Cited by 424interferon and immune responsesHerpesvirus Infections and TreatmentsImmune Response and Inflammation

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Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein

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Orzalli, Megan H., DeLuca, Neal A., Knipe, David M.·2012·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1211302109PMC PMC3497734

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Abstract

Innate sensing of microbial components is well documented to occur at many cellular sites, including at the cell surface, in the cytosol, and in intracellular vesicles, but there is limited evidence of nuclear innate signaling. In this study we have defined the mechanisms of interferon regulatory factor-3 (IRF-3) signaling in primary human foreskin fibroblasts (HFF) infected with herpes simplex virus 1 (HSV-1) in the absence of viral gene expression. We found that the interferon inducible protein 16 (IFI16) DNA sensor, which is required for induction of IRF-3 signaling in these cells, is nuclear, and its localization does not change detectably upon HSV-1 d 109 infection and induction of IRF-3 signaling. Consistent with the IFI16 sensor being nuclear, conditions that block viral DNA release from incoming capsids inhibit IRF-3 signaling. An unknown factor must be exported from the nucleus to activate IRF-3 through cytoplasmic STING, which is required for IRF-3 activation and signaling. However, when the viral ICP0 protein is expressed in the nucleus, it causes the nuclear relocalization and degradation of IFI16, inhibiting IRF-3 signaling. Therefore, HSV-1 infection is sensed in HFF by nuclear IFI16 upon release of encapsidated viral DNA into the nucleus, and the viral nuclear ICP0 protein can inhibit the process by targeting IFI16 for degradation. Together these results define a pathway for nuclear innate sensing of HSV DNA by IFI16 in infected HFF and document a mechanism by which a virus can block this nuclear innate response.

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Janeway, C. (1989) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1989.054.01.003 · Cited by 3,396
NF-κB: linking inflammation and immunity to cancer development and progression
Karin, M., & Greten, F. R. (2005) · Nature reviews. Immunology · doi:10.1038/nri1703 · Cited by 3,175
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
Ishikawa, H., Ma, Z., & Barber, G. N. (2009) · Nature · doi:10.1038/nature08476 · Cited by 2,759 · cited 1×
“STING, a cytoplasmic scaffolding protein, is essential for the IFN-β response to immunostimulatory DNA molecules and HSV-1 infection in mouse embryonic fibroblasts (33).”
Background
IKKε and TBK1 are essential components of the IRF3 signaling pathway
Fitzgerald, K. A., McWhirter, S. M., Faia, K. L., Rowe, D. C., Latz, E., Golenbock, D. T., Coyle, A. J., Liao, S.-M., & Maniatis, T. (2003) · Nature Immunology · doi:10.1038/ni921 · Cited by 2,680
5'-Triphosphate RNA Is the Ligand for RIG-I
Hornung, V., Ellegast, J., Kim, S., Brzózka, K., Jung, A., Kato, H., Poeck, H., Akira, S., Conzelmann, K.-K., Schlee, M., et al. (2006) · Science · doi:10.1126/science.1132505 · Cited by 2,474
Regulation of Adaptive Immunity by the Innate Immune System
Iwasaki, A., & Medzhitov, R. M. (2010) · Science · doi:10.1126/science.1183021 · Cited by 2,220
The roles of TLRs, RLRs and NLRs in pathogen recognition
Kawai, T., & Akira, S. (2009) · International Immunology · doi:10.1093/intimm/dxp017 · Cited by 1,725
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response
Takaoka, A., Wang, Z., Choi, M. K., Yanai, H., Negishi, H., Ban, T., Lu, Y., Miyagishi, M., Kodama, T., Honda, K., et al. (2007) · Nature · doi:10.1038/nature06013 · Cited by 1,704
Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5
Kato, H., Takeuchi, O., Mikamo, E., Hirai, R., Kawai, T., Matsushita, K., Hiiragi, A., Dermody, T. S., Fujita, T., & Akira, S. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080091 · Cited by 1,649
IFI16 is an innate immune sensor for intracellular DNA
Unterholzner, L., Keating, S. E., Baran, M., Horan, K. A., Jensen, S. B., Sharma, S., Sirois, C. M., Jin, T., Latz, E., Xiao, T. S., et al. (2010) · Nature Immunology · doi:10.1038/ni.1932 · Cited by 1,643
Type I Interferons in Host Defense
Stetson, D. B., & Medzhitov, R. M. (2006) · Immunity · doi:10.1016/j.immuni.2006.08.007 · Cited by 1,225
Toll-like Receptor 9–mediated Recognition of Herpes Simplex Virus-2 by Plasmacytoid Dendritic Cells
Lund, J. M., Sato, A., Akira, S., Medzhitov, R. M., & Iwasaki, A. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030162 · Cited by 1,197
RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway
Chiu, Y., MacMillan, J. B., & Chen, Z. J. (2009) · Cell · doi:10.1016/j.cell.2009.06.015 · Cited by 1,185
Toll-like receptor 3 promotes cross-priming to virus-infected cells
Schulz, O., Diebold, S. S., Chen, M., Näslund, T. I., Nolte, M. A., Alexopoulou, L., Azuma, Y., Flavell, R. A., Liljeström, P., & Sousa, C. R. E. (2005) · Nature · doi:10.1038/nature03326 · Cited by 919
RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III–transcribed RNA intermediate
Ablasser, A., Bauernfeind, F. G., Hartmann, G., Latz, E., Fitzgerald, K. A., & Hornung, V. (2009) · Nature Immunology · doi:10.1038/ni.1779 · Cited by 892
The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells
Zhang, Z., Yuan, B., Bao, M., Lu, N., Kim, T., & Liu, Y. (2011) · Nature Immunology · doi:10.1038/ni.2091 · Cited by 874
Virus Infection Induces the Assembly of Coordinately Activated Transcription Factors on the IFN-β Enhancer In Vivo
Wathelet, M. G., Lin, C. H., Parekh, B. S., Ronco, L. V., Howley, P. M., & Maniatis, T. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80051-9 · Cited by 730
Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments
Ahmad‐Nejad, P., Häcker, H., Rutz, M., Bauer, S., Vabulas, R. M., & Wagner, H. (2002) · European Journal of Immunology · doi:10.1002/1521-4141(200207)32:7 · Cited by 728
IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection
Kerur, N., Veettil, M. V., Sharma-Walia, N., Bottero, V., Sadagopan, S., Otageri, P., & Chandran, B. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.04.008 · Cited by 702
Herpes Simplex Viruses
Whitley, R. J., & Roizman, B. (2002) · ASM Press eBooks · doi:10.1002/0471203076.emm0597 · Cited by 702
IFN-regulatory factor 3-dependent gene expression is defective in Tbk1 -deficient mouse embryonic fibroblasts
McWhirter, S. M., Fitzgerald, K. A., Rosains, J., Rowe, D. C., Golenbock, D. T., & Maniatis, T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2237236100 · Cited by 542
The Ubiquitin Ligase RNF5 Regulates Antiviral Responses by Mediating Degradation of the Adaptor Protein MITA
Zhong, B., Zhang, L., Lei, C., Li, Y., Mao, A., Yang, Y. F., Wang, Y., Zhang, X., & Shu, H. (2009) · Immunity · doi:10.1016/j.immuni.2009.01.008 · Cited by 487
Ligand-induced conformational changes allosterically activate Toll-like receptor 9
Latz, E., Verma, A., Visintin, A., Gong, M., Sirois, C. M., Klein, D. C. G., Monks, B. G., McKnight, C. J., Lamphier, M. S., Duprex, W. P., et al. (2007) · Nature Immunology · doi:10.1038/ni1479 · Cited by 462
Herpes Simplex Virus Type 1 Immediate-Early Protein ICP0 and Its Isolated RING Finger Domain Act as Ubiquitin E3 Ligases In Vitro
Boutell, C., Sadis, S., & Everett, R. D. (2002) · Journal of Virology · doi:10.1128/jvi.76.2.841-850.2002 · Cited by 386
Persistence and Expression of the Herpes Simplex Virus Genome in the Absence of Immediate-Early Proteins
Samaniego, L. A., Neiderhiser, L., & DeLuca, N. A. (1998) · Journal of Virology · doi:10.1128/jvi.72.4.3307-3320.1998 · Cited by 373
Self-citation
Recognition of herpesviruses by the innate immune system
Paludan, S. R., Bowie, A., Horan, K., & Fitzgerald, K. A. (2011) · Nature reviews. Immunology · doi:10.1038/nri2937 · Cited by 353
Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16
Li, T., Diner, B. A., Chen, J., & Cristea, I. M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1203447109 · Cited by 297
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Mossman, K. L., Macgregor, P. F., Rozmus, J., Goryachev, A. B., Edwards, A. M., & Smiley, J. R. (2001) · Journal of Virology · doi:10.1128/jvi.75.2.750-758.2001 · Cited by 268
DNA repair proteins affect the lifecycle of herpes simplex virus 1
Lilley, C. E., Carson, C. T., Muotri, A. R., Gage, F. H., & Weitzman, M. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501916102 · Cited by 253
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Herpes simplex virus type 1 ICP0 plays a critical role in the de novo synthesis of infectious virus following transfection of viral DNA
Cai, W. Z., & Schaffer, P. A. (1989) · Journal of Virology · doi:10.1128/jvi.63.11.4579-4589.1989 · Cited by 237
The herpes simplex virus type 1 regulatory protein ICP0 enhances virus replication during acute infection and reactivation from latency
Cai, W., Astor, T. L., Liptak, L. M., Cho, C., Coen, D. M., & Schaffer, P. A. (1993) · Journal of Virology · doi:10.1128/jvi.67.12.7501-7512.1993 · Cited by 233
Herpes Simplex Virus ICP0 Promotes both Histone Removal and Acetylation on Viral DNA during Lytic Infection
Cliffe, A. R., & Knipe, D. M. (2008) · Journal of Virology · doi:10.1128/jvi.01575-08 · Cited by 210
Self-citation
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Melroe, G. T., DeLuca, N. A., & Knipe, D. M. (2004) · Journal of Virology · doi:10.1128/jvi.78.16.8411-8420.2004 · Cited by 197
Self-citation
Recruitment of Cellular Recombination and Repair Proteins to Sites of Herpes Simplex Virus Type 1 DNA Replication Is Dependent on the Composition of Viral Proteins within Prereplicative Sites and Correlates with the Induction of the DNA Damage Response
Wilkinson, D. E., & Weller, S. K. (2004) · Journal of Virology · doi:10.1128/jvi.78.9.4783-4796.2004 · Cited by 187
Control of TANK-binding Kinase 1-mediated Signaling by the γ134.5 Protein of Herpes Simplex Virus 1
Verpooten, D., Ma, Y., Hou, S., Yan, Z., & He, B. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805905200 · Cited by 186
Interaction of herpes simplex virus 1 alpha regulatory protein ICP0 with elongation factor 1delta: ICP0 affects translational machinery
Kawaguchi, Y., Bruni, R., & Roizman, B. (1997) · Journal of Virology · doi:10.1128/jvi.71.2.1019-1024.1997 · Cited by 182
Expression of Herpes Simplex Virus ICP0 Inhibits the Induction of Interferon-Stimulated Genes by Viral Infection
Eidson, K. M., Hobbs, W. E., Manning, B. J., Carlson, P. E., & DeLuca, N. A. (2002) · Journal of Virology · doi:10.1128/jvi.76.5.2180-2191.2002 · Cited by 180
Self-citation
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Xing, J., Wang, S., Lin, R., Mossman, K. L., & Zheng, C. (2012) · Journal of Virology · doi:10.1128/jvi.06713-11 · Cited by 178
Type I Interferon Production during Herpes Simplex Virus Infection Is Controlled by Cell-Type-Specific Viral Recognition through Toll-Like Receptor 9, the Mitochondrial Antiviral Signaling Protein Pathway, and Novel Recognition Systems
Rasmussen, S. B., Sørensen, L. N., Malmgaard, L., Ank, N., Baines, J. D., Chen, Z. J., & Paludan, S. R. (2007) · Journal of Virology · doi:10.1128/jvi.01167-07 · Cited by 169
Human Cytomegalovirus pUL83 Stimulates Activity of the Viral Immediate-Early Promoter through Its Interaction with the Cellular IFI16 Protein
Cristea, I. M., Moorman, N. J., Terhune, S. S., Cuevas, C. D., O'Keefe, E. S., Rout, M. P., Chait, B. T., & Shenk, T. (2010) · Journal of Virology · doi:10.1128/jvi.00139-10 · Cited by 155
Temporal Association of the Herpes Simplex Virus Genome with Histone Proteins during a Lytic Infection
Oh, J., & Fraser, N. W. (2007) · Journal of Virology · doi:10.1128/jvi.00586-07 · Cited by 147
Activation of Interferon Response Factor-3 in Human Cells Infected with Herpes Simplex Virus Type 1 or Human Cytomegalovirus
Preston, C. M., Harman, A. N., & Nicholl, M. J. (2001) · Journal of Virology · doi:10.1128/jvi.75.19.8909-8916.2001 · Cited by 146
Recruitment of activated IRF-3 and CBP/p300 to herpes simplex virus ICP0 nuclear foci: Potential role in blocking IFN-β induction
Melroe, G. T., Silva, L., Schaffer, P. A., & Knipe, D. M. (2006) · Virology · doi:10.1016/j.virol.2006.10.028 · Cited by 145
Self-citation
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Shirata, N., Kudoh, A., Daikoku, T., Tatsumi, Y., Fujita, M., Kiyono, T., Sugaya, Y., Isomura, H., Ishizaki, K., & Tsurumi, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500976200 · Cited by 141
IKK-i and TBK-1 are Enzymatically Distinct from the Homologous Enzyme IKK-2
Kishore, N. N., Huynh, Q. K., Mathialagan, S., Hall, T., Rouw, S., Creely, D., Lange, G., Caroll, J., Reitz, B. A., Donnelly, A. M., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110474200 · Cited by 138
Reciprocal Activities between Herpes Simplex Virus Type 1 Regulatory Protein ICP0, a Ubiquitin E3 Ligase, and Ubiquitin-Specific Protease USP7
Boutell, C., Canning, M., Orr, A., & Everett, R. D. (2005) · Journal of Virology · doi:10.1128/jvi.79.19.12342-12354.2005 · Cited by 137
Phenotype of a Herpes Simplex Virus Type 1 Mutant That Fails To Express Immediate-Early Regulatory Protein ICP0
Everett, R. D., Boutell, C., & Orr, A. (2004) · Journal of Virology · doi:10.1128/jvi.78.4.1763-1774.2004 · Cited by 136
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Knipe, D. M., & Spang, A. (1982) · Journal of Virology · doi:10.1128/jvi.43.1.314-324.1982 · Cited by 129
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Johnstone, R. W., Wu, W., Greenway, A. L., & Trapani, J. A. (2000) · Oncogene · doi:10.1038/sj.onc.1204005 · Cited by 109
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Cellular Localization of the Herpes Simplex Virus ICP0 Protein Dictates Its Ability to Block IRF3-Mediated Innate Immune Responses
Paladino, P., Collins, S. E., & Mossman, K. L. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010428 · Cited by 100
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Lopez, P., Sant, C. V., & Roizman, B. (2001) · Journal of Virology · doi:10.1128/jvi.75.8.3832-3840.2001 · Cited by 98
Differential Roles for the Interferon-Inducible IFI16 and AIM2 Innate Immune Sensors for Cytosolic DNA in Cellular Senescence of Human Fibroblasts
Duan, X., Ponomareva, L. V., Veeranki, S., Panchanathan, R., Dickerson, E., & Choubey, D. (2011) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-10-0565 · Cited by 95
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Lium, E. K., & Silverstein, S. J. (1997) · Journal of Virology · doi:10.1128/jvi.71.11.8602-8614.1997 · Cited by 94
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Sharma, S., & Fitzgerald, K. A. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1001310 · Cited by 79
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Interferon Regulatory Factor 3-Dependent Pathways Are Critical for Control of Herpes Simplex Virus Type 1 Central Nervous System Infection
Menachery, V. D., Pasieka, T. J., & Leib, D. A. (2010) · Journal of Virology · doi:10.1128/jvi.00706-10 · Cited by 48
STAT-1- and IRF-3-Dependent Pathways Are Not Essential for Repression of ICP0-Null Mutant Herpes Simplex Virus Type 1 in Human Fibroblasts
Everett, R. D., Young, D. F., Randall, R. E., & Orr, A. (2008) · Journal of Virology · doi:10.1128/jvi.00613-08 · Cited by 42
Functional Characterization of Residues Required for the Herpes Simplex Virus 1 E3 Ubiquitin Ligase ICP0 To Interact with the Cellular E2 Ubiquitin-Conjugating Enzyme UBE2D1 (UbcH5a)
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Research works printed but not linked: 5

10.1038/ni.1932 · DOI · Paper page
10.1128/JVI.75.2.750-758.2001 · DOI
10.1128/JVI.78.16.8411-8420.2004 · DOI
10.1128/jvi.76.5.2180-2191.2002 · DOI
10.1016/j.chom.2011.04.008 · DOI · Paper page

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Authors: Orzalli, M. H., DeLuca, N. A., & Knipe, D. M.
Affiliations: Harvard University (US)
University of Pittsburgh (US)
Corresponding author: Knipe, David M.
ORCID: Orzalli, Megan H.
DeLuca, Neal A.
Knipe, David M.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2012-10
Volume: 109
Issue: 44
Pages: E3008-17
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1211302109
PMC: PMC3497734
OpenAlex: W2163362670
Cited by: 422
References: 65
Citations by year: 2026: 13 · 2025: 20 · 2024: 21 · 2023: 15 · 2022: 25 · 2021: 35 · 2020: 32 · 2019: 44 · 2018: 30 · 2017: 24 · 2016: 38 · 2015: 49 · 2014: 34 · 2013: 39 · 2012: 3
FWCI: 17.56
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Allergy and Infectious Diseases (R01AI099081, AI099081, R01AI044821, P01AI083215, AI83215)
Topics: Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Health Sciences › Medicine › Infectious Diseases › Herpesvirus Infections and Treatments
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: IFI16, herpes simplex virus type 1, ICP0, viral DNA sensing, STING, protein degradation
MeSH terms: Cells, Cultured, DNA, Viral, Flow Cytometry, Herpes Labialis, Humans, Nuclear Proteins, Phosphoproteins, Signal Transduction, Polymerase Chain Reaction, Immediate-Early Proteins, Herpesvirus 1, Human, Fluorescent Antibody Technique, Indirect, Ubiquitin-Protein Ligases, Interferon Regulatory Factor-3

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Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein

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