The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Circadian clock regulates the host response to Salmonella
Open accessAbstract
Organisms adapt to day–night cycles through highly specialized circadian machinery, whose molecular components anticipate and drive changes in organism behavior and metabolism. Although many effectors of the immune system are known to follow daily oscillations, the role of the circadian clock in the immune response to acute infections is not understood. Here we show that the circadian clock modulates the inflammatory response during acute infection with the pathogen Salmonella enterica serovar Typhimurium ( S. Typhimurium). Mice infected with S. Typhimurium were colonized to higher levels and developed a higher proinflammatory response during the early rest period for mice, compared with other times of the day. We also demonstrate that a functional clock is required for optimal S. Typhimurium colonization and maximal induction of several proinflammatory genes. These findings point to a clock-regulated mechanism of activation of the immune response against an enteric pathogen and may suggest potential therapeutic strategies for chronopharmacologic interventions.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mutagenesis and Mapping of a Mouse Gene, Clock , Essential for Circadian Behavior
Vitaterna, M. H., King, D. P., Chang, A.-M., Kornhauser, J. M., Lowrey, P. L., McDonald, J. D., Dove, W. F., Pinto, L. H., Turek, F. W., & Takahashi, J. S. (1994) · Science · doi:10.1126/science.8171325 · Cited by 1,632
A circadian clock in macrophages controls inflammatory immune responses
Keller, M., Mazuch, J., Abraham, U., Eom, G. D., Herzog, E. D., Volk, H.-D., Kramer, A., & Maier, B. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906361106 · Cited by 843 · cited 1×
“Moreover, macrophages have an efficient clock machinery, and LPS-activated pathways in these cells are under tight circadian regulation at multiple levels (3, 4).”
BackgroundRaffatellu, M., George, M. D., Akiyama, Y., Hornsby, M. J., Nuccio, S.-P., Paixao, T. A., Butler, B. P., Chu, H., Santos, R. L., Berger, T., et al. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.03.011 · Cited by 525
Self-citationLiu, J. Z., Jellbauer, S., Poe, A. J., Ton, V., Pesciaroli, M., Kehl-Fie, T. E., Restrepo, N. A., Hosking, M. P., Edwards, R. A., Battistoni, A., et al. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.01.017 · Cited by 328
Self-citationThe pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2
Fischbach, M. A., Lin, H., Zhou, L., Yu, Y., Abergel, R. J., Liu, D. R., Raymond, K. N., Wanner, B. L., Strong, R. K., Walsh, C. T., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604636103 · Cited by 319
Transcriptional oscillation of canonical clock genes in mouse peripheral tissues
Yamamoto, T., Nakahata, Y., Soma, H., Akashi, M., Mamine, T., & Takumi, T. (2004) · BMC Molecular Biology · doi:10.1186/1471-2199-5-18 · Cited by 308
Susceptibility Rhythm to E. coli Endotoxin and Bioassay.
Halberg, F., Johnson, E. A., Brown, B. W., & Bittner, J. J. (1960) · Experimental Biology and Medicine · doi:10.3181/00379727-103-25439 · Cited by 280 · cited 1×
“It is known that mice are susceptible to LPS-induced endotoxic shock as well as to TNF-α toxicity, depending upon the administration time during the 24-h light–dark (LD) cycle (15, 16).”
Background
Cited by
Time for food: the intimate interplay between nutrition, metabolism, and the circadian clock
Asher, G., & Sassone-Corsi, P. (2015) · Cell · doi:10.1016/j.cell.2015.03.015 · Cited by 844
Self-citationCircadian Clocks in the Immune System
Labrecque, N., & Cermakian, N. (2015) · Journal of Biological Rhythms · doi:10.1177/0748730415577723 · Cited by 466
An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action
Gibbs, J., Ince, L., Matthews, L., Mei, J., Bell, T., Yang, N., Saer, B., Begley, N., Poolman, T., Pariollaud, M., et al. (2014) · Nature Medicine · doi:10.1038/nm.3599 · Cited by 455
Circadian control of innate immunity in macrophages by miR-155 targeting Bmal1
Curtis, A. M., Fagundes, C. T., Yang, G., Palsson-McDermott, E. M., Wochal, P., McGettrick, A. F., Foley, N. H., Early, J. O., Chen, L., Zhang, H., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1501327112 · Cited by 311
Potential Role for the Gut Microbiota in Modulating Host Circadian Rhythms and Metabolic Health
Parkar, S. G., Kalsbeek, A., & Cheeseman, J. F. (2019) · Microorganisms · doi:10.3390/microorganisms7020041 · Cited by 285
Metadata
- Authors
- Bellet, M. M., Deriu, E., Liu, J. Z., Grimaldi, B., Blaschitz, C., Zeller, M., Edwards, R. A., Sahar, S., Dandekar, S., Baldi, P., George, M. D., Raffatellu, M., & Sassone-Corsi, P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-05-28
- Volume
- 110
- Issue
- 24
- Pages
- 9897-9902
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2058237889
- Cited by
- 259
- References
- 7
- FWCI
- 8.00
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Circadian clock regulates the host response to Salmonella. https://app.cochat.ai/papers/10.1073/pnas.1120636110
- The paper
- Bellet, M. M., Deriu, E., Liu, J. Z., Grimaldi, B., Blaschitz, C., Zeller, M., Edwards, R. A., Sahar, S., Dandekar, S., Baldi, P., George, M. D., Raffatellu, M., & Sassone-Corsi, P. (2013). Circadian clock regulates the host response to Salmonella. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1120636110
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
