Cited by 295Bacterial Genetics and BiotechnologyDNA Repair MechanismsEvolution and Genetic Dynamics

The DOI matches its Crossref record; 83 of the 85 references it cites were found in a registry or an index.

The SOS response regulates adaptive mutation

Open access

McKenzie, Gregory J., Harris, Reuben S., Lee, Peter L., Rosenberg, Susan M.·2000·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.120161797PMC PMC18688

Open this paper in CoChat — free account

Abstract

Upon starvation some Escherichia coli cells undergo a transient, genome-wide hypermutation (called adaptive mutation) that is recombination-dependent and appears to be a response to a stressful environment. Adaptive mutation may reflect an inducible mechanism that generates genetic variability in times of stress. Previously, however, the regulatory components and signal transduction pathways controlling adaptive mutation were unknown. Here we show that adaptive mutation is regulated by the SOS response, a complex, graded response to DNA damage that includes induction of gene products blocking cell division and promoting mutation, recombination, and DNA repair. We find that SOS-induced levels of proteins other than RecA are needed for adaptive mutation. We report a requirement of RecF for efficient adaptive mutation and provide evidence that the role of RecF in mutation is to allow SOS induction. We also report the discovery of an SOS-controlled inhibitor of adaptive mutation, PsiB. These results indicate that adaptive mutation is a tightly regulated response, controlled both positively and negatively by the SOS system.

Integrity signals

Registry

Crossref · 10.1073/pnas.120161797

Cites

83 of 83 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Escherichia coli and Salmonella :cellular and molecular biology
Neidhardt, F. C. (1996) · ASM Press eBooks · Cited by 8,197
DNA Repair and Mutagenesis
Friedberg, E. C., Walker, G. C., Siede, W., Wood, R. D., Schultz, R. A., & Ellenberger, T. (2005) · doi:10.1128/9781555816704 · Cited by 5,683
A short course in bacterial genetics
Miller, J. H. (1992) · Cited by 4,391
DNA repair and mutagenesis
Bootsma, D., & Hoeijmakers, J. H. J. (1996) · Trends in Genetics · doi:10.1016/0168-9525(96)81408-9 · Cited by 2,285
The origin of mutants
Cairns, J., Overbaugh, J., & Miller, S. (1988) · Nature · doi:10.1038/335142a0 · Cited by 1,025
SOS Repair Hypothesis: Phenomenology of an Inducible DNA Repair Which is Accompanied by Mutagenesis
Radman, M. (1975) · Springer eBooks · doi:10.1007/978-1-4684-2895-7_48 · Cited by 666
Cleavage of the Escherichia coli lexA protein by the recA protease.
Little, J. W., Edmiston, S. H., Pacelli, L. Z., & Mount, D. W. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.6.3225 · Cited by 546
Nature of the SOS-inducing signal in Escherichia coli
Sassanfar, M., & Roberts, J. W. (1990) · Journal of Molecular Biology · doi:10.1016/0022-2836(90)90306-7 · Cited by 541
DNA-damaging agents stimulate gene expression at specific loci in Escherichia coli.
Kenyon, C. J., & Walker, G. C. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.5.2819 · Cited by 537
UmuD′ 2 C is an error-prone DNA polymerase, Escherichia coli pol V
Tang, M., Shen, X., Frank, E. G., O’Donnell, M. E., Woodgate, R., & Goodman, M. F. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.16.8919 · Cited by 537
Adaptive reversion of a frameshift mutation in Escherichia coli.
Cairns, J., & Foster, P. L. (1991) · Genetics · doi:10.1093/genetics/128.4.695 · Cited by 493
The dinB Gene Encodes a Novel E. coli DNA Polymerase, DNA Pol IV, Involved in Mutagenesis
Wagner, J. E., Grúz, P., Kim, S.-R., Yamada, M., Matsui, K., Fuchs, R. P., & Nohmi, T. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80376-7 · Cited by 474
RecA Protein: Structure, Function, and Role in Recombinational DNA Repair
Roca, A. I., & Cox, M. M. (1997) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(08)61005-3 · Cited by 426
DNA double‐strand breaks caused by replication arrest
Michel, B., Ehrlich, S. D., & Uzest, M. (1997) · The EMBO Journal · doi:10.1093/emboj/16.2.430 · Cited by 426
Collapse and repair of replication forks in Escherichia coli
Kuzminov, A. (1995) · Molecular Microbiology · doi:10.1111/j.1365-2958.1995.tb02403.x · Cited by 363
Multiple pathways for SOS-induced mutagenesis in Escherichia coli: an overexpression of dinB/dinP results in strongly enhancing mutagenesis in the absence of any exogenous treatment to damage DNA.
Kim, S.-R., Maenhaut-Michel, G., Yamada, M., Yamamoto, Y., Matsui, K., Sofuni, T., Nohmi, T., & Ohmori, H. (1997) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.94.25.13792 · Cited by 343
Dominant Mutations ( lex ) in Escherichia coli K-12 Which Affect Radiation Sensitivity and Frequency of Ultraviolet Light-Induced Mutations
Mount, D. W., Low, K. B., & Edmiston, S. H. (1972) · Journal of Bacteriology · doi:10.1128/jb.112.2.886-893.1972 · Cited by 304
Interspecies gene exchange in bacteria: The role of SOS and mismatch repair systems in evolution of species
Matić, I., Rayssiguier, C., & Radman, M. (1995) · Cell · doi:10.1016/0092-8674(95)90501-4 · Cited by 302
Genome‐wide hypermutation in a subpopulation of stationary‐phase cells underlies recombination‐dependent adaptive mutation
Torkelson, J. D., Harris, R. S., Lombardo, M., Nagendran, J., Thulin, C., & Rosenberg, S. M. (1997) · EMBO Journal · doi:10.1093/emboj/16.11.3303 · Cited by 273
Self-citation
Recombination in Adaptive Mutation
Harris, R. S., Longerich, S., & Rosenberg, S. M. (1994) · Science · doi:10.1126/science.8146657 · Cited by 262
Self-citation
ADAPTIVE MUTATION: The Uses of Adversity
Foster, P. L. (1993) · Annual Review of Microbiology · doi:10.1146/annurev.mi.47.100193.002343 · Cited by 262
Inhibition of FtsZ polymerization by SulA, an inhibitor of septation in Escherichia coli
Mukherjee, A., Cao, C., & Lutkenhaus, J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.2885 · Cited by 247
A mutant of Escherichia coli showing constitutive expression of the lysogenic induction and error-prone DNA repair pathways.
Mount, D. W. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.1.300 · Cited by 230
Adaptive mutation by deletions in small mononucleotide repeats.
Rosenberg, S. M., Longerich, S., Gee, P., & Harris, R. S. (1994) · Science · doi:10.1126/science.8023163 · Cited by 229
Self-citation
Plant responses to environmental stress
Vierling, E., & Kimpel, J. A. (1992) · Current Opinion in Biotechnology · doi:10.1016/0958-1669(92)90147-b · Cited by 210
Plant Responses to Environmental Stresses: From Phytohormones to Genome Reorganization
Tudzynski, B. (2001) · Phytochemistry · doi:10.1016/s0031-9422(00)00375-7 · Cited by 209
Homologous Genetic Recombination: The Pieces Begin to Fall into Place
Clark, A. J., & Sandler, S. J. (1994) · Critical Reviews in Microbiology · doi:10.3109/10408419409113552 · Cited by 197
cAMP-dependent SOS induction and mutagenesis in resting bacterial populations.
Taddéi, F., Matić, I., & Radman, M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.25.11736 · Cited by 197
Adaptive Reversion of a Frameshift Mutation in Escherichia coli by Simple Base Deletions in Homopolymeric Runs
Foster, P. L., & Trimarchi, J. M. (1994) · Science · doi:10.1126/science.8023164 · Cited by 192
Bacterial SOS Checkpoint Protein SulA Inhibits Polymerization of Purified FtsZ Cell Division Protein
Trusca, D., Scott, S., Thompson, C., & Bramhill, D. (1998) · Journal of Bacteriology · doi:10.1128/jb.180.15.3946-3953.1998 · Cited by 187
χ AND THE RecBC D ENZYME OF ESCHERICHIA COLI
Myers, R. S., & Stahl, F. W. (1994) · Annual Review of Genetics · doi:10.1146/annurev.ge.28.120194.000405 · Cited by 186
Mismatch repair protein MutL becomes limiting during stationary-phase mutationPreprint
Harris, R. S., Feng, G., Ross, K. J., Sidhu, R., Thulin, C., Longerich, S., Szigety, S. K., Winkler, M. E., & Rosenberg, S. M. (1997) · Genes & Development · doi:10.1101/gad.11.18.2426 · Cited by 155
Self-citation
Two Enzymes, Both of Which Process Recombination Intermediates, Have Opposite Effects on Adaptive Mutation in Escherichia coli
Foster, P. L., Trimarchi, J. M., & Maurer, R. (1996) · Genetics · doi:10.1093/genetics/142.1.25 · Cited by 148
Opposing Roles of the Holliday Junction Processing Systems of Escherichia coli in Recombination-Dependent Adaptive Mutation
Harris, R. S., Ross, K. J., & Rosenberg, S. M. (1996) · Genetics · doi:10.1093/genetics/142.3.681 · Cited by 142
Self-citation
Control of recA gene RNA in E. coli: Regulatory and signal genes
McPartland, A., Green, L., & Echols, H. (1980) · Cell · doi:10.1016/0092-8674(80)90319-0 · Cited by 137
The role of transient hypermutators in adaptive mutation in Escherichia coli.
Rosche, W. A., & Foster, P. L. (1999) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.96.12.6862 · Cited by 137
Adaptive reversion of an episomal frameshift mutation in Escherichia coli requires conjugal functions but not actual conjugation.
Foster, P. L., & Trimarchi, J. M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5487 · Cited by 137
SPONTANEOUS MUTATION
Drake, J. W. (1991) · Annual Review of Genetics · doi:10.1146/annurev.ge.25.120191.001013 · Cited by 135
Evidence that F plasmid transfer replication underlies apparent adaptive mutation.
Galitski, T., & Roth, J. R. (1995) · Science · doi:10.1126/science.7716546 · Cited by 133
DNA polymerase II is encoded by the DNA damage-inducible dinA gene of Escherichia coli.
Bonner, C. A., Hays, S. L., McEntee, K., & Goodman, M. F. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.19.7663 · Cited by 130
Role of RecA protein in untargeted UV mutagenesis of bacteriophage lambda: evidence for the requirement for the dinB gene.
Brotcorne-Lannoye, A., & Maenhaut-Michel, G. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.11.3904 · Cited by 125
Nucleotide sequence of the lexA gene of E. coli
Horii, T., Ogawa, T., & Ogawa, H. (1981) · Cell · doi:10.1016/0092-8674(81)90432-3 · Cited by 124
Genetic requirements and mutational specificity of the Escherichia coli SOS mutator activity
Fijałkowska, I. J., Dunn, R. L., & Schaaper, R. M. (1997) · Journal of Bacteriology · doi:10.1128/jb.179.23.7435-7445.1997 · Cited by 119
Transient and Heritable Mutators in Adaptive Evolution in the Lab and in Nature
Rosenberg, S. M., Thulin, C., & Harris, R. S. (1998) · Genetics · doi:10.1093/genetics/148.4.1559 · Cited by 114
Self-citation
Construction of a umuDC operon substitution mutation in Escherichia coli
Woodgate, R. (1992) · Mutation Research Letters · doi:10.1016/0165-7992(92)90012-7 · Cited by 112
Proofreading-defective DNA polymerase II increases adaptive mutation in Escherichia coli.
Foster, P. L., Gudmundsson, G., Trimarchi, J. M., Cai, H., & Goodman, M. F. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.17.7951 · Cited by 109
Isolation and characterization of noncleavable (Ind-) mutants of the LexA repressor of Escherichia coli K-12
Lin, L.-L., & Little, J. W. (1988) · Journal of Bacteriology · doi:10.1128/jb.170.5.2163-2173.1988 · Cited by 105
The Escherichia coli polB gene, which encodes DNA polymerase II, is regulated by the SOS system
Iwasaki, H., Nakata, A., Walker, G. C., & Shinagawa, H. (1990) · Journal of Bacteriology · doi:10.1128/jb.172.11.6268-6273.1990 · Cited by 93
Nucleotide sequence of the lexA gene of Escherichia coli K-12
Markham, B. E., Little, J. W., & Mount, D. W. (1981) · Nucleic Acids Research · doi:10.1093/nar/9.16.4149 · Cited by 90
Molecular analysis of the recF gene of Escherichia coli.
Blanar, M. A., Sandler, S. J., Armengod, M. E., Ream, L. W., & Clark, A. J. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.15.4622 · Cited by 88
Autodigestion and RecA-dependent cleavage of Ind− mutant LexA proteins
Lin, L.-L., & Little, J. W. (1989) · Journal of Molecular Biology · doi:10.1016/0022-2836(89)90121-6 · Cited by 87
Inhibition of Escherichia coli RecA coprotease activities by DinI
Yasuda, T., Morimatsu, K., Horii, T., Nagata, T., & Ohmori, H. (1998) · The EMBO Journal · doi:10.1093/emboj/17.11.3207 · Cited by 87
Adaptive mutation sequences reproduced by mismatch repair deficiency.
Longerich, S., Galloway, A. M., Harris, R. S., Wong, C., & Rosenberg, S. M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.26.12017 · Cited by 81
Self-citation
PsiB, an anti‐SOS protein, is transiently expressed by the F sex factor during its transmission to an Escherichia coli K‐12 recipient
Bagdasarian, M. M., Bailone, A., Angulo, J. F., Scholz, P., Bagdasarian, M., & Devoret, R. (1992) · Molecular Microbiology · doi:10.1111/j.1365-2958.1992.tb01539.x · Cited by 78
Double-strand-break repair recombination in Escherichia coli: physical evidence for a DNA replication mechanism in vivoPreprint
Motamedi, M. R., Szigety, S. K., & Rosenberg, S. M. (1999) · Genes & Development · doi:10.1101/gad.13.21.2889 · Cited by 77
Self-citation
Somatic hypermutation and the three R's: repair, replication and recombination
Harris, R. S., Kong, Q., & Maizels, N. (1999) · Mutation Research/Reviews in Mutation Research · doi:10.1016/s1383-5742(99)00003-4 · Cited by 74
Self-citation
Hypermutation in derepressed operons of Escherichia coli K12
Wright, B. E., Longacre, A., & Reimers, J. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.9.5089 · Cited by 73
Escherichia coli MutY protein has a guanine-DNA glycosylase that acts on 7,8-dihydro-8-oxoguanine:guanine mispair to prevent spontaneous G:C->C:G transversions
Zhang, Q.-M., Ishikawa, N., Nakahara, T., & Yonei, S. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.20.4669 · Cited by 72
Mutation for survival.
Rosenberg, S. M. (1997) · Current Opinion in Genetics and Development · doi:10.1016/s0959-437x(97)80047-0 · Cited by 70
Self-citation
Mismatch repair is diminished during stationary-phase mutation.
Harris, R. S., Feng, G., Ross, K. J., Sidhu, R., Thulin, C., Longerich, S., Szigety, S. K., Hastings, P. J., Winkler, M. E., & Rosenberg, S. M. (1999) · PubMed · Cited by 68
Self-citation
Genetic analysis of mutagenesis in aging Escherichia coli colonies
Taddéi, F., Halliday, J. A., Matić, I., & Radman, M. (1997) · Molecular and General Genetics MGG · doi:10.1007/s004380050570 · Cited by 67
Reconstitution of an SOS Response Pathway
Anderson, D. G., & Kowalczykowski, S. C. (1998) · Cell · doi:10.1016/s0092-8674(00)81721-3 · Cited by 66
Embryonic Encyclopedia of Life Sciences
Gilmour, R. (2001) · Reference Reviews · doi:10.1108/rr.2001.15.2.36.96 · Cited by 62
Some Features of the Mutability of Bacteria During Nonlethal Selection
Godoy, V. G., Gizatullin, F., & Fox, M. S. (2000) · Genetics · doi:10.1093/genetics/154.1.49 · Cited by 60
Evidence That Stationary-Phase Hypermutation in the Escherichia coli Chromosome Is Promoted by Recombination
Bull, H. J., McKenzie, G. J., Hastings, P. J., & Rosenberg, S. M. (2000) · Genetics · doi:10.1093/genetics/154.4.1427 · Cited by 60
Self-citation
Molecular handles on adaptive mutation
Rosenberg, S. M., Harris, R. S., & Torkelson, J. D. (1995) · Molecular Microbiology · doi:10.1111/j.1365-2958.1995.mmi_18020185.x · Cited by 56
Self-citation
A direct role for DNA polymerase III in adaptive reversion of a frameshift mutation in Escherichia coli.
Harris, R. S., Bull, H. J., & Rosenberg, S. M. (1997) · Mutation research · doi:10.1016/s0027-5107(96)00244-8 · Cited by 52
Self-citation
ATP Hydrolysis and DNA Binding by the Escherichia coli RecF Protein
Webb, B. L., Cox, M. M., & Inman, R. B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.22.15367 · Cited by 50
Hypermutability in Carcinogenesis
Strauss, B. S. (1998) · Genetics · doi:10.1093/genetics/148.4.1619 · Cited by 49
Hypermutation under stress
Bridges, B. A. (1997) · Nature · doi:10.1038/42370 · Cited by 48
The effect of the stringent response on mutation rates in Escherichia coli K‐12
Wright, B. E. (1996) · Molecular Microbiology · doi:10.1046/j.1365-2958.1996.367892.x · Cited by 39
Recombination-dependent mutation in Escherichia coli occurs in stationary phase.
McKenzie, G. J., Lombardo, M., & Rosenberg, S. M. (1998) · Genetics · doi:10.1093/genetics/149.2.1163 · Cited by 39
Self-citation
Recombination-dependent mutation in non-dividing cells.
Rosenberg, S. M., Harris, R. S., Longerich, S., & Galloway, A. (1996) · Mutation research · doi:10.1016/0027-5107(95)00092-5 · Cited by 37
Self-citation
SOS induction in Escherichia coli by infection with mutant filamentous phage that are defective in initiation of complementary-strand DNA synthesis
Higashitani, N., Higashitani, A., Roth, A., & HORIUCHI, K. (1992) · Journal of Bacteriology · doi:10.1128/jb.174.5.1612-1618.1992 · Cited by 36
Adaptive Mutagenesis at ebgR Is Regulated by PhoPQ
Hall, B. G. (1998) · Journal of Bacteriology · doi:10.1128/jb.180.11.2862-2865.1998 · Cited by 35
Evidence that rnmB is the operator of the Escherichia coli recA gene.
Volkert, M. R., Margossian, L. J., & Clark, A. J. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.3.1786 · Cited by 35
Discussion
Finch, C. E., & Goodman, M. F. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01143-0 · Cited by 30
Discussion
(1999) · Mutation Research/Reviews in Mutation Research · doi:10.1016/s1383-5742(99)00064-2 · Cited by 30
Selection-induced mutations.
Hall, B. G. (1992) · Current Opinion in Genetics and Development · doi:10.1016/s0959-437x(05)80120-0 · Cited by 26
The β subunit sliding DNA clamp is responsible for unassisted mutagenic translesion replication by DNA polymerase III holoenzyme
Tomer, G., Reuven, N. B., & Livneh, Z. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.24.14106 · Cited by 23
A UmuD,C-dependent pathway for spontaneous G:C to C:G transversions in stationary phase Escherichia coli mut Y
Timms, A. R., Muriel, W. J., & Bridges, B. A. (1999) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(99)00035-x · Cited by 21
Mechanisms of Genome‐Wide Hypermutation in Stationary Phasea
Lombardo, M., Torkelson, J. D., Bull, H. J., McKenzie, G. J., & Rosenberg, S. M. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb08888.x · Cited by 19
Self-citation
Hypermutation in stationary-phaseE. coli: tales from thelac operon
Lombardo, M., & Rosenberg, S. M. (1999) · Journal of Genetics · doi:10.1007/bf02994698 · Cited by 10
Self-citation

Research works printed but not linked: 2

M Radman Basic Life Sci 5A, 355–367 (1975).
R S Harris Ph.D. Thesis (University of Alberta, Edmonton, Alberta, Canada, 1997).

Sorted by citations

Signals, Regulatory Networks, and Materials That Build and Break Bacterial Biofilms
Karatan, E., & Watnick, P. I. (2009) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00041-08 · Cited by 1,099
Mutation as a Stress Response and the Regulation of Evolvability
Galhardo, R. S., Hastings, P. J., & Rosenberg, S. M. (2007) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230701648502 · Cited by 643
Self-citation
Cell Death in Pseudomonas aeruginosa Biofilm Development
Webb, J. S., Thompson, L. S., James, S., Charlton, T., Tolker‐Nielsen, T., Koch, B. M., Givskov, M., & Kjelleberg, S. J. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.15.4585-4592.2003 · Cited by 600
Stress-Induced Mutagenesis in Bacteria
Bjedov, I., Tenaillon, O., Gérard, B., Souza, V., Denamur, É., Radman, M., Taddéi, F., & Matić, I. (2003) · Science · doi:10.1126/science.1082240 · Cited by 588
Antimicrobial resistance: Prevalence, economic burden, mechanisms of resistance and strategies to overcome
Pulingam, T., Parumasivam, T., Gazzali, A. M., Sulaiman, A. M., Chee, J. Y., Lakshmanan, M., Chin, C. F., & Sudesh, K. (2021) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2021.106103 · Cited by 591

See all 295

Authors: McKenzie, G. J., Harris, R. S., Lee, P. L., & Rosenberg, S. M.
Affiliations: University of Alberta (CA)
ORCID: Harris, Reuben S.
Rosenberg, Susan M.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2000-05-30
Volume: 97
Issue: 12
Pages: 6646-6651
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.120161797
PMC: PMC18688
OpenAlex: W2037722651
Cited by: 295
References: 85
Citations by year: 2026: 5 · 2025: 8 · 2024: 12 · 2023: 16 · 2022: 16 · 2021: 9 · 2020: 8 · 2019: 12 · 2018: 28 · 2017: 6 · 2016: 12 · 2015: 3 · 2014: 6 · 2013: 7 · 2012: 12
FWCI: 8.70
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Defense
Fondation pour la Recherche Médicale
National Institutes of Health (5r01ai043917-05)
National Institute of General Medical Sciences (R01GM053158)
National Institute of Allergy and Infectious Diseases (R01-AI43917)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Keywords: adaptive mutation, SOS response, Escherichia coli, starvation, recF, RecA, DNA damage response, signal transduction regulation
MeSH terms: LexA Repressor Protein, Adaptation, Physiological, Bacterial Proteins, DNA Repair, DNA-Binding Proteins, Mutation, Serine Endopeptidases, SOS Response, Genetics, Signal Transduction, Regulon, Escherichia coli Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The SOS response regulates adaptive mutation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks