Cited by 295Bacterial Genetics and BiotechnologyDNA Repair MechanismsEvolution and Genetic Dynamics

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The SOS response regulates adaptive mutation

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McKenzie, Gregory J., Harris, Reuben S., Lee, Peter L., Rosenberg, Susan M.·2000·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.120161797PMC PMC18688

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Abstract

Upon starvation some Escherichia coli cells undergo a transient, genome-wide hypermutation (called adaptive mutation) that is recombination-dependent and appears to be a response to a stressful environment. Adaptive mutation may reflect an inducible mechanism that generates genetic variability in times of stress. Previously, however, the regulatory components and signal transduction pathways controlling adaptive mutation were unknown. Here we show that adaptive mutation is regulated by the SOS response, a complex, graded response to DNA damage that includes induction of gene products blocking cell division and promoting mutation, recombination, and DNA repair. We find that SOS-induced levels of proteins other than RecA are needed for adaptive mutation. We report a requirement of RecF for efficient adaptive mutation and provide evidence that the role of RecF in mutation is to allow SOS induction. We also report the discovery of an SOS-controlled inhibitor of adaptive mutation, PsiB. These results indicate that adaptive mutation is a tightly regulated response, controlled both positively and negatively by the SOS system.

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Escherichia coli and Salmonella :cellular and molecular biology
Neidhardt, F. C. (1996) · ASM Press eBooks · Cited by 8,197
DNA Repair and Mutagenesis
Friedberg, E. C., Walker, G. C., Siede, W., Wood, R. D., Schultz, R. A., & Ellenberger, T. (2005) · doi:10.1128/9781555816704 · Cited by 5,683
A short course in bacterial genetics
Miller, J. H. (1992) · Cited by 4,391
DNA repair and mutagenesis
Bootsma, D., & Hoeijmakers, J. H. J. (1996) · Trends in Genetics · doi:10.1016/0168-9525(96)81408-9 · Cited by 2,285
The origin of mutants
Cairns, J., Overbaugh, J., & Miller, S. (1988) · Nature · doi:10.1038/335142a0 · Cited by 1,025
SOS Repair Hypothesis: Phenomenology of an Inducible DNA Repair Which is Accompanied by Mutagenesis
Radman, M. (1975) · Springer eBooks · doi:10.1007/978-1-4684-2895-7_48 · Cited by 666
Cleavage of the Escherichia coli lexA protein by the recA protease.
Little, J. W., Edmiston, S. H., Pacelli, L. Z., & Mount, D. W. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.6.3225 · Cited by 546
Nature of the SOS-inducing signal in Escherichia coli
Sassanfar, M., & Roberts, J. W. (1990) · Journal of Molecular Biology · doi:10.1016/0022-2836(90)90306-7 · Cited by 541
DNA-damaging agents stimulate gene expression at specific loci in Escherichia coli.
Kenyon, C. J., & Walker, G. C. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.5.2819 · Cited by 537
UmuD′ 2 C is an error-prone DNA polymerase, Escherichia coli pol V
Tang, M., Shen, X., Frank, E. G., O’Donnell, M. E., Woodgate, R., & Goodman, M. F. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.16.8919 · Cited by 537

Show all 85 references

Research works printed but not linked: 2

M Radman Basic Life Sci 5A, 355–367 (1975).
R S Harris Ph.D. Thesis (University of Alberta, Edmonton, Alberta, Canada, 1997).

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Authors: McKenzie, G. J., Harris, R. S., Lee, P. L., & Rosenberg, S. M.
Affiliations: University of Alberta (CA)
ORCID: Harris, Reuben S.
Rosenberg, Susan M.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2000-05-30
Volume: 97
Issue: 12
Pages: 6646-6651
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.120161797
PMC: PMC18688
OpenAlex: W2037722651
Cited by: 295
References: 85
Citations by year: 2026: 5 · 2025: 8 · 2024: 12 · 2023: 16 · 2022: 16 · 2021: 9 · 2020: 8 · 2019: 12 · 2018: 28 · 2017: 6 · 2016: 12 · 2015: 3 · 2014: 6 · 2013: 7 · 2012: 12
FWCI: 8.70
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Defense
Fondation pour la Recherche Médicale
National Institutes of Health (5r01ai043917-05)
National Institute of General Medical Sciences (R01GM053158)
National Institute of Allergy and Infectious Diseases (R01-AI43917)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Keywords: adaptive mutation, SOS response, Escherichia coli, starvation, recF, RecA, DNA damage response, signal transduction regulation
MeSH terms: LexA Repressor Protein, Adaptation, Physiological, Bacterial Proteins, DNA Repair, DNA-Binding Proteins, Mutation, Serine Endopeptidases, SOS Response, Genetics, Signal Transduction, Regulon, Escherichia coli Proteins

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The SOS response regulates adaptive mutation

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