The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Bottom-up construction of in vitro switchable memories
Open accessAbstract
Reaction networks displaying bistability provide a chemical mechanism for long-term memory storage in cells, as exemplified by many epigenetic switches. These biological systems are not only bistable but switchable, in the sense that they can be flipped from one state to the other by application of specific molecular stimuli. We have reproduced such functions through the rational assembly of dynamic reaction networks based on basic DNA biochemistry. Rather than rewiring genetic systems as synthetic biology does in vivo, our strategy consists of building simplified dynamic analogs in vitro, in an artificial, well-controlled milieu. We report successively a bistable system, a two-input switchable memory element, and a single-input push-push memory circuit. These results suggest that it is possible to build complex time-responsive molecular circuits by following a modular approach to the design of dynamic in vitro behaviors. Our approach thus provides an unmatched opportunity to study topology/function relationships within dynamic reaction networks.
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Cited by
Materials learning from life: concepts for active, adaptive and autonomous molecular systems
Merindol, R., & Walther, A. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00738d · Cited by 533
Song, T., Eshra, A., Shah, S., Bui, H., Fu, D., Yang, M., Mokhtar, R., & Reif, J. (2019) · Nature Nanotechnology · doi:10.1038/s41565-019-0544-5 · Cited by 240
van Roekel, H. W. H., Rosier, B. J. H. M., Meijer, L. H. H., Hilbers, P. A. J., Markvoort, A. J., Huck, W. T. S., & de Greef, T. F. A. (2015) · Chemical Society Reviews · doi:10.1039/c5cs00361j · Cited by 171
Su, H., Xu, J., Wang, Q., Wang, F., & Zhou, X. (2019) · Nature Communications · doi:10.1038/s41467-019-13310-2 · Cited by 94
A structural classification of candidate oscillatory and multistationary biochemical systems
Blanchini, F., Franco, E., & Giordano, G. (2014) · Bulletin of Mathematical Biology · doi:10.1007/s11538-014-0023-y · Cited by 54
Metadata
- Authors
- Padirac, A., Fujii, T., & Rondelez, Y.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2012-10-29
- Volume
- 109
- Issue
- 47
- Pages
- E3212-20
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1964850787
- Cited by
- 175
- References
- 6
- FWCI
- 6.04
- Type
- journal article
- Language
- en
- Open access
- bronze
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