The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
SOX2–LIN28/let-7 pathway regulates proliferation and neurogenesis in neural precursors
Open accessAbstract
Significance: The transcription factor SOX2 plays a critical role in self-renewal and neuronal differentiation of neural precursors (NPCs); however, the molecular mechanisms underlying its functions are poorly understood. We found that SOX2 regulates the expression of LIN28, a suppressor of let-7 microRNA biogenesis. Exogenous LIN28 rescued the NPC proliferation and some neurogenic deficits in the absence of SOX2. We identified let-7i as a novel and potent inhibitor of neuronal differentiation that represses proneural genes. The discovery of SOX2–LIN28/let-7 pathway that maintains both NPC proliferation and neurogenic potential will enhance our understanding and therapeutic development relevant to neurodegeneration and brain tumors.
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Cites
The widespread regulation of microRNA biogenesis, function and decay
Krol, J., Loedige, I., & Filipowicz, W. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2843 · Cited by 4,672
miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche
Cheng, L.-C., Pastrana, E., Tavazoie, M., & Doetsch, F. (2009) · Nature Neuroscience · doi:10.1038/nn.2294 · Cited by 1,001
Fluoxetine targets early progenitor cells in the adult brain
Encinas, J. M., Vaahtokari, A., & Enikolopov, G. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601992103 · Cited by 637
Cross talk between microRNA and epigenetic regulation in adult neurogenesis
Szulwach, K. E., Li, X., Smrt, R. D., Li, Y., Luo, Y., Lin, L., Santistevan, N. J., Li, W., Zhao, X., & Jin, P. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200908151 · Cited by 493
Cited by
Zheng, X., Boyer, L., Jin, M., Mertens, J., Kim, Y., Ma, L., Ma, L., Hamm, M., Gage, F. H., & Hunter, T. (2016) · eLife · doi:10.7554/elife.13374 · Cited by 671
“Neuron-specific genes such as NEUROD2, MYT1L, MAPT (Tau), SYN1 (synapsin), CHD5 (Egan et al., 2013) were significantly increased (Figure 1E), whereas the markers associated with proliferating NPCs, LIN28A/B and FOXM1 (Cimadamore et al., 2013; Karsten et al., 2003), were considerably decreased (Figure 1F).”
BackgroundInfluentialMellios, N., Feldman, D. A., Sheridan, S. D., Ip, J. P. K., Kwok, S., Amoah, S. K., Rosen, B., Rodriguez, B. A., Crawford, B., Swaminathan, R., et al. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.86 · Cited by 292
Lin28 promotes the proliferative capacity of neural progenitor cells in brain development
Yang, M., Yang, S.-L., Herrlinger, S., Liang, C., Dzieciatkowska, M., Hansen, K. C., Desai, R., Nagy, A., Niswander, L., Moss, E. G., et al. (2015) · Development · doi:10.1242/dev.120543 · Cited by 127
Sequential regulatory loops as key gatekeepers for neuronal reprogramming in human cells
Xue, Y., Qian, H., Hu, J., Zhou, B., Zhou, Y., Hu, X., Karakhanyan, A., Pang, Z., & Fu, X.-D. (2016) · Nature Neuroscience · doi:10.1038/nn.4297 · Cited by 118
let-7 miRNAs Can Act through Notch to Regulate Human Gliogenesis
Patterson, M., Gaeta, X., Loo, K., Edwards, M., Smale, S., Cinkornpumin, J., Xie, Y., Listgarten, J., Azghadi, S., Douglass, S. M., et al. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.08.015 · Cited by 103
Metadata
- Authors
- Cimadamore, F., Amador-Arjona, A., Chen, C., Huang, C.-T., & Terskikh, A. V.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-07-24
- Volume
- 110
- Issue
- 32
- Pages
- E3017-26
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2160783784
- Cited by
- 219
- References
- 4
- FWCI
- 7.77
- Type
- journal article
- Language
- en
- Open access
- green
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- Cimadamore, F., Amador-Arjona, A., Chen, C., Huang, C.-T., & Terskikh, A. V. (2013). SOX2–LIN28/let-7 pathway regulates proliferation and neurogenesis in neural precursors. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1220176110
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