The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Genome-wide reprogramming of the chromatin landscape underlies endocrine therapy resistance in breast cancer
Open accessAbstract
Significance: Resistance to treatment with endocrine therapy occurs in ∼50% of all breast cancer patients. The pathway(s) leading to drug resistance is ill-defined. We show that accessibility to the genome is altered in drug-resistant compared with responsive breast cancer cells. This coincides with the overactivation of the NOTCH pathway in drug-resistant compared with responsive cancer cells. The transcription factor PBX1, a known NOTCH target gene, is required for the growth of endocrine therapy-resistant breast cancer cells. Accordingly, a gene expression signature based on NOTCH-PBX1 activity can discriminate a priori breast cancer patients that are responsive or not to endocrine therapy.
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Cites
Gene expression profiling predicts clinical outcome of breast cancer
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Self-citationHistone modifications at human enhancers reflect global cell-type-specific gene expression
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Self-citationA unique chromatin signature uncovers early developmental enhancers in humans
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Yang, L., Shi, P., Zhao, G., Xu, J., Peng, W., Zhang, J., Zhang, G., Wang, X., Dong, Z., Chen, F., et al. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0110-5 · Cited by 1,906
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High-throughput single-cell ChIP-seq identifies heterogeneity of chromatin states in breast cancer
Grosselin, K., Durand, A., Marsolier, J., Poitou, A., Marangoni, E., Nemati, F., Dahmani, A., Lameiras, S., Reyal, F., Frenoy, O., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0424-9 · Cited by 466
Therapeutic Implications of Cellular Heterogeneity and Plasticity in Breast Cancer
Brooks, M. D., Burness, M. L., & Wicha, M. S. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.08.014 · Cited by 374
Poised epigenetic states and acquired drug resistance in cancer
Brown, R., Curry, E., Magnani, L., Wilhelm-Benartzi, C. S., & Borley, J. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3819 · Cited by 301
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Metadata
- Authors
- Magnani, L., Stoeck, A., Zhang, X., Lánczky, A., Mirabella, A. C., Wang, T.-L., Gyorffy, B., & Lupien, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-04
- Volume
- 110
- Issue
- 16
- Pages
- E1490-9
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2109600062
- Cited by
- 181
- References
- 10
- FWCI
- 12.54
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Magnani, L., Stoeck, A., Zhang, X., Lánczky, A., Mirabella, A. C., Wang, T.-L., Gyorffy, B., & Lupien, M. (2013). Genome-wide reprogramming of the chromatin landscape underlies endocrine therapy resistance in breast cancer. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1219992110
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