Stress-induced epigenetic transcriptional memory of acetylcholinesterase by HDAC4

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Aberrant Expression of Histone Deacetylases 4 in Cognitive Disorders: Molecular Mechanisms and a Potential Target

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Moringa isothiocyanate-1 regulates Nrf2 and NF-κB pathway in response to LPS-driven sepsis and inflammation

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Modulation of Nerve Injury–induced HDAC4 Cytoplasmic Retention Contributes to Neuropathic Pain in Rats

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HDAC4 Does Not Act as a Protein Deacetylase in the Postnatal Murine Brain In Vivo

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Bisphenol A single and repeated treatment increases HDAC2, leading to cholinergic neurotransmission dysfunction and SN56 cholinergic apoptotic cell death through AChE variants overexpression and NGF/TrkA/P75NTR signaling disruption

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Neonatal Lipopolysaccharide Challenge Induces Long-lasting Spatial Cognitive Impairment and Dysregulation of Hippocampal Histone Acetylation in Mice

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Autism Spectrum Disorder: A Neuro-Immunometabolic Hypothesis of the Developmental Origins

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Protective Role of Acetate Against Depressive-Like Behaviour Associated with Letrozole-Induced PCOS Rat Model: Involvement of HDAC2 and DNA Methylation

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New perspectives for multi-level regulations of neuronal acetylcholinesterase by dioxins

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α7 Nicotinic Acetylcholine Receptor Signaling Modulates Ovine Fetal Brain Astrocytes Transcriptome in Response to Endotoxin

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Apocynin Prevents Abnormal Megakaryopoiesis and Platelet Activation Induced by Chronic Stress

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Behavioral stress reduces RIP140 expression in astrocyte and increases brain lipid accumulation

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A natural antisense transcript regulates acetylcholinesterase gene expression via epigenetic modification in Hepatocellular Carcinoma

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Dioxin and Dioxin-Like Compounds Suppress Acetylcholinesterase Activity via Transcriptional Downregulations In Vitro

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The characterization of an intestine-like genomic signature maintained during Barrett’s-associated adenocarcinogenesis reveals an NR5A2-mediated promotion of cancer cell survival

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The Stress-Responding miR-132-3p Shows Evolutionarily Conserved Pathway Interactions

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Differentiation of human glioblastoma U87 cells into cholinergic neuron

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Gut feeling: MicroRNA discriminators of the intestinal TLR9–cholinergic links

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Impairments in laterodorsal tegmentum to VTA projections underlie glucocorticoid-triggered reward deficits

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Histone deacetylase 4 (HDAC4): a new player in anorexia nervosa?

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A novel understanding of postoperative complications: In vitro study of the impact of propofol on epigenetic modifications in cholinergic genes

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Butyrate reduction and HDAC4 increase underlie maternal high fructose-induced metabolic dysfunction in hippocampal astrocytes in female rats

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Apocynin Prevents Anxiety-Like Behavior and Histone Deacetylases Overexpression Induced by Sub-Chronic Stress in Mice

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Grafting improves drought stress memory by increasing the P5CS1 gene expression in Brassica rapa

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Cognitive Improvement by Vorinostat through Modulation of Endoplasmic Reticulum Stress in a Corticosterone-Induced Chronic Stress Model in Mice

K V, A., Madhana, R. M., Bais, A. K., Singh, V. B., Malik, A., Sinha, S., Lahkar, M., Kumar, P., & Samudrala, P. K. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00315 · Cited by 15

Cholinesterase Inhibitors

Waiskopf, N., & Soreq, H. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800159-2.00052-x · Cited by 15

UHRF2 decreases H3K9ac expression by interacting with it through the PHD and SRA/YDG domain in HepG2 hepatocellular carcinoma cells

Zhang, T., Linglin, Z., Zeng, S., Bai, L., Chen, J., Zhang, Z., Wang, Y., & Duan, C. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2805 · Cited by 14

Histone Deacetylase 4 Controls Extracellular Matrix Production in Orbital Fibroblasts from Graves' Ophthalmopathy Patients

Ekronarongchai, S., Palaga, T., Saonanon, P., Pruksakorn, V., Hirankarn, N., van Hagen, P. M., Dik, W. A., & Virakul, S. (2021) · Thyroid · doi:10.1089/thy.2020.0948 · Cited by 14

Activation of HDAC4 and GR signaling contributes to stress-induced hyperalgesia in the medial prefrontal cortex of rats

Zhang, L., Chen, C., & Qi, J. (2020) · Brain Research · doi:10.1016/j.brainres.2020.147051 · Cited by 13

HP1BP3 expression determines maternal behavior and offspring survival

Garfinkel, B. P., Arad, S., Neuner, S. M., Netser, S., Wagner, S., Kaczorowski, C. C., Rosen, C. J., Gal, M., Soreq, H., & Orly, J. (2016) · Genes Brain & Behavior · doi:10.1111/gbb.12312 · Cited by 13

Serum cholinesterase activity is elevated in female diarrhea‐predominant irritable bowel syndrome patients compared to matched controls

Hod, K., Sperber, A. D., Maharshak, N., Ron, Y., Shapira, I., Zeltser, D., Rogowski, O., Berliner, S. A., Shenhar‐Tsarfaty, S., & Dekel, R. (2018) · Neurogastroenterology & Motility · doi:10.1111/nmo.13464 · Cited by 13

How Epigenetics Can Enhance Pig Welfare?

da Silva, A. N., Araújo, M. S., Pértille, F., & Zanella, A. J. (2021) · Animals · doi:10.3390/ani12010032 · Cited by 19

Sodium butyrate enhances fear extinction and rescues hippocampal acetylcholinesterase activity in a rat model of posttraumatic stress disorder

Mohammadi-Farani, A., Limoee, M., & Shirooie, S. (2021) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000633 · Cited by 11

Histone deacetylase inhibition abolishes stress-induced spatial memory impairment

Vargas-López, V., Lamprea, M. R., & Múnera, A. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.08.009 · Cited by 12

Prolonged 5-week and 12-week chronic stress differentially modulates CNS expression of pro- and anti-neuroinflammatory biomarkers, brain monoamines and affective behavior in adult zebrafish

Kotova, M. M., Amikishiev, S. V., Apukhtin, K. V., Galstyan, D. S., de Abreu, M. S., Stewart, A., Yang, L., & Kalueff, A. V. (2025) · Journal of Comparative Physiology B · doi:10.1007/s00360-025-01613-4 · Cited by 10

Sex differences in acetylcholinesterase modulation during spatial and fear memory extinction in the amygdala; an animal study in the single prolonged stress model of PTSD

Mohammadi-Farani, A., Farhangian, S., & Shirooie, S. (2022) · Research in Pharmaceutical Sciences · doi:10.4103/1735-5362.359435 · Cited by 9

Brain region-specific effects of immobilization stress on cholinesterases in mice

Valuskova, P., Farár, V., Janisova, K., Ondičová, K., Mravec, B., Květňanský, R., & Mysliveček, J. (2016) · Stress · doi:10.1080/10253890.2016.1263836 · Cited by 9

The effect of sodium channels on neurological/neuronal disorders: A systematic review

Bagheri, S., Haddadi, R., Saki, S., Kourosh‐Arami, M., & Komaki‬, A. (2021) · International Journal of Developmental Neuroscience · doi:10.1002/jdn.10153 · Cited by 8

OCT4 induces long-lived dedifferentiated kidney progenitors poised to redifferentiate in 3D kidney spheroids

Omer, D., Cohen-Zontag, O., Gnatek, Y., Harari‐Steinberg, O., Pleniceanu, O., Namestnikov, M., Cohen, A.-H., Nissim‐Rafinia, M., Tam, G., Tomer Kalisky, C., et al. (2023) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2023.04.005 · Cited by 6

Histone Deacetylation in Alzheimer’s Diseases (AD); Hope or Hype

Ateya, N. H., Al-Taie, S. F., Jasim, S. A., Uthirapathy, S., Chaudhary, K., Rani, P., Kundlas, M., Naidu, K. S., Amer, N. A., & Ahmed, J. K. (2025) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-025-01670-0 · Cited by 7

The Current and Future Role of Drugs and Probiotics in the Management of Inflammatory Bowel Disease

de Souza, M. D. S. S., Barbalho, S. M., Goulart, R. D. Á., & de Carvalho, A. D. C. A. (2015) · Journal of Biosciences and Medicines · doi:10.4236/jbm.2015.38008 · Cited by 7

A non‐adaptationist hypothesis of play behaviour

Lewis, A. (2023) · The Journal of Physiology · doi:10.1113/jp284413 · Cited by 7

Pesticide tolerance induced by a generalized stress response in wood frogs (Rana sylvatica)

Billet, L. S., & Hoverman, J. T. (2020) · Ecotoxicology · doi:10.1007/s10646-020-02277-2 · Cited by 7

Role of histone deacetylases in neuroplasticity impairments and inflammation in major depression

Garayo, A., Azqueta, A., & Tordera, R. M. (2024) · Neuroscience Applied · doi:10.1016/j.nsa.2024.104081 · Cited by 7

Septohippocampal cholinergic system at the intersection of stress and cognition: Current trends and translational implications

Kniffin, A. R., Bangasser, D. A., & Parikh, V. (2023) · European Journal of Neuroscience · doi:10.1111/ejn.15999 · Cited by 7

Transcriptional activity of acetylcholinesterase gene is regulated by DNA methylation during C2C12 myogenesis

Lau, K. M., Gong, A. G. W., Xu, M. L., Lam, C. T. W., Zhang, L. M. L., Bi, C. W. C., Cui, D., Cheng, A. W. M., Dong, T. T.-X., Tsim, K. W. K., et al. (2016) · Brain Research · doi:10.1016/j.brainres.2016.03.013 · Cited by 5

Does stress remove the HDAC brakes for the formation and persistence of long-term memory?

White, A. O., & Wood, M. A. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.10.007 · Cited by 28

Previous History of Chronic Stress Changes the Transcriptional Response to Glucocorticoid Challenge in the Dentate Gyrus Region of the Male Rat Hippocampus

Datson, N. A., van den Oever, J. M. E., Korobko, O. B., Magariños, A. M., de Kloet, E. R., & McEwen, B. S. (2013) · Endocrinology · doi:10.1210/en.2012-2233 · Cited by 108

Class I histone deacetylases inhibition reverses memory impairment induced by acute stress in mice

Martínez-Pacheco, H., Zepeda, R. C., Picazo, O., Quirarte, G. L., & Roldán-Roldán, G. (2024) · PLoS ONE · doi:10.1371/journal.pone.0302374 · Cited by 3

Investigation of the role of histone acetylation in hippocampus-dependent memory formation

Hawk, J. D. (2011) · ScholarlyCommons (University of Pennsylvania)

Acetylcholinesterase as a window onto stress responses

Soreq, H., Yirmiya, R., Cohen, O., & Glick, D. (2005) · Techniques in the behavioral and neural sciences · doi:10.1016/s0921-0709(05)80032-x · Cited by 12