The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Chemoselective Ligation and Modification Strategies for Peptides and Proteins
Abstract
The investigation of biological processes by chemical methods, commonly referred to as chemical biology, often requires chemical access to biologically relevant macromolecules such as peptides and proteins. Building upon solid‐phase peptide synthesis, investigations have focused on the development of chemoselective ligation and modification strategies to link synthetic peptides or other functional units to larger synthetic and biologically relevant macromolecules. This Review summarizes recent developments in the field of chemoselective ligation and modification strategies and illustrates their application, with examples ranging from the total synthesis of proteins to the semisynthesis of naturally modified proteins.
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Cites
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Cited by
Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
Sletten, E. M., & Bertozzi, C. R. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200900942 · Cited by 3,165
Native Chemical Ligation and Extended Methods: Mechanisms, Catalysis, Scope, and Limitations
Agouridas, V., El Mahdi, O., Diemer, V., Cargoët, M., Monbaliu, J.-C. M., & Melnyk, O. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00712 · Cited by 650
Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition
Debets, M. F., van Berkel, S. S., Schoffelen, S., Rutjes, F. P. J. T., van Hest, J. C. M., & van Delft, F. L. (2010) · Chem. Commun. · doi:10.1039/b917797c · Cited by 580
Jo, S., Cheng, X., Islam, S. M., Huang, L., Rui, H., Zhu, A., Lee, H. S., Qi, Y., Han, W., Vanommeslaeghe, K., et al. (2014) · Advances in Protein Chemistry and Structural Biology · doi:10.1016/bs.apcsb.2014.06.002 · Cited by 363
Expanding the chemical toolbox for the synthesis of large and uniquely modified proteins
Bondalapati, S., Jbara, M., & Brik, A. (2016) · Nature Chemistry · doi:10.1038/nchem.2476 · Cited by 359
Metadata
- Authors
- Hackenberger, C. P. R., & Schwarzer, D.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2008-12-12
- Volume
- 47
- Issue
- 52
- Pages
- 10030-10074
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W1982807734
- Cited by
- 761
- References
- 11
- FWCI
- 22.58
- Type
- journal article
- Language
- en
- Open access
- closed
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