The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Long noncoding RNAs regulate adipogenesis
Open accessAbstract
The prevalence of obesity has led to a surge of interest in understanding the detailed mechanisms underlying adipocyte development. Many protein-coding genes, mRNAs, and microRNAs have been implicated in adipocyte development, but the global expression patterns and functional contributions of long noncoding RNA (lncRNA) during adipogenesis have not been explored. Here we profiled the transcriptome of primary brown and white adipocytes, preadipocytes, and cultured adipocytes and identified 175 lncRNAs that are specifically regulated during adipogenesis. Many lncRNAs are adipose-enriched, strongly induced during adipogenesis, and bound at their promoters by key transcription factors such as peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer-binding protein α (CEBPα). RNAi-mediated loss of function screens identified functional lncRNAs with varying impact on adipogenesis. Collectively, we have identified numerous lncRNAs that are functionally required for proper adipogenesis.
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Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
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Self-citationLong Noncoding RNA as Modular Scaffold of Histone Modification Complexes
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Cited by
Long non-coding RNAs: new players in cell differentiation and development
Fatica, A., & Bozzoni, I. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3606 · Cited by 2,980
What we talk about when we talk about fat
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How do lncRNAs regulate transcription?
Long, Y., Wang, X., Youmans, D. T., & Cech, T. R. (2017) · Science Advances · doi:10.1126/sciadv.aao2110 · Cited by 689
Multiple knockout mouse models reveal lincRNAs are required for life and brain development
Sauvageau, M., Goff, L. A., Lodato, S., Bonev, B., Groff, A. F., Gerhardinger, C., Sanchez-Gomez, D. B., Hacisuleyman, E., Li, E., Spence, M., et al. (2013) · eLife · doi:10.7554/elife.01749 · Cited by 678
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Metadata
- Authors
- Sun, L., Goff, L. A., Trapnell, C., Alexander, R., Lo, K. A., Hacisuleyman, E., Sauvageau, M., Tazon-Vega, B., Kelley, D. R., Hendrickson, D. G., Yuan, B., Kellis, M., Lodish, H. F., & Rinn, J. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-02-11
- Volume
- 110
- Issue
- 9
- Pages
- 3387-3392
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1977093862
- Cited by
- 423
- References
- 10
- FWCI
- 28.77
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sun, L., Goff, L. A., Trapnell, C., Alexander, R., Lo, K. A., Hacisuleyman, E., Sauvageau, M., Tazon-Vega, B., Kelley, D. R., Hendrickson, D. G., Yuan, B., Kellis, M., Lodish, H. F., & Rinn, J. L. (2013). Long noncoding RNAs regulate adipogenesis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1222643110
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