The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Specific protein methylation defects and gene expression perturbations in coactivator-associated arginine methyltransferase 1-deficient mice
Open accessAbstract
Arginine methylation has been implicated in the regulation of gene expression. The coactivator-associated arginine methyltransferase 1 (CARM1/PRMT4) binds the p160 family of steroid receptor coactivators (SRCs). This association enhances transcriptional activation by nuclear receptors. Here, we show that embryos with a targeted disruption of CARM1 are small in size and die perinatally. The methylation of two known CARM1 substrates, poly(A)-binding protein (PABP1) and the transcriptional cofactor p300, was abolished in knockout embryos and cells. However, CARM1-dependent methylation of histone H3 was not observed. Furthermore, estrogen-responsive gene expression was aberrant in Carm1 – / – fibroblasts and embryos, thus emphasizing the role of arginine methylation as a transcription activation tag. These findings provide genetic evidence for the essential role of CARM1 in estrogen-mediated transcriptional activation.
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Cites
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Cited by
Protein arginine methyltransferases and cancer
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Self-citationRoles and regulation of histone methylation in animal development
Jambhekar, A., Dhall, A., & Shi, Y. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0151-1 · Cited by 556
Immunoaffinity Enrichment and Mass Spectrometry Analysis of Protein Methylation
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Self-citationRegulation of the p300 HAT domain via a novel activation loop
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Metadata
- Authors
- Yadav, N., Lee, J., Kim, J., Shen, J., Hu, M. C.-T., Aldaz, C. M., & Bedford, M. T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-05-19
- Volume
- 100
- Issue
- 11
- Pages
- 6464-6468
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2070057671
- Cited by
- 287
- References
- 38
- FWCI
- 5.25
- Type
- journal article
- Language
- en
- Open access
- green
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- Yadav, N., Lee, J., Kim, J., Shen, J., Hu, M. C.-T., Aldaz, C. M., & Bedford, M. T. (2003). Specific protein methylation defects and gene expression perturbations in coactivator-associated arginine methyltransferase 1-deficient mice. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1232272100
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