Potential Role for the Gut Microbiota in Modulating Host Circadian Rhythms and Metabolic Health
Open accessAbstract
This article reviews the current evidence associating gut microbiota with factors that impact host circadian-metabolic axis, such as light/dark cycles, sleep/wake cycles, diet, and eating patterns. We examine how gut bacteria possess their own daily rhythmicity in terms of composition, their localization to intestinal niches, and functions. We review evidence that gut bacteria modulate host rhythms via microbial metabolites such as butyrate, polyphenolic derivatives, vitamins, and amines. Lifestyle stressors such as altered sleep and eating patterns that may disturb the host circadian system also influence the gut microbiome. The consequent disruptions to microbiota-mediated functions such as decreased conjugation of bile acids or increased production of hydrogen sulfide and the resultant decreased production of butyrate, in turn affect substrate oxidation and energy regulation in the host. Thus, disturbances in microbiome rhythms may at least partially contribute to an increased risk of obesity and metabolic syndrome associated with insufficient sleep and circadian misalignment. Good sleep and a healthy diet appear to be essential for maintaining gut microbial balance. Manipulating daily rhythms of gut microbial abundance and activity may therefore hold promise for a chrononutrition-based approach to consolidate host circadian rhythms and metabolic homeorhesis.
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The variability in gut microbiota is explained only in part by diet composition itself, with intrinsic and extrinsic factors such as circadian rhythm and feeding behaviours contributing.
“This variability is explained only in part by the diet composition itself, with a number of intrinsic and extrinsic factors thought to contribute such as circadian rhythm and feeding behaviours [20,21].”
From Effect of Diet on the Gut Microbiota: Rethinking Intervention Duration (2019) · cites this paper as [21]
Manipulation of feeding time, including time and duration of consumption and frequency, may influence the gut microbial composition and function and possibly host health.
“It is possible therefore that manipulation of feeding time, including time and duration of consumption and frequency, may influence the gut microbial composition and function and possibly host health [21,27].”
From Effect of Diet on the Gut Microbiota: Rethinking Intervention Duration (2019) · cites this paper as [21]
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Effect of Diet on the Gut Microbiota: Rethinking Intervention Duration
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Gut microbiome diversity is associated with sleep physiology in humans
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Mashaqi, S., & Gozal, D. (2020) · Sleep Medicine · doi:10.1016/j.sleep.2020.03.020 · Cited by 40 · see citing works
- Authors
- Parkar, S. G., Kalsbeek, A., & Cheeseman, J. F.
- Affiliations
- Plant & Food Research (NZ)
- Netherlands Institute for Neuroscience (NL)
- University of Auckland (NZ)
- Corresponding author
- Parkar, Shanthi G.
- Venue
- Microorganisms
- Publisher
- MDPI AG
- Published
- 2019-01-31
- Volume
- 7
- Issue
- 2
- Pages
- 41
- ISSN
- 2076-2607 (ISSN-L)
- PMC
- PMC6406615
- OpenAlex
- W2912735166
- Cited by
- 285
- References
- 108
- Citations by year
- 2026: 24 · 2025: 28 · 2024: 35 · 2023: 34 · 2022: 45 · 2021: 59 · 2020: 43 · 2019: 15 · 2017: 1
- FWCI
- 3.55
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Microorganisms (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- KNAW research portal (Royal Academy of Art and Sciences (KNAW)) (publishedVersion, other-oa)
- Pure Amsterdam UMC (acceptedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- ResearchSpace (University of Auckland) (submittedVersion, cc-by)
- Funders
- The New Zealand Institute for Plant & Food Research Limited (P/225005/01)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- gut microbiota, circadian rhythm, microbial metabolites, butyrate, bile acid conjugation, hydrogen sulfide, sleep disruption, circadian misalignment, obesity, metabolic syndrome, diet, chrononutrition, energy homeostasis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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