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Cited by 57

The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.

Impact of experience-dependent and -independent factors on gene expression in songbird brain

Drnevich, Jenny, Replogle, Kirstin L., Lovell, Peter, Hahn, Thomas P., Johnson, Frank, Mast, Thomas G., Nordeen, Ernest, Nordeen, Kathy, Strand, Christy, London, Sarah E., Mukai, Motoko, Wingfield, John C., Arnold, Arthur P., Ball, Gregory F., Brenowitz, Eliot A., Wade, Juli, Mello, Claudio V., Clayton, David F.·2012·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1200655109
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Abstract

Songbirds provide rich natural models for studying the relationships between brain anatomy, behavior, environmental signals, and gene expression. Under the Songbird Neurogenomics Initiative, investigators from 11 laboratories collected brain samples from six species of songbird under a range of experimental conditions, and 488 of these samples were analyzed systematically for gene expression by microarray. ANOVA was used to test 32 planned contrasts in the data, revealing the relative impact of different factors. The brain region from which tissue was taken had the greatest influence on gene expression profile, affecting the majority of signals measured by 18,848 cDNA spots on the microarray. Social and environmental manipulations had a highly variable impact, interpreted here as a manifestation of paradoxical “constitutive plasticity” (fewer inducible genes) during periods of enhanced behavioral responsiveness. Several specific genes were identified that may be important in the evolution of linkages between environmental signals and behavior. The data were also analyzed using weighted gene coexpression network analysis, followed by gene ontology analysis. This revealed modules of coexpressed genes that are also enriched for specific functional annotations, such as “ribosome” (expressed more highly in juvenile brain) and “dopamine metabolic process” (expressed more highly in striatal song control nucleus area X). These results underscore the complexity of influences on neural gene expression and provide a resource for studying how these influences are integrated during natural experience.

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Metadata

Authors
Drnevich, J., Replogle, K. L., Lovell, P., Hahn, T. P., Johnson, F., Mast, T. G., Nordeen, E., Nordeen, K., Strand, C., London, S. E., Mukai, M., Wingfield, J. C., Arnold, A. P., Ball, G. F., Brenowitz, E. A., Wade, J., Mello, C. V., & Clayton, D. F.
Affiliations
  • Carver Biotechnology Center and the High-Performance Biological Computing Group and
  • Institute for Genomic Biology and Department of Cell and Developmental Biology, University of Illinois at Urbana–Champaign, Urbana, IL 61801;
  • Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239;
  • Department of Neurobiology, Physiology, and Behavior, University of California, Davis, CA 95616;
  • Department of Psychology, Florida State University, Tallahassee, FL 32306;
  • Department of Brain and Cognitive Sciences, University of Rochester, Rochester, NY 14627;
  • Biological Sciences, California Polytechnic State University, San Luis Obispo, CA 93407;
  • Department of Psychology, University of Chicago, Chicago, IL 60637;
  • Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853;
  • Department of Integrative Biology and Physiology, University of California, Los Angeles, CA 90095;
  • Department of Psychological and Brain Sciences, The Johns Hopkins University, Baltimore, MD 21218;
  • Department of Psychology, University of Washington, Seattle, WA 98195; and
  • Departments of Psychology and Zoology, Program in Neuroscience, Michigan State University, East Lansing, MI 48824
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2012-10-08
Volume
109
Issue
supplement_2
Pages
17245-17252
ISSN
  • 0027-8424
  • 1091-6490
DOI
10.1073/pnas.1200655109
Cited by
57
References
44
Language
en

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