The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Protein chemical synthesis by serine and threonine ligation
Open accessAbstract
An efficient method has been developed for the salicylaldehyde ester-mediated ligation of unprotected peptides at serine (Ser) or threonine (Thr) residues. The utility of this peptide ligation approach has been demonstrated through the convergent syntheses of two therapeutic peptides––ovine-corticoliberin and Forteo––and the human erythrocyte acylphosphatase protein (∼11 kDa). The requisite peptide salicylaldehyde ester precursor is prepared in an epimerization-free manner via Fmoc–solid-phase peptide synthesis.
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Cites
Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide
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Cited by
The Current State of Peptide Drug Discovery: Back to the Future?
Henninot, A., Collins, J. C., & Nuss, J. M. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b00318 · Cited by 1,113
Native Chemical Ligation and Extended Methods: Mechanisms, Catalysis, Scope, and Limitations
Agouridas, V., El Mahdi, O., Diemer, V., Cargoët, M., Monbaliu, J.-C. M., & Melnyk, O. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00712 · Cited by 650
Scinto, S. L., Bilodeau, D. A., Hincapie, R., Lee, W., Nguyen, S. S., Xu, M., am Ende, C. W., Finn, M. G., Lang, K., Lin, Q., et al. (2021) · Nature Reviews Methods Primers · doi:10.1038/s43586-021-00028-z · Cited by 592
Sustainability Challenges in Peptide Synthesis and Purification: From R&D to Production
Isidro-Llobet, A., Kenworthy, M. N., Mukherjee, S., Kopach, M. E., Wegner, K., Gallou, F., Smith, A. G., & Roschangar, F. (2019) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.8b03001 · Cited by 473
Expanding the chemical toolbox for the synthesis of large and uniquely modified proteins
Bondalapati, S., Jbara, M., & Brik, A. (2016) · Nature Chemistry · doi:10.1038/nchem.2476 · Cited by 359
Metadata
- Authors
- Zhang, Y., Xu, C., Lam, H. Y., Lee, C. L., & Li, X.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-04-08
- Volume
- 110
- Issue
- 17
- Pages
- 6657-6662
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2043820375
- Cited by
- 272
- References
- 36
- FWCI
- 9.01
- Type
- journal article
- Language
- en
- Open access
- green
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- Zhang, Y., Xu, C., Lam, H. Y., Lee, C. L., & Li, X. (2013). Protein chemical synthesis by serine and threonine ligation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1221012110
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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