The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Mechanisms of white matter changes induced by meditation
Open accessAbstract
Using diffusion tensor imaging, several recent studies have shown that training results in changes in white matter efficiency as measured by fractional anisotropy (FA). In our work, we found that a form of mindfulness meditation, integrative body-mind training (IBMT), improved FA in areas surrounding the anterior cingulate cortex after 4-wk training more than controls given relaxation training. Reductions in radial diffusivity (RD) have been interpreted as improved myelin but reductions in axial diffusivity (AD) involve other mechanisms, such as axonal density. We now report that after 4-wk training with IBMT, both RD and AD decrease accompanied by increased FA, indicating improved efficiency of white matter involves increased myelin as well as other axonal changes. However, 2-wk IBMT reduced AD, but not RD or FA, and improved moods. Our results demonstrate the time-course of white matter neuroplasticity in short-term meditation. This dynamic pattern of white matter change involving the anterior cingulate cortex, a part of the brain network related to self-regulation, could provide a means for intervention to improve or prevent mental disorders.
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“A longitudinal study in healthy students showed decreased RAD and AXD accompanied by increased FA after a 4-week integrative body-mind training compared to a relaxation training (Tang et al., 2012).”
From Acceptance and Commitment Therapy and white matter plasticity in individuals with subclinical depression and psychotic experiences: A Randomised Controlled Trial (2023) · cites this paper as Tang et al., 2012
In the citing paper
“For example, enhanced activation of the ACC and other prefrontal regions was observed in novice and experienced meditators (120–122), and as a result of ayahuasca administration (33, 63).”
From Examining the Potential Synergistic Effects Between Mindfulness Training and Psychedelic-Assisted Therapy (2021) · cites this paper as [122]
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Advances in functional and structural MR image analysis and implementation as FSL
Smith, S. M., Jenkinson, M., Woolrich, M. W., Beckmann, C. F., Behrens, T. E. J., Johansen-Berg, H., Bannister, P. R., De Luca, M., Drobnjak, I., Flitney, D. E., et al. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.07.051 · Cited by 13,630
Tract-based spatial statistics: Voxelwise analysis of multi-subject diffusion data
Smith, S. M., Jenkinson, M., Johansen‐Berg, H., Rueckert, D., Nichols, T. E., Mackay, C. E., Watkins, K. E., Ciccarelli, O., Cader, M. Z., Matthews, P. M., et al. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.02.024 · Cited by 6,598
Cognitive and emotional influences in anterior cingulate cortex
Bush, G., Luu, P., & Posner, M. I. (2000) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(00)01483-2 · Cited by 6,259
Self-citationNonrigid registration using free-form deformations: application to breast mr images
Rueckert, D., Sonoda, L. I., Hayes, C., Hill, D. L. G., Leach, M. O., & Hawkes, D. J. (1999) · IEEE Transactions on Medical Imaging · doi:10.1109/42.796284 · Cited by 5,265
SMITH, S., & NICHOLS, T. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2008.03.061 · Cited by 5,250
Hölzel, B. K., Lazar, S. W., Gard, T., Schuman-Olivier, Z., Vago, D. R., & Ott, U. (2011) · Perspectives on Psychological Science · doi:10.1177/1745691611419671 · Cited by 3,024
Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water
Song, S.-K., Sun, S.-W., Ramsbottom, M. J., Chang, C., Russell, J., & Cross, A. H. (2002) · NeuroImage · doi:10.1006/nimg.2002.1267 · Cited by 2,582
Song, S.-K., Sun, S.-W., Ju, W.-K., Lin, S.-J., Cross, A. H., & Neufeld, A. H. (2003) · NeuroImage · doi:10.1016/j.neuroimage.2003.07.005 · Cited by 1,738
Plasticity in gray and white: neuroimaging changes in brain structure during learning
Zatorre, R. J., Fields, R. D., & Johansen-Berg, H. (2012) · Nature Neuroscience · doi:10.1038/nn.3045 · Cited by 1,685
Short-term meditation training improves attention and self-regulation
Tang, Y.-Y., Ma, Y., Wang, J., Fan, Y., Feng, S., Lu, Q., Yu, Q., Sui, D., Rothbart, M. K., Fan, M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707678104 · Cited by 1,597
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The Neuroscience of Mindfulness Meditation
Tang, Y.-Y., Hölzel, B. K., & Posner, M. I. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn3916 · Cited by 2,889
Self-citationFox, K. C. R., Nijeboer, S., Dixon, M. L., Floman, J. L., Ellamil, M., Rumak, S. P., Sedlmeier, P., & Christoff, K. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.03.016 · Cited by 804
Brühl, A. B., Delsignore, A., Komossa, K., & Weidt, S. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.08.003 · Cited by 439
“2012) including the connectivity in the respective circuits (Tang et al., 2012).”
White matter injury in ischemic stroke
Wang, Y., Liu, G., Hong, D., Chen, F., Ji, X., & Cao, G. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.04.005 · Cited by 316
Mindfulness meditation improves emotion regulation and reduces drug abuse
Tang, Y.-Y., Tang, R., & Posner, M. I. (2016) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2015.11.041 · Cited by 306
Self-citation
Metadata
- Authors
- Tang, Y.-Y., Lu, Q., Fan, M., Yang, Y., & Posner, M. I.
- Affiliations
- Texas Tech University (US)
- Dalian University of Technology (CN)
- Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences (CN)
- National Institutes of Health (US)
- University of Oregon (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2012-06-11
- Volume
- 109
- Issue
- 26
- Pages
- 10570-10574
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3387117
- OpenAlex
- W1988224232
- Cited by
- 335
- References
- 46
- Citations by year
- 2026: 9 · 2025: 9 · 2024: 13 · 2023: 26 · 2022: 15 · 2021: 14 · 2020: 23 · 2019: 30 · 2018: 33 · 2017: 36 · 2016: 22 · 2015: 33 · 2014: 36 · 2013: 28 · 2012: 8
- FWCI
- 38.02
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (R21DA030066)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- mindfulness meditation, white matter plasticity, fractional anisotropy, radial diffusivity, axial diffusivity, anterior cingulate cortex, myelination, axon density, mood, self-regulation, neuroplasticity
- MeSH terms
- Brain, Humans, Myelin Sheath, Meditation, Self Efficacy
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