The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Origin of metazoan cadherin diversity and the antiquity of the classical cadherin/β-catenin complex
Open accessAbstract
The evolution of cadherins, which are essential for metazoan multicellularity and restricted to metazoans and their closest relatives, has special relevance for understanding metazoan origins. To reconstruct the ancestry and evolution of cadherin gene families, we analyzed the genomes of the choanoflagellate Salpingoeca rosetta , the unicellular outgroup of choanoflagellates and metazoans Capsaspora owczarzaki , and a draft genome assembly from the homoscleromorph sponge Oscarella carmela . Our finding of a cadherin gene in C. owczarzaki reveals that cadherins predate the divergence of the C. owczarzaki , choanoflagellate, and metazoan lineages. Data from these analyses also suggest that the last common ancestor of metazoans and choanoflagellates contained representatives of at least three cadherin families, lefftyrin, coherin, and hedgling. Additionally, we find that an O. carmela classical cadherin has predicted structural features that, in bilaterian classical cadherins, facilitate binding to the cytoplasmic protein β-catenin and, thereby, promote cadherin-mediated cell adhesion. In contrast with premetazoan cadherin families (i.e., those conserved between choanoflagellates and metazoans), the later appearance of classical cadherins coincides with metazoan origins.
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Citations
Cites
De novo assembly of human genomes with massively parallel short read sequencing
Li, R., Zhu, H., Ruan, J., Qian, W., Fang, X., Shi, Z., Li, Y., Li, S., Shan, G., Kristiansen, K., et al. (2010) · Genome Research · doi:10.1101/gr.097261.109 · Cited by 2,926 · cited 4×
“For example, classical cadherins are distinguished by the presence of a cytoplasmic cadherin domain (CCD) at the C terminus that regulates interactions with the cytoplasmic protein β-catenin (2, 3, 12, 15).”
BackgroundMethodInfluentialThe Pfam protein families database
Finn, R. D., Mistry, J., Tate, J., Coggill, P., Heger, A., Pollington, J. E., Gavin, O. L., Gunasekaran, P., Ceric, G., Forslund, K., et al. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkp985 · Cited by 2,694
Sea Anemone Genome Reveals Ancestral Eumetazoan Gene Repertoire and Genomic Organization
Putnam, N. H., Srivastava, M., Hellsten, U., Dirks, B., Chapman, J., Salamov, A., Terry, A., Shapiro, H., Lindquist, E., Kapitonov, V. V., et al. (2007) · Science · doi:10.1126/science.1139158 · Cited by 1,555
The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans
King, N., Westbrook, M. J., Young, S. L., Kuo, A., Abedin, M., Chapman, J., Fairclough, S., Hellsten, U., Isogai, Y., Letunic, I., et al. (2008) · Nature · doi:10.1038/nature06617 · Cited by 1,139
Self-citationEvolution of Key Cell Signaling and Adhesion Protein Families Predates Animal Origins
King, N., Hittinger, C. T., & Carroll, S. B. (2003) · Science · doi:10.1126/science.1083853 · Cited by 424
Self-citationGenomic, phylogenetic, and cell biological insights into metazoan origins
Nichols, S. A., Dayel, M. J., & King, N. (2009) · Animal Evolution · doi:10.1093/acprof:oso/9780199549429.003.0003 · Cited by 24
Self-citation
Cited by
Keeling, P. J., Burki, F., Wilcox, H. M., Allam, B., Allen, E. E., Amaral-Zettler, L. A., Armbrust, E. V., Archibald, J. M., Bharti, A. K., Bell, C. J., et al. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001889 · Cited by 1,042
Programming self-organizing multicellular structures with synthetic cell-cell signaling
Toda, S., Blauch, L. R., Tang, S. K. Y., Morsut, L., & Lim, W. A. (2018) · Science · doi:10.1126/science.aat0271 · Cited by 470
The Origin of Animal Multicellularity and Cell Differentiation
(2017) · doi:10.1016/j.devcel.2017.09.016 · Cited by 419
The origin of Metazoa: a unicellular perspective
Sebé-Pedrós, A., Degnan, B. M., & Ruiz-Trillo, I. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.21 · Cited by 332
The Capsaspora genome reveals a complex unicellular prehistory of animals
Suga, H., Chen, Z., de Mendoza, A., Sebé-Pedrós, A., Brown, M. W., Kramer, E., Carr, M., Kerner, P., Vervoort, M., Sánchez-Pons, N., et al. (2013) · Nature Communications · doi:10.1038/ncomms3325 · Cited by 317
Metadata
- Authors
- Nichols, S. A., Roberts, B. W., Richter, D. J., Fairclough, S. R., & King, N.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2012-07-25
- Volume
- 109
- Issue
- 32
- Pages
- 13046-13051
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2079193485
- Cited by
- 193
- References
- 6
- FWCI
- 12.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Nichols, S. A., Roberts, B. W., Richter, D. J., Fairclough, S. R., & King, N. (2012). Origin of metazoan cadherin diversity and the antiquity of the classical cadherin/β-catenin complex. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1120685109
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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