

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Genetic cartography of longevity in humans and mice: Current landscape and horizons

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The future of heart failure with preserved ejection fraction

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The Central Role of PAI-1 in COVID-19: Thrombosis and beyond

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Knockdown of angiopoietin-like 2 induces clearance of vascular endothelial senescent cells by apoptosis, promotes endothelial repair and slows atherogenesis in mice

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DNA methylation and gene expression signatures are associated with ataxia-telangiectasia phenotype

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TP53/miR-34a-associated signaling targets SERPINE1 expression in human pancreatic cancer

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Coordinated reprogramming of renal cancer transcriptome, metabolome and secretome associates with immune tumor infiltration

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A new assay for global fibrinolysis capacity (GFC): Investigating a critical system regulating hemostasis and thrombosis and other extravascular functions

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Hawthorn fruit extract ameliorates H 2 O 2 -induced oxidative damage in neuronal PC12 cells and prolongs the lifespan of Caenorhabditis elegans via the IIS signaling pathway

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Identification of Cardiac Fibrosis in Young Adults With a Homozygous Frameshift Variant in SERPINE1

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Single cell RNA sequencing unravels mechanisms underlying senescence-like phenotypes of alveolar macrophages

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Integrated analysis of long non-coding RNAs (lncRNAs) and mRNA expression profiles identifies lncRNA PRKG1-AS1 playing important roles in skeletal muscle aging

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Aging, Plasminogen Activator Inhibitor 1, Brain Cell Senescence, and Alzheimer's Disease.

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The onset and the development of cardiometabolic aging: an insight into the underlying mechanisms

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Networks of blood proteins in the neuroimmunology of schizophrenia

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SerpinE1 drives a cell-autonomous pathogenic signaling in Hutchinson–Gilford progeria syndrome

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Genomics-driven drug discovery based on disease-susceptibility genes

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Derangement of cell cycle markers in peripheral blood mononuclear cells of asthmatic patients as a reliable biomarker for asthma control

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Deep mutational scanning of the plasminogen activator inhibitor-1 functional landscape

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D-Dimer and Outcomes in Hospitalized Heart Failure Patients Across the Ejection Fraction Phenotypes

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Characterizing 3T3-L1 MBX Adipocyte Cell Differentiation Maintained with Fatty Acids as an In Vitro Model to Study the Effects of Obesity

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PAI-1 Regulates the Cytoskeleton and Intrinsic Stiffness of Vascular Smooth Muscle Cells

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Dual-reporter high-throughput screen for small-molecule in vivo inhibitors of plasminogen activator inhibitor type-1 yields a clinical lead candidate

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BAP1-Related ceRNA (NEAT1/miR-10a-5p/SERPINE1) Promotes Proliferation and Migration of Kidney Cancer Cells

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Role of plasminogen activator inhibitor-1 (PAI-1) in age-related cardiovascular pathophysiology

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Circadian rhythm of plasminogen activator inhibitor-1 and cardiovascular complications in type 2 diabetes

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Candesartan Neuroprotection in Rat Primary Neurons Negatively Correlates with Aging and Senescence: a Transcriptomic Analysis

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Senotherapy for chronic lung disease

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A novel PAI-1 inhibitor prevents ageing-related muscle fiber atrophy

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Measuring Fibrinolysis

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SIRT6-PAI-1 axis is a promising therapeutic target in aging-related bone metabolic disruption

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Higher testosterone and testosterone/estradiol ratio in men are associated with decreased Pheno-/GrimAge and DNA-methylation based PAI1

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Identification and exploration of aging‐related subtypes and distinctive role of SERPINE1 in heart failure based on single‐cell and bulk RNA sequencing data

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Maximum reproductive lifespan correlates with CD33rSIGLEC gene number: Implications for NADPH oxidase‐derived reactive oxygen species in aging

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Overview: PAI-1 inhibitors and clinical applications

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Age-dependent transcriptional alterations in cardiac endothelial cells

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PAI-1 is a common driver of aging and diverse diseases

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Liver-derived plasminogen mediates muscle stem cell expansion during caloric restriction through the plasminogen receptor Plg-RKT

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Aging, Age-Related Diseases, and the Zebrafish Model

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Neuroprotective effects of trigonelline in eggplant on oxidative damage of PC12 cells and cognitive impairment in aging mice

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Measurement of blood activation markers applied to the early diagnosis of cardiovascular alterations

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Heterogeneity of thymic output in the elderly and its association with sex and smoking

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Senescent cells in systemic aging: SASP heterogeneity, immune escape, and endocrine modulation

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Deep mutational scanning and massively parallel kinetics of plasminogen activator inhibitor-1 functional stability to probe its latency transition

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Proteome Analysis of PC12 Cells Reveals Alterations in Translation Regulation and Actin Signaling Induced by Clozapine

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Altered expression of telomere‐associated genes in leukocytes among BRCA1 and BRCA2 carriers

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Human placental extract improves liver cirrhosis in mice with regulation of macrophages and senescent cells

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Accelerated aging and altered subclinical response to ozone exposure in young, healthy adults

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Molecular and Environmental Modulators of Aging: Interplay Between Inflammation, Epigenetics, and RNA Stability

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The Cbs Locus Affects the Expression of Senescence Markers and mtDNA Copy Number, but not Telomere Dynamics in Mice

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Effects of lisinopril treatment on the pathophysiology of PCOS and plasminogen activator inhibitor-1 concentrations in rats

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Impact of Aging and Cellular Senescence in the Pathophysiology of Preeclampsia

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MXene-enhanced electrochemiluminescence biosensor for SERPINE1 detection via β-turn-responsive peptide as a functional biological macromolecule switch

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The Evolving Landscape of Systemic Sclerosis Pathogenesis: From Foundational Mechanisms to Organ-Specific Modifiers

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