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Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons
Open accessAbstract
To maintain homeostasis, hypothalamic neurons in the arcuate nucleus must dynamically sense and integrate a multitude of peripheral signals. Blood-borne molecules must therefore be able to circumvent the tightly sealed vasculature of the blood-brain barrier to rapidly access their target neurons. However, how information encoded by circulating appetite-modifying hormones is conveyed to central hypothalamic neurons remains largely unexplored. Using in vivo multiphoton microscopy together with fluorescently labeled ligands, we demonstrate that circulating ghrelin, a versatile regulator of energy expenditure and feeding behavior, rapidly binds neurons in the vicinity of fenestrated capillaries, and that the number of labeled cell bodies varies with feeding status. Thus, by virtue of its vascular connections, the hypothalamus is able to directly sense peripheral signals, modifying energy status accordingly.
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“Peripherally produced ghrelin exerts its appetite-inducing effects centrally after passing through the BBB [112, 302-304].”
From Anxiety, depression, and the microbiome: A role for gut peptides (2018) · cites this paper as [302]
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Metadata
- Authors
- Schaeffer, M., Langlet, F., Lafont, C., Molino, F., Hodson, D. J., Roux, T., Lamarque, L., Verdié, P., Bourrier, E., Dehouck, B., Banères, J.-L., Martinez, J., Méry, P.-F., Marie, J., Trinquet, E., Fehrentz, J.-A., Prévot, V., & Mollard, P.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Cisbio (France) (FR)
- Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5247, Institut des Biomolécules Max Mousseron, Faculty of Pharmacy, Universities of Montpellier 1 and 2, F-34093 Montpellier Cedex 5, France; and
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2013-01-07
- Volume
- 110
- Issue
- 4
- Pages
- 1512-1517
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3557016
- OpenAlex
- W2152571442
- Semantic Scholar
- 95d156475087f3165a661ace77280d02caabbebe
- Cited by
- 325
- References
- 46
- Citations by year
- 2026: 13 · 2025: 22 · 2024: 25 · 2023: 17 · 2022: 28 · 2021: 25 · 2020: 28 · 2019: 19 · 2018: 26 · 2017: 28 · 2016: 25 · 2015: 28 · 2014: 26 · 2013: 14
- FWCI
- 16.69
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- ghrelin, hypothalamus, arcuate nucleus, blood-brain barrier, fenestrated capillaries, feeding behavior, energy homeostasis, neuropeptide binding
- MeSH terms
- Animals, Appetite Regulation, Blood-Brain Barrier, Capillary Permeability, Eating, Fasting, Hypothalamus, Male, Median Eminence, Mice, Inbred C57BL, Mice, Transgenic, Models, Neurological, Neurons, Microscopy, Fluorescence, Multiphoton, Mice, Ghrelin
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