Circadian control of innate immunity in macrophages by miR-155 targeting Bmal1
Open accessAbstract
Significance: The circadian clock allows an organism to anticipate daily changes imposed by the environment. The response to LPS is altered depending on time of day; however, the molecular mechanisms underlying this are unclear. We find that the clock in myeloid cells plays a role in LPS-induced sepsis by altering NF-κB activity and the induction of the microRNA miR-155. LPS causes the repression of BMAL1 via the targeting of miR-155 to two seed sequences in the 3′-untranslated region of Bmal1 . Lack of miR-155 has profound effects on circadian function and circadian induction of cytokines by LPS. Thus, the molecular clock is using miR-155 as an important regulatory component to control inflammation variably across the circadian day in myeloid cells.
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Macrophage development is regulated by miR-155 and miR-146a expression.
“Macrophage development is regulated by miR-155 and miR-146a expression [54,55,56,57].”
From MicroRNAs as Regulators of Phagocytosis (2022) · cites this paper as [54]
The Results section (“Mice Deficient in Myeloid BMAL1”; page unavailable) shows that miR-155 regulates BMAL1 expression and inflammatory responses in macrophages. It does not show that miR-155 regulates macrophage development, and the passages found do not address miR-146a (searched: miR-146a, macrophage development and differentiation). (LLM, conf=0.76)
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Self-citation
- Authors
- Curtis, A. M., Fagundes, C. T., Yang, G., Palsson-McDermott, E. M., Wochal, P., McGettrick, A. F., Foley, N. H., Early, J. O., Chen, L., Zhang, H., Xue, C., Geiger, S. S., Hokamp, K., Reilly, M. P., Coogan, A. N., Vigorito, E., FitzGerald, G. A., & O’Neill, L. A. J.
- Affiliations
- School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland;
- Trinity College Dublin (IE)
- University of Pennsylvania (US)
- National University of Ireland, Maynooth (IE)
- Babraham Institute (GB)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2015-05-20
- Volume
- 112
- Issue
- 23
- Pages
- 7231-7236
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4466714
- OpenAlex
- W1530925068
- Cited by
- 311
- References
- 2
- Citations by year
- 2026: 31 · 2025: 23 · 2024: 24 · 2023: 27 · 2022: 28 · 2021: 37 · 2020: 40 · 2019: 20 · 2018: 19 · 2017: 31 · 2016: 26 · 2015: 5
- FWCI
- 14.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Maynooth University ePrints and eTheses Archive (Maynooth University) (acceptedVersion)
- Arrow@dit (Dublin Institute of Technology) (submittedVersion)
- Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion, cc-by-nc-sa)
- Funders
- EC | European Research Council (268155-MicroInnate)
- Science Foundation Ireland (13/SIRG/2130)
- HHS | NIH | National Heart, Lung, and Blood Institute (HL097800)
- European Commission (TIMER)
- Ministry of Science, Technology and Innovation | Conselho Nacional de Desenvolvimento Científico e Tecnológico (Science without borders)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- circadian clock, innate immunity, macrophages, miR-155, Bmal1, lipopolysaccharide, NF-κB, sepsis, microRNA target regulation, 3' UTR binding sites, cytokine response, circadian period, myeloid cells
- MeSH terms
- Adipose Tissue, Animals, Circadian Rhythm, Immunity, Innate, Macrophages, Cytokines, NF-kappa B, Mice, Knockout, 3' Untranslated Regions, MicroRNAs, Mice, ARNTL Transcription Factors
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