The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Polycation-siRNA nanoparticles can disassemble at the kidney glomerular basement membrane
Open accessAbstract
Despite being engineered to avoid renal clearance, many cationic polymer (polycation)-based siRNA nanoparticles that are used for systemic delivery are rapidly eliminated from the circulation. Here, we show that a component of the renal filtration barrier—the glomerular basement membrane (GBM)—can disassemble cationic cyclodextrin-containing polymer (CDP)-based siRNA nanoparticles and, thereby, facilitate their rapid elimination from circulation. Using confocal and electron microscopies, positron emission tomography, and compartment modeling, we demonstrate that siRNA nanoparticles, but not free siRNA, accumulate and disassemble in the GBM. We also confirm that the siRNA nanoparticles do not disassemble in blood plasma in vitro and in vivo. This clearance mechanism may affect any nanoparticles that assemble primarily by electrostatic interactions between cationic delivery components and anionic nucleic acids (or other therapeutic entities).
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Renal clearance of quantum dots
Soo Choi, H., Liu, W., Misra, P., Tanaka, E., Zimmer, J. P., Itty Ipe, B., Bawendi, M. G., & Frangioni, J. V. (2007) · Nature Biotechnology · doi:10.1038/nbt1340 · Cited by 4,476
Nanoparticle therapeutics: an emerging treatment modality for cancer
Davis, M. E., Chen, Z., & Shin, D. M. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2614 · Cited by 4,233
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The Effect of Nanoparticle Size on In Vivo Pharmacokinetics and Cellular Interaction
Hoshyar, N., Gray, S., Han, H., & Bao, G. (2016) · Nanomedicine · doi:10.2217/nnm.16.5 · Cited by 1,990
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Manzari, M. T., Shamay, Y., Kiguchi, H., Rosen, N., Scaltriti, M., & Heller, D. A. (2021) · Nature Reviews Materials · doi:10.1038/s41578-020-00269-6 · Cited by 1,183
Metadata
- Authors
- Zuckerman, J. E., Choi, C. H. J., Han, H., & Davis, M. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2012-02-06
- Volume
- 109
- Issue
- 8
- Pages
- 3137-3142
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2067302150
- Cited by
- 372
- References
- 2
- FWCI
- 11.85
- Type
- journal article
- Language
- en
- Open access
- green
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- Zuckerman, J. E., Choi, C. H. J., Han, H., & Davis, M. E. (2012). Polycation-siRNA nanoparticles can disassemble at the kidney glomerular basement membrane. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1200718109
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