The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Dynamics and biological relevance of DNA demethylation in Arabidopsis antibacterial defense
Open accessAbstract
DNA methylation is an epigenetic mark that silences transposable elements (TEs) and repeats. Whereas the establishment and maintenance of DNA methylation are relatively well understood, little is known about their dynamics and biological relevance in plant and animal innate immunity. Here, we show that some TEs are demethylated and transcriptionally reactivated during antibacterial defense in Arabidopsis . This effect is correlated with the down-regulation of key transcriptional gene silencing factors and is partly dependent on an active demethylation process. DNA demethylation restricts multiplication and vascular propagation of the bacterial pathogen Pseudomonas syringae in leaves and, accordingly, some immune-response genes, containing repeats in their promoter regions, are negatively regulated by DNA methylation. This study provides evidence that DNA demethylation is part of a plant-induced immune response, potentially acting to prime transcriptional activation of some defense genes linked to TEs/repeats.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Jones, J. D. G., & Dangl, J. L. (2006) · Nature · doi:10.1038/nature05286 · Cited by 13,177
Boller, T., & Felix, G. (2009) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.57.032905.105346 · Cited by 3,387
Durrant, W. E., & Dong, X. (2004) · Annual Review of Phytopathology · doi:10.1146/annurev.phyto.42.040803.140421 · Cited by 3,184
MAP kinase signalling cascade in Arabidopsis innate immunity
Asai, T., Tena, G., Plotnikova, J., Willmann, M. R., Chiu, W.-L., Gomez-Gomez, L., Boller, T., Ausubel, F. M., & Sheen, J. (2002) · Nature · doi:10.1038/415977a · Cited by 2,726
Rushton, P. J., Somssich, I. E., Ringler, P., & Shen, Q. J. (2010) · Trends in Plant Science · doi:10.1016/j.tplants.2010.02.006 · Cited by 2,700
Bacterial disease resistance in Arabidopsis through flagellin perception
Zipfel, C., Robatzek, S., Navarro, L., Oakeley, E. J., Jones, J. D. G., Felix, G., & Boller, T. (2004) · Nature · doi:10.1038/nature02485 · Cited by 1,790
Self-citationEpigenetic Reprogramming in Plant and Animal Development
Feng, S., Jacobsen, S. E., & Reik, W. (2010) · Science · doi:10.1126/science.1190614 · Cited by 1,167
Widespread dynamic DNA methylation in response to biotic stress
Dowen, R. H., Pelizzola, M., Schmitz, R. J., Lister, R., Dowen, J. M., Nery, J. R., Dixon, J. E., & Ecker, J. R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209329109 · Cited by 1,005
Epigenetic Reprogramming and Small RNA Silencing of Transposable Elements in Pollen
Slotkin, R. K., Vaughn, M., Borges, F., Tanurdžić, M., Becker, J. D., Feijó, J. A., & Martienssen, R. A. (2009) · Cell · doi:10.1016/j.cell.2008.12.038 · Cited by 946
Plant disease-resistance proteins and the gene-for-gene concept
Van Der Biezen, E. A., & Jones, J. D. G. (1998) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(98)01311-5 · Cited by 877
Cited by
Transgenerational epigenetic inheritance: myths and mechanisms
Heard, E., & Martienssen, R. A. (2014) · Cell · doi:10.1016/j.cell.2014.02.045 · Cited by 1,864
Araport11: a complete reannotation of the Arabidopsis thaliana reference genome
Cheng, C., Krishnakumar, V., Chan, A. P., Thibaud‐Nissen, F., Schobel, S., & Town, C. D. (2017) · The Plant Journal · doi:10.1111/tpj.13415 · Cited by 1,317
A DEMETER-like DNA demethylase governs tomato fruit ripening
Liu, R., How-Kit, A., Stammitti, L., Teyssier, E., Rolin, D., Mortain-Bertrand, A., Halle, S., Liu, M., Kong, J., Wu, C., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1503362112 · Cited by 371
Plant Transgenerational Epigenetics
Quadrana, L., & Colot, V. (2016) · Annual Review of Genetics · doi:10.1146/annurev-genet-120215-035254 · Cited by 331
Plant Immunity: From Signaling to Epigenetic Control of Defense
Ramirez-Prado, J. S., Abulfaraj, A. A., Rayapuram, N., Benhamed, M., & Hirt, H. (2018) · Trends in Plant Science · doi:10.1016/j.tplants.2018.06.004 · Cited by 294
Metadata
- Authors
- Yu, A., Lepère, G., Jay, F., Wang, J., Bapaume, L., Wang, Y., Abraham, A.-L., Penterman, J., Fischer, R. L., Voinnet, O., & Navarro, L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-01-18
- Volume
- 110
- Issue
- 6
- Pages
- 2389-2394
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2147465115
- Cited by
- 462
- References
- 38
- FWCI
- 14.12
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Dynamics and biological relevance of DNA demethylation in Arabidopsis antibacterial defense. https://app.cochat.ai/papers/10.1073/pnas.1211757110
- The paper
- Yu, A., Lepère, G., Jay, F., Wang, J., Bapaume, L., Wang, Y., Abraham, A.-L., Penterman, J., Fischer, R. L., Voinnet, O., & Navarro, L. (2013). Dynamics and biological relevance of DNA demethylation in Arabidopsis antibacterial defense. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1211757110
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
